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1. 发明申请

WO2020191082A1 BIOCONJUGATES OF E. COLI O-ANTIGEN POLYSACCHARIDES, METHODS OF PRODUCTION THEREOF, AND METHODS OF USE THEREOF 审中-公开
公开(公告)号：WO2020191082A1
公开(公告)日：2020-09-24
申请号：PCT/US2020/023404
申请日：2020-03-18
申请人： JANSSEN PHARMACEUTICALS, INC. , GLAXOSMITHKLINE BIOLOGICALS S.A.
发明人： GEURTSEN, Jeroen , POOLMAN, Jan, Theunis , FAE, Kellen, Cristhina , BURGHOUT, Pieter, Jan , WEERDENBURG, Eveline, Marleen , IBARRA YON, Patricia , ABBANAT, Darren, Robert , KEMMLER, Stefan, Jochen , KOWARIK, Michael, Thomas , MALLY, Manuela , GAMBILLARA FONCK, Veronica , BRAUN, Martin, Edward , CARRANZA SANDMEIER, Maria, Paula
IPC分类号： A61K39/108 , A61P13/02
摘要： A bioconjugate of an E. coli glucosylated O4 antigen polysaccharide covalently linked to a carrier protein and compositions thereof are provided. Also provided are recombinant host cells for producing the bioconjugate, and methods of producing the bioconjugate using the recombinant host cells. The recombinant host cells contain a nucleic acid encoding a glucosyl transferase capable of modifying the E. coli O4 antigen with glucose branching to produce the glucosylated O4 antigen polysaccharide. Bioconjugates of an E. coli glucosylated O4 antigen polysaccharide described herein can be used alone or in combination with one or more additional E. coli O-antigen polysaccharides to induce antibodies against an E. coli glucosylated antigen, and to vaccinate a subject against extra-intestinal pathogenic E. coli (ExPEC).

2. 发明申请

WO2018046460A1 IMIDAZOQUINOLINE DERIVATIVES AND THEIR USE IN THERAPY 审中-公开
标题翻译：咪唑喹啉衍生物及其在治疗中的应用
公开(公告)号：WO2018046460A1
公开(公告)日：2018-03-15
申请号：PCT/EP2017/072152
申请日：2017-09-05
申请人： GLAXOSMITHKLINE BIOLOGICALS S.A.
发明人： BAZIN-LEE, Helene G , BURKHART, David , COCHRAN, Michael , EVANS, Jay T , JOHNSON, David A
IPC分类号： C07D487/14 , A61K31/4745 , C07F9/6561 , A61P37/04
摘要： This invention relates inter alia to novel imidazoquinoline derivatives and their use in therapy, particularly as vaccine adjuvants. The imidazoquinoline derivatives are of formula (I):
摘要翻译：本发明尤其涉及新的咪唑并喹啉衍生物及其在治疗中的用途，特别是作为疫苗佐剂。咪唑并喹啉衍生物具有式（I）：

3. 发明申请

WO2017167768A1 NOVEL VACCINE COMPOSITION 审中-公开
标题翻译：新型疫苗组合物
公开(公告)号：WO2017167768A1
公开(公告)日：2017-10-05
申请号：PCT/EP2017/057344
申请日：2017-03-28
申请人： GLAXOSMITHKLINE BIOLOGICALS S.A. , ZHEJIANG TIANYUAN BIO-PHARMACEUTICAL CO., LTD.
发明人： TING, Teck Yeo
IPC分类号： A61K39/12 , A61K39/145 , A61K47/22 , A61K47/26
CPC分类号： A61K39/12 , A61K9/0019 , A61K39/145 , A61K47/22 , A61K47/26 , A61K2039/5252 , A61K2039/55566 , A61K2039/70 , C12N2760/16134 , C12N2760/16234
摘要： The present invention relates to novel vaccine compositions, vials comprising such compositions, as well as to uses of and to methods for producing said compositions. In particular, the invention relates to vaccine compositions comprising certain excipient components and their use for the vaccination against influenza virus disease.
摘要翻译：本发明涉及新型疫苗组合物，包含此类组合物的小瓶以及制备所述组合物的方法和用途。具体而言，本发明涉及包含某些赋形剂成分的疫苗组合物及其用于针对流感病毒疾病的疫苗接种。

4. 发明申请

WO2017134086A1 APPARATUS AND METHOD FOR DETECTING A CRACK IN AN OPTICALLY TRANSPARENT ARTICLE 审中-公开
标题翻译：用于检测透光物品中裂纹的装置和方法
公开(公告)号：WO2017134086A1
公开(公告)日：2017-08-10
申请号：PCT/EP2017/052117
申请日：2017-02-01
申请人： GLAXOSMITHKLINE BIOLOGICALS S.A.
发明人： VEILLON, Romain Marie
IPC分类号： G01N21/23 , G01N21/88 , G01N21/90
CPC分类号： G01N21/90 , G01N21/8806 , G01N2021/8848
摘要： Apparatus for detecting cracks in optically transparent articles e.g vials, comprising a mount for the article, a light source to direct light at a mounted article, an optical detector positioned to receive light from the light source passed through the article and to generate an electronic signal responsive to received light, first and second (analyzer) polarizers such that light from the light source passes through the first polarizer then through the article, then through the second polarizer on its path to the optical detector, with an optical wave plate positioned between the mount and the second polarizer, and an image processing system to process the electronic signal generated by the optical detector and to indicate the presence or absence of a crack in the article supported on the mount. A method of crack detection using the apparatus is also provided.
摘要翻译：用于检测例如小瓶的光学透明制品中的裂缝的设备包括用于制品的支架，用于将光引导到安装的制品上的光源，定位成接收来自通过的光源的光的光学检测器并且产生响应于接收到的光的电子信号，第一和第二（分析仪）偏振器，使得来自光源的光穿过第一偏振器然后穿过物品，然后通过第二偏振器到达光学检测器，其中光学波片位于底座和第二偏振器之间;以及图像处理系统，用于处理由光学检测器产生的电子信号，并指示支撑在底座上的物品中是否存在裂缝。还提供了使用该设备的裂缝检测方法。

5. 发明申请

WO2017102939A1 USE OF ADJUVANTS FOR THE PREVENTION AND/OR TREATMENT OF AUTOIMMUNE DISEASES 审中-公开
标题翻译：使用佐剂预防和/或治疗自身免疫疾病
公开(公告)号：WO2017102939A1
公开(公告)日：2017-06-22
申请号：PCT/EP2016/081181
申请日：2016-12-15
申请人： GLAXOSMITHKLINE BIOLOGICALS S.A. , UNIVERSITE PIERRE ET MARIE CURIE (PARIS 6) , INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
发明人： MOREL, Sandra , POUCHY, Charlotte, Véronique , SALOMON, Benoit, Laurent , VANERHEYDE, Nathalie, Raoul, Liliane
IPC分类号： A61K39/39 , A61K47/22
CPC分类号： A61K39/39 , A61K2039/55555 , A61K2039/55572 , A61K2039/55577 , A61K2039/57
摘要： The invention provides an adjuvant for use in the prevention and/or treatment of an autoimmune disease.
摘要翻译：本发明提供了用于预防和/或治疗自身免疫性疾病的佐剂。

6. 发明申请

WO2017102703A1 VACCINE 审中-公开
标题翻译：疫苗
公开(公告)号：WO2017102703A1
公开(公告)日：2017-06-22
申请号：PCT/EP2016/080754
申请日：2016-12-13
申请人： GLAXOSMITHKLINE BIOLOGICALS S.A.
发明人： DIDIERLAURENT, Arnauld, Michel , HERVE, Caroline, Christiane
IPC分类号： A61K39/39 , A61P31/00
CPC分类号： A61K39/39 , A61K2039/555 , Y02A50/386 , Y02A50/466
摘要： The invention provides a pro-resolving mediator for use in the reduction of reactogenicity induced by administration of a vaccine or immunogenic composition comprising at least an antigen, and vaccines or immunogenic compositions comprising such a pro-resolving mediator.
摘要翻译：本发明提供了用于减少由施用包含至少一种抗原的疫苗或免疫原性组合物诱导的反应原性的促分解介体以及包含这种促分解介体的疫苗或免疫原性组合物

7. 发明申请

WO2016107818A8 COMPOSITIONS AND METHODS FOR PROTEIN GLYCOSYLATION 审中-公开
公开(公告)号：WO2016107818A8
公开(公告)日：2016-07-07
申请号：PCT/EP2015/081229
申请日：2015-12-24
申请人： GLAXOSMITHKLINE BIOLOGICALS S.A.
发明人： HAAS, Jurgen , IHSSEN, Julian , KOWARIK, Michael Thomas , SCHWEDE, Torsten Franz , THÖNY-MEYER, Linda Christiane
IPC分类号： C12N9/10 , C12P21/00
摘要： Described herein are oligosaccharyl transferases for use in N-glycosylating proteins of interest in vitro and in host cells. Methods for using such oligosaccharyl transferases, nucleic acids encoding such oligosaccharyl transferases, and host cells comprising such oligosaccharyl transferases are also provided herein. Glycoconjugates generated by using such oligosaccharyl transferases are also provided herein.

8. 发明申请

WO2016020413A1 CARRIER MOLECULE FOR ANTIGENS 审中-公开
标题翻译：载体分子抗原
公开(公告)号：WO2016020413A1
公开(公告)日：2016-02-11
申请号：PCT/EP2015/068012
申请日：2015-08-05
申请人： GLAXOSMITHKLINE BIOLOGICALS S.A.
发明人： BERTI, Francesco , COZZI, Roberta , GRANDI, Guido , MAIONE, Domenico , MARGARIT Y ROS, Immaculada , RINAUDO, Daniela Cira
IPC分类号： A61K47/48 , A61P37/04
CPC分类号： A61K47/646
摘要： The invention provides a conjugate comprising an antigen and a carrier molecule, wherein the carrier molecule comprises a BP-2a antigen and a spb1 antigen. BP-2a and spb1 are Streptococcus agalactiae antigens. The conjugate may be used in a method for raising an immune response in a mammal, the method comprising administering the conjugate to the mammal. Also provided are pharmaceutical compositions, particularly vaccines, comprising the conjugate.
摘要翻译：本发明提供了包含抗原和载体分子的缀合物，其中载体分子包含BP-2a抗原和spb1抗原。 BP-2a和spb1是无乳链球菌抗原。缀合物可以用于在哺乳动物中提高免疫应答的方法，该方法包括向哺乳动物施用该缀合物。还提供了包含缀合物的药物组合物，特别是疫苗。

9. 发明申请

WO2015028478A1 NOVEL INFLUENZA ANTIGENS AND ANTIBODIES 审中-公开
标题翻译：新型流感抗体和抗体
公开(公告)号：WO2015028478A1
公开(公告)日：2015-03-05
申请号：PCT/EP2014/068108
申请日：2014-08-26
申请人： GLAXOSMITHKLINE BIOLOGICALS S.A. , THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY OF THE DEPARTMENT OF HEALTH AND HUMAN SERVICES
发明人： STEVENS, James , DONIS, Ruben , SHORE, David , WAN, Hongquan , VASSILEV, Ventzislav Bojidarov
IPC分类号： C07K16/10 , A61K39/145
CPC分类号： C07K14/005 , A61K39/00 , A61K2039/505 , C07K16/1018 , C07K2317/24 , C07K2317/33 , C07K2317/34 , C07K2317/54 , C07K2317/55 , C07K2317/76 , C12N2760/16122 , C12N2760/16134
摘要： Novel influenza antigens, novel immunogenic or vaccine compositions, as well as uses of and methods for producing said antigens and compositions, are described.
摘要翻译：描述了新型流感抗原，新型免疫原性或疫苗组合物，以及产生所述抗原和组合物的用途和方法。

10. 发明申请

WO2015018806A1 COMBINATION IMMUNOGENIC COMPOSITIONS 审中-公开
标题翻译：组合免疫组化
公开(公告)号：WO2015018806A1
公开(公告)日：2015-02-12
申请号：PCT/EP2014/066756
申请日：2014-08-04
申请人： GLAXOSMITHKLINE BIOLOGICALS S.A.
发明人： STEFF, Ann-Muriel , TEMMERMAN, Stéphane T. , TOUSSAINT, Jean-François
IPC分类号： A61K39/02 , A61K39/155 , A61K39/00 , A61K39/10
CPC分类号： A61K39/155 , A61K39/05 , A61K39/08 , A61K39/095 , A61K39/099 , A61K39/12 , A61K39/13 , A61K39/145 , A61K39/292 , A61K39/295 , A61K39/385 , A61K2039/10 , A61K2039/545 , A61K2039/55 , A61K2039/55505 , A61K2039/55561 , A61K2039/55566 , A61K2039/55572 , A61K2039/55577 , A61K2039/575 , A61K2039/6031 , A61K2039/70 , C12N2760/18534 , Y02A50/466
摘要： Combination immunogenic compositions capable of eliciting protection against both RSV and B. pertussis infection and disease are disclosed. More specifically, this disclosure concerns such compositions which comprise a recombinant F protein analog of RSV, together with B. pertussis acellular (Pa) or whole cell (Pw) antigens and the use of the same, particularly in the context of neonatal and maternal immunization. Also disclosed are vaccine regimens, methods, as well as uses, and kits, of immunogenic compositions for protecting infants against disease caused by RSV and B. pertussis by maternal immunization.
摘要翻译：公开了能够引发针对RSV和百日咳杆菌感染和疾病的保护的组合免疫原性组合物。更具体地，本公开涉及包含RSV的重组F蛋白类似物，以及百日咳杆菌无细胞（Pa）或全细胞（Pw）抗原的组合物，以及其使用，特别是在新生儿和母亲免疫的情况下。还公开了免疫原性组合物的疫苗方案，方法，用途和试剂盒，用于通过母体免疫来保护婴儿免于RSV和百日咳杆菌引起的疾病。

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