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81. 发明申请

WO00051496A1 BIOLOGICAL SAMPLING AND STORAGE CONTAINER UTILIZING A DESICCANT 审中-公开
标题翻译：生物采样和储存容器
公开(公告)号：WO00051496A1
公开(公告)日：2000-09-08
申请号：PCT/US2000/005838
申请日：2000-03-03
IPC分类号： A61B10/00
CPC分类号： A61B10/0096 , A61B10/0038 , Y10T436/25375 , Y10T436/255
摘要： The invention provides a biological sampling and storage container (10) which is easy and sanitary to use, may be shipped through regular mail, and includes a drying material (26) or desiccant for drying feces samples that are stored therein. The sampling and storage container (10) consists of a body having a sampling chamber (18) and a drying chamber (20) which are in gaseous communication with each other. Preferably, a sampling wand (14) is frictionally retained in the sampling chamber (18) and the drying material (26) is disposed in the drying chamber (20).
摘要翻译：本发明提供了一种容易且卫生的使用的生物取样和储存容器（10），可以通过普通邮寄运输，并且包括用于干燥储存在其中的粪便样品的干燥剂（26）或干燥剂。采样和存储容器（10）由具有彼此气体连通的采样室（18）和干燥室（20）的主体组成。优选地，采样棒（14）摩擦地保持在采样室（18）中，并且干燥材料（26）设置在干燥室（20）中。

82. 发明申请

WO00048735A2 MATRIX STORAGE AND DISPENSING SYSTEM 审中-公开
标题翻译：矩阵存储和分配系统
公开(公告)号：WO00048735A2
公开(公告)日：2000-08-24
申请号：PCT/US2000/003841
申请日：2000-02-15
IPC分类号： A61J3/00 , A61J3/06 , A61J3/07 , B01J4/02 , B01J19/00 , C40B60/14 , C40B70/00 , G01N35/00 , G01N35/02 , G01N35/04 , G01N35/10 , B01L
CPC分类号： B01J4/02 , B01J19/0046 , B01J2219/00274 , B01J2219/00306 , B01J2219/00308 , B01J2219/0031 , B01J2219/00322 , B01J2219/00333 , B01J2219/00351 , B01J2219/00409 , B01J2219/00459 , B01J2219/00461 , B01J2219/00463 , B01J2219/00466 , B01J2219/00468 , B01J2219/005 , B01J2219/00547 , B01J2219/00596 , B01J2219/00689 , B01J2219/00691 , B01J2219/00693 , C40B60/14 , C40B70/00 , G01N35/0099 , G01N35/025 , G01N35/026 , G01N35/028 , G01N35/1002 , G01N2035/00158 , G01N2035/00752 , G01N2035/042 , G01N2035/0425 , G01N2035/1041 , Y10T436/25375 , Y10T436/255 , Y10T436/2575
摘要： The present invention provides a system and process providing variable access to, as well as quick and accurate dispensing of, numerous selected reagents from a mass storage arrangement. According to one embodiment, an array of reagent dispensers is supported over a movable platform assembly. The platform assembly aligns a designated receiving receptacle under a selected dispenser of the array so that a respective reagent can be dispensed therein. Advantageously, the apparatus and process can be carried out under the control of a programmed computer.
摘要翻译：本发明提供了一种系统和方法，其提供了从大容量存储装置的多种选择的试剂的可变存取以及快速和准确的分配。根据一个实施例，一组试剂分配器被支撑在可移动平台组件上。平台组件将指定的接收容器对准阵列的所选择的分配器，使得可以在其中分配相应的试剂。有利的是，装置和过程可以在编程计算机的控制下进行。

83. 发明申请

WO9913976A9 APPARATUSES AND METHODS FOR ISOLATING NUCLEIC ACID 审中-公开
标题翻译：用于分离核酸的装置和方法
公开(公告)号：WO9913976A9
公开(公告)日：2000-06-08
申请号：PCT/US9819291
申请日：1998-09-17
申请人： GENTRA SYSTEMS INC
发明人： HEATH ELLEN M , SHUMAN RUTH M
IPC分类号： C12M1/00 , B01J8/06 , C07H21/04 , C12N15/10 , G01N1/34 , G01N35/00 , G01N35/02 , G01N35/10
CPC分类号： G01N1/405 , C12N15/1006 , G01N35/025 , G01N2035/00752 , G01N2035/103 , G01N2035/1053 , Y10T436/114998 , Y10T436/119163 , Y10T436/143333 , Y10T436/25375 , Y10T436/255 , Y10T436/2575
摘要： Apparatus and methods for isolating nucleic acids use a loading station (2200, 2500) to load a sample onto a solid support in a container (2424) using a pump or vacuum source, a fluidic station (2420) to remove contaminants using a centrifuge, pump or vacuum source, and a sample collection station (2800) to separate the nucleic acids from the support using a centrifuge, pump or vacuum source.
摘要翻译：用于分离核酸的装置和方法使用装载站（2200,2500）使用泵或真空源将样品装载到容器（2424）中的固体支持物上，使用离心机去除污染物的流体站（2420）泵或真空源，以及样品收集站（2800），以使用离心机，泵或真空源将核酸与载体分离。

84. 发明申请

WO00025924A1 AUTOMATED SAMPLE PROCESSOR 审中-公开
标题翻译：自动样品处理器
公开(公告)号：WO00025924A1
公开(公告)日：2000-05-11
申请号：PCT/US1999/025917
申请日：1999-11-04
IPC分类号： B01L3/00 , B01L3/02 , G01N1/18
CPC分类号： B01L3/502 , B01L2400/0478 , B01L2400/0622 , B01L2400/0644 , Y10T436/25375 , Y10T436/255 , Y10T436/2575
摘要： Provided is a liquid handling device (100) comprising: a cylindrical actuator cavity (120) in a substrate (101), the actuator cavity (120) intersected by two or more actuator channels (122); one or more chambers (110) with an access channel (112) adapted to connect to a separate one of actuator channels (122); and an actuator (150) comprising a cylindrical body having a cylinder axis and having therein a liquid-handling compartment (160) arrayed along the cylinder axis, a first end and a second end, the liquid-handling compartment (160) being closed at the second end, a dispensing channel (151) located at the second end and traversing the cylindrical body, the dispensing channel (151) adapted to be separately aligned with the actuator channels, wherein the actuator (150) is adapted to receive in a seal-tight manner a plunger (170) that operates to confine an effective chamber defined by the plunger (170) and the second end by moving toward the second end or to expand the effective chamber by moving toward the first end. Preferably, one or more of the chambers are formed within the substrate (101).
摘要翻译：提供了一种液体处理装置（100），包括：在基板（101）中的圆柱形致动器腔（120），所述致动器腔（120）由两个或更多个致动器通道（122）相交; 具有适于连接到单独的一个致动器通道（122）的进入通道（112）的一个或多个腔室（110）; 以及致动器（150），其包括具有气缸轴线的圆柱形主体，并且其中具有沿着所述气缸轴线排列的液体处理室（160），第一端和第二端，所述液体处理室（160）在第二端，位于第二端并横穿圆柱体的分配通道（151），分配通道（151）适于与致动器通道单独对准，其中致动器（150）适于接收密封件一个柱塞（170），其操作以通过朝着第二端移动来限制由柱塞（170）和第二端限定的有效室，或通过向第一端移动而使有效室膨胀。优选地，一个或多个室形成在衬底（101）内。

85. 发明申请

WO9922244B1 METHOD FOR DETERMINATION OF DRUGS OF ABUSE IN BIOLOGICAL SAMPLES 审中-公开
标题翻译：用于确定生物样品中滥用药物的方法
公开(公告)号：WO9922244B1
公开(公告)日：1999-09-10
申请号：PCT/US9822462
申请日：1998-10-22
申请人： VARIAN INC
发明人： NAU DAVID R
IPC分类号： G01N30/08 , B01J20/285 , B01L3/00 , G01N30/88 , G01N33/94
CPC分类号： G01N33/94 , Y10S436/901 , Y10T436/141111 , Y10T436/145555 , Y10T436/255
摘要： A high purity styrene-divinyl benzene resin is used for rapid solid phase extraction of drugs of abuse from body fluid samples. Simple extraction procedures are described which provide high recovery and selectivity for a wide variety of drugs. A convenient method of increasing flow rate in such solid phase extractions is also described.
摘要翻译：高纯度苯乙烯 - 二乙烯基苯树脂用于从体液样品中快速固相萃取药物。描述了简单的提取程序，其为各种药物提供高回收率和选择性。还描述了在这种固相萃取中增加流速的方便方法。

86. 发明申请

WO99039196A1 DETERMINATION OF NONIONIC SURFACTANTS IN AQUEOUS ALKALINE SOLUTIONS 审中-公开
标题翻译：在碱性溶液中测定非离子表面活性剂
公开(公告)号：WO99039196A1
公开(公告)日：1999-08-05
申请号：PCT/EP1999/000200
申请日：1999-01-15
IPC分类号： G01N31/22
CPC分类号： G01N31/22 , Y10T436/255
摘要： The present invention is a process for precisely measuring the concentration of a nonionic surfactant in an aqueous alkaline solution. The process comprises extracting the surfactant into an organic solvent, separating the solvent and forming a colored complex that can be quantitatively measured to give the actual concentration of the surfactant.
摘要翻译：本发明是精确测定碱性水溶液中非离子表面活性剂的浓度的方法。该方法包括将表面活性剂萃取到有机溶剂中，分离溶剂并形成可定量测量的着色络合物，得到表面活性剂的实际浓度。

87. 发明申请

WO9857746A3 DIFFERENTIAL VACUUM CHAMBER FOR DIRECTED TRANSPORT OF A SUBSTANCE 审中-公开
标题翻译：差分真空室进行有针对性的运输的物质
公开(公告)号：WO9857746A3
公开(公告)日：1999-06-03
申请号：PCT/EP9803763
申请日：1998-06-19
申请人： BIOTECHNOLOG FORSCHUNG GMBH , BLOECKER HELMUT , KAUER GERHARD
发明人： BLOECKER HELMUT , KAUER GERHARD
IPC分类号： G01N1/10 , B01J3/02 , B01L3/00 , C12M3/06 , C12Q1/68 , G01N1/34 , G01N35/00
CPC分类号： B01L3/5025 , B01L3/50255 , G01N1/34 , G01N35/0099 , G01N2035/00485 , Y10T436/25 , Y10T436/25375 , Y10T436/255
摘要： The invention relates to a vacuum chamber comprising at least two vacuum areas, wherein substances, specially liquids, are transported in a targeted manner from one area to the other by creating an appropriate vacuum. Using filter supports or carrier supports, it is possible to automatically transport a liquid during a plasmid preparation through appropriate filter carrier. The vacuum chamber is charged by an automatic gripper robot and switched by a corresponding valve control device. By integrating the vacuum chamber with its gripper robot and drive mechanism into a pipette robot system, an automatic plasmid preparation, e.g. according to the Qiagen protocol, is possible.
摘要翻译：在真空室中，其具有至少两个真空区，是这样的物质，尤其是液体，从一个区域特异性运送到其他通过施加适当的真空。这使得有可能通过使用过滤器或记录介质的自动输送的液体，同时用适当的过滤器支撑的质粒。真空室是由自动操作的机器人夹持器馈送，并通过相应的阀控制连接。通过在Pipettierrobotersystem真空腔与它的夹持器机器人和驱动集成的自动质粒制备是可能的，例如，根据Qiagen公司的协议。

88. 发明申请

WO99008095A1 ANALYTICAL CARTRIDGE 审中-公开
标题翻译：分析盒
公开(公告)号：WO99008095A1
公开(公告)日：1999-02-18
申请号：PCT/US1998/015616
申请日：1998-07-28
IPC分类号： G01N31/20 , B01L3/00 , G01N1/36 , G01N1/38 , G01N21/07 , G01N33/48 , G01N35/00 , G01N37/00
CPC分类号： B01L3/502 , B01L3/5027 , G01N1/38 , G01N21/07 , Y10T436/111666 , Y10T436/25 , Y10T436/25375 , Y10T436/255 , Y10T436/25625 , Y10T436/2575
摘要： An analytical cartridge (10) adapted for use in analyzing fluids which contain liquid and solid components. The cartridge includes a plumbing system composed of various wells (38, 48, 50, 55) or chambers which are interconnected by passageways (60, 62, 66, 56, 68). After introduction into the cartridge, liquid samples are separated and transported to a test well utilizing a sequential application of centrifugal force followed by pressurization of the system. The cartridge may be used to measure the concentration of a wide variety of chemical constituents in bodily fluids and is useful in measuring other properties of these fluids which contain liquid and solid components.
摘要翻译：适用于分析含有液体和固体组分的流体的分析盒（10）。墨盒包括由通过通道（60,62,66,56,68）互连的各种孔（38,48,50,55）或腔室组成的管道系统。引入墨盒后，液体样品被分离并运送到测试孔，利用离心力的顺序施加，然后加压该系统。药筒可用于测量体液中各种化学成分的浓度，并且可用于测量含有液体和固体组分的这些流体的其它性质。

89. 发明申请

WO99004260A1 DETERMINING ALCOHOL INTAKE USING SIALIC ACID/APO J 审中-公开
标题翻译：使用SIALIC ACID / APO确定酒精饮料J
公开(公告)号：WO99004260A1
公开(公告)日：1999-01-28
申请号：PCT/US1998/014501
申请日：1998-07-15
IPC分类号： G01N33/92 , G01N33/50 , G01N33/66
CPC分类号： G01N33/92 , Y10S436/811 , Y10T436/104165 , Y10T436/105831 , Y10T436/25 , Y10T436/25125 , Y10T436/25375 , Y10T436/255
摘要： Disclosed is a method for determining alcohol intake or alcohol liver damage in a subject by quantifying the content of sialic acid in apolipoprotein J (Apo J). In particular the present invention involves the steps of (a) providing a sample containing Apo J from the subject; (b) purifying the Apo J from the sample; (c) determining sialylation index, i.e. moles sialic acid per mole of Apo J in the sample; and evaluating whether the sialylation index is an indication of alcohol intake or alcohol related liver damage recovery from alcohol addiction or alcohol relapse in the subject.
摘要翻译：公开了通过量化载脂蛋白J（Apo J）中唾液酸的含量来测定受试者的酒精摄入或酒精肝损伤的方法。特别地，本发明涉及以下步骤：（a）从受试者提供含有Apo J的样品; （b）从样品中纯化Apo J; （c）测定唾液酸化指数，即样品中每摩尔Apo J的唾液酸摩尔数; 并评估唾液酸化指数是否是受试者酒精成瘾或酒精复发中酒精摄入或酒精相关肝损伤恢复的指征。

90. 发明申请

WO98046648A1 INTERACTIVE SYSTEM FOR SUBSTANCE PRESENTATION AND ELIMINATION 审中-公开
标题翻译：为了呈现相互作用体系或物质的去除
公开(公告)号：WO98046648A1
公开(公告)日：1998-10-22
申请号：PCT/EP1998/002183
申请日：1998-04-14
IPC分类号： A23L33/00 , A61F2/06 , A61F2/30 , A61K9/00 , A61K31/74 , A61K38/00 , A61K45/00 , A61K47/32 , A61K47/48 , A61L27/00 , A61L29/00 , A61M1/16 , A61P3/00 , A61P7/02 , A61P31/04 , A61P31/10 , A61P33/00 , A61P35/00 , B01D67/00 , B01D69/14 , B01D71/40 , C07K16/24 , C08F8/00 , C08G65/00 , C08G85/00 , C12N11/08 , C08G81/02 , G01N33/545
CPC分类号： B01D67/0093 , A61K31/74 , A61M1/16 , B01D69/141 , B01D71/40 , C07K16/241 , C08G81/02 , C12N11/08 , Y10T436/25125 , Y10T436/255
摘要： The present invention relates to an interactive system comprising at least one active surface of plastic from monomers containing at least one structural element derived from a carbon dioxide (A), and at least one substance associated to a linker with at least one structural element (B) capable of establishing a hydrogen bond, and involving an interaction between the structural elements (A) and (B). That interactive system is suitable for presenting and eliminating substances in liquids.
摘要翻译：本发明涉及一种交互系统，耦接包括单体，其含有至少一个羧酸结构单元（A）的衍生物的基础上，至少一个塑料的活性表面，并具有至少一个能够形成氢键结构元件（B）的接头中的至少一个物质，结构构件之间的相互作用发生（A）和（B）。这种相互作用系统适用于呈现和在液体中除去的物质。

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