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1. 发明申请

WO2016168343A1 THIOCYANATE SALTS FOR ANTI-INFLAMMATION 审中-公开
标题翻译： THIOCYANATE SALTS FOR Anti-InFLAMMATION
公开(公告)号：WO2016168343A1
公开(公告)日：2016-10-20
申请号：PCT/US2016/027348
申请日：2016-04-13
申请人： NATIONAL JEWISH HEALTH , AEOLUS PHARMACEUTICALS, INC.
发明人： DAY, Brian, J. , MCMANUS, John
IPC分类号： A61K31/4164 , A61K31/4425 , C07D487/22
CPC分类号： C07D487/22
摘要： Described herein, inter alia , are thiocyanate salt compositions and methods for treating or preventing inflammation using the same.
摘要翻译：本文所描述的是硫氰酸盐组合物和使用其的治疗或预防炎症的方法。

2. 发明申请

WO2015034777A1 METHODS OF TREATING BIOFILMS 审中-公开
标题翻译：处理生物膜的方法
公开(公告)号：WO2015034777A1
公开(公告)日：2015-03-12
申请号：PCT/US2014/053436
申请日：2014-08-29
申请人： BIOMIMETIX J.V., LLC , NATIONAL JEWISH HEALTH
发明人： CRAPO, MD, James, D. , REGAN, Elizabeth , LINDSAY, Sarah
IPC分类号： A61K31/555 , A01N25/00 , C02F1/00 , C09K8/00 , C11D3/00 , A61P31/00 , A61P31/04 , A61P43/00
CPC分类号： A61K31/555 , A01N55/02 , A01N59/16 , A01N59/20 , A61K8/19 , A61K8/494 , A61K8/58 , A61K45/06 , A61K2800/58 , A61Q11/00 , C02F1/30 , C02F1/32 , C02F1/50 , C02F5/12 , C02F2103/026 , C02F2103/42 , C02F2303/04 , C02F2303/20 , C02F2305/04 , C02F2307/14 , C09K8/035 , C09K8/524 , C11D3/0078 , Y02A50/473 , A61K2300/00 , A01N43/713 , A01N2300/00
摘要： A method of treating or preventing a condition caused by a biofilm in a subject is carried out by: providing a subject having, or susceptible to, a condition mediated by a biofilm produced by a microorganism, where the biofilm comprises a matrix and the microorganism on a surface and administering to the subject an active agent under conditions effective for the condition caused by a biofilm in the subject to be treated or prevented, where the active agent is a compound of general Formula (I): or a pharmaceutically acceptable salt thereof.
摘要翻译：通过以下方式进行治疗或预防由生物膜引起的病症的方法：提供具有由微生物产生的生物膜介导的病症或易受其影响的受试者，其中生物膜包含基质，微生物在或其药学上可接受的盐，其中所述活性剂在通常被治疗或预防的受试者中由生物膜引起的病症有效的条件下给予受试者活性剂。

3. 发明申请

WO2014089327A1 TREATMENT FOR AIRWAY CAST OBSTRUCTION 审中-公开
标题翻译：空中客车施工的处理
公开(公告)号：WO2014089327A1
公开(公告)日：2014-06-12
申请号：PCT/US2013/073372
申请日：2013-12-05
申请人： NATIONAL JEWISH HEALTH
发明人： WHITE, Carl, W. , VERESS, Livia, A.
IPC分类号： A61K35/12 , C12Q1/56
CPC分类号： C12N9/6459 , A61K9/0078 , A61K38/482 , A61K38/49 , C12N9/6462 , C12Y304/21068 , C12Y304/21073
摘要： The present invention is directed to methods of treatment of airway obstruction associated with fibrin-containing cast formation by administering a fibrinolytic agent.
摘要翻译：本发明涉及通过施用纤维蛋白溶解剂治疗与含纤维蛋白的铸造形成相关的气道阻塞的方法。

4. 发明申请

WO2011115793A1 AIRWAY ANCHOR SUTURE TO PREVENT AIRWAY STENT MIGRATION 审中-公开
标题翻译： AIRWAY锚栓防止空中移动
公开(公告)号：WO2011115793A1
公开(公告)日：2011-09-22
申请号：PCT/US2011/027688
申请日：2011-03-09
申请人： NATIONAL JEWISH HEALTH , MUSANI, Ali, I.
发明人： MUSANI, Ali, I.
IPC分类号： A61F2/20
CPC分类号： A61B17/0401 , A61B2017/0406 , A61B2017/0411 , A61B2017/0417 , A61B2017/0464 , A61B2017/0488 , A61B2017/06052 , A61F2/04 , A61F2002/046
摘要： An airway stent with an integral suture anchor is used to prevent migration of the stent within the airway. The suture anchor is incorporated by percutaneous placement of a suture through the neck and into the stent. The distal end of the suture includes an anchor element to secure the suture to the stent. The opposite end of the suture is tensioned and held in place by a suture clamp and a pledget routed over the stent and placed against the neck. Airway stents such as tracheal stents are effective at maintaining airway patency however; a common complication is stent migration. The integral suture anchor provides a reliable, economical, and non-intrusive solution to stent migration.
摘要翻译：使用具有整体缝合锚的气道支架来防止支架在气道内移动。通过将缝合线穿过颈部经皮放置并穿入支架而并入缝合锚。缝合线的远端包括将缝合线固定到支架上的锚定元件。缝合线的相对端被张紧并通过缝线夹固定在适当的位置，并且穿过支架并将其放置在颈部上。气管支架如气管支架有效维持气道通畅; 常见并发症是支架移植。整体缝合锚钉为支架移植提供了可靠，经济和非侵入性的解决方案。

5. 发明申请

WO2011060093A2 COMPOSITIONS, METHODS AND USES FOR STIMULATING IMMUNE RESPONSES 审中-公开
标题翻译：用于刺激免疫应答的组合物，方法和用途
公开(公告)号：WO2011060093A2
公开(公告)日：2011-05-19
申请号：PCT/US2010/056266
申请日：2010-11-10
申请人： NATIONAL JEWISH HEALTH , LENZ, Laurel L. , SCHMIDT, Rebecca L.
发明人： LENZ, Laurel L. , SCHMIDT, Rebecca L.
IPC分类号： A61K39/00
CPC分类号： C12N9/52 , A61K38/208 , A61K39/0208 , A61K39/39 , A61K45/06 , A61K2039/55516 , A61K2039/57
摘要： Embodiments herein report compositions, methods and uses for inducing an innate immune response in a subject. Embodiments herein also generally report compositions, methods and uses for bacterial-derived peptides to induce an innate immune response in a subject having a bacterial or viral disorder and/or cancer. In certain embodiments, compositions herein concern derivatives of p60 protein of Listeria monocytogenes.
摘要翻译：本文的实施方案报道了在受试者中诱导先天免疫应答的组合物，方法和用途。本文的实施方案还通常报道了细菌衍生肽在具有细菌或病毒病症和/或癌症的受试者中诱导先天免疫应答的组合物，方法和用途。在某些实施方案中，本文的组合物涉及单核细胞增生利斯特氏菌的p60蛋白的衍生物。

6. 发明申请

WO2011025814A1 METHODS AND COMPOSITIONS FOR TREATMENT OF LUNG INJURY 审中-公开
标题翻译：用于治疗肺损伤的方法和组合物
公开(公告)号：WO2011025814A1
公开(公告)日：2011-03-03
申请号：PCT/US2010/046607
申请日：2010-08-25
申请人： NATIONAL JEWISH HEALTH , DELANGHE, Stijn, P.
发明人： DELANGHE, Stijn, P.
IPC分类号： A61K39/395
CPC分类号： C07K16/2863 , A61K2039/505
摘要： The present invention provides a method to treat a condition related to injury of lung epithelial cells in a subject by administering a compound that binds FgfR2b, for example to promote proliferation of lung epithelial stem cells, as well as such compounds in pharmaceutical formulations. The invention also provides for methods to treat a condition related to injury of lung epithelial cells by isolating cells expressing FgfR2b, multiplying the cells and introducing the multiplied cells for repair of lung injury. Related methods for detecting lung injury by detecting the level of expression of FgfR2b as well as for treating a condition related to proliferation of lung epithelial cells by administering a compound that binds to FgfR2b, to block receptor signaling are also provided.
摘要翻译：本发明提供了通过施用结合FgfR2b的化合物来治疗受试者与肺上皮细胞损伤相关的病症的方法，例如以促进肺上皮干细胞的增殖，以及药物制剂中的这些化合物。本发明还提供了通过分离表达FgfR2b的细胞来治疗与肺上皮细胞损伤相关的病症的方法，使细胞倍增并引入繁殖细胞以修复肺损伤。还提供了通过检测FgfR2b的表达水平以及通过施用与FgfR2b结合的化合物来治疗与肺上皮细胞增殖有关的病症来检测肺损伤的相关方法，以阻断受体信号传导。

7. 发明申请

WO2010016965A2 METHODS FOR TREATING INJURY ASSOCIATED WITH EXPOSURE TO AN ALKYLATING SPECIES 审中-公开
标题翻译：用于治疗与接触物种相关的伤害的方法
公开(公告)号：WO2010016965A2
公开(公告)日：2010-02-11
申请号：PCT/US2009/045198
申请日：2009-05-26
申请人： NATIONAL JEWISH HEALTH , DAY, Brian, J. , WHITE, Carl, W.
发明人： DAY, Brian, J. , WHITE, Carl, W.
CPC分类号： A61K31/4178 , A61K31/409 , A61K31/427 , A61K31/555 , A61K45/06 , A61K2300/00
摘要： Compounds may be administered to prevent or rescue organ injury following exposure to alkylating agents, such as sulfur mustards. The compounds may be substituted metalloporphyrins.
摘要翻译：可以施用化合物以在暴露于烷化剂（例如硫芥末）后预防或抢救器官损伤。化合物可以是取代的金属卟啉。

8. 发明申请

WO2022177897A1 METHODS OF TREATING A SUBJECT EXPOSED TO A TOXIC INHALED CHEMICAL WITH MESNA 审中-公开
公开(公告)号：WO2022177897A1
公开(公告)日：2022-08-25
申请号：PCT/US2022/016445
申请日：2022-02-15
申请人： THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE , NATIONAL JEWISH HEALTH , SOUTH DAKOTA STATE UNIVERSITY
发明人： WHITE, Carl W. , NICK, Heidi , BRATCHER, Preston , LOGUE, Brian
IPC分类号： A61K31/155 , A61K31/18 , A61K33/40
摘要： In one aspect, the present disclosure provides a method of treating a subject exposed to as toxic inhaled chemical, the method comprising administering to the subject a therapeutically effective amount of 2-mercaptoethane sulfonic acid, or a salt or solvate thereof. In some embodiments, the method further comprises administering to the subject a therapeutically effective amount of tissue plasminogen activator. In some embodiments, the toxic inhaled chemical is sulfur mustard, methyl isocyanate, or a combination thereof.

9. 发明申请

WO2022056289A1 METHODS AND COMPOSITIONS FOR TREATING RESPIRATORY DISEASES OR CONDITIONS RELATED TO INNATE LYMPHOID CELLS 审中-公开
公开(公告)号：WO2022056289A1
公开(公告)日：2022-03-17
申请号：PCT/US2021/049909
申请日：2021-09-10
申请人： NATIONAL JEWISH HEALTH
发明人： REINHARDT, R. Lee , MILLER, Mindy
IPC分类号： A61K39/00 , A61K39/395 , A61K45/00 , A61K45/06 , A61P11/00 , A61P35/00
摘要： Disclosed herein are methods and compositions for treating Group 2 innate lymphoid cell (ILC2) mediated diseases or conditions comprising administering a killer cell lectin-like receptor G1 (KLRG1) binding agent or KLRG1 ligand binding agent or antagonist thereof.

10. 发明申请

WO2021202898A1 METHODS OF MAKING PLURIPOTENT STEM CELLS AND USES THEREOF 审中-公开
公开(公告)号：WO2021202898A1
公开(公告)日：2021-10-07
申请号：PCT/US2021/025414
申请日：2021-04-01
申请人： NATIONAL JEWISH HEALTH
发明人： SEIBOLD, Max A. , LI, Yingchun
IPC分类号： A61K48/00 , C12N5/02 , C12N5/071 , C12N15/00 , G01N33/567 , C12N5/00 , C12M1/00
摘要： Disclosed herein are methods to reliably and robustly generate a pure population of airway basal cells that are capable of producing a normal mucociliary epithelium. Such basal cells may be used to treat chronic respiratory diseases, such as cystic fibrosis, chronic obstructive pulmonary disease, and asthma.

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