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1. 发明申请

WO2023031082A1 DEVICE FOR ADMINISTERING A PHARMACEUTICAL SUSPENSION 审中-公开
公开(公告)号：WO2023031082A1
公开(公告)日：2023-03-09
申请号：PCT/EP2022/073887
申请日：2022-08-29
申请人： NOVO NORDISK A/S
发明人： BENGTSSON, Henrik , DEHLI, Jeppe, Ibsen , HELBO, Janus , EGENFELDT, Svend , WINDUM, Jesper, Peter
IPC分类号： A61M5/20 , A61M5/24 , A61M5/28 , A61M5/31 , A61M5/315
摘要： The present invention provides a dose delivery device (1, 100, 200, 300, 400) comprising: a variable volume reservoir (10, 110, 210, 310, 410) holding a pharmaceutical suspension and comprising an outlet (12, 112, 212, 312, 412), a dose expelling mechanism adapted for activation to expel a volume of the pharmaceutical suspension through the outlet (12, 112, 5 212, 312, 412), and a dose preparation system comprising a preparation member (30, 130, 230, 330, 430) operable prior to activation of the dose expelling mechanism to enable administration of the volume of the pharmaceutical suspension to a subject, wherein the dose preparation system further comprises an agitation member (40, 140, 240, 340, 440) capable of agitating relative motion with respect to the variable volume reservoir (10, 110, 210, 310, 10 410), the agitating relative motion causing a re-suspending agitation of the pharmaceutical suspension, and wherein the agitation member (40, 140, 240, 340, 440) is operatively coupled with the preparation member (30, 130, 230, 330, 430) and configured to undergo said agitating relative motion in response to the operation of the preparation member (30, 130, 230, 330, 430).

2. 发明申请

WO2023285580A1 TABLET COMPRISING A SALT OF N-(8-(2-HYDROXYBENZOYL)AMINO)CAPRYLIC ACID 审中-公开
公开(公告)号：WO2023285580A1
公开(公告)日：2023-01-19
申请号：PCT/EP2022/069704
申请日：2022-07-14
申请人： NOVO NORDISK A/S
发明人： VILHELMSEN, Thomas , CHRISTENSEN, Isabell, Vargas
IPC分类号： A61K9/20 , A61K31/00 , A61P3/04 , A61P3/10 , C07C235/60
摘要： The invention relates to a tablet comprising a salt of N-(8-(2-hydroxybenzoyl)amino)caprylic acid. The invention further relates to processes for the preparation such a tablet, and its use in medicine.

3. 发明申请

WO2022234032A2 METHODS AND SYSTEMS FOR ESTIMATING FASTING GLUCOSE VALUES 审中-公开
公开(公告)号：WO2022234032A2
公开(公告)日：2022-11-10
申请号：PCT/EP2022/062183
申请日：2022-05-05
申请人： NOVO NORDISK A/S
发明人： BENGTSSON, Henrik , ARADÓTTIR, Tina, Björk , ENGELL, Sarah, Ellinor , MAHMOUDI, Zeinab , RYDE, Thomas, Emil , LIANG, Bo
IPC分类号： G16H20/17 , A61B5/00 , A61M5/00 , G06N3/00 , G06N20/00 , G16H50/20 , G16H50/30 , A61B5/145 , A61M5/172 , A61B5/14532 , A61B5/7221 , A61B5/7267
摘要： A method for estimating a fasting blood glucose (FBG) value for a subject, comprising the steps of obtaining a first data set representing a blood glucose history (BGH), obtaining a second data set representing a basal insulin injection history (IH) of the subject, and based on BGH and IH and using a mathematical model: calculating a predicted FBG for the time t+1, where t+1 is the current time. The method comprises the further steps of obtaining at time t+1 a current measured FBG from the subject, and based on the predicted FBG and the current measured FBG: calculating an updated estimated FBG.

4. 发明申请

WO2022175242A1 DRUG DELIVERY DEVICE FOR DELIVERING A PREDEFINED FIXED DOSE 审中-公开
公开(公告)号：WO2022175242A1
公开(公告)日：2022-08-25
申请号：PCT/EP2022/053627
申请日：2022-02-15
申请人： NOVO NORDISK A/S
发明人： KVOLSBJERG, Bo , VILLADSEN, Nicolai, Michael
IPC分类号： A61M5/20 , A61M5/32 , A61M5/315
摘要： 1. A drug delivery device for delivering a plurality of fixed doses of a medicament, wherein the drug delivery device comprises a needle magazine with a plurality of needle assemblies, a needle positioning mechanism, a drive mechanism for delivering a fixed dose of the plurality of fixed doses, in response to activation, an activation mechanism for activating the drive mechanism comprising a movable shield (110, 310), wherein the shield (110, 310) is adapted to activate the drive mechanism, in response moving the shield to the proximal position. The drug delivery device further comprises a drop lock mechanism comprising a non-blocking state and a blocking state.

5. 发明申请

WO2022162103A1 MEDICAL DEVICE WITH FLUID ACIVATED ACTUATION MECHANISM 审中-公开
公开(公告)号：WO2022162103A1
公开(公告)日：2022-08-04
申请号：PCT/EP2022/051968
申请日：2022-01-27
申请人： NOVO NORDISK A/S
发明人： SIGURDARSON, Nökkvi, Steinn
IPC分类号： A61M31/00 , A61J3/07 , A61M5/20 , A61M37/00
摘要： A capsule device (100), comprising: a) a capsule housing (110, 120) having proximal and distal ends and defining a main axis, the capsule housing comprising a plurality of retainer portions (113a) distributed around the main axis, and b) an actuation mechanism (140, 150) operable between a pre-actuation configuration and an actuating configuration, wherein the actuation mechanism (140, 150) comprises: b1) an actuation member (150) configured for axial distal movement, the actuation member (150) comprising a base portion (151) and a plurality of radially deflectable latch arms (153) extending proximally therefrom, wherein each latch arm (153) defines a radially inwards facing latch surface (153b) being inclined with respect to the axis and a radially outwards facing latch surface (153a) in retaining engagement with a respective retainer portion (113a) of the capsule housing (110, 120), b2) a drive spring (140) exerting mechanical load onto the actuation member (150) for driving the actuation member axially in the distal direction, and b3) a dissolvable latch support (160) having radially outwards facing surfaces (163b) being inclined relative to the axis, wherein the dissolvable latch support (160) is arranged centrally on-axis and wherein the plurality of radially deflectable latch arms (163) are distributed around the main axis so that each latch arm (163) is releasably retained radially between a respective one of said inclined outwards facing surfaces (163b) of the dissolvable latch support (160) and a respective one the retainer portions (113a).

6. 发明申请

WO2022162102A1 MEDICAL DEVICE WITH IMPROVED ACTUATION MECHANISM 审中-公开
公开(公告)号：WO2022162102A1
公开(公告)日：2022-08-04
申请号：PCT/EP2022/051967
申请日：2022-01-27
申请人： NOVO NORDISK A/S
发明人： SIGURDARSON, Nökkvi, Steinn , HOUGAARD, Finn
IPC分类号： A61J3/07 , A61M31/00
摘要： A capsule device (100) suitable for ingestion for travelling into a lumen of the gastrointestinal tract of a patient, the lumen having a lumen wall, wherein the capsule device (100) is configured as a self-righting capsule comprising: a) a capsule housing (110, 120) comprising a compartment and an exterior tissue engaging surface (123) defining an exit opening (124) leading from the compartment to the capsule exterior, b) a tissue penetrating member (130) arranged along an axis and configured to be advanced axially from a first position in the compartment through the exit opening (124) and into the lumen wall at a target location, and c) an actuator (140, 150) for coupling to the tissue penetrating member (130), the actuator (140, 150) configured, upon actuation, to move from the a first configuration to a second configuration thereby advancing the tissue penetrating member (130) axially from the first position and into the lumen wall, wherein the actuator (140, 150) comprises a spring (140) formed as a tapered helical tension spring, the spring (140) having a wide first end coupled to the capsule housing (110, 120) and a narrow second end that couples to the tissue penetrating member (130), wherein, in the first configuration, accumulated tension in the spring (140) is maintained, and wherein, upon actuation, accumulated tension in the spring (140) is released thereby moving the actuator (140, 150) towards the second configuration.

7. 发明申请

WO2022069605A1 A SWALLOWABLE CAPSULE DEVICE 审中-公开
公开(公告)号：WO2022069605A1
公开(公告)日：2022-04-07
申请号：PCT/EP2021/076892
申请日：2021-09-29
申请人： NOVO NORDISK A/S
发明人： WATER, Jorrit, Jeroen , MOURIDSEN, Brian , STICKER, Drago , GHAZAL, Aghiad , BOHR, Adam, Jun , JEPSEN, Jacob, Pyung, Hwa , HERSKIND, Peter , CLEVELAND, Cody, Edward , LAURSEN, Jens, Lolle
IPC分类号： A61M31/00
摘要： A capsule device (10) suitable for swallowing into a lumen of an intestinal tract of a patient comprises a housing section (12), a delivery outlet (20) for jet injection by a delivery assembly (22), an expansion assembly (26) and an expansion control mechanism (30). The expansion section (28) is arranged laterally opposite to and physically separated from the delivery outlet (20). An expansion section (28) of the expansion assembly (26) is laterally expandable from a non-expanded configuration to an expanded configuration for positioning the delivery outlet (20) against the lumen wall (14). The expansion control mechanism (30) is configured to activate the expansion assembly (26) under a predetermined condition to permit change of the expansion section (28) from the non-expanded configuration to the expanded configuration.

8. 发明申请

WO2022069604A1 LUMEN INSERTABLE CAPSULE 审中-公开
公开(公告)号：WO2022069604A1
公开(公告)日：2022-04-07
申请号：PCT/EP2021/076891
申请日：2021-09-29
申请人： NOVO NORDISK A/S
发明人： MOURIDSEN, Brian , STICKER, Drago , GHAZAL, Aghiad , LARSEN, André , JEPSEN, Jacob, Pyung, Hwa
IPC分类号： A61M31/00
摘要： A capsule device (100) suitable for insertion into a lumen, such as a gastrointestinal lumen, of a subject. The capsule device (100) comprises: a capsule housing (110, 120), a drug chamber (B) configured to accommodate a drug substance, the drug chamber leading to a drug outlet (190), - an actuation chamber (A), - a movable separator (160) arranged between the actuation chamber and the drug chamber, wherein movement of the movable separator expels drug substance from the drug chamber (B) through the drug outlet (190), and - a gas generator (140, 150) configured actuatable to generate pressurized gas in the actuation chamber (A) for exerting mechanical load on the moveable separator (160) to expel the drug substance. A burst gate (170) is arranged between the gas generator (140, 150) and the movable separator (160), the burst gate (170) configured to release mechanical load onto the movable separator (160) upon increase in gas pressure in the actuation chamber (A) above a threshold pressure level to thereby initiate expelling of the drug substance.

9. 发明申请

WO2022018186A1 CO-AGONISTS AT GLP-1 AND GIP RECEPTORS SUITABLE FOR ORAL DELIVERY 审中-公开
公开(公告)号：WO2022018186A1
公开(公告)日：2022-01-27
申请号：PCT/EP2021/070485
申请日：2021-07-22
申请人： NOVO NORDISK A/S
发明人： KNERR, Patrick, J. , FINAN, Brian , DIMARCHI, Richard , LINDEROTH, Lars
IPC分类号： C07K14/605 , A61K38/26 , A61P1/16 , A61P3/04 , A61P3/10
摘要： Peptide co-agonists of the human GLP-1 and GIP receptors suitable for oral delivery, including long-acting derivatives, and their medical use in treatment and/or prevention of obesity, diabetes, and/or liver diseases are described.

10. 发明申请

WO2021249967A1 AN INJECTION DEVICE WITH A CLEANING RESERVOIR 审中-公开
公开(公告)号：WO2021249967A1
公开(公告)日：2021-12-16
申请号：PCT/EP2021/065214
申请日：2021-06-08
申请人： NOVO NORDISK A/S
发明人： PEDERSEN, Simon, Munch
IPC分类号： A61M5/00 , A61M5/315 , A61M5/32 , A61M5/24 , A61M2005/2474 , A61M2005/31521 , A61M2005/3267 , A61M5/001 , A61M5/31548 , A61M5/3202 , A61M5/326 , A61M5/3293
摘要： The invention relates to an injection device wherein the distal tip of the needle cannula is cleaned between subsequent injections. The cleaning is executed in a cleaning chamber carried by a telescopically movable needle shield. The radial walls of the cleaning chamber are according to the present invention provided with one or more ring-shaped trenches or ridges to prevent air-bobbles in the liquid drug from obtaining physical contact with the needle cannula.

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