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1. 发明申请

WO2021116960A1 CLASSIFICATION MODELS FOR ANALYZING A SAMPLE 审中-公开
公开(公告)号：WO2021116960A1
公开(公告)日：2021-06-17
申请号：PCT/IB2020/061732
申请日：2020-12-10
申请人： S.D. SIGHT DIAGNOSTICS LTD
发明人： ZAIT, Amir , GLUCK, Dan , HOURI YAFIN, Arnon , BRAILOVSKY, David , ESHEL, Yochay Shlomo , LEVY, Sarah , POLLAK, Joseph Joel
IPC分类号： G06K9/00
摘要： Apparatus and methods are described including analyzing one or more microscopic images of the blood sample using a machine-learning classifier. An entity within the one or more microscopic images is identified using a first classification model, and a first estimated concentration of the entity within the sample is determined, based upon the entity as identified using the first classification model. The entity is identified within the one or more microscopic images using a second classification model, and a second estimated concentration of the entity within the sample is determined, based upon the entity as identified using the second classification model. The first and second estimated concentrations are compared to each other, and, in response to the comparison, a hybrid classification model that is a hybrid of the first and second classification models is used. Other applications are also described.

2. 发明申请

WO2021079306A1 ACCOUNTING FOR ERRORS IN OPTICAL MEASUREMENTS 审中-公开
公开(公告)号：WO2021079306A1
公开(公告)日：2021-04-29
申请号：PCT/IB2020/059925
申请日：2020-10-22
申请人： S.D. SIGHT DIAGNOSTICS LTD
发明人： PECKER, Sharon , ESHEL, Yochay Shlomo , ZAIT, Amir , GLUCK, Dan , YORAV-RAPHAEL, Noam , HOURI YAFIN, Arnon , LEVY SCHREIER, Sarah , POLLAK, Joseph Joel , LEVNER, Daniel , HALPERIN, Yonatan , LEZMY, Natalie , WEISS, Itamar
IPC分类号： G06K9/00 , G01N33/49
摘要： Apparatus and methods are described including placing at least a portion of a blood sample within a sample chamber (52), and acquiring microscopic images of the portion of the blood sample. Candidates of a given entity within the blood sample are identified, within the microscopic image. At least some of the candidates as being the given entity are validated, by performing further analysis of the candidates. A count of the candidates of the given entity is compared to a count of the validated candidates of the given entity, and at least the portion of the sample is invalidated from being used for performing at least some measurements upon the sample, at least partially based upon a relationship between the count of candidates and the count of validated candidates. Other applications are also described.

3. 发明申请

WO2017195205A1 SAMPLE CARRIER FOR OPTICAL MEASUREMENTS 审中-公开
标题翻译：样品载体用于光学测量
公开(公告)号：WO2017195205A1
公开(公告)日：2017-11-16
申请号：PCT/IL2017/050523
申请日：2017-05-11
申请人： S.D. SIGHT DIAGNOSTICS LTD
发明人： POLLAK, Joseph Joel , LEVY SCHREIER, Sarah , ESHEL, Yochay Shlomo , ZAIT, Amir , PECKER, Sharon
IPC分类号： G01N21/03 , G01N33/49
摘要： Apparatus and methods are described for determining a property of a biological sample. A sample carrier (22) includes one or more sample chambers (40) that define at least a first region (42) and a second region (44), the height of the one or more sample chambers varying between the first and second regions in a predefined manner. A computer processor (28) receives data relating to a first optical measurement that is performed upon a portion of the sample that is disposed within the first region, receives data relating to a second optical measurement that is performed upon a portion of the sample that is disposed within the second region, and determines the property of the sample by using a relationship between the first optical measurement, the second optical measurement, and the predefined variation in height between the regions. Other applications are also described.
摘要翻译：描述了用于确定生物样品的性质的设备和方法。样本载体（22）包括限定至少第一区域（42）和第二区域（44）的一个或多个样本室（40），一个或多个样本室的高度在第一和第二区域预定义的方式。计算机处理器（28）接收与第一光学测量有关的数据，所述第一光学测量对布置在第一区域内的样品的一部分执行，接收与第二光学测量有关的数据，所述第二光学测量是对样品的一部分设置在所述第二区域内，并通过使用所述第一光学测量，所述第二光学测量和所述区域之间的所述预定高度变化之间的关系来确定所述样本的性质。还介绍了其他应用程序。

4. 发明申请

WO2017168411A1 IMAGE PROCESSING DEVICE FOR IDENTIFYING BLOOD PARASITES 审中-公开
标题翻译：用于识别血液寄生虫的图像处理装置
公开(公告)号：WO2017168411A1
公开(公告)日：2017-10-05
申请号：PCT/IL2017/050363
申请日：2017-03-23
申请人： S.D. SIGHT DIAGNOSTICS LTD
发明人： ESHEL, Yochay Shlomo , HOURI YAFIN, Arnon , POLLAK, Joseph Joel , BACHAR, Neta , MARCIANO, Annael , LEVY SCHREIER, Sarah
IPC分类号： G02B21/36 , G06K9/00 , G06K9/46 , G01N15/14
摘要： Apparatus and methods are described for use with an output device (34), and a blood sample (12) that was drawn from a subject. A microscope system (10) acquires first and second images of the blood sample at respective times. A computer processor (28) determines whether, between acquisitions of the first and second images, there was relative motion between at least one erythrocyte within the sample and at least one entity within the sample, by comparing the first and second images to one another. At least partially in response thereto, the computer processor determines whether the entity is an extra- erythrocytic or an intra-erythrocytic entity, and generates an output on the output device, at least partially in response thereto. Other applications are also described.
摘要翻译：描述了用于输出设备（34）和从对象抽取的血液样本（12）的设备和方法。显微镜系统（10）分别获取血液样本的第一和第二图像。计算机处理器（28）通过将第一图像和第二图像彼此比较来确定在采集第一图像和第二图像之间是否存在样本内的至少一个红血球与样本内的至少一个实体之间的相对运动。至少部分响应于此，计算机处理器确定实体是红血球细胞实体还是红血球细胞实体，并且至少部分地响应于此而在输出装置上生成输出。还介绍了其他应用程序。

5. 发明申请

WO2017046799A1 METHODS AND APPARATUS FOR DETECTING AN ENTITY IN A BODILY SAMPLE 审中-公开
标题翻译：用于检测生物样品中的实体的方法和装置
公开(公告)号：WO2017046799A1
公开(公告)日：2017-03-23
申请号：PCT/IL2016/051025
申请日：2016-09-15
申请人： S.D. SIGHT DIAGNOSTICS LTD
发明人： ESHEL, Yochay Shlomo , LEZMY, Natalie , GLUCK, Dan , HOURI YAFIN, Arnon , POLLAK, Joseph Joel
IPC分类号： G02B21/36
CPC分类号： G02B21/365 , G02B21/367
摘要： Apparatus and methods are described including a microscope system (11) configured to acquire one or more microscope images of a bodily sample, an output device (34), and at least one computer processor (28). The computer processor identifies, in the one or more images, at least one element as being a pathogen candidate, and extracts, from the one or more images, at least one candidate-informative feature associated with the pathogen candidate. The compute processor extracts, from the one or more images, at least one sample-informative feature that is indicative of contextual information related to the bodily sample. The computer processor classifies a likelihood of the bodily sample being infected with a pathogenic infection, by processing the candidate-informative feature in combination with the sample- informative feature, and generates an output upon the output device, in response thereto. Other applications are also described.
摘要翻译：描述了包括被配置为获取身体样本的一个或多个显微镜图像，输出装置（34）和至少一个计算机处理器（28）的显微镜系统（11）的装置和方法。所述计算机处理器将所述一个或多个图像中的至少一个元素识别为病原体候选者，并从所述一个或多个图像中提取与所述病原体候选物相关联的至少一个候选信息特征。计算处理器从一个或多个图像提取指示与身体样本相关的上下文信息的至少一个样本信息特征。计算机处理器通过结合采样信息特征处理候选信息特征，将身体样本感染病原体感染的可能性分类，并响应于此在输出设备上生成输出。还描述了其它应用。

6. 发明申请

WO2022009104A2 FOCUSING A MICROSCOPE USING FLUORESCENT IMAGES 审中-公开
公开(公告)号：WO2022009104A2
公开(公告)日：2022-01-13
申请号：PCT/IB2021/056073
申请日：2021-07-07
申请人： S.D. SIGHT DIAGNOSTICS LTD
发明人： ZAIT, Amir , HOURI YAFIN, Arnon , PADAN, Roi , GLUCK, Dan , RIMER, Ofir , GROSS, Sar , OFER, Lior , ESHEL, Yochay Shlomo , LEVY, Sarah , POLLAK, Joseph Joel
IPC分类号： G02B21/16 , G01N15/14 , G01N21/64 , G02B21/24 , G02B21/36
摘要： Apparatus and methods are described for use with a microscope (24) that acquires images of a bodily sample disposed in a sample carrier (22). A fluorescent, microscopic image of a given x-y region is acquired, while a focal plane of the microscope (24) is set at an estimated optimum focal plane. A focusing region-of-interest is identified within the acquired image, based on fluorescent entities that are disposed within the focusing region-of interest. A set of fluorescent focusing images of the region-of-interest are acquired with the microscope (24) focused at respective focusing levels. An optimum focal plane at which to acquire a microscopic image of the region is determined, at least partially based upon a relationship between a contrast-indicative parameter of each of the images and the focusing level at which the microscope (24) was focused when the image was acquired. Other applications are also described.

7. 发明申请

WO2021116957A1 OFF-FOCUS MICROSCOPIC IMAGES OF A SAMPLE 审中-公开
公开(公告)号：WO2021116957A1
公开(公告)日：2021-06-17
申请号：PCT/IB2020/061728
申请日：2020-12-10
申请人： S.D. SIGHT DIAGNOSTICS LTD
发明人： GLUCK, Dan , ZAIT, Amir , HOURI YAFIN, Arnon , HALPERIN, Yonatan , ESHEL, Yochay Shlomo , LEVY, Sarah , POLLAK, Joseph Joel , PECKER, Sharon , YAFIN, Peretz , BENNASSAT, Dana , BRAILOVSKY, David , PUMERANTZ, Uriyah
IPC分类号： G01N15/14
摘要： Apparatus and methods are described use with a bodily sample that contains cells. A microscope (24) is focused, such that a focal plane of the microscope (24) at least approximately coincides with a level at which at least some cells belonging to the sample are at least partially disposed. At least one on-focus microscopic image of the sample, while the focal plane of the microscope (24) approximately coincides with the level. The microscope (24) is focused such that the focal plane of the microscope is offset with respect to the level, at least one off-focus microscopic image of the sample is acquired, while the focal plane of the microscope (24) is offset with respect to the level. A property of at least a portion of the sample is determined, at least partially based upon the on-focus and off-focus images. Other applications are also described.

8. 发明申请

WO2017195208A1 PERFORMING OPTICAL MEASUREMENTS ON A SAMPLE 审中-公开
标题翻译：在样品上进行光学测量
公开(公告)号：WO2017195208A1
公开(公告)日：2017-11-16
申请号：PCT/IL2017/050526
申请日：2017-05-11
申请人： S.D. SIGHT DIAGNOSTICS LTD
发明人： ZAIT, Amir , HOURI YAFIN, Arnon , GLUCK, Dan , PECKER, Sharon , ESHEL, Yochay Shlomo , LEVY SCHREIER, Sarah , POLLAK, Joseph Joel
IPC分类号： G01N33/50 , G01N33/49 , G01N21/49
摘要： Apparatus and methods are described for use with a blood sample (48, 50), including measuring hemoglobin concentration within at least a portion (48) of the blood sample, by performing a first measurement on the blood sample. Mean corpuscular hemoglobin in the blood sample (48, 50) is measured, by performing a second measurement on the blood sample (48, 50). A parameter of the blood sample is determined, based on a relationship between the concentration of hemoglobin and the mean corpuscular hemoglobin. Other applications are also described.
摘要翻译：描述了与血液样品（48,50）一起使用的设备和方法，包括通过对血液进行第一次测量来测量血液样品的至少一部分（48）内的血红蛋白浓度样品。通过对血液样本（48,50）进行第二次测量，测量血液样本（48,50）中的平均血球血红蛋白。基于血红蛋白浓度与平均红细胞血红蛋白之间的关系确定血液样品的参数。还介绍了其他应用程序。

9. 发明申请

WO2016030897A1 SYSTEM AND METHOD FOR CALCULATING FOCUS VARIATION FOR A DIGITAL MICROSCOPE 审中-公开
标题翻译：用于计算数字显微镜聚焦变化的系统和方法
公开(公告)号：WO2016030897A1
公开(公告)日：2016-03-03
申请号：PCT/IL2015/050864
申请日：2015-08-27
申请人： S.D. SIGHT DIAGNOSTICS LTD
发明人： YORAV-RAPHAEL, Noam , WOLFOVITZ, Uri , POLLAK, Joseph Joel
IPC分类号： G06T7/00
CPC分类号： G06T7/0002 , G02B21/244 , G06T2207/10056 , G06T2207/30072
摘要： A digital microscopy method, comprising: obtaining data representative of a series of images of at least a portion of a cell sample, the images being captured by performing a depth scan using a digital microscope, the series of images being associated with a series of depth levels of the cell sample, wherein the portion encompasses a mapping field, and the mapping field comprises a plurality of focus analysis regions; and calculating, using the images, a focus configuration for at least two of the focus analysis regions within the mapping field, giving rise to data indicative of focus variations within the mapping field.
摘要翻译：一种数字显微镜方法，包括：获得表示细胞样品的至少一部分的一系列图像的数据，通过使用数字显微镜执行深度扫描来捕获所述图像，所述一系列图像与一系列深度相关联所述小区样本的级别，其中所述部分包含映射字段，并且所述映射字段包括多个焦点分析区域; 以及使用所述图像计算所述映射场内的所述焦点分析区域中的至少两个的焦点配置，从而产生指示所述映射场内的焦点变化的数据。

10. 发明申请

WO2021116955A1 DETECTING PLATELETS IN A BLOOD SAMPLE 审中-公开
公开(公告)号：WO2021116955A1
公开(公告)日：2021-06-17
申请号：PCT/IB2020/061724
申请日：2020-12-10
申请人： S.D. SIGHT DIAGNOSTICS LTD
发明人： YAFIN, Peretz , GLUCK, Dan , ZAIT, Amir , ESHEL, Yochay Shlomo , LEVY, Sarah , POLLAK, Joseph Joel
IPC分类号： G01N33/49 , G01N15/14 , G01N15/00 , G01N15/10
摘要： Apparatus and methods are provided including imaging a blood sample that is a cell suspension deposited in a sample chamber. The cells are allowed to settle in the sample chamber to form a monolayer of cells. At least one microscopic image is acquired of the monolayer of cells using a microscope (24) while the microscope is focused at a monolayer-depth-level, and a first platelet count of platelets that have settled within the monolayer, is determined. An additional microscopic image of the sample is acquired, while the microscope is focused at a different depth level from the monolayer-depth-level, and a second platelet count of platelets that have not settled within the monolayer is determined. An output is generated based upon the first and second platelet counts. Other applications are also described.

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