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81. 发明申请

WO2007004549A1 ２－ヒドロキシイソ酪酸グリシジルの製造法及び該製造物を含む組成物审中-公开
标题翻译：生产甘油二羟基异丁酸酯和含有产品的组合物的方法
公开(公告)号：WO2007004549A1
公开(公告)日：2007-01-11
申请号：PCT/JP2006/313081
申请日：2006-06-30
申请人：三菱瓦斯化学株式会社 , 中野里愛子 , 竹本眞規 , 島義和
发明人：中野里愛子 , 竹本眞規 , 島義和
IPC分类号： C07D301/12 , C07D303/16
CPC分类号： C07D301/12 , C07D303/16
摘要：【課題】反応性希釈剤として有用な２－ヒドロキシイソ酪酸グリシジルの効率的な製造方法を提供する。【解決手段】２－ヒドロキシイソ酪酸アリルと過酸化水素を反応させて２－ヒドロキシイソ酪酸グリシジルを製造する際、結晶性チタノシリケート触媒の存在下、２－ヒドロキシイソ酪酸アリルを溶媒である脂肪族エステル類に溶解させた溶液と過酸化水素を反応させることにより、過酸化物等の生成による純度や収率の低下が少ない２－ヒドロキシイソ酪酸グリシジルの製造法及び製造物を提供することができる。
摘要翻译： [问题]提供可用作反应性稀释剂的2-羟基异丁酸缩水甘油酯的有效方法。解决问题的手段2-羟基异丁酸缩水甘油酯的制备方法包括使2-羟基异丁酸烯丙酯与过氧化氢反应，生成2-羟基异丁酸缩水甘油酯，其中通过将2-羟基异丁酸烯丙酯溶解在脂族酯溶剂中而获得的溶液与过氧化氢在结晶钛硅酸盐催化剂存在下。因此，可以制造2-羟基异丁酸缩水甘油酯，同时通过产生过氧化物等抑制纯度和产率的降低。

82. 发明申请

WO2005066197A3 INHIBITORS OF METHIONINE AMINOPEPTIDASE-2 AND USES THEREOF 审中-公开
标题翻译：甲氨酸氨基转移酶-2的抑制剂及其用途
公开(公告)号：WO2005066197A3
公开(公告)日：2006-01-26
申请号：PCT/US2004043586
申请日：2004-12-29
申请人： PRAECIS PHARM INC , THOMPSON CHARLES , ARICO-MUENDEL CHRISTOPHER C
发明人： THOMPSON CHARLES , ARICO-MUENDEL CHRISTOPHER C
IPC分类号： A61K31/336 , C07C271/34 , C07D303/14 , C07D303/16 , C07D303/22 , C07K5/00
CPC分类号： C07C271/34 , C07C2601/14 , C07D303/14 , C07D303/16 , C07D303/22
摘要： The instant invention provides compositions and methods for treating a subject suffering from one of a number of conditions, including an angiogenic disease, such as cancer, an autoimmune disorder or a parasitic infection.
摘要翻译：本发明提供用于治疗患有多种病症之一的患者的组合物和方法，所述病症包括血管生成疾病，例如癌症，自身免疫病症或寄生虫感染。

83. 发明申请

WO2005079378A2 SYNTHETIC TECHNIQUES AND INTERMEDIATES FOR POLYHYDROXY DIENYL LACTONES AND MIMICS THEREOF 审中-公开
标题翻译：合成技术和中间体的聚羟基二烯基酯及其制备方法
公开(公告)号：WO2005079378A2
公开(公告)日：2005-09-01
申请号：PCT/US2005/004643
申请日：2005-02-11
申请人： THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA , SMITH, Amos, B., III , QUI, Yuping , KAUFMAN, Michael , ARIMOTO, Hirokazu , JONES, David, R. , KOBAYASHI, Kaoru , BEAUCHAMP, Thomas, J.
发明人： SMITH, Amos, B., III , QUI, Yuping , KAUFMAN, Michael , ARIMOTO, Hirokazu , JONES, David, R. , KOBAYASHI, Kaoru , BEAUCHAMP, Thomas, J.
IPC分类号： C07C271/12 , C07D213/30 , C07D263/22 , C07D303/16 , C07D309/10 , C07D309/30 , C07D309/32 , C07D319/06 , C07D339/08 , C07D407/06 , C07D413/06 , C07D413/12 , C07D417/06 , C07F7/18 , C07F9/54
CPC分类号： C07C271/12 , C07B2200/07 , C07D213/30 , C07D263/22 , C07D303/16 , C07D309/10 , C07D309/30 , C07D309/32 , C07D319/06 , C07D339/08 , C07D407/06 , C07D413/06 , C07D413/12 , C07D417/06 , C07F7/1852 , C07F7/1856 , C07F7/1892 , C07F9/5428 , C07F9/5442
摘要： Synthetic methods and intermediates useful in the preparation of lactone containing compounds such as discodermolide and compounds which mimic the chemical or biological activity of discodermolide are provided.
摘要翻译：提供了可用于制备含内酯化合物如discodermolide的合成方法和中间体以及模拟discodermolide的化学或生物活性的化合物。

84. 发明申请

WO2005054219A1 PROCESS TO MODIFY NON GLYCIDYL FUNCTIONAL IMPURITIES OF GLYCIDYL ESTERS TO BE USED IN FURTHER RADICAL POLYMERISATION 审中-公开
标题翻译：改进用于进一步光谱聚合的甘氨酸酯的非糖苷官能度的方法
公开(公告)号：WO2005054219A1
公开(公告)日：2005-06-16
申请号：PCT/EP2004/013541
申请日：2004-11-30
申请人： RESOLUTION RESEARCH BELGIUM S.A. , HEYMANS, Denis, Marie, Charles , HENRY, Nathalie, Solange, Jeanne, Yvette , UYTTERHOEVEN, Griet
发明人： HEYMANS, Denis, Marie, Charles , HENRY, Nathalie, Solange, Jeanne, Yvette , UYTTERHOEVEN, Griet
IPC分类号： C07D303/16
CPC分类号： C07D301/32 , C07D303/16
摘要： The present invention relates to a process to modify the non glycidyl functional products occurring in industrially produced glycidyl esters, which are currently used in the synthesis of radical polymerisable acrylic or methacrylic acid derivatives, to be further reacted too resins for coating applications. The process to modify non glycidyl functional impurities in glycidyl esters of branched alkane carboxylic acids, by reacting the fraction of non-glycidyl functional products with ethylenically unsaturated anhydride. Another aspect of the present invention is formed by the cured coating films derived from the hereinbefore defined coating compositions and applied an a shaped substrate, and more in particular an automotives.
摘要翻译：本发明涉及在工业生产的缩水甘油酯中发生的非缩水甘油基官能产物的改性方法，其目前用于合成可自由基聚合的丙烯酸或甲基丙烯酸衍生物，以进一步反应用于涂料应用的树脂。通过使非缩水甘油基官能产物的部分与烯键式不饱和酸酐反应来改性支链烷烃羧酸的缩水甘油酯中的非缩水甘油基官能杂质的方法。本发明的另一方面是通过由上述定义的涂料组合物衍生的固化涂膜形成的，并施加成形基材，更特别是汽车。

85. 发明申请

WO2004064972A9 CAPTURE COMPOUNDS, COLLECTIONS THEREOF AND METHODS FOR ANALYZING THE PROTEOME AND COMPLEX COMPOSITIONS 审中-公开
标题翻译：捕获化合物，其收集物和用于分析蛋白质和复合物组合物的方法
公开(公告)号：WO2004064972A9
公开(公告)日：2004-09-16
申请号：PCT/US2004001037
申请日：2004-01-16
申请人： HK PHARMACEUTICALS INC , KOESTER HUBERT , LITTLE DANIEL PAUL , SIDDIQI SUHAIB MAHMOOD , GREALISH MATTHEW PETER , MARAPPAN SUBRAMANIAN , HASSMAN III CHESTER FREDERICK , YIP PING
发明人： KOESTER HUBERT , LITTLE DANIEL PAUL , SIDDIQI SUHAIB MAHMOOD , GREALISH MATTHEW PETER , MARAPPAN SUBRAMANIAN , HASSMAN III CHESTER FREDERICK , YIP PING
IPC分类号： C07C69/76 , C07C69/96 , C07D207/40 , C07D207/404 , C07D207/46 , C07D209/48 , C07D211/60 , C07D211/78 , C07D213/79 , C07D215/48 , C07D239/54 , C07D239/545 , C07D241/44 , C07D261/12 , C07D271/06 , C07D271/07 , C07D303/14 , C07D303/16 , C07D317/36 , C07D401/12 , C07D405/10 , C07D405/12 , C07D495/04 , C07D498/18 , C07D519/00 , G01N33/68 , B01D
CPC分类号： C07D495/04 , C07C69/76 , C07C69/96 , C07C2603/74 , C07D207/404 , C07D207/46 , C07D209/48 , C07D211/60 , C07D211/78 , C07D213/79 , C07D215/48 , C07D239/54 , C07D239/545 , C07D241/44 , C07D261/12 , C07D271/07 , C07D303/14 , C07D303/16 , C07D317/36 , C07D401/12 , C07D405/10 , C07D405/12 , C07D417/12 , C07D417/14 , C07D519/00 , G01N33/6803 , G01N33/6842 , G01N33/6845 , G01N33/6848
摘要： Capture compounds and collections thereof and methods using the compounds for the analysis of biomolecules are provided. In particular, collections, compounds and methods are provided for analyzing complex protein mixtures, such as the proteome. The compounds are multifunctional reagents that provide for the separation and isolation of complex protein mixtures. Automated systems for performing the methods also are provided.
摘要翻译：提供捕获化合物及其集合和使用该化合物分析生物分子的方法。具体而言，提供用于分析复杂蛋白质混合物（例如蛋白质组）的收集物，化合物和方法。这些化合物是多功能试剂，可用于分离和分离复杂的蛋白质混合物。还提供了用于执行这些方法的自动化系统。

86. 发明申请

WO0242295A3 PEPTIDES AS MET-AP2 INHIBITORS 审中-公开
标题翻译：作为MET-AP2抑制剂的肽
公开(公告)号：WO0242295A3
公开(公告)日：2003-02-20
申请号：PCT/US0146086
申请日：2001-11-01
申请人： PRAECIS PHARM INC , OLSON GARY L , SELF CHRISTOPHER , LEE LILY , COOK CHARLES MICHAEL , BIRKTOFT JENS , MORGAN BARRY , ARICO-MUENDEL CHRISTOPHER C
发明人： OLSON GARY L , SELF CHRISTOPHER , LEE LILY , COOK CHARLES MICHAEL , BIRKTOFT JENS , MORGAN BARRY , ARICO-MUENDEL CHRISTOPHER C
IPC分类号： C07D303/22 , A61K31/336 , A61K38/00 , A61K38/48 , A61K47/48 , A61P9/00 , A61P19/02 , A61P35/00 , A61P37/00 , A61P37/02 , C07D405/14 , C07K5/02 , C07K5/06 , C07K5/083 , C07K5/09 , C07K5/103 , C07K14/00 , C07K14/81 , C07D303/16 , A61K31/335
CPC分类号： A61K38/4886 , A61K47/64 , C07D405/14 , C07K5/0202 , C07K5/0606 , C07K5/0806 , C07K5/081 , C07K5/0817 , C07K5/1008 , C07K14/8146
摘要： The present invention provides angiogenesis inhibitor compounds comprising a MetAP-2 inhibitory core coupled to a peptide, as well as pharmaceutical compositions comprising the angiogenesis inhibitor compounds and a pharmaceutically acceptable carrier. The present invention also provides methods of treating an angiogenic disease, e.g., cancer, in a subject by administering to the subject a therapeutically effective amount of one or more of the angiogenesis of the invention.
摘要翻译：本发明提供包含与肽偶联的MetAP-2抑制性核心的血管生成抑制剂化合物，以及包含血管生成抑制剂化合物和药学上可接受的载体的药物组合物。本发明还提供了通过向受试者施用治疗有效量的本发明血管生成中的一种或多种来治疗受试者中血管生成疾病例如癌症的方法。

87. 发明申请

WO02016303A1 PROCESS FOR PRODUCING METHACRYLOYL REACTION PRODUCT 审中-公开
标题翻译：生产甲基丙烯酸反应产物的方法
公开(公告)号：WO02016303A1
公开(公告)日：2002-02-28
申请号：PCT/JP2001/006916
申请日：2001-08-10
IPC分类号： C07D211/46 , C08F8/50 , C08F220/12 , C07C67/08 , C07C67/26 , C07C69/54 , C07D211/44 , C07D303/16
CPC分类号： C08F220/12 , C07D211/46
摘要： An efficient process for producing a methacryloyl reaction product. In the process, the reaction of a methacryloyl compound as a starting material with a functional compound as another starting material is conducted at a temperature sufficient to thermally depolymerize methacryloyl groups which have polymerized. Thus, a methacryloyl reaction product can be obtained which is not polymeric and has relatively high polymerizability and curability.
摘要翻译：用于生产甲基丙烯酰基反应产物的有效方法。在此过程中，作为起始原料的甲基丙烯酰基化合物与功能性化合物作为另一起始原料的反应在足以热解聚已经聚合的甲基丙烯酰基的温度下进行。因此，可以获得不是聚合物并且具有相对高的聚合性和固化性的甲基丙烯酰基反应产物。

88. 发明申请

WO0156965A3 MANUFACTURING PROCESS FOR THE PREPARATION OF alpha , alpha , alpha ', alpha '-BRANCHED DICARBOXYLIC ACIDS 审中-公开
标题翻译：制备α，α，α'，α' - 支链二羧酸的方法
公开(公告)号：WO0156965A3
公开(公告)日：2001-12-27
申请号：PCT/EP0101233
申请日：2001-02-02
申请人： RESOLUTION RES NEDERLAND BV
发明人： PETRUS LEONARDUS , STICHTER HENDRIK , STIL HANS ARIE , WALHOF JUDITH JOHANNA BERENDIN
IPC分类号： C07C51/14 , C07C69/34 , C07D303/16 , C07C55/02 , C07C69/01
CPC分类号： C07D303/16 , C07C51/14 , C07C69/34 , C07C55/02
摘要： Manufacturing process for the preparation of alpha , alpha , alpha ', alpha '-branched dicarboxylic acids by reacting an olefin or precursor thereof, with carbon monoxide in the presence of a strong acid catalyst, characterized in that the starting olefin is an oligomer containing from 6 to 25 carbon atoms, that the acid catalyst is composed by BF3/H3PO4 in a molar ratio BF3/H3PO4 being in the range of 0.5:1 to 5.0:1, that the weight ratio of the catalyst relative to the mono-olefin is in the range of from 2:1 to 20:1, that the reaction is carried out at a temperature in the range of from 30 to 130 DEG C, and at a carbon monoxide pressure in the range of from 20 to 200 bar, that the water/catalyst weight ratio during the reaction is in the range of from 1:5 to 1:50, alpha , alpha , alpha ', alpha '-branched dicarboxylic acids mixtures obtainable by said process, and derivatives of these branched dicarboxylic acid components.
摘要翻译：通过使烯烃或其前体与一氧化碳在强酸催化剂存在下反应制备α，α，α'，α'-支链二羧酸的制造方法，其特征在于起始烯烃是含有 6至25个碳原子，所述酸催化剂由BF 3 / H 3 PO 4以BF 3 / H 3 PO 4的摩尔比在0.5:1至5.0:1的范围内组成，催化剂相对于单烯烃的重量比为在2:1至20:1的范围内，反应在30-130℃的温度和20-200巴的一氧化碳压力下进行，反应温度范围为反应过程中水/催化剂重量比在1:5至1:50的范围内，通过所述方法可获得的α，α，α'，α'-支链二羧酸混合物以及这些支化二羧酸组分的衍生物。

89. 发明申请

WO01079190A1 METHOD OF SYNTHESIZING GLYCERYL MONO-ESTERS 审中-公开
标题翻译：合成甘蔗单糖的方法
公开(公告)号：WO01079190A1
公开(公告)日：2001-10-25
申请号：PCT/ZA2001/000045
申请日：2001-04-17
IPC分类号： C07C67/29 , C07C227/18 , C07C229/60 , C07D301/30 , C07D303/16
CPC分类号： C07D303/16 , C07C67/29 , C07C227/18 , C07C69/533 , C07C69/30 , C07C229/60
摘要： The invention provides a method of manufacturing a glycerol monoester which comprises reacting epichlorohydrin with the metal salt of a fatty acid, an aliphatic acid or an aromatic carboxyl acid to form an ester compound with a closed expoxide ring, and opening the closed expoxide ring by adding acidified water.
摘要翻译：本发明提供一种制备甘油单酯的方法，其包括使表氯醇与脂肪酸，脂肪酸或芳族羧酸的金属盐反应，以形成具有封闭的环氧化物环的酯化合物，并通过加入酸化水。

90. 发明申请

WO01062752A1 PROCESS FOR THE PREPARATION OF GLYCIDYLESTERS OF BRANCHED CARBOXYLIC ACIDS 审中-公开
标题翻译：制备分支羧酸的甘油三酯的方法
公开(公告)号：WO01062752A1
公开(公告)日：2001-08-30
申请号：PCT/EP2001/002129
申请日：2001-02-22
IPC分类号： C07D301/30 , C07D303/16
CPC分类号： C07D303/16
摘要： Process for the manufacture of diglycidylesters of alpha , alpha '-branched dicarboxylic acids, comprising (a) the reaction of the alpha , alpha '-branched dicarboxylic acid with a halo substituted monoepoxide such as an epihalohydrin, in a 1.1-20 acid equivalent ratio relative to the alpha , alpha '-branched aliphatic dicarboxylic acid, optionally in the presence of water and water-miscible solvent, and in the presence of a catalyst in an amount of at most 45 mol% of the acid equivalent amount of the alpha , alpha '-branched aliphatic dicarboxylic acid, at a temperature in the range of from 30 to 110 DEG C, during a period in the range of from 0.5 to 2.5 hr, (b) addition of alkali metal hydroxide or alkali metal alkanolate up to an acid equivalent ratio as to the alpha , alpha '-branched aliphatic dicarboxylic acid in the range of from 0.9:1 to 1.2:1, and reaction at a temperature of from 0 to 80 DEG C, (c) distillation of the obtained reaction mixture to remove the excess halo substituted monoepoxide and the solvent and water formed, and (d) removal of alkali metal halide salt, preferably by washing the obtained diglycidylester with water mixed with an inert organic solvent, after optionally treating the residual product with a concentrated aqueous alkali metal hydroxide solution, in order to complete the dehydrohalogenation.
摘要翻译：制备α，α'-支化二羧酸的二缩水甘油酯的方法，包括（a）α，α'-支化的二羧酸与卤代取代的单环氧化物如表卤代醇以1.1-20酸当量比的反应任选地在水和水混溶性溶剂的存在下，并且在催化剂存在下，相对于α，α'-支化的脂肪族二羧酸，其量为α-酸的当量的至多45摩尔％ α支链脂族二羧酸，温度范围为30〜110℃，时间范围为0.5〜2.5小时，（b）加入碱金属氢氧化物或碱金属链烷醇酯直至相对于α，α'-支化的脂肪族二羧酸的酸当量比为0.9:1至1.2:1，在0至80℃的温度下反应，（c）将所得反应混合物去除多余的卤素取代基蒸发单环氧化物，形成溶剂和水，以及（d）除去碱金属卤化物盐，优选通过用浓缩的碱金属氢氧化物水溶液处理残留物后，用与惰性有机溶剂混合的水洗涤所得二缩水甘油酯，以完成脱卤化氢。

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