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1. 发明申请

WO2005070110A2 MULTILUMEN CATHETERS AND METHODS FOR THEIR USE 审中-公开
标题翻译：多用途导管及其使用方法
公开(公告)号：WO2005070110A2
公开(公告)日：2005-08-04
申请号：PCT/US2005/000617
申请日：2005-01-07
申请人： CORAZON TECHNOLOGIES, INC. , CONSTANTZ, Brent R.
发明人： CONSTANTZ, Brent R.
IPC分类号： A61F2/958 , A61M25/00
CPC分类号： A61M25/0032 , A61M25/0097 , A61M2025/1052
摘要： Multilumen aspiration and delivery catheters, as well as methods for their use, are provided. The subject multilumen catheters include a proximal end and a distal end separated by a non-coaxial multilumen tube. Also provided are systems for use in flushing a vascular site with fluid, usually at least two different fluids, where the subject systems are made up of a delivery catheter inside of an aspiration catheter. In addition, kits comprising various components of the subject systems, e.g., at least two different multilumen catheters, are provided. The subject multilumen aspiration and delivery catheters, systems and kits find use in a variety of different applications in which it is desired to flush a vascular site with at least one and preferably two different fluids, where particular applications of interest include the treatment of vascular lesions.
摘要翻译：提供多次抽吸和输送导管，以及其使用方法。主体多腔导管包括由非同轴多管管分隔开的近端和远端。还提供了用于通过流体（通常为至少两种不同流体）冲洗血管部位的系统，其中主体系统由抽吸导管内部的输送导管组成。此外，提供了包含受试系统的各种组分的试剂盒，例如至少两种不同的多孔导管。受试者多腔抽吸和输送导管，系统和试剂盒可用于各种不同的应用，其中期望用至少一种并优选两种不同的流体冲洗血管部位，其中特别的关注的应用包括治疗血管病变。

2. 发明申请

WO02053203A3 PROTON GENERATING CATHETERS AND METHODS FOR THEIR USE 审中-公开
标题翻译：原子生成导管及其使用方法
公开(公告)号：WO02053203A3
公开(公告)日：2002-08-29
申请号：PCT/US0146834
申请日：2001-12-05
申请人： CORAZON TECHNOLOGIES INC , CONSTANTZ BRENT R , ROSS JOHN
发明人： CONSTANTZ BRENT R , ROSS JOHN
IPC分类号： A61B17/22 , A61B18/00 , A61B18/14 , A61M31/00
CPC分类号： A61N1/306 , A61B17/22 , A61B18/00 , A61B18/1492 , A61B2017/22082
摘要： Catheter devices and methods are provided for enhancing fluid flow through a vascular site occupied by a calcified lesion. The catheter devices of the subject invention include, at their distal end, a proton generating device including a cathode (13) and an anode (15) mounted on a first tube (14) and a second tube (16).
摘要翻译：提供导管装置和方法用于增强通过钙化损伤占据的血管部位的流体流动。本发明的导管装置在其远端包括质子产生装置，其包括安装在第一管（14）和第二管（16）上的阴极（13）和阳极（15）。

3. 发明申请

WO2005070109A3 MULTILUMEN CATHETERS AND METHODS FOR THEIR USE 审中-公开
公开(公告)号：WO2005070109A3
公开(公告)日：2005-08-04
申请号：PCT/US2005/000616
申请日：2005-01-07
申请人： CORAZON TECHNOLOGIES, INC. , CONSTANTZ, Brent R.
发明人： CONSTANTZ, Brent R.
IPC分类号： A61M31/00 , A61M37/00
摘要： Multilumen fluid delivery systems, as well as methods for their use, are provided. The subject multilumen fluid delivery systems include a multilumen aspiration catheter over a guidewire, which in many embodiments is a hollow guidewire. Also provided are kits comprising various components of the subject systems. The subject multilumen fluid delivery systems and kits find use in a variety of different applications in which it is desired to flush a vascular site with at least one and preferably two different fluids, where particular applications of interest include the treatment of vascular lesions, and particularly coronary vascular lesions.

4. 发明申请

WO03080151A2 MULTILUMEN CATHETERS AND METHODS FOR THEIR USE 审中-公开
标题翻译：多用途导管及其使用方法
公开(公告)号：WO03080151A2
公开(公告)日：2003-10-02
申请号：PCT/US0308706
申请日：2003-03-18
申请人： CORAZON TECHNOLOGIES INC
发明人： CONSTANTZ BRENT R
IPC分类号： A61B17/22 , A61B17/00 , A61F2/958 , A61M25/00 , A61M
CPC分类号： A61M25/0032 , A61M25/10 , A61M2025/1052
摘要： Multilumen catheters are provided. The subject multilumen catheters include a proximal end and a distal end separated by a non-coaxial multilumen tube. The subject catheters are further characterized in that they include a multiport manifold at their proximal ends, where at least two of the ports of the multiport manifold may comprise luer valves. Also provided are systems for use in flushing a vascular site with fluid, usually at least two different fluids, where the subject systems are made up of two multilumen catheters according to the subject invention, where one of the catheters is inserted inside of the other. In addition, kits comprising various components of the subject systems, e.g., at least two different multilumen catheters, are provided. The subject multilumen catheters, systems and kits find use in a variety of different applications in which it is desired to flush a vascular site with at least one and preferably two different fluids, where particular applications of interest include the treatment of vascular lesions.
摘要翻译：提供多元导管。主体多腔导管包括由非同轴多管管分隔开的近端和远端。主题导管的特征还在于它们在其近端包括多端口歧管，其中多端口歧管的至少两个端口可以包括鲁尔阀。还提供了用于通过流体（通常为至少两种不同流体）冲洗血管部位的系统，其中主体系统由根据本发明的两个多腔导管组成，其中一个导管插入另一个中。此外，提供了包含受试系统的各种组分的试剂盒，例如至少两种不同的多孔导管。本发明的多腔导管，系统和试剂盒可用于各种不同的应用，其中期望用至少一种并优选两种不同的流体冲洗血管部位，其中感兴趣的特定应用包括血管损伤的治疗。

5. 发明申请

WO0215958A3 FLUID DELIVERY SYSTEMS FOR DELIVERING FLUIDS TO MULTI-LUMEN CATHETERS 审中-公开
标题翻译：用于将流体输送到多孔导管的流体输送系统
公开(公告)号：WO0215958A3
公开(公告)日：2003-08-21
申请号：PCT/US0125696
申请日：2001-08-15
申请人： CORAZON TECHNOLOGIES INC , CONSTANTY BRENT R , JOHANSSON PETER K
发明人： CONSTANTY BRENT R , JOHANSSON PETER K
IPC分类号： A61M5/142 , A61M5/168 , A61M25/14 , A61M5/00
CPC分类号： A61M5/142 , A61M5/16827 , A61M5/19 , A61M25/0026 , A61M25/104 , A61M2025/1052
摘要： Fluid delivery system (10) capable of introducing first (14) and second (12) fluids into first and second lumens of a multi-lumen catheter are provided. The first and second fluids are generally a dissolution fluid and a dissolution fluid attenuating fluid. Also provided are fluid delivery and kits that include the subject systems. The subject fluid delivery systems find use in a variety of different applications, and are particularly suited for use in the chemical ablation of internal vascular lesions.
摘要翻译：提供能够将第一（14）和第二（12）流体引入多腔导管的第一和第二腔的流体输送系统（10）。第一和第二流体通常是溶解流体和溶解流体衰减流体。还提供了包括主题系统的流体递送和试剂盒。本发明的流体输送系统可用于各种不同的应用，并且特别适用于内部血管损伤的化学消融。

6. 发明申请

WO2004039432A2 DEVICES AND METHODS FOR TREATING AORTIC VALVE STENOSIS 审中-公开
标题翻译：用于治疗气管狭窄的装置和方法
公开(公告)号：WO2004039432A2
公开(公告)日：2004-05-13
申请号：PCT/US2003/034480
申请日：2003-10-28
申请人： CORAZON TECHNOLOGIES, INC.
发明人： CONSTANTZ, Brent, R. , JOHANSSON, Peter, K.
IPC分类号： A61M
CPC分类号： A61M25/10 , A61B17/22 , A61B17/320708 , A61B2017/22082 , A61B2017/22097 , A61M25/1011 , A61M2025/1013 , A61M2025/1015 , A61M2025/1052
摘要： Devices and methods for their use in increasing the aortic valve flow of a stenotic aortic valve are provided. The subject devices include an aortic valve isolation element and an aortic valve flushing element. The aortic valve isolation element is made up of a ventricular side aortic valve occlusion element, coronary ostia occlusion elements and an ascending aorta occlusion element. The aortic valve flushing element is made up of a dissolution fluid introducing element and a fluid removal element. In practicing the subject methods, a stenotic aortic valve is first isolated. Next, the isolated valve is flushed with a dissolution fluid, e.g., an acidic dissolution fluid, for a period of time sufficient for the aortic valve flow of the treated valve to be increased. In certain embodiments, the valve is also contacted with a dissolution fluid attenuating fluid, e.g., a buffer, during the flushing step in order to limit the contact of non-valve tissue with the dissolution fluid. Also provided are systems and kits that include the subject devices and can be employed in practicing the subject methods. The subject devices, methods, systems and kits find use in treating conditions associated with the presence of stenotic aortic valves.
摘要翻译：提供了用于增加狭窄主动脉瓣主动脉瓣流量的装置和方法。主体装置包括主动脉瓣隔离元件和主动脉瓣冲洗元件。主动脉瓣隔离元件由心室侧主动脉瓣闭塞元件，冠状动脉闭塞元件和升主动脉闭塞元件组成。主动脉瓣冲洗元件由溶解流体引入元件和流体移除元件构成。在实践主题方法中，首先分离狭窄的主动脉瓣。接下来，将隔离的阀用溶解流体例如酸性溶解流体冲洗一段足以使经处理的阀的主动脉瓣流动增加的时间。在某些实施方案中，在冲洗步骤期间，阀还与溶解流体衰减流体例如缓冲液接触，以限制非阀组织与溶解流体的接触。还提供了包括主题装置并且可以用于实践主题方法的系统和工具包。主题装置，方法，系统和试剂盒可用于治疗与狭窄主动脉瓣的存在相关的病症。

7. 发明申请

WO2003079994A2 METHODS AND DEVICES FOR THE IN SITU DISSOLUTION OF RENAL CALCULI 审中-公开
标题翻译：方法和设备用于血浆胰岛素溶解症
公开(公告)号：WO2003079994A2
公开(公告)日：2003-10-02
申请号：PCT/US2003/008705
申请日：2003-03-18
申请人： CORAZON TECHNOLOGIES, INC.
发明人： CONSTANTZ, Brent, R.
IPC分类号： A61K
CPC分类号： A61K33/00 , A61B17/22 , A61B2017/22084 , Y10S514/891
摘要： Methods and devices for at least reducing the mass of, if not dissolving, renal calculi in situ are provided. In the subject methods, a renal calculus is contacted, e.g. flushed, with an acidic dissolution solution in situ, where the acidic dissolution solution is a solution of a strong, inorganic acid, e.g. hydrochloric acid. In many embodiments, the renal calculus is first enclosed in an isolated local environment of a device prior contact with the dissolution solution. Also provided are novel devices and kits for practicing the subject invention.
摘要翻译：提供了用于至少减少原位肾结块质量（如不溶解）的方法和装置。在本发明的方法中，使肾结石接触。用酸性溶解溶液原位冲洗，其中酸性溶解溶液是强无机酸（例如，无机酸）的溶液。盐酸。在许多实施方案中，肾结石首先在与溶解溶液接触之前封闭在器件的隔离局部环境中。还提供了用于实践本发明的新颖的装置和试剂盒。

8. 发明申请

WO2005009505A3 DEVICES AND METHODS FOR PERCUTANEOUSLY TREATING AORTIC VALVE STENOSIS 审中-公开
标题翻译：用于治疗气管狭窄的装置和方法
公开(公告)号：WO2005009505A3
公开(公告)日：2005-09-22
申请号：PCT/US2004022800
申请日：2004-07-16
申请人： CORAZON TECHNOLOGIES INC , LAIRD ROB , HELKOWSKI RICK
发明人： LAIRD ROB , HELKOWSKI RICK
IPC分类号： A61B17/12 , A61B17/22 , A61F2/958 , A61M20060101 , A61M29/00 , A61M29/02
CPC分类号： A61B17/22 , A61B17/12045 , A61B17/12131 , A61B17/12136 , A61B2017/12127 , A61B2017/22054 , A61B2017/22067 , A61B2017/22084 , A61M25/10 , A61M2025/1052 , A61M2025/109 , A61M2025/1095
摘要： Devices and methods for their use in percutaneously increasing the aortic valve flow of a stenotic aortic valve are provided. The subject devices include an aortic valve isolation element (10), a shunt element (16) and an aortic valve flushing element (not shown). Also provided are systems and kits that include the subject devices and can be employed in practicing the subject methods. The subject devices, methods, systems and kits find use in treating conditions associated with the presence of stenotic aortic valves.
摘要翻译：提供了用于经皮增加狭窄主动脉瓣主动脉瓣流量的装置和方法。主体装置包括主动脉瓣隔离元件（10），分流元件（16）和主动脉瓣冲洗元件（未示出）。还提供了包括主题装置并且可以用于实践主题方法的系统和工具包。主题设备，方法，系统和试剂盒可用于治疗与狭窄主动脉瓣的存在相关的病症。

9. 发明申请

WO2004039432A3 DEVICES AND METHODS FOR TREATING AORTIC VALVE STENOSIS 审中-公开
标题翻译：用于治疗动脉瓣狭窄的装置和方法
公开(公告)号：WO2004039432A3
公开(公告)日：2005-09-09
申请号：PCT/US0334480
申请日：2003-10-28
申请人： CORAZON TECHNOLOGIES INC
发明人： CONSTANTZ BRENT R , JOHANSSON PETER K
IPC分类号： A61B17/22 , A61M29/00
CPC分类号： A61M25/10 , A61B17/22 , A61B17/320708 , A61B2017/22082 , A61B2017/22097 , A61M25/1011 , A61M2025/1013 , A61M2025/1015 , A61M2025/1052
摘要： Devices and methods for their use in increasing the aortic valve flow of a stenotic aortic valve are provided. The subject devices include an aortic valve isolation element and an aortic valve flushing element. The aortic valve isolation element is made up of a ventricular side aortic valve occlusion element, coronary ostia occlusion elements and an ascending aorta occlusion element. The aortic valve flushing element is made up of a dissolution fluid introducing element and a fluid removal element. In practicing the subject methods, a stenotic aortic valve is first isolated. Next, the isolated valve is flushed with a dissolution fluid, e.g., an acidic dissolution fluid, for a period of time sufficient for the aortic valve flow of the treated valve to be increased.
摘要翻译：提供了用于增加狭窄主动脉瓣主动脉瓣流量的装置和方法。主体装置包括主动脉瓣隔离元件和主动脉瓣冲洗元件。主动脉瓣隔离元件由心室侧主动脉瓣闭塞元件，冠状动脉闭塞元件和升主动脉闭塞元件组成。主动脉瓣冲洗元件由溶解流体引入元件和流体去除元件组成。在实践主题方法中，首先分离狭窄的主动脉瓣。接下来，将隔离的阀用溶解流体例如酸性溶解流体冲洗一段足以使被处理的阀的主动脉瓣流动增加的时间。

10. 发明申请

WO2005070109A2 MULTILUMEN CATHETERS AND METHODS FOR THEIR USE 审中-公开
标题翻译：多用途导管及其使用方法
公开(公告)号：WO2005070109A2
公开(公告)日：2005-08-04
申请号：PCT/US2005000616
申请日：2005-01-07
申请人： CORAZON TECHNOLOGIES INC , CONSTANTZ BRENT R
发明人： CONSTANTZ BRENT R
IPC分类号： A61F2/958 , A61M25/00 , A61M29/02
CPC分类号： A61M25/0032 , A61M2025/0079 , A61M2025/09008 , A61M2025/1052 , A61M2025/109 , A61M2025/1095 , A61M2025/1097
摘要： Multilumen fluid delivery systems, as well as methods for their use, are provided. The subject multilumen fluid delivery systems include a multilumen aspiration catheter over a guidewire, which in many embodiments is a hollow guidewire. Also provided are kits comprising various components of the subject systems. The subject multilumen fluid delivery systems and kits find use in a variety of different applications in which it is desired to flush a vascular site with at least one and preferably two different fluids, where particular applications of interest include the treatment of vascular lesions, and particularly coronary vascular lesions.
摘要翻译：提供了多液体流体输送系统，以及它们使用的方法。主题多腔液体递送系统包括导丝上的多腔吸引导管，在许多实施例中，导尿管是中空导丝。还提供了包括主题系统的各种组件的套件。本发明的多腔液体递送系统和试剂盒可用于各种不同的应用中，其中期望用至少一种优选两种不同的流体冲洗血管部位，其中特别的关注的应用包括血管损伤的治疗，特别是冠状动脉血管病变。

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