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81. 发明申请

WO2015135071A1 DIAGNOSTIC FOR SEPSIS 审中-公开
标题翻译：诊断诊断
公开(公告)号：WO2015135071A1
公开(公告)日：2015-09-17
申请号：PCT/CA2015/000160
申请日：2015-03-13
申请人： HANCOCK, Robert E. W. , PENA SERRATO, Olga M. , HANCOCK, David G. , BOYD, John
发明人： HANCOCK, Robert E. W. , PENA SERRATO, Olga M. , HANCOCK, David G. , BOYD, John
IPC分类号： C40B40/08 , C12Q1/68 , C40B30/04 , G01N33/48
CPC分类号： C12Q1/689 , A61K35/15 , C12N15/1068 , C12Q1/6883 , C12Q2600/118 , C12Q2600/136 , C12Q2600/158 , C12Q2600/16 , C12Q2600/172
摘要： A method of diagnosing severe sepsis prior to definitive clinical diagnosis. A pattern of gene expression that correlates strongly with a future diagnosis of severe sepsis and organ failure was identified in patients who had their blood drawn at first clinical presentation. The methods comprise identifying a pattern of two or more polynucleotides, whereby the altered expression of these polynucleotides correlates with prospective and actual sepsis. Also methods of identifying agents for treating sepsis based on the characteristics of this gene expression pattern are provided.
摘要翻译：在确定临床诊断前诊断严重脓毒症的方法。在首次临床表现时抽取血液的患者中确定了与严重脓毒症和器官功能衰竭的未来诊断密切相关的基因表达模式。所述方法包括鉴定两个或多个多核苷酸的模式，由此这些多核苷酸的改变的表达与预期和实际败血症相关。还提供了基于该基因表达模式的特征鉴定用于治疗败血症的药剂的方法。

82. 发明申请

WO2015133800A1 EGFR 티로신 키나아제 억제제에 대한 항암 치료 반응 예측 마커 审中-公开
标题翻译：关于EGFR酪氨酸激酶抑制剂预防抗生素治疗反应的标记
公开(公告)号：WO2015133800A1
公开(公告)日：2015-09-11
申请号：PCT/KR2015/002054
申请日：2015-03-03
申请人： 연세대학교 산학협력단
发明人： 조병철 , 김한상
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2600/118
摘要： 본 발명은 EGFR 티로신 키나아제 억제제에 의한 암 치료의 예후를 예측하기 위한 정보 제공 방법, 암 치료의 예후 예측용 조성물, 및 키트를 제공한다. 본 발명에 따르면 IL6, IL8, PLA2G2A, IL1A, TNF, MMP3 및 PTGS2로 이루어진 군으로부터 선택되는 하나 이상의 유전자 또는 단백질 발현 수준을 측정함으로써 EGFR 티로신 키나아제 억제제에 의한 암 치료의 예후를 예측할 수 있게 되므로 환자를 치료하기 위한 약제 선택을 위해 유용하게 활용될 수 있다.
摘要翻译：本发明提供了一种提供用于预测癌症治疗预后的信息的方法，以及用于使用EGFR酪氨酸激酶抑制剂预测癌症治疗的预后的组合物和试剂盒。本发明涉及测量选自IL6，IL8，PLA2G2A，IL1A，TNF，MMP3和PTGS2的基因或蛋白质的表达水平，从而可以预测使用EGFR酪氨酸的癌症治疗的预后激酶抑制剂，因此为了选择用于治疗患者的药物，本发明可以有利地使用。

83. 发明申请

WO2015131095A1 METHODS AND COMPOSITIONS FOR PROGNOSTIC RISK ANALYSIS OF CLEAR CELL RENAL CELL CARCINOMA 审中-公开
标题翻译：清除细胞细胞癌的预防风险分析方法及组合
公开(公告)号：WO2015131095A1
公开(公告)日：2015-09-03
申请号：PCT/US2015/018093
申请日：2015-02-27
申请人： THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL
发明人： RATHMELL, W., Kimryn , BROOKS, Samira , JOEL, Parker , BRANNON, A., Rose
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2600/112 , C12Q2600/118 , C12Q2600/158
摘要： Provided are methods for distinguishing clear cell type A (ccA) renal cell carcinoma from clear cell type B (ccB) renal cell carcinoma in a subject. In some embodiments, the method include the steps of obtaining a biological sample from a subject that has clear cell renal cell carcinoma (ccRCC); assaying the biological sample to determine an expression level for one or more and optionally all thirty-four of the gene products listed in Table 1 in the biological sample; and comparing the expression level(s) determined to a statistically validated reference. Also provided are methods for generating prognostic signatures for subject with ccRCC, methods for assessing risk of an adverse outcome of a subject with ccRCC, methods for predicting a clinical outcome of a treatment in a subject having ccRCC, and arrays that can be employed in the practice of the presently disclosed methods.
摘要翻译：本发明提供了一种将透明细胞型A（ccA）肾细胞癌与受试者的透明细胞B型（ccB）肾细胞癌区分开的方法。在一些实施方案中，该方法包括从具有透明细胞肾细胞癌（ccRCC）的受试者获得生物样品的步骤; 测定生物样品以确定生物样品中表1中列出的一种或多种并任选地全部三十四种基因产物的表达水平; 并将确定的表达水平与统计学验证的参考值进行比较。还提供了用于产生具有ccRCC的受试者的预后特征的方法，用于使用ccRCC评估受试者的不良结果的风险的方法，用于预测具有ccRCC的受试者的治疗的临床结果的方法，以及可用于本方法的实践。

84. 发明申请

WO2015130968A2 T CELL BALANCE GENE EXPRESSION, COMPOSITIONS OF MATTERS AND METHODS OF USE THEREOF 审中-公开
标题翻译： T细胞平衡基因表达，物质组合物及其使用方法
公开(公告)号：WO2015130968A2
公开(公告)日：2015-09-03
申请号：PCT/US2015/017826
申请日：2015-02-26
申请人： THE BROAD INSTITUTE INC. , THE BRIGHAM AND WOMEN'S HOSPITAL, INC. , PRESIDENT AND FELLOWS OF HARVARD COLLEGE , MASSACHUSETTS INSTITUTE OF TECHNOLOGY
发明人： KUCHROO, Vijay , REGEV, Aviv , GAUBLOMME, Jellert , LEE, Youjin , SHALEK, Alexander, K. , WANG, Chao , YOSEF, Nir
IPC分类号： C12Q1/68
CPC分类号： G01N33/6863 , C07K16/2866 , C07K16/2896 , C07K2317/21 , C07K2317/24 , C07K2317/75 , C07K2317/76 , C12Q1/6883 , C12Q2600/112 , C12Q2600/118 , C12Q2600/158 , G01N2800/50 , G01N2800/52 , G01N2800/56
摘要： This invention relates generally to compositions and methods for identifying the regulatory network that modulates, controls or otherwise influences T cell balance, for example, Th17 cell differentiation, maintenance and/or function, as well, compositions and methods for exploiting the regulatory network that modulates, controls or otherwise influences T cell balance in a variety of therapeutic and/or diagnostic indications. This invention also relates generally to identifying and exploiting target genes and/or target gene products that modulate, control or otherwise influence T cell balance in a variety of therapeutic and/or diagnostic indications.
摘要翻译：本发明一般涉及用于鉴定调节，控制或以其他方式影响T细胞平衡（例如Th17细胞分化，维持和/或功能）的调节网络的组合物和方法，以及组合物和利用调节，控制或以其他方式影响各种治疗和/或诊断指征中的T细胞平衡的调节网络的方法。本发明还一般涉及鉴定和开发在多种治疗和/或诊断适应症中调节，控制或以其他方式影响T细胞平衡的靶基因和/或靶基因产物。

85. 发明申请

WO2015126904A1 BACTERIAL IDENTIFICATION IN CLINICAL INFECTIONS 审中-公开
标题翻译：临床感染中的细菌鉴定
公开(公告)号：WO2015126904A1
公开(公告)日：2015-08-27
申请号：PCT/US2015/016319
申请日：2015-02-18
申请人： THE ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA
发明人： WATTS, George, S. , HURWITZ, Bonnie, L.
IPC分类号： C12Q1/68 , C40B20/00 , C40B30/02 , G01N33/50
CPC分类号： C40B30/02 , C12Q1/04 , C12Q1/6869 , C12Q1/689 , C12Q2600/118 , C12Q2600/158 , C12Q2600/16 , G06F19/18 , G06F19/24
摘要： Disclosed herein are methods of identifying infections, such as methods of identifying bacterial infections which utilize whole metagenome sequence analysis to sequence the entire wound microbiome of clinical samples. The disclosed methods use fast k-mer based sequence analysis, predictive modeling, and Bayesian network analysis, to analyze bacterial metagenomic sequence compositions in conjunction with clinical factors to stratify communities of bacteria into healing versus non-healing clusters. The methods of identifying infections can include performing molecular analysis of a patient wound sample, preparing the data obtained from the molecular analysis, diagnosing the wound sample and/or prognosing the wound sample. The disclosed methods can also be used to identify protein function as well as novel biomarkers.
摘要翻译：本文公开了鉴定感染的方法，例如鉴定细菌感染的方法，其利用整个宏基因组序列分析来对临床样品的整个伤口微生物群进行排序。所公开的方法使用基于快速k-mer的序列分析，预测建模和贝叶斯网络分析，分析细菌宏基因组序列组合物与临床因素，以将细菌群落分解成愈合与非愈合簇。识别感染的方法可以包括对患者伤口样品进行分子分析，制备从分子分析获得的数据，诊断伤口样品和/或预测伤口样品。所公开的方法也可用于鉴定蛋白质功能以及新型生物标志物。

86. 发明申请

WO2015126886A1 MIR-320E AND COLORECTAL CANCER 审中-公开
标题翻译： MIR-320E和COLORECTAL CANCER
公开(公告)号：WO2015126886A1
公开(公告)日：2015-08-27
申请号：PCT/US2015/016285
申请日：2015-02-18
申请人： BAYLOR RESEARCH INSTITUTE
发明人： GOEL, Ajay , PEREZ-CARBONELL, Lucia , BOLAND, C., Richard
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , A61K31/513 , C12N15/113 , C12N2310/14 , C12N2320/30 , C12Q2600/118 , C12Q2600/158 , C12Q2600/178 , G06F19/00 , G16H10/60 , G16H40/63 , Y02A90/22 , Y02A90/26
摘要： Embodiments provide methods and compositions related to determining treatments for colorectal cancer patients by detection and analysis of the expression level of miRNA such as miR-320e in the patients. Embodiments provide predictive, prognostic and/or diagnostics methods by identifying miRNAs that are useful for clinical management of cancer patients, particularly colorectal cancer patients or patients at risk or determined to have colorectal cancer. Methods and compositions are based, in part, on the discovery that expression of certain miRNAs in cancer patients is associated with advancing cancer stages and/or can predict the responsiveness of cancer therapy, and can, therefore, provide basis for designing treatment strategies. In particular embodiments, the miRNA molecule is miR-320, particularly miR-320e.
摘要翻译：实施例提供了通过检测和分析患者诸如miR-320e之类的miRNA的表达水平来确定结肠直肠癌患者治疗相关的方法和组合物。实施例通过鉴定可用于临床治疗癌症患者，特别是结肠直肠癌患者或处于风险中或确定为结肠直肠癌的患者的miRNA来提供预测，预后和/或诊断方法。方法和组合部分地基于发现癌症患者中某些miRNA的表达与癌症阶段的进展和/或可以预测癌症治疗的反应性相关联，并且因此可以为设计治疗策略提供依据。在具体实施方案中，miRNA分子是miR-320，特别是miR-320e。

87. 发明申请

WO2015126557A1 IDENTIFICATION OF CATTLE AT RISK OF HIGH ALTITUDE PULMONARY HYPERTENSION 审中-公开
标题翻译：识别高海拔肺动脉高压风险
公开(公告)号：WO2015126557A1
公开(公告)日：2015-08-27
申请号：PCT/US2015/012242
申请日：2015-01-21
申请人： VANDERBILT UNIVERSITY , COLORADO STATE UNIVERSITY RESEARCH FOUNDATION
发明人： NEWMAN, John, H. , HAMID, Rizwan , PHILLIPS, John, A. , COGAN, Joy , HOLT, Timothy, N.
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6883 , C12Q2600/118 , C12Q2600/156
摘要： Provided herein are methods and compositions for determining the susceptibility of cattle to High Altitude Pulmonary Hypertension. Also provide are kits and reagents for performing such methods.
摘要翻译：本文提供了确定牛对高原肺高血压的易感性的方法和组合物。还提供用于进行这些方法的试剂盒和试剂。

88. 发明申请

WO2015125027A2 KIT AND METHOD FOR DETECTING BLADDER CANCER 审中-公开
标题翻译：用于检测刀片癌的试剂盒和方法
公开(公告)号：WO2015125027A2
公开(公告)日：2015-08-27
申请号：PCT/IB2015000919
申请日：2015-02-11
申请人： LEICA BIOSYSTEMS NEWCASTLE LTD
发明人： SCHOENMAKERS SASKIA , SCHRICKX HARRY , VOLKERS HERMAN
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q1/68 , C12Q1/6841 , C12Q2600/118 , C12Q2600/156 , C12Q2600/16 , C12Q2537/16
摘要： Methods and kits are provided for screening a patient for bladder cancer. Embodiments include those involving centromeric probes to chromosomes 3, 7, and 10 and a locus- specific probe to 5pl5.
摘要翻译：提供了用于筛选患者膀胱癌的方法和试剂盒。实施方案包括涉及到染色体3,7和10的着丝粒探针和5位5位点特异性探针。

89. 发明申请

WO2015124080A1 ZFP28的变异位点在制备诊断精神分裂症的试剂盒中的用途审中-公开
公开(公告)号：WO2015124080A1
公开(公告)日：2015-08-27
申请号：PCT/CN2015/072866
申请日：2015-02-12
申请人：中国医学科学院基础医学研究所
发明人：许琪 , 饶书权 , 沈岩
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6883 , C12Q2600/118 , C12Q2600/156
摘要：本发明公开了ZFP28的变异位点在制备诊断精神分裂症的试剂盒中的用途。本发明运用外显子组测序方法发现了精神分裂症的一个新的易感基因ZFP28。ZFP28基因的变异位点选自c.1441T>C、c.961G>A、c.1052T>C、c.1081C>T、c.1511C>T、c.1170G>T、c.1208A>G和c.2017T>C；其中变异位点c.1441T>C与精神分裂存在共分离。本发明还公开了ZFP28基因在药物开发中的用途，ZFP28基因作为潜在的药物靶点。

90. 发明申请

WO2015103293A3 SYSTEMS, COMPOSITIONS AND METHODS FOR DETECTING AND ANALYZING MICRO-RNA PROFILES FROM A BIOLOGICAL SAMPLE 审中-公开
标题翻译：用于从生物样品中检测和分析微RNA谱的系统，组合物和方法
公开(公告)号：WO2015103293A3
公开(公告)日：2015-08-27
申请号：PCT/US2014072802
申请日：2014-12-30
申请人： MIROCULUS INC
发明人： TOCIGL ALEJANDRO , CHRISTODOULOU FOTEINI , OLIVARES PABLO , GALINDO FERRAN , SOTO JORGE
IPC分类号： C12P19/34 , C12N9/00 , C12N15/11 , C12Q1/68
CPC分类号： C12Q1/6883 , B01L7/00 , B01L2300/023 , B01L2300/027 , B01L2300/0654 , B01L2300/0829 , B01L2300/18 , C12Q1/6806 , C12Q1/6853 , C12Q1/6886 , C12Q2600/118 , C12Q2600/158 , C12Q2600/16 , C12Q2600/178 , G01N35/00871 , G01N2035/00891 , G01N2035/009 , C12Q2525/155 , C12Q2525/207 , C12Q2531/119 , C12Q2533/107 , C12Q2537/143 , C12Q2521/501 , C12Q2525/161 , C12Q2525/301
摘要： Methods and apparatuses for detecting microRNA from a tissue sample. In particular, described herein are multiplexed methods and apparatuses for implementing them for rapid and parallel detection of a profile of different microRNAs in a patient sample using a modified loop-mediated isothermal amplification ("LAMP") technique.
摘要翻译：用于从组织样品检测微小RNA的方法和装置。特别地，这里描述了用于实施它们的多路复用方法和装置，用于使用修改的环介导的等温放大（“LAMP”）技术来快速和平行地检测患者样品中不同微小RNA的谱。

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