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1. 发明申请

WO2021011344A1 DEVICE, SYSTEM, AND METHOD FOR CHANGING ANGLE OF INCIDENCE OF A FILTER OR FILTER WHEEL 审中-公开
公开(公告)号：WO2021011344A1
公开(公告)日：2021-01-21
申请号：PCT/US2020/041523
申请日：2020-07-10
申请人： RARECYTE, INC.
发明人： COOPER, Jeremy, Ryan , STEWART, David
IPC分类号： G02B5/28 , G01N21/43 , G01N21/78
摘要： This disclosure is directed to a system and method for changing an angle of incidence of a filter or filter wheel.

2. 发明申请

WO2020159569A1 SPECTRAL EDGE DETECTION 审中-公开
公开(公告)号：WO2020159569A1
公开(公告)日：2020-08-06
申请号：PCT/US2019/042124
申请日：2019-07-17
申请人： RARECYTE, INC.
发明人： COOPER, Jeremy, Ryan
IPC分类号： G01N21/64
摘要： This disclosure relates generally to detecting multiple biomarkers on or within a sample, though more specifically, to detecting individual detection moieties within a plurality of detection moieties.

3. 发明申请

WO2017192274A1 SOLUTIONS FOR SAMPLE PROCESSING 审中-公开
标题翻译：样品处理解决方案
公开(公告)号：WO2017192274A1
公开(公告)日：2017-11-09
申请号：PCT/US2017/028550
申请日：2017-04-20
申请人： RARECYTE, INC.
发明人： CAMPTON, Daniel
IPC分类号： G01N15/14 , G01N21/64 , G01N33/58 , B82Y5/00 , B82Y15/00 , B82Y30/00
摘要： This disclosure is directed to solutions and methods of using the solutions. A first solution includes a polymer, a polyol, and a buffer. A second solution includes a polymer, a polyol, and an alcohol.
摘要翻译：本公开针对使用该解决方案的解决方案和方法。第一种溶液包括聚合物，多元醇和缓冲剂。第二种解决方案包括聚合物，多元醇和酒精。

4. 发明申请

WO2015080791A1 APPARATUS, SYSTEM, AND METHOD FOR COLLECTING A TARGET MATERIAL 审中-公开
标题翻译：装置，系统和收集目标材料的方法
公开(公告)号：WO2015080791A1
公开(公告)日：2015-06-04
申请号：PCT/US2014/057296
申请日：2014-09-24
申请人： RARECYTE, INC.
发明人： CAMPTON, Daniel , STEWART, David , LUNDT, Jonathan , NORDBERG, Joshua , QUARRE, Steve , SEUBERT, Ronald , U'REN, Lance
IPC分类号： C12M1/26 , C12M1/34
CPC分类号： B01D21/26 , B01D21/262 , B01L3/5021 , B01L3/50215 , B01L3/5635 , B01L9/50 , B01L2200/026 , B01L2300/0672 , B01L2300/0851 , B01L2400/0683
摘要： This disclosure is directed to an apparatus, system and method for retrieving a target material from a suspension. A system includes a processing vessel, such as an Eppendorf tube, a syringe or a test tube, and a collector. The collector is sized and shaped to fit into a primary vessel, such as a test tube. The collector funnels the target material from the suspension through a cannula and into the processing vessel. The cannula extends into a cavity at a first end of the collector that holds the processing vessel. The collector includes a funnel at a second end in fluid communication with the cannula. In one implementation, the processing vessel includes at least one displacement fluid to be expelled, such that the at least one displacement fluid pushes the target material into the collector.
摘要翻译：本公开涉及一种用于从暂停中检索目标材料的装置，系统和方法。系统包括处理容器，例如Eppendorf管，注射器或试管，以及收集器。收集器的尺寸和形状适于装入初级容器，例如试管。收集器通过套管将悬浮液中的目标材料漏出并进入处理容器。套管延伸到容纳处理容器的收集器的第一端处的空腔中。收集器包括在与插管流体连通的第二端的漏斗。在一个实施方案中，处理容器包括要排出的至少一个排出流体，使得至少一个排出流体将目标材料推入收集器。

5. 发明申请

WO2015009431A1 SOLUTION AND METHOD FOR ADHERING SUSPENSION COMPONENTS TO A SUBSTRATE 审中-公开
标题翻译：悬挂组件到底板的方法和方法
公开(公告)号：WO2015009431A1
公开(公告)日：2015-01-22
申请号：PCT/US2014/044686
申请日：2014-06-27
申请人： RARECYTE, INC.
发明人： CAMPTON, Daniel , NORDBERG, Joshua , SEUBERT, Ronald
IPC分类号： G01N1/36 , G02B21/34 , G01N33/49
CPC分类号： G02B21/34 , G01N1/2813
摘要： This disclosure is directed to a method and an attachment solution for adhering a cytological or histological sample, such as buffy coat, to a substrate, such as a microscope slide. The attachment solution includes an attachment base and an anti-coagulant. The attachment base may be an alcohol, an acid, an oxidizer, an organohalogen, a ketone, such as acetone, or any combination thereof, such as Carnoy's solution. Once a sample is obtained, the sample may be re-suspended in the attachment solution or the attachment solution may be added to the sample. The sample may then be dispensed onto an analysis platform as one or more droplets and cured. The sample may be spread on the analysis platform after having been dispensed. The sample may then be fixed, permeabilized, labeled, blocked, and washed. The sample may then be imaged and analyzed.
摘要翻译：本公开涉及用于将细胞学或组织学样品（例如血沉棕黄层）粘附到底物（例如显微镜载玻片）上的方法和附着溶液。附着溶液包括附着基和抗凝剂。附着物可以是醇，酸，氧化剂，有机卤素，酮，如丙酮，或其任何组合，如卡诺伊溶液。一旦获得样品，样品可以重新悬浮在附着溶液中，或者可以将附着溶液加入到样品中。然后将样品作为一个或多个液滴分配到分析平台上并固化。样品在分配后可能会分散在分析平台上。然后可以将样品固定，透化，标记，封闭和洗涤。然后可以对样品进行成像和分析。

6. 发明申请

WO2014153287A1 DEVICE, SYSTEMS AND METHODS FOR ANALYZING A TARGET ANALYTE 审中-公开
标题翻译：用于分析目标分析仪的设备，系统和方法
公开(公告)号：WO2014153287A1
公开(公告)日：2014-09-25
申请号：PCT/US2014/030502
申请日：2014-03-17
申请人： RARECYTE, INC.
发明人： CAMPTON, Daniel , STILWELL, Jackie Lynn , RAMIREZ, Arturo , CHOW, Jennifer
IPC分类号： G01N33/487 , G01N33/49
CPC分类号： G01N1/4077 , B01L3/50215 , B01L3/50825 , B01L2200/0668 , B01L2300/042 , B01L2300/046 , B01L2300/047 , B01L2400/043 , G01N1/28 , G01N33/487 , G01N33/49 , G01N2001/4083
摘要： This disclosure is directed to a cap for obtaining a target analyte from a suspension. The cap introduces a magnetic field or a magnetic gradient to the tube to draw the target analyte bound to a particle to the cap. In one aspect, a cap includes a magnetic insert and a receiving piece. The magnetic insert includes a stopper and a magnet extending from the stopper; and, the receiving piece, which is configured to hold the magnetic insert, includes a receiving stopper and a sheath. The sheath may include imaging slides on opposite sides of the sheath. In another aspect, the cap may include a stopper and an embedded magnet. The cap may include an analysis piece on a bottom end of the stopper. In yet another aspect, the cap may include a fluid compartment and a filter at a bottom end of the stopper.
摘要翻译：本公开涉及从悬浮液获得目标分析物的盖。帽向管引入磁场或磁梯度，以将与颗粒结合的靶分析物吸引到帽上。一方面，盖包括磁性插入件和接收件。磁性插入件包括止动件和从止动件延伸的磁体; 并且构造成保持磁性插入件的接收片包括接收塞子和护套。护套可以包括在护套的相对侧上的成像载片。在另一方面，盖可以包括止动器和嵌入式磁体。帽可以包括在止动器的底端上的分析片。在另一方面，盖子可以包括在塞子的底端处的流体隔室和过滤器。

7. 发明申请

WO2013158340A1 SYSTEMS AND METHODS FOR SEPARATION AND ANALYSIS OF TARGET ANALYTES 审中-公开
标题翻译：目标分析的分离和分析系统和方法
公开(公告)号：WO2013158340A1
公开(公告)日：2013-10-24
申请号：PCT/US2013/033761
申请日：2013-03-25
申请人： RARECYTE, INC. , SEUBERT, Ronald, C. , LUNDT, Jonathan, E. , NORDBERG, Joshua, J.
发明人： SEUBERT, Ronald, C. , LUNDT, Jonathan, E. , NORDBERG, Joshua, J.
IPC分类号： G01N1/38 , G01N21/64 , G01N33/49 , B01D21/26
CPC分类号： B04B7/08 , B01L3/50215 , B01L2200/0668 , B01L2200/0684 , B01L2400/043 , G01N33/491
摘要： Systems for analyzing multiple target analytes of a suspension include a tube and multiple floats. The target analytes are conjugated with at least one fluorescent marker, and the tube, multiple floats and suspension are centrifuged so that at least a portion of each target analyte is located between the inner wall of the tube and the surface of the respective float. In order to identify each target analyte, the portions of the suspension between the tube and each float is illuminated with one or more channels of excitation light, which causes the at least one fluorescent marker to become excited and emit light at longer wavelengths. One of the target analytes may be used to assess quality control or may aid in a subsequent analysis or diagnosis.
摘要翻译：用于分析悬浮液的多种目标分析物的系统包括管和多个漂浮物。目标分析物与至少一个荧光标记物缀合，并将管，多个浮游物和悬浮液离心，使得每个目标分析物的至少一部分位于管的内壁和相应浮子的表面之间。为了识别每个目标分析物，管和每个浮子之间的悬浮液的部分用一个或多个激发光通道照射，这导致至少一个荧光标记物被激发并发射较长波长的光。目标分析物之一可用于评估质量控制或可能有助于后续分析或诊断。

8. 发明申请

WO2013090189A1 TUBE AND FLOAT SYSTEMS AND METHODS OF USING THE SAME 审中-公开
标题翻译：管和浮标系统及其使用方法
公开(公告)号：WO2013090189A1
公开(公告)日：2013-06-20
申请号：PCT/US2012/068749
申请日：2012-12-10
申请人： RARECYTE, INC. , STILWELL, Jackie L. , RAMIREZ, Arturo , NORDBERG, Joshua , FRIEMEL, Barry
发明人： STILWELL, Jackie L. , RAMIREZ, Arturo , NORDBERG, Joshua , FRIEMEL, Barry
IPC分类号： C12M1/24 , C12M1/42
CPC分类号： C12M47/04
摘要： This disclosure is directed to systems for analyzing target materials of a suspension. In one aspect, the systems include a tube and a float that is at least partially coated with a coating having a high affinity for target analytes of a suspension. The coating provides an adhesion or an attraction force with the target analytes through chemical means. In another aspect, the coating can be a changeable material that when stimulated by application of an appropriate stimulus attracts and/or attaches the target analytes to the coated surface of the float. In another aspect, a coating applied to the float may also be used to form a sealing engagement between the float and the inner surface of the tube in order to inhibit fluids from flowing past the coated float in the tube.
摘要翻译：本公开涉及用于分析悬架的目标材料的系统。在一个方面，所述系统包括至少部分涂覆有对悬浮液的目标分析物具有高亲和力的涂层的管和浮子。涂层通过化学方法提供与目标分析物的粘合或吸引力。在另一方面，涂层可以是可变材料，当通过施加适当的刺激刺激时，吸附和/或将目标分析物附着在浮选的涂覆表面上。在另一方面，施加到浮子上的涂层也可以用于在浮子和管的内表面之间形成密封接合，以便阻止流体流过管中涂覆的浮子。

9. 发明申请

WO2021206768A1 OPTICAL TRAINS FOR IMAGING SYSTEMS AND SPECTRAL EDGE DETECTION 审中-公开
公开(公告)号：WO2021206768A1
公开(公告)日：2021-10-14
申请号：PCT/US2020/066873
申请日：2020-12-23
申请人： RARECYTE, INC.
发明人： COOPER, Jeremy, Ryan , STEWART, David
IPC分类号： G02B21/16 , G01N21/64 , G02B7/00 , G02B21/36
摘要： This disclosure relates generally to optical trains for imaging systems. More particularly, this disclosure relates to imaging systems configured to limit optical aberrations. Furthermore, this disclosure relates to methods of limiting optical aberrations in imaging systems configured for imaging a sample, though more specifically, for detecting individual detection moieties within a plurality of detection moieties.

10. 发明申请

WO2020185585A1 DEVICE, SYSTEM, AND METHOD FOR SELECTING A TARGET ANALYTE 审中-公开
公开(公告)号：WO2020185585A1
公开(公告)日：2020-09-17
申请号：PCT/US2020/021452
申请日：2020-03-06
申请人： RARECYTE, INC.
发明人： QUARRE, Steve , SEUBERT, Ronald, C.
IPC分类号： B01L3/02 , G01N1/14
摘要： This disclosure is directed to a device and a system for picking a target material from a sample.

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