专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

WO2004103313A2 METHODS OF REDUCING VASCULAR PERMEABILITY IN TISSUE BY INHIBITION OF TISSUE PLASMINOGEN ACTIVATOR (TPA) AND TPA INHIBITORS USEFUL THEREIN 审中-公开
标题翻译：通过抑制组织培养基激活剂（TPA）和有用的TPA抑制剂来减少组织中血管渗透性的方法
公开(公告)号：WO2004103313A2
公开(公告)日：2004-12-02
申请号：PCT/US2004/015873
申请日：2004-05-20
申请人： THE AMERICAN NATIONAL RED CROSS , LAWRENCE, Daniel, A. , YEPES, Manuel, S. , STRICKLAND, Dudley
发明人： LAWRENCE, Daniel, A. , YEPES, Manuel, S. , STRICKLAND, Dudley
IPC分类号： A61K
CPC分类号： G01N33/5088 , G01N2333/9726 , G01N2800/2871
摘要： The present invention is a method of reducing vascular permeability in tissue of a subject comprising inhibiting the activity of serine proteinase tissue-type plasminogen activator (tPA). This tPA activity which increases permeability of the tissue in a subject results in edema in the tissue is separate from tPA's thrombolytic activity. The present invention more specifically relates to administering an amount of a tPA inhibitor sufficient to reduce the vascular permeability increasing activity of tPA in a subject. Useful tPA inhibitors for the present method are neuroserpin, mutant neuroserpin, wild-type PAI- 1, mutant PAI- 1, an antibody that binds to tPA, an antibody that binds to the low-density lipoprotein (LDL) receptor or a low-density lipoprotein (LDL) receptor family antagonist.
摘要翻译：本发明是减少受试者组织中血管通透性的方法，包括抑制丝氨酸蛋白酶组织型纤溶酶原激活物（tPA）的活性。增加受试者组织渗透性的这种tPA活性导致组织水肿与tPA的溶栓活性分开。本发明更具体地涉及给予一定量的足以降低受试者中tPA的血管通透性增加活性的量的tPA抑制剂。用于本方法的有用的tPA抑制剂是神经丝氨酸蛋白酶抑制剂，突变型神经丝氨酸蛋白酶抑制剂，野生型PAI-1，突变型PAI-1，结合tPA的抗体，结合低密度脂蛋白（LDL）受体的抗体或低密度脂蛋白密度脂蛋白（LDL）受体家族拮抗剂。

2. 发明申请

WO2004091523A2 METHOD FOR IDENTIFYING LIGANDS SPECIFIC FOR STRUCTURAL ISOFORMS OF PROTEINS 审中-公开
标题翻译：用于识别蛋白质结构体系特异性配体的方法
公开(公告)号：WO2004091523A2
公开(公告)日：2004-10-28
申请号：PCT/US2004/011402
申请日：2004-04-14
申请人： AMERICAN NATIONAL RED CROSS , LATHROP, Julia, T. , HAMMOND, David, J. , CERVENAKOVA, Larisa , GHEORGHIU, Liliana , YAKOVLEVA, Oksana
发明人： LATHROP, Julia, T. , HAMMOND, David, J. , CERVENAKOVA, Larisa , GHEORGHIU, Liliana , YAKOVLEVA, Oksana
IPC分类号： A61K
CPC分类号： G01N33/54306 , G01N33/6896 , G01N2800/2828
摘要： A method of identifying a ligand specific for a structural isoform of a protein by the binding of the structural isoform to a ligand on a support, a direct positional transfer of the structural isoform and a control isoform between two or more different solid or semi-solid supports and detection of at least one of the isoforms on each support, thus allowing for subtractive identification techniques to be used to identify the subset of ligands, or a ligand, specific for the structural isoform.
摘要翻译：通过结构同种型与支持体上的配体的结合，结构同种型的直接位置转移和两种或多种不同固体或半固体之间的对照同种型来鉴定对蛋白质的结构同种型特异性的配体的方法支持和检测每个支持物上的至少一种同种型，从而允许消减识别技术用于鉴定对结构亚型特异的配体子集或配体。

3. 发明申请

WO2004050851A2 PRION PROTEIN LIGANDS AND METHODS OF USE 审中-公开
标题翻译： PRION蛋白配体及其使用方法
公开(公告)号：WO2004050851A2
公开(公告)日：2004-06-17
申请号：PCT/US2003/038343
申请日：2003-12-03
申请人： THE AMERICAN NATIONAL RED CROSS , NORTH CAROLINA STATE UNIVERSITY , HAMMOND, David, J. , LATHROP, Julia, T. , CERVENAKOVA, Larisa , CARBONELL, Ruben, G.
发明人： HAMMOND, David, J. , LATHROP, Julia, T. , CERVENAKOVA, Larisa , CARBONELL, Ruben, G.
IPC分类号： C12N
CPC分类号： G01N33/6896 , C07K5/0808 , C07K5/081 , C07K5/0812 , C07K5/0819 , C07K5/0821 , C07K14/47 , G01N2800/2828
摘要： Ligands that bind to prion proteins and methods for using the ligands for detecting or removing a prion protein from a sample, such as a biological fluid or an environmental sample. The ligands are capable of binding to one or more forms of prion protein including cellular prion protein (PrPc), infectious prion protein (PrPsc), and recombinant prion protein (PrPr). Prions from various species, including humans and hamsters, are bound by the ligands. Also provided is a method of treating or retarding the development of a prion-associated pathology in a subject.
摘要翻译：与朊病毒蛋白结合的配体和使用配体检测或从样品例如生物液体或环境样品中除去朊病毒蛋白的方法。配体能够结合一种或多种形式的朊病毒蛋白，包括细胞朊蛋白（PrPc），感染性朊病毒蛋白（PrPsc）和重组朊蛋白（PrPr）。来自各种物种的朊病毒，包括人类和仓鼠，都被配体结合。还提供了治疗或延缓受试者中朊病毒相关病理学发展的方法。

4. 发明申请

WO2004024195A1 HEMOSTATIC DRESSING 审中-公开
标题翻译：麻醉服装
公开(公告)号：WO2004024195A1
公开(公告)日：2004-03-25
申请号：PCT/US2003/028100
申请日：2003-09-09
申请人： AMERICAN NATIONAL RED CROSS , MACPHEE, Martin, J.
发明人： MACPHEE, Martin, J.
IPC分类号： A61L15/00
CPC分类号： A61F13/00034 , A61F13/00029 , A61F13/00063 , A61F13/00991 , A61F2013/00106 , A61F2013/00463 , A61F2013/00472 , A61F2013/0054 , A61F2013/0091 , A61F2013/00927 , A61K38/4833 , A61L15/225 , A61L15/32 , A61L15/64 , A61L2400/04 , C08L89/00
摘要： The present invention relates to a hemostatic dressing which comprises a plurality of layers that contain resorbable materials and/or coagulation proteins. In particular, the invention includes dressings in which a layer of thrombin is sandwiched between a first and second layer of fibrinogen and wherein the layer of thrombin is not coextensive with the first and/or second layer of fibrinogen. The hemostatic dressings are useful for the treatment of wounded tissue.
摘要翻译：本发明涉及一种止血敷料，其包含含有可再吸收材料和/或凝结蛋白质的多个层。特别地，本发明包括敷料，其中一层凝血酶夹在第一和第二层纤维蛋白原之间，其中凝血酶层与纤维蛋白原的第一和/或第二层不共同延伸。止血敷料可用于治疗伤口组织。

5. 发明申请

WO1998001464A1 METHODS FOR THE SELECTIVE SEPARATION OF ORGANIC COMPONENTS FROM BIOLOGICAL FLUIDS 审中-公开
标题翻译：从生物流体中选择性分离有机成分的方法
公开(公告)号：WO1998001464A1
公开(公告)日：1998-01-15
申请号：PCT/US1996020034
申请日：1996-12-20
申请人： AMERICAN NATIONAL RED CROSS , KENT, Randall, S. , DROHAN, William, N.
发明人： AMERICAN NATIONAL RED CROSS
IPC分类号： C07K01/22
CPC分类号： C12N9/644 , A61K35/14 , A61K35/16 , C07K1/22 , C12Y304/21022
摘要： The present invention pertains to improved methods for the selective separation of organic components from biological fluids. More particularly, the present invention pertains to methods for the selective separation of organic components from biological fluids which comprise the step of contacting the biological fluid with a synthetic hydrated alkaline earth silicate (i.e., SHAES), such as synthetic hydrated calcium silicate (i.e., SHCS or synthetic hydrated magnesium silicate (i.e., SHMS). In a preferred embodiment, the present invention pertains to such methods where the biological fluid is a mammalian blood fluid (e.g., whole blood, blood plasma, blood serum, blood fraction, plasma fraction, serum fraction).
摘要翻译：本发明涉及用于从生物流体中选择性分离有机组分的改进方法。更具体地，本发明涉及从生物流体中选择性分离有机组分的方法，其包括使生物流体与合成的水合碱土金属硅酸盐（即SHAES）接触的步骤，例如合成的水合硅酸钙（即， SHCS或合成水合硅酸镁（即SHMS）在优选的实施方案中，本发明涉及生物流体是哺乳动物血液流体（例如，全血，血浆，血清，血液分数，血浆级分，血清分数）。

6. 发明申请

WO1996029865A1 ORGAN EVALUATION AND RESUSCITATION DEVICE AND METHOD 审中-公开
标题翻译：有机评估与恢复装置及方法
公开(公告)号：WO1996029865A1
公开(公告)日：1996-10-03
申请号：PCT/US1996004205
申请日：1996-03-27
申请人： ORGAN, INC. , LIFE RESUSCITATION TECHNOLOGIES, INC. , AMERICAN NATIONAL RED CROSS
发明人： ORGAN, INC. , LIFE RESUSCITATION TECHNOLOGIES, INC. , AMERICAN NATIONAL RED CROSS , FAHY, Gregory, M. , ARNAUD, Francois
IPC分类号： A01N01/02
CPC分类号： A01N1/0247 , A01N1/02
摘要： A computer-based organ perfusion apparatus is described which is capable of perfusing organs (1) at near-normal temperatures with blood or other oxygen-carrying substances. The apparatus permits organ viability to be evaluated by on-line measurements of physiological performance. Embodiments of the apparatus use a computer-driven blood pump (30) to allow physiological perfusion conditions to be established. The apparatus includes provisions (48) for the replacement of lost circulating volume and for the infusion of nutrients, drugs, and altered perfusates to assist in maintenance or recovery of organs. The apparatus may further sense perfusate gas tensions, pH, and temperature without electrical cross-interference (15 and 16), automatically measure production rates of urine, bile, pancreatic duct secretions, or other physiological exudations (8), and determine organ blood or perfusate flow rates, vascular resistance, and organ edema (4).
摘要翻译：描述了一种基于计算机的器官灌注装置，其能够在近乎正常温度下用血液或其它含氧物质灌注器官（1）。该装置允许通过在线测量生理性能来评估器官存活力。该装置的实施例使用计算机驱动的血液泵（30）来允许建立生理灌注条件。该装置包括用于替换丢失的循环体积和用于输注营养物质，药物和改变的灌注液以协助维持或恢复器官的规定（48）。该设备可以进一步感测灌注液气体的张力，pH和温度而没有电气交叉干扰（15和16），自动测量尿液，胆汁，胰管分泌物或其他生理渗出物的生产速率（8），并确定器官血液或灌洗液流速，血管阻力和器官水肿（4）。

7. 发明申请

WO1992009301A1 TISSUE SEALANT AND GROWTH FACTOR CONTAINING COMPOSITIONS THAT PROMOTE ACCELERATED WOUND HEALING 审中-公开
标题翻译：组织密封剂和生长因子，包含促进加速治疗的组合物
公开(公告)号：WO1992009301A1
公开(公告)日：1992-06-11
申请号：PCT/US1991008869
申请日：1991-11-27
申请人： THE AMERICAN NATIONAL RED CROSS , GREISLER, Howard, P.
发明人： THE AMERICAN NATIONAL RED CROSS , NUNEZ, Hernan, A. , DROHAN, William, N. , BURGESS, Wilson, H.
IPC分类号： A61K37/02
CPC分类号： C12N5/069 , A61K38/18 , A61L15/32 , A61L24/0015 , A61L24/106 , A61L26/0042 , A61L26/0066 , A61L26/0085 , A61L2300/414 , C07K14/501 , C07K14/503 , C12N2533/56
摘要： This invention provides a growth factor-supplemented tissue sealant and methods for using said sealant to promote wound healing, endothelialization of vascular protheses, and the in vitro proliferation and differentiation of animal cells. In particular, this invention provides fibrin glue that is supplemented with at least one growth factor, such as a heparin binding growth factor and/or bone morphogenic proteins. The particular growth factor or factors selected is a function of its use.
摘要翻译：本发明提供补充生长因子的组织密封剂和使用所述密封剂促进伤口愈合，血管皱纹内皮化和动物细胞的体外增殖和分化的方法。特别地，本发明提供补充有至少一种生长因子如肝素结合生长因子和/或骨形态发生蛋白的纤维蛋白胶。选择的特定生长因子或因子是其使用的函数。

8. 发明申请

WO1991015583A1 A PROTEIN FAMILY RELATED TO IMMEDIATE-EARLY PROTEIN EXPRESSED BY HUMAN ENDOTHELIAL CELLS DURING DIFFERENTIATION 审中-公开
标题翻译：在分化期间由人内皮细胞表达的即时蛋白相关的蛋白家族
公开(公告)号：WO1991015583A1
公开(公告)日：1991-10-17
申请号：PCT/US1991002344
申请日：1991-04-04
申请人： THE AMERICAN NATIONAL RED CROSS
发明人： THE AMERICAN NATIONAL RED CROSS , HLA, Timothy, Tun , MACIAG, Thomas
IPC分类号： C12N15/12
CPC分类号： C07K14/705
摘要： This invention provides a novel family of tissue specific genes and proteins that are related to a G-protein-coupled receptor gene and the receptor protein. The gene is an intermediate early gene that is expressed in differentiating endothelial cells. In particular, this invention provides a gene, edg-1, that is an immediate-early gene that encodes a G-protein-coupled receptor in endothelial cells. This invention also provides the G-protein-coupled receptor protein that is encoded by edg-1.
摘要翻译：本发明提供了与G蛋白偶联受体基因和受体蛋白相关的组织特异性基因和蛋白质的新家族。该基因是在分化内皮细胞中表达的中间早期基因。特别地，本发明提供了一种基因edg-1，其是在内皮细胞中编码G蛋白偶联受体的立即早期基因。本发明还提供由edg-1编码的G蛋白偶联受体蛋白。

9. 发明申请

WO1983003760A1 PLASMA PROTEIN CONCENTRATES OF REDUCED THROMBOGENICITY AND THEIR USE IN CLINICAL REPLACEMENT THERAPY 审中-公开
标题翻译：降低血液发生的血浆蛋白浓度及其在临床替代治疗中的应用
公开(公告)号：WO1983003760A1
公开(公告)日：1983-11-10
申请号：PCT/US1983000549
申请日：1983-04-14
申请人： AMERICAN NATIONAL RED CROSS
发明人： AMERICAN NATIONAL RED CROSS , MENACHE-ARONSON, Doris , KOSOW, David, P. , ORTHNER, Carolyn, L. , BEHRE, H., Evan
IPC分类号： A61K35/14
CPC分类号： C12N9/647 , A61K38/00
摘要： Plasma concentrates of vitamin-K dependent clotting factors of reduced thrombogenic potential useful for clinical replacement therapy in deficiency diseases of these clotting factors are provided. Preferably, concentrates substantially devoid of zymogens extraneous to the deficient factor are employed.
摘要翻译：提供了可用于临床替代治疗这些凝血因子的缺陷性疾病中的血栓形成潜能降低的维生素K依赖性凝血因子的血浆浓缩物。优选采用基本上不含与缺陷因子无关的酶原的浓缩物。

10. 发明申请

WO2005094467A2 METHODS FOR REDUCING THE RANGE IN CONCENTRATIONS OF ANALYTE SPECIES IN A SAMPLE 审中-公开
标题翻译：降低分析物种浓度范围的方法
公开(公告)号：WO2005094467A2
公开(公告)日：2005-10-13
申请号：PCT/US2005/009539
申请日：2005-03-23
申请人： CIPHERGEN BIOSYSTEMS, INC. , AMERICAN NATIONAL RED CROSS , BOSCHETTI, Egisto , HAMMOND, David
发明人： BOSCHETTI, Egisto , HAMMOND, David
IPC分类号： C12Q1/68 , G01N33/53 , G01N33/543 , G01N33/68
CPC分类号： G01N33/6803 , C40B30/04 , G01N33/543 , G01N33/54306 , G01N33/6845
摘要： The present invention relates to the fields of molecular biology, combinatorial chemistry and biochemistry. Particularly, the present invention describes methods and kits for dynamically reducing the variance between analyte taken from complex mixtures.
摘要翻译：本发明涉及分子生物学，组合化学和生物化学领域。特别地，本发明描述了用于动态地减少从复杂混合物中取出的分析物之间的方差的方法和试剂盒。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式