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1. 发明申请

WO2023002215A1 BREATH SAMPLING DEVICE 审中-公开
公开(公告)号：WO2023002215A1
公开(公告)日：2023-01-26
申请号：PCT/GB2022/051927
申请日：2022-07-22
申请人： OWLSTONE MEDICAL LIMITED
发明人： JESSOP, David , ALLSWORTH, Max
IPC分类号： A61B10/00
摘要： The present techniques relate to sampling devices, and in particular to breath sampling devices. We describe a computer-implemented method of designing a breath sampling device comprising a housing through which a substantial portion of an exhaled breath passes and sorbent material which extends across a cross-section of the housing. The method comprises identifying a plurality of parameters of the device which are variable with different designs of the breath sampling device and selecting values of the plurality of parameters which maximise a global fitness value. The plurality of parameters comprises at least two of mass of the sorbent material, size of the sorbent material, thickness of the sorbent material, breakthrough volume and flowrate within the device.

2. 发明申请

WO2019106373A1 SPECTROMETRY SYSTEM 审中-公开
公开(公告)号：WO2019106373A1
公开(公告)日：2019-06-06
申请号：PCT/GB2018/053460
申请日：2018-11-29
申请人： OWLSTONE MEDICAL LIMITED , OWLSTONE INC.
发明人： ALLSWORTH, Max , FEW, Julian William , SILLERO, Isabel Marguez , PEARSON, Jon
IPC分类号： G01N27/62
摘要： We describe a method and apparatus for detecting humidity using a Field Asymmetric Ion Mobility Spectrometry (FAIMS) system. The system may comprise an ionizer for generating ions within a gas sample, wherein each ion has an associated ion mobility; an ion filter for separating the ions by applying a compensation field and a dispersion field to the generated ions; a detector for detecting an output from the ion filter; and a processor. The processor may be configured to extract a spectrum of peak intensity of the detected output as a function of the compensation field and the dispersion field; calculate a turning point for the extracted spectrum; determine operating parameters of the field asymmetric ion mobility system; obtain, from a database, a plurality of known turning points each of which have an associated humidity and each of which were obtained using a field asymmetric ion mobility system having operating parameters aligned with the determined operating parameters; and determine the humidity by comparing the calculated turning point with known turning points.

3. 发明申请

WO2017187120A1 SYSTEMS AND DEVICE FOR CAPTURING BREATH SAMPLES 审中-公开
标题翻译：用于捕获呼吸样本的系统和设备
公开(公告)号：WO2017187120A1
公开(公告)日：2017-11-02
申请号：PCT/GB2017/050094
申请日：2017-01-16
申请人： OWLSTONE MEDICAL LIMITED
发明人： ALLSWORTH, Max , APTHORP, Duncan , VANDERSCHEE, Marc , SMITH, Rob , BOSCHMANS, Jasper , KITCHEN, Simon
IPC分类号： A61B5/097 , A61B5/08
摘要： There is provided a device (10) for collecting a breath portion from a patient for analysis, comprising a housing structure including an inlet port (30) associated with a mask structure for receiving a portion of the patient's breath, at least one sensor (22) operatively coupled to the inlet port (30) for detecting one or more parameters regarding the patient's breath, at least one collection container (20) for collecting a portion of the patient's breath received in the inlet port (30), at least one pump (28) for pumping a selective portion of the patient's breath from the inlet port (30) to the at least one collection container (20) and a control system (32) for controlling operation of the at least one sensor and at least one pump (30). The control system (32) selectively operates the pump based on sensed parameters such as CO 2 and/or pressure to collect breath samples.
摘要翻译：提供了一种用于从患者收集呼吸部分用于分析的装置（10），包括壳体结构，该壳体结构包括与面罩结构相关联的入口端口（30），用于接收患者的一部分呼吸;至少一个传感器（22），其可操作地耦合到所述入口端口（30），用于检测关于患者呼吸的一个或多个参数;至少一个收集容器（20），用于收集在所述入口端口中接收的患者呼吸的一部分（30）;至少一个泵（28），用于将患者呼吸的选择性部分从入口端口（30）泵送至至少一个收集容器（20）;以及控制系统（32），用于控制至少一个传感器和至少一个泵（30）。控制系统（32）基于感测的参数（例如CO 2和/或压力）选择性地操作泵以收集呼吸样本。

4. 发明申请

WO2020240201A1 SENSOR SYSTEM 审中-公开
公开(公告)号：WO2020240201A1
公开(公告)日：2020-12-03
申请号：PCT/GB2020/051308
申请日：2020-05-29
申请人： OWLSTONE MEDICAL LIMITED , OWLSTONE INC.
发明人： ALLSWORTH, Max
IPC分类号： G01N27/62
摘要： The present disclosure relates to sensor systems and methods for analysing fluid samples. The sensor system comprises a housing (220) having an inlet for a fluid sample to enter the housing, an outlet for the fluid sample to exit the housing, and a fluid sample path within the housing for the fluid sample to flow between the inlet and the outlet. The sensor system also comprises an ionizer (210) which is external to the housing and which is for ionizing the fluid sample at a first location on the fluid sample path to generate sample ions, an ion mobility filter (212) which is at least partially located within the housing and which is for filtering the generated sample ions at a second location on the fluid sample path, and a detector (214) which is external to the housing and which is for detecting the sample ions which pass through the ion mobility filter at a third location on the fluid sample path.

5. 发明申请

WO2019016530A1 WAVEFORM GENERATOR, SYSTEM AND METHOD 审中-公开
公开(公告)号：WO2019016530A1
公开(公告)日：2019-01-24
申请号：PCT/GB2018/052014
申请日：2018-07-16
申请人： OWLSTONE MEDICAL LIMITED , OWLSTONE INC.
发明人： PEARSON, Jonathan , NEGRI, Antoni
IPC分类号： H03K3/57
摘要： A waveform generator (200) configured to generate two waveforms (211, 213) of opposite polarity so as to provide a voltage gain across a load (207). The waveform generator (200) has a primary side circuit comprising a first inductor (201). The waveform generator (200) has a secondary side circuit comprising a second inductor (203), a first output region (231) conductively coupled to the load (207), and a second output region (233) conductively coupled to the load (207). The second inductor (203) is inductively coupled to the first inductor (201). The first inductor (201) is conductively coupled to the first output region (231) so as to supply a first (211) of the two waveforms (211, 213) to the load (207). The second inductor (203) is conductively coupled to the second output region (233) so as to supply a second (213) of the two waveforms (211, 213) to the load (207). A system (500) incorporating the waveform generator (200) and a method of driving the waveform generator (200) are also provided.

6. 发明申请

WO2023084219A1 ASSAY 审中-公开
公开(公告)号：WO2023084219A1
公开(公告)日：2023-05-19
申请号：PCT/GB2022/052849
申请日：2022-11-10
申请人： OWLSTONE MEDICAL LIMITED
发明人： LABUSHAGNE, Christiaan
IPC分类号： C12Q1/54 , G01N33/574 , A61K31/70 , C12Q1/34
摘要： A method for the detection or prognosis of cancer comprising; administering an exogenous substrate in combination with a sugar to a subject, measuring the concentration of a metabolite of said substrate in a biological sample that has been obtained from said subject. The invention extends to a kit comprising an exogenous substrate, a sugar and a device for obtaining a biological sample from a subject, and a composition comprising an exogenous compound and a sugar.

7. 发明申请

WO2019145678A1 APPARATUS AND METHOD FOR OBTAINING A BREATH SAMPLE 审中-公开
公开(公告)号：WO2019145678A1
公开(公告)日：2019-08-01
申请号：PCT/GB2019/050112
申请日：2019-01-16
申请人： OWLSTONE MEDICAL LIMITED
发明人： ALLSWORTH, Max , APTHORP, Duncan , BICKERSTAFFE, Jeremy , COX, Michael , GORDON, Patrick , KARECLA, Georgina , KITCHEN, Simon , SPINKS, Jeremy , TAYLOR, Alastair
IPC分类号： A61B5/097 , A61B5/083 , A61B5/087 , A61B5/11 , A61B5/00
CPC分类号： A61B5/097 , A61B5/0836 , A61B5/087 , A61B5/1116 , A61B5/746 , A61B2562/24
摘要： Disclosed is apparatus for use in obtaining a breath sample from a mammalian, preferably human, subject, the apparatus comprising: a headset which is attachable to the subject; a separate suction pump; and an umbilical connecting the suction pump to the headset so as to allow the suction pump to create a lower than ambient pressure within the headset; wherein the headset comprises: a mask piece which fits over the nostrils and mouth of the subject; at least one breath sample capture device, and at least one valve to regulate the passage of gas into the sample capture device.

8. 发明申请

WO2019058115A1 SPECTROMETRY SYSTEM 审中-公开
公开(公告)号：WO2019058115A1
公开(公告)日：2019-03-28
申请号：PCT/GB2018/052675
申请日：2018-09-19
申请人： OWLSTONE MEDICAL LIMITED , OWLSTONE INC.
发明人： ALLSWORTH, Max
IPC分类号： G01N27/62
CPC分类号： G01N27/624
摘要： A spectrometry system is provided. The spectrometry system has an ionizer (210) for generating ions within a sample with an associated ion mobility. The spectrometry system has an excitation source (240) for generating an excitation signal to modulate the ion mobility associated with ions from a target chemical within the gas sample. The spectrometry system has an ion filter (220) for separating the ions having modulated ion mobility from the gas sample. The spectrometry system has a detector (230) for detecting an output from the ion filter (220).

9. 发明申请

WO2023062386A1 METHOD FOR THE SYNTHESIS OF EVOC PROBES 审中-公开
公开(公告)号：WO2023062386A1
公开(公告)日：2023-04-20
申请号：PCT/GB2022/052621
申请日：2022-10-14
申请人： OWLSTONE MEDICAL LIMITED
发明人： ALLSWORTH, Max , LABUSHAGNE, Christiaan
IPC分类号： C07H15/04 , A61K31/7012 , A61P35/00
摘要： A process for the synthesis of a glycoside, comprising the step of; performing hydrolysis of a methyl ester glycoside in the presence of a base in water, to form a glycoside, wherein the propensity to reform the methyl ester glycoside is reduced. The invention also extends to methods for the detection or prognosis of cancer using a glycoside obtained by said process.

10. 发明申请

WO2019220145A1 METHOD TO EVALUATE METABOLIC ACTIVITY OF LIVER ENZYMES 审中-公开
公开(公告)号：WO2019220145A1
公开(公告)日：2019-11-21
申请号：PCT/GB2019/051381
申请日：2019-05-17
申请人： OWLSTONE MEDICAL LIMITED
发明人： GAUDE, Edoardo , ALLSWORTH, Max , VAN DER SCHEE, Marc
IPC分类号： C12Q1/26 , G01N33/497
摘要： The invention provides a breath test for assessing a metabolic phenotypeand/or assessing a disease state.

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