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81. 发明申请

WO03008941A3 COMBINED MOLECULAR BLINDING DETECTION THROUGH FORCE MICROSCOPY AND MASS SPECTROMETRY 审中-公开
标题翻译：通过强力显微镜和质谱分析的组合分子检测
公开(公告)号：WO03008941A3
公开(公告)日：2003-05-30
申请号：PCT/US0222646
申请日：2002-07-17
申请人： BIOFORCE NANOSCIENCES INC , HENDERSON ERIC
发明人： HENDERSON ERIC
IPC分类号： G01Q30/02 , G01Q30/14 , G01Q60/10 , G01Q60/18 , G01Q60/24 , G01Q60/42 , G01N13/00
CPC分类号： G01Q30/02 , G01Q60/42
摘要： The present invention includes a method for analyzing and characterizing molecular interaction events utilizing a combined scanning probe microscope (SPM) and a mass spectrometer (MS). An array of one or more deposition materials may be randomly deposited on a suitable surface, scanned with the SPM ( or AFM) to take an initial reading of the topography of the deposition materials on the surface, and then exposed to a target sample containing a target material which may bind or interact to one or more of the deposition materials on the surface. The surface is then scanned again with the SPM to determine the molecular interaction sites and then these sites are analyzed using the MS to determine both the unknown and the deposition material.
摘要翻译：本发明包括利用组合扫描探针显微镜（SPM）和质谱仪（MS）分析和表征分子相互作用事件的方法。可以将一个或多个沉积材料的阵列随机沉积在合适的表面上，用SPM（或AFM）扫描以对表面上的沉积材料的形貌进行初步读取，然后暴露于含有可能与表面上的一种或多种沉积材料结合或相互作用的靶材料。然后再次用SPM扫描表面以确定分子相互作用位点，然后使用MS分析这些位点以确定未知和沉积材料。

82. 发明申请

WO1995006138A1 MICROSCOPIC METHOD FOR DETECTING MICROMOTIONS 审中-公开
标题翻译：用于检测微量的微观方法
公开(公告)号：WO1995006138A1
公开(公告)日：1995-03-02
申请号：PCT/US1994009678
申请日：1994-08-25
申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
发明人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA , HOLZRICHTER, John, F. , SIEKHAUS, Wigbert, J.
IPC分类号： C12Q01/68
CPC分类号： G01Q60/42 , C12Q1/6869 , G01Q60/04 , Y10S977/853 , C12Q2565/601
摘要： A scanning probe microscope, such as an atomic force microscope (AFM) or a scanning tunneling microscope (STM), is operated in a stationary mode on a site where an activity of interest occurs to measure and identify characteristic time-varying micromotions caused by biological, chemical, mechanical, electrical, optical or physical processes. The tip and cantilever assembly of an AFM is used as a micromechnaical detector of characteristic micromotions transmitted either directly by a site of interest or indirectly through the surrounding medium. Alternatively, the exponential dependence of the tunneling current on the size of the gap in the STM is used to detect micromechanical movement. The stationary mode of operation can be used to observe dynamic biological processes in real time and in a natural environment, such as polymerase processing of DNA for determining the sequence of a DNA molecule.
摘要翻译：诸如原子力显微镜（AFM）或扫描隧道显微镜（STM）的扫描探针显微镜在静息模式下在感兴趣的活动位置进行操作，以测量和识别由生物引起的特征性时变微型化学，机械，电气，光学或物理过程。 AFM的尖端和悬臂组件被用作直接通过感兴趣的位置或间接地通过周围介质传输的特征微量级的微技术检测器。或者，隧道电流对STM中间隙大小的指数依赖性用于检测微机械运动。固定操作模式可以用于实时和自然环境中观察动态生物过程，例如用于确定DNA分子序列的DNA的聚合酶处理。

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