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1. 发明申请

WO2007063543A3 SYSTEM FOR COUNTING BACTERIA AND DETERMINING THEIR SUSCEPTIBILITY TO ANTIBIOTICS 审中-公开
标题翻译：细菌计数系统和确定其对抗生素的敏感性
公开(公告)号：WO2007063543A3
公开(公告)日：2009-04-16
申请号：PCT/IL2006001379
申请日：2006-11-29
申请人： BACTERIOSCAN LTD , WEICHSELBAUM AMNON , DE LA ZERDA JAIME
发明人： WEICHSELBAUM AMNON , DE LA ZERDA JAIME
IPC分类号： C12Q1/68
CPC分类号： G01N21/51 , B01L3/50 , B01L3/508 , B01L2300/04 , B01L2300/0809 , C12Q1/04 , C12Q1/06 , C12Q1/10 , C12Q1/18 , G01N21/03 , G01N21/49 , G01N33/4875 , G01N33/493 , G01N2015/0693 , G01N2021/0346 , G01N2021/0389 , G01N2021/513
摘要： A method for detecting and counting particles suspended in fluids, such as bacteria suspended in urine, utilizing dynamic features of the suspended particles and employing light scattering measurements. The disclosed method is suitable for determining the susceptibility of bacteria to antibiotics. A cuvette for detecting bacteria in fluids, which is especially suited for the light scattering measurements, is provided.
摘要翻译：一种利用悬浮颗粒的动态特征并采用光散射测量来检测和计数悬浮在流体中的悬浮在尿液中的细菌的方法。所公开的方法适用于确定细菌对抗生素的易感性。提供了用于检测流体中的细菌的比色杯，其特别适用于光散射测量。

2. 发明申请

WO2016088108A1 MULTI-SAMPLE LASER-SCATTER MEASUREMENT INSTRUMENT WITH INCUBATION FEATURE, AND SYSTEMS FOR USING THE SAME 审中-公开
标题翻译：具有激光功能的多样本激光扫描仪测量仪器及其使用系统
公开(公告)号：WO2016088108A1
公开(公告)日：2016-06-09
申请号：PCT/IB2015/059385
申请日：2015-12-04
申请人： BACTERIOSCAN LTD.
发明人： MARSHALL, Dana, A. , MCMINN, Theodore, S. , REGELMAN, Dan, Vadim
IPC分类号： G01N21/00
CPC分类号： G01N21/51 , G01N21/0332 , G01N2021/4707
摘要： An optical measurement instrument is an integrated instrument that includes an optical cavity with a light source, a sample cuvette, and an optical sensor. The light source and sensor are on a bench that is on a translational or rotational mechanical platform such that optical beam can be moved to multiple sample containers. The instrument can be used for taking measurements of organism concentration in multiple samples as a production tool for microbiology. Preferably, the instrument holds multiple, individually-loaded, independent fluid samples and determines bacteria concentration via a forward-scattering signal. The instrument can incorporate onboard incubation to promote bacterial growth in the samples during the test. In another aspect, the instrument can be a part of a network for medical diagnostic testing data where data is stored in a manner that is inherently untainted by patient identifiable information.
摘要翻译：光学测量仪器是一种集成的仪器，其包括具有光源的光学腔，样品比色皿和光学传感器。光源和传感器位于平移或旋转机械平台上的工作台上，使得光束可以移动到多个样品容器。该仪器可用于测量多个样品中的生物体浓度，作为微生物学的生产工具。优选地，该仪器保持多个单独加载的独立流体样品，并通过前向散射信号确定细菌浓度。该仪器可以包含板内孵化，以在测试过程中促进样品中的细菌生长。另一方面，仪器可以是用于医疗诊断测试数据的网络的一部分，其中数据以由患者可识别信息固有地保持的方式存储。

3. 发明申请

WO2007063543A2 SYSTEM FOR COUNTING BACTERIA AND DETERMINING THEIR SUSCEPTIBILITY TO ANTIBIOTICS 审中-公开
标题翻译：细菌计数系统，并确定其对抗生素的敏感性
公开(公告)号：WO2007063543A2
公开(公告)日：2007-06-07
申请号：PCT/IL2006/001379
申请日：2006-11-29
申请人： BACTERIOSCAN LTD. , WEICHSELBAUM, Amnon , DE LA ZERDA, Jaime
发明人： WEICHSELBAUM, Amnon , DE LA ZERDA, Jaime
IPC分类号： C12Q1/04
CPC分类号： G01N21/51 , B01L3/50 , B01L3/508 , B01L2300/04 , B01L2300/0809 , C12Q1/04 , C12Q1/06 , C12Q1/10 , C12Q1/18 , G01N21/03 , G01N21/49 , G01N33/4875 , G01N33/493 , G01N2015/0693 , G01N2021/0346 , G01N2021/0389 , G01N2021/513
摘要： A method for detecting and counting particles suspended in fluids, such as bacteria suspended in urine, utilizing dynamic features of the suspended particles and employing light scattering measurements. The disclosed method is suitable for determining the susceptibility of bacteria to antibiotics. A cuvette for detecting bacteria in fluids, which is especially suited for the light scattering measurements, is provided.
摘要翻译：一种用于检测和计数悬浮在流体中的颗粒的方法，例如悬浮在尿液中的细菌，利用悬浮颗粒的动态特征并采用光散射测量。所公开的方法适用于确定细菌对抗生素的敏感性。提供了用于检测流体中的细菌的比色皿，其特别适用于光散射测量。

4. 发明申请

WO2016108186A1 PIPETTE HAVING INTEGRATED FILTRATION ASSEMBLY 审中-公开
标题翻译：配套集成过滤装置
公开(公告)号：WO2016108186A1
公开(公告)日：2016-07-07
申请号：PCT/IB2015/060033
申请日：2015-12-29
申请人： BACTERIOSCAN LTD.
发明人： MARSHALL, Dana, A. , BECKMANN, Robert, W.
IPC分类号： B01L3/02 , G01N35/10
CPC分类号： B01L3/0275 , B01L2300/0681 , B01L2400/0605
摘要： The present invention is a pipette-filtration assembly having a main body defining a first channel, a second channel, a first valve, and a second valve. The first valve is associated with the first channel and permits flow in a first direction while substantially hindering flow in a second direction. The second valve is associated with the second channel and permits flow in the second direction while substantially hindering flow in the first direction. At least one filter is used to filter a fluid sample as the fluid sample flows in the first direction and/or the second direction. The pipette-filtration assembly is preferably disposable and includes one or two stages of integral filtration, primarily for use with an air-displacement pipetting or transfer system.
摘要翻译：本发明是一种移液管过滤组件，其具有限定第一通道，第二通道，第一阀和第二阀的主体。第一阀门与第一通道相关联并且允许沿第一方向流动，同时基本上妨碍沿第二方向的流动。第二阀与第二通道相关联并且允许沿第二方向的流动，同时基本上妨碍沿第一方向的流动。当流体样品沿第一方向和/或第二方向流动时，使用至少一个过滤器来过滤流体样品。移液器 - 过滤组件优选是一次性的并且包括一个或两个阶段的整体过滤，主要用于空气置换移液或转移系统。

5. 发明申请

WO2009083963A2 DETECTING AND COUNTING BACTERIA SUSPENDED IN BIOLOGICAL FLUIDS 审中-公开
标题翻译：检测和计数在生物流体中悬浮的细菌
公开(公告)号：WO2009083963A2
公开(公告)日：2009-07-09
申请号：PCT/IL2008/001663
申请日：2008-12-24
申请人： BACTERIOSCAN LTD. , WEICHSELBAUM, Amnon
发明人： WEICHSELBAUM, Amnon , DE LA ZERDA, Jaime , REGEV, Issakhar
IPC分类号： G01N21/00 , G01N1/10
CPC分类号： G01N21/51 , G01N21/0303 , G01N33/493 , G01N2021/0382 , G01N2021/4769 , G01N2021/479 , G01N2021/513 , G01N2201/064
摘要： System and method for detecting and counting bacteria suspended in a biological fluid by means of light scattering measurements is provided. In accordance with the method of the invention the level of signal to noise of the measured intensities of light scattered by a sample of the biological fluid is significantly enhanced for forwardly scattered light within a range of scattering angles which are smaller compared to a predefined maximal scattering angle. The system of the invention includes a cuvette adapted to contain a sample of the biological fluid whose sidewalls and windows are suitably constructed and arranged to significantly reduce the level of reflected light obscuring the scattering patterns measured within the range of scattering angles considered.
摘要翻译：提供了通过光散射测量来检测和计数悬浮在生物流体中的细菌的系统和方法。根据本发明的方法，在与预定的最大散射相比较小的散射角范围内的向前散射光显着增强了由生物流体样本散射的光的测量强度的信噪比水平角度。本发明的系统包括适于容纳生物流体的样本的比色皿，其侧壁和窗口被适当地构造和布置，以显着降低反射光的水平，遮蔽在所考虑的散射角度范围内测量的散射图案。

6. 发明申请

WO2016120779A1 LASER-SCATTER MEASUREMENT INSTRUMENT HAVING CAROUSEL-BASED FLUID SAMPLE ARRANGEMENT 审中-公开
标题翻译：具有基于卡路里的流体样品装置的激光扫描仪测量仪器
公开(公告)号：WO2016120779A1
公开(公告)日：2016-08-04
申请号：PCT/IB2016/050364
申请日：2016-01-25
申请人： BACTERIOSCAN LTD.
发明人： MARSHALL, Dana, A. , MCMINN, Theodore, S. , REGELMAN, Dan, Vadim
IPC分类号： G01N21/47
CPC分类号： G01N21/51 , G01N21/0303 , G01N2021/513 , G01N2201/0231 , G01N2201/0415
摘要： An instrument determines a concentration of bacteria in a plurality of fluid samples, and comprises a housing, a rotatable platform, a plurality of fluid containers, a light source, a sensor, and a motor. The rotatable platform is within the housing. The fluid containers are located on the rotatable platform. Each fluid container holds a corresponding one of the plurality of fluid samples, and has an input window and an output window. The light source provides an input beam for transmission into the input windows of the fluid containers and through the corresponding fluid samples. The input beam creates a forward-scatter signal associated with the concentration of bacteria. The motor rotates the rotatable platform so that the input beam sequentially passes through each fluid sample. A sensor within the housing detects the forward-scatter signal exiting from the output window associated with the fluid sample receiving the input beam.
摘要翻译：仪器确定多个流体样品中细菌的浓度，并且包括壳体，可旋转平台，多个流体容器，光源，传感器和马达。可旋转平台位于外壳内。流体容器位于可旋转平台上。每个流体容器保持多个流体样本中的相应的一个，并且具有输入窗口和输出窗口。光源提供输入光束，用于传输到流体容器的输入窗口并通过相应的流体样品。输入光束产生与细菌浓度相关联的前向散射信号。马达旋转可旋转平台，使得输入光束顺序地通过每个流体样品。壳体内的传感器检测从与接收输入光束的流体样品相关联的输出窗口离开的前向散射信号。

7. 发明申请

WO2009083963A3 DETECTING AND COUNTING BACTERIA SUSPENDED IN BIOLOGICAL FLUIDS 审中-公开
标题翻译：检测和计数在生物流体中悬浮的细菌
公开(公告)号：WO2009083963A3
公开(公告)日：2010-03-11
申请号：PCT/IL2008001663
申请日：2008-12-24
申请人： BACTERIOSCAN LTD , WEICHSELBAUM AMNON
发明人： WEICHSELBAUM AMNON , DE LA ZERDA JAIME , REGEV ISSAKHAR
IPC分类号： C12M1/34
CPC分类号： G01N21/51 , G01N21/0303 , G01N33/493 , G01N2021/0382 , G01N2021/4769 , G01N2021/479 , G01N2021/513 , G01N2201/064
摘要： System and method for detecting and counting bacteria suspended in a biological fluid by means of light scattering measurements is provided. In accordance with the method of the invention the level of signal to noise of the measured intensities of light scattered by a sample of the biological fluid is significantly enhanced for forwardly scattered light within a range of scattering angles which are smaller compared to a predefined maximal scattering angle. The system of the invention includes a cuvette adapted to contain a sample of the biological fluid whose sidewalls and windows are suitably constructed and arranged to significantly reduce the level of reflected light obscuring the scattering patterns measured within the range of scattering angles considered.
摘要翻译：提供了通过光散射测量来检测和计数悬浮在生物流体中的细菌的系统和方法。根据本发明的方法，在与预定的最大散射相比较小的散射角范围内的向前散射光显着增强了由生物流体样本散射的光的测量强度的信噪比水平角度。本发明的系统包括适于容纳生物流体的样本的比色皿，其侧壁和窗口被适当地构造和布置，以显着降低反射光的水平，遮蔽在所考虑的散射角度范围内测量的散射图案。

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