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1. 发明申请

WO2009066893A3 APPARATUS FOR SUPPLYING AUTOMATICALLY GOLF BALL 审中-公开
公开(公告)号：WO2009066893A3
公开(公告)日：2009-05-28
申请号：PCT/KR2008/006567
申请日：2008-11-07
申请人： KIM, Young Deug
发明人： KIM, Young Deug
IPC分类号： A63B69/36
摘要： An apparatus for automatically supplying a golf ball to an upper portion of a golf tee in a rectangular frame is disclosed. The pusher 20 is connected to a rear end of the golf tee 10 by means of a flexible material, in which the golf tee 10 and the pusher 20 are horizontally and vertically moved to lift or lower the golf ball to the hitting position of the trainee by using guide means 100 for horizontally and vertically guiding the golf tee, the guide means having a guide roller for vertically guiding the golf tee and a guide roller for turning a guide direction, and linearly operating means 200 for moving a fixture 25 back and forth which is installed at a rear end of the pusher 20 by a driving motor M.

2. 发明申请

WO2008044846A1 PEPTIDES HAVING ACTIVITIES OF EPIDERMAL GROWTH FACTOR AND ITS USES 审中-公开
标题翻译：具有活性生长因子活性及其用途的肽
公开(公告)号：WO2008044846A1
公开(公告)日：2008-04-17
申请号：PCT/KR2007/004895
申请日：2007-10-08
申请人： CAREGEN CO., LTD , CHUNG, Yong-Ji , KIM, Young Deug , KIM, Eun Mi , CHOI, Jun Young , SONG, Sang Su
发明人： CHUNG, Yong-Ji , KIM, Young Deug , KIM, Eun Mi , CHOI, Jun Young , SONG, Sang Su
IPC分类号： C07K14/485 , A61K38/00
CPC分类号： C07K14/485 , A61K8/64 , A61K38/00 , A61Q7/00 , A61Q19/00 , A61Q19/08 , Y02P20/55
摘要： The present invention relates to peptides comprising the amino acid sequence represented by the following formula 1 and having the activities of epidermal growth factor and their uses: Cys-Met-Tyr-Ile-Glu-Linker-Arg-Gly-Asp (1) The EGF-mimicking peptides of the present invention possess identical functions or activities to natural-occurring human EGF and are able to promote the generation of autocrine EGF in cells. In addition the peptides of the present invention are much higher stability and skin penetration potency than natural- occurring EGF. Therefore, the composition containing the peptide exhibits excellent treatment and prevention efficacies on diseases or conditions demanding EGF activities, and can be advantageously applied to pharmaceutical compositions, quasi- drugs and cosmetics.
摘要翻译：本发明涉及包含由下式1表示的氨基酸序列并具有表皮生长因子活性及其用途的肽：Cys-Met-Tyr-Ile-Glu-Linker-Arg-Gly-Asp（1）本发明的EGF模拟肽对天然存在的人类EGF具有相同的功能或活性，并且能促进细胞中自分泌EGF的产生。此外，本发明的肽比天然发生的EGF具有更高的稳定性和皮肤穿透效力。因此，含有肽的组合物对于要求EGF活性的疾病或病症表现出优异的治疗和预防功效，并且可以有利地应用于药物组合物，准药物和化妆品。

3. 发明申请

WO1998017638A1 N'alpha'-2-(4-NITROPHENYLSULFONYL)ETHOXYCARBONYL-AMINO ACIDS 审中-公开
标题翻译： Nα-2-（4-硝基苯基）乙氧基羰基氨基酸
公开(公告)号：WO1998017638A1
公开(公告)日：1998-04-30
申请号：PCT/KR1996000179
申请日：1996-10-19
申请人： HYUNDAI PHARM. IND. CO., LTD. , SAMUKOV, Vladimir V. , SABIROV, Aydar N. , POZDNYAKOV, Pavel I. , KIM, Hack-Joo , KIM, Young-Deug
发明人： HYUNDAI PHARM. IND. CO., LTD.
IPC分类号： C07C317/18
CPC分类号： C07C317/18
摘要： Protected amino acid derivatives of general formula (I) wherein R1 represent hydrogen atom, and R2 may represent hydroxymethyl, 1-hydroxyethyl, 4-hydroxybenzyl, imidazolyl-2-methyl, benzyloxymethyl, 1-benzyloxyethyl, 4-benzyloxybenzyl, benzyloxycarbonylmethyl, 2-(benzyloxycarbonyl)ethyl, S-benzylthiomethyl, S-(diphenylmethyl)thiomethyl, 4-(benzyloxycarbamido)butyl, 3-guanidinopropyl, 3-(N -toluenesulfonyl)guanidinopropyl, 3-(N -nitro)guanidinopropyl, 3-[N -(4-methoxy-2,3,6-trimethylbenzenesulfonyl)]-guanidinopropyl, N-(4,4'-dimethoxybenzhydryl)carboxamidomethyl, 2-[N-(4,4'-dimethoxybenzhydryl)carboxamido]ethyl, S-tert-butyldithiomethyl, 4-[2-(4-nitrophenylsulfonyl)ethoxycarbamido]-butyl, propyl, butyl, ethyl, 3-(benzyloxycarbamido)propyl, or 3-(tert-butoxycarbamido)propyl. Methods for the preparation of said derivatives are provided.
摘要翻译：通式（I）的保护性氨基酸衍生物，其中R 1表示氢原子，R 2可以表示羟甲基，1-羟基乙基，4-羟基苄基，咪唑基-2-甲基，苄氧基甲基，1-苄氧基乙基，4-苄氧基苄基，苄氧羰基甲基，（苄氧基羰基）乙基，S-苄硫基甲基，S-（二苯基甲基）硫代甲基，4-（苄氧基氨基甲酰基）丁基，3-胍基丙基，3-（N'-甲苯磺酰基）胍基丙基，3-（硝基），3- [N，N-（4-甲氧基-2,3,6-三甲基苯磺酰基）] - 胍基丙基，N-（4,4'-二甲氧基二苯甲基）羧酰胺基甲基，2- [N-（4,4'-二甲氧基二苯甲基丙基，丁基，乙基，3-（苄氧基氨基甲酰基）丙基或3-（叔丁氧基氨基甲酰氨基）丙基。提供了制备所述衍生物的方法。

4. 发明申请

WO2009125925A3 GROWTH FACTOR-MIMICKING PEPTIDES AND USES THEREOF 审中-公开
标题翻译：生长因子模拟肽及其用途
公开(公告)号：WO2009125925A3
公开(公告)日：2009-12-17
申请号：PCT/KR2009001134
申请日：2009-03-06
申请人： CAREGEN CO LTD , CHUNG YOUNG JI , KIM YOUNG DEUG , KIM EUN MI , CHOI JUN YOUNG
发明人： CHUNG YOUNG JI , KIM YOUNG DEUG , KIM EUN MI , CHOI JUN YOUNG
IPC分类号： C07K14/71
CPC分类号： C07K14/475 , A61K8/64 , A61K38/00 , A61Q7/02 , A61Q19/00 , A61Q19/02 , A61Q19/06 , C07K14/50
摘要： The present invention relates to growth factor-mimicking peptides, and a method and a composition containing the same for improving skin condition or treating a wound. The disclosed growth factor-mimicking peptides have the same functions or activities as a natural human growth factor. Additionally, the peptides ensure excellent stability and skin permeability. Accordingly, the composition containing the peptides exhibits excellent effects on treatment, prevention or improvement of diseases or conditions which are required for activities of the growth factor. Also, the excellent activities and stability of the peptides allow the peptides to be applied to medicines, sanitary aids and cosmetics.
摘要翻译：本发明涉及生长因子模拟肽，以及含有其的用于改善皮肤状况或治疗伤口的方法和组合物。所公开的生长因子模拟肽具有与天然人生长因子相同的功能或活性。此外，这些肽可确保出色的稳定性和皮肤渗透性。因此，含有肽的组合物对于生长因子活性所需的疾病或病症的治疗，预防或改善显示出优异的效果。而且，肽的优异活性和稳定性使肽可以应用于药物，卫生用品和化妆品。

5. 发明申请

WO2007049904A1 PEPTIDES EXHIBITING EFFICACIES OF IMPROVEMENT IN SKIN CONDITIONS OR TREATMENT OF PERIODENTAL DISEASES 审中-公开
标题翻译：皮肤改善皮肤病症或治疗周期性疾病的效果
公开(公告)号：WO2007049904A1
公开(公告)日：2007-05-03
申请号：PCT/KR2006/004350
申请日：2006-10-24
申请人： CAREGEN CO., LTD , CHUNG, Yong ji , KIM, Young deug , KIM, Chung Ryul
发明人： CHUNG, Yong ji , KIM, Young deug , KIM, Chung Ryul
IPC分类号： C07K14/50
CPC分类号： C07K14/503
摘要： The present invention relates to a composition for improving a skin condition or treating a periodontal disease, which comprises as an active ingredient a basic fibroblast growth factor-derived peptide. The peptides of this invention exhibit superior efficacies and much better stability and skin permeation than natural- occurring bFGF. In these connections, the composition comprising the peptides of this invention can exhibit excellent efficacies on improvement in skin conditions and treatment of periodontal diseases. In addition, the peptides of this invention can be advantageously applied to pharmaceutical compositions, cosmetics, toothpaste and compositions for mouth cleaning and caring.
摘要翻译：本发明涉及一种用于改善皮肤状况或治疗牙周病的组合物，其包含作为活性成分的碱性成纤维细胞生长因子衍生肽。与天然存在的bFGF相比，本发明的肽具有优异的功效和更好的稳定性和皮肤渗透性。在这些连接中，包含本发明的肽的组合物可以在改善皮肤状况和治疗牙周病方面表现出优异的效果。此外，本发明的肽可以有利地应用于药物组合物，化妆品，牙膏和用于口腔清洁和护理的组合物。

6. 发明申请

WO2007102686A8 PEPTIDES HAVING ACTIVITIES OF INSULIN LIKE GROWTH FACTOR-1 AND THEIR USES 审中-公开
标题翻译：胰岛素样生长因子-1及其用途的活性肽
公开(公告)号：WO2007102686A8
公开(公告)日：2010-03-04
申请号：PCT/KR2007001086
申请日：2007-03-06
申请人： CAREGEN CO LTD , CHUNG YONG JI , KIM YOUNG DEUG , KIM EUN MI
发明人： CHUNG YONG JI , KIM YOUNG DEUG , KIM EUN MI
IPC分类号： C07K14/65
CPC分类号： C07K14/65 , A61K38/00
摘要： The present invention relates to a peptide having the activity of insulin like growth factor-1 (IGF-I) and derived from IGF-I, a composition for improving skin conditions or treating a periodontal disease comprising the peptide. The IGF-I mimicking peptides of this invention have identical functions or actions to natural- occurring IGF-I and much better stability and skin permeation than natural-occurring IGF-I. In these connections, the composition comprising the peptides of this invention can exhibit excellent efficacies on the treatment, prevention and improvement of diseases or conditions demanding IGF-I activities. In addition, the peptides of this invention can be advantageously applied to pharmaceutical compositions, quasi-drugs and cosmetics.
摘要翻译：本发明涉及具有胰岛素样生长因子-1（IGF-I）的活性并且衍生自IGF-I的肽，用于改善皮肤病症或治疗包含该肽的牙周病的组合物。本发明的IGF-I模拟肽对天然存在的IGF-I具有相同的功能或作用，并且比天然存在的IGF-I具有更好的稳定性和皮肤渗透性。在这些连接中，包含本发明的肽的组合物可以在治疗，预防和改善需要IGF-I活性的疾病或病症方面表现出优异的功效。此外，本发明的肽可以有利地应用于药物组合物，准药物和化妆品。

7. 发明申请

WO2009066893A2 APPARATUS FOR SUPPLYING AUTOMATICALLY GOLF BALL 审中-公开
标题翻译：提供自动高尔夫球的设备
公开(公告)号：WO2009066893A2
公开(公告)日：2009-05-28
申请号：PCT/KR2008006567
申请日：2008-11-07
申请人： KIM YOUNG DEUG
发明人： KIM YOUNG DEUG
IPC分类号： A63B69/36
CPC分类号： A63B57/0006
摘要： An apparatus for automatically supplying a golf ball to an upper portion of a golf tee in a rectangular frame is disclosed. The pusher 20 is connected to a rear end of the golf tee 10 by means of a flexible material, in which the golf tee 10 and the pusher 20 are horizontally and vertically moved to lift or lower the golf ball to the hitting position of the trainee by using guide means 100 for horizontally and vertically guiding the golf tee, the guide means having a guide roller for vertically guiding the golf tee and a guide roller for turning a guide direction, and linearly operating means 200 for moving a fixture 25 back and forth which is installed at a rear end of the pusher 20 by a driving motor M.
摘要翻译：公开了一种用于将高尔夫球自动提供给矩形框架中的高尔夫球座上部的装置。推动器20通过柔性材料连接到高尔夫球座10的后端，其中高尔夫球座10和推动器20水平和垂直移动，以将高尔夫球提升或降低到受训者的击球位置通过使用用于水平和垂直引导高尔夫球座的引导装置100，引导装置具有用于垂直引导高尔夫球座的导辊和用于转动导向方向的导辊，以及用于使夹具25来回移动的线性运动装置200 其通过驱动电动机M安装在推动器20的后端。

8. 发明申请

WO2011087343A3 COMPOSITION FOR TREATING CANCER RELATED TO AN HPV INFECTION 审中-公开
标题翻译：用于治疗与HPV感染有关的癌症的组合物
公开(公告)号：WO2011087343A3
公开(公告)日：2011-12-01
申请号：PCT/KR2011000365
申请日：2011-01-18
申请人： EGENBIOTECH INC , SHIN YOUNG KEE , JUNG HUN SOON , KIM YOUNG-DEUG
发明人： SHIN YOUNG KEE , JUNG HUN SOON , KIM YOUNG-DEUG
IPC分类号： A61K38/16 , A61K31/7088 , A61K31/7105 , A61P35/00
CPC分类号： A61K31/713 , A61K31/7088 , A61K31/7105 , C12N15/1131 , C12N2310/11
摘要： The present invention relates to a chemosensitizer or radiosensitizer for the treatment of cancer caused by a human papillomavirus (hereinafter referred to as HPV) infection. More particularly, the present invention relates to a chemosensitizer or radiosensitizer for treating cancer caused by a HPV infection, which contains, as an active ingredient, small interfering RNA, short hairpin RNA (shRNA) or antisense oligonucleotide (ASO) selected from a group consisting of nucleotide sequence numbers 1 to 10. The siRNA of the present invention has superior effects in treating cervical cancer when compared to cases in which therapy using HPV-specific siRNA, chemotherapy, or radiotherapy is performed alone, and increases the sensitivity of cervical cancer cells to radiation or anticancer agents to thereby achieve maximized apoptotic effects.
摘要翻译：本发明涉及用于治疗由人乳头瘤病毒（以下称为HPV）感染引起的癌症的化学增敏剂或放射增敏剂。更具体地说，本发明涉及用于治疗由HPV感染引起的癌症的化学增敏剂或放射增敏剂，其包含作为活性成分的选自下组的小干扰RNA，短发夹RNA（shRNA）或反义寡核苷酸（ASO）的核苷酸序列编号1〜10。与使用HPV特异性siRNA的单独治疗，化学疗法或放疗单独进行的情况相比，本发明的siRNA在宫颈癌治疗中具有优异的效果，并且提高宫颈癌细胞的灵敏度辐射或抗癌剂从而实现最大程度的细胞凋亡效应。

9. 发明申请

WO2010085039A3 NOGGIN-DERIVED PEPTIDE AND USE THEREOF 审中-公开
标题翻译： NOGGIN衍生肽及其用途
公开(公告)号：WO2010085039A3
公开(公告)日：2010-09-16
申请号：PCT/KR2009006930
申请日：2009-11-24
申请人： CAREGEN CO LTD , CHUNG YOUNG JI , KIM YOUNG DEUG , KIM EUN MI , SONG SANG SU , HONG IL , CHO KYOUNG MI , KIM SU MI , HAN SANG MIN
发明人： CHUNG YOUNG JI , KIM YOUNG DEUG , KIM EUN MI , SONG SANG SU , HONG IL , CHO KYOUNG MI , KIM SU MI , HAN SANG MIN
IPC分类号： C07K7/08 , C07K7/06 , C07K14/47
CPC分类号： C07K14/475 , A61K38/00 , C07K5/1019 , C07K2319/00
摘要： The present invention relates to a noggin-derived peptide and to a composition containing same for promoting hair growth, enhancing the condition of the skin, providing an anti-inflammatory function, or preventing or treating bone diseases. The noggin-derived peptide of the present invention performs a function identical or similar to that of natural human noggin, and has a superior stability and skin permeability as compared to the natural human noggin. The composition containing the peptide of the present invention as an active ingredient exhibits remarkably superior effects in treating, preventing, or improving growth factor-related symptoms, e.g. hair loss, skin conditions or stab wounds, and in treating, preventing, or improving symptoms of growth factor over-expression. Therefore, the superior activity and stability of the peptide of the present invention are greatly advantageous for using the peptide of the present invention in medicine, quasi-drugs, and cosmetics.
摘要翻译：本发明涉及一种头蛋白衍生肽及其含有促进毛发生长，增强皮肤状态，提供抗炎功能，或预防或治疗骨病的组合物。本发明的来源于肽的肽具有与天然人头蛋白相同或相似的功能，与天然人头蛋白相比具有优异的稳定性和皮肤透过性。含有本发明的肽作为活性成分的组合物在治疗，预防或改善生长因子相关症状方面表现出显着优异的效果。脱发，皮肤状况或刺伤，以及治疗，预防或改善生长因子过表达的症状。因此，本发明的肽的优异活性和稳定性对于在医药，准药物和化妆品中使用本发明的肽是非常有利的。

10. 发明申请

WO2012093821A3 GENE FOR PREDICTING THE PROGNOSIS FOR EARLY-STAGE BREAST CANCER, AND A METHOD FOR PREDICTING THE PROGNOSIS FOR EARLY-STAGE BREAST CANCER BY USING THE SAME 审中-公开
标题翻译：用于预测早期乳腺癌预后的基因，以及通过使用该方法预测早期乳腺癌的预后的方法
公开(公告)号：WO2012093821A3
公开(公告)日：2013-01-24
申请号：PCT/KR2012000021
申请日：2012-01-02
申请人： BIOTRON CO LTD , SHIN YOUNG KEE , CHOI YOON LA , KIM YOUNG-DEUG , OH EU SEL , KIM SI EUN
发明人： SHIN YOUNG KEE , CHOI YOON LA , KIM YOUNG-DEUG , OH EU SEL , KIM SI EUN
IPC分类号： C12Q1/68 , C12N15/11
CPC分类号： C12Q1/6886 , C12Q2600/118 , C12Q2600/158 , G01N33/57415 , G01N33/57484 , G01N2333/723 , G06F19/20
摘要： The present invention relates to a method for selecting a gene intended to predict the prognosis for a cancer, to the selected gene for predicting the prognosis of cancer and to a kit for predicting and a method for predicting metastasis in breast-cancer patients by using the same. In the present invention, a straightforward method is used to achieve high-reliability prediction of the patient's prognosis by analysing for the genetic characteristics of early stage breast cancer, and thus the present invention can be used to advantage in prognosis diagnosis which can reduce unnecessary anticancer therapy.
摘要翻译：本发明涉及选择用于预测癌症预后的基因的方法，所选择的用于预测癌症预后的基因和用于预测的试剂盒和用于预测乳腺癌患者转移的方法的方法，所述方法通过使用相同。在本发明中，通过分析早期乳腺癌的遗传特征，采用直接的方法来实现患者预后的高可靠性预测，因此本发明可用于预后诊断中，可以减少不必要的抗癌作用治疗。

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