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81. 发明申请

WO1993015113A1 AN IMMUNOTOXIN INCLUDING A CYTOTOXIN WITH AN UNPAIRED CYSTEINE RESIDUE IN OR NEAR ITS RECEPTOR-BINDING SITE 审中-公开
标题翻译：包括在其受体结合位点或其附近存在未经考察的CYSTEINE残留的细胞毒素的免疫原
公开(公告)号：WO1993015113A1
公开(公告)日：1993-08-05
申请号：PCT/US1993000358
申请日：1993-01-15
申请人： TANOX BIOSYSTEMS, INC.
发明人： TANOX BIOSYSTEMS, INC. , CHANG, Tse, Wen
IPC分类号： C07K13/00
CPC分类号： C07K14/21 , A61K38/00 , A61K47/642 , A61K47/68 , A61K47/6829 , C07K14/34
摘要： Disclosed are site-specifically mutated cytotoxins which have an unpaired cysteine residue in or near the cytotoxin's receptor-binding site, and which retain essentially the same receptor-binding ability and cytotoxicity as the native cytotoxins provided they are not conjugated with a binding molecule. The cytotoxins suitable for use in the invention include pseudomonas exotoxin, and diphtheria toxin, and other proteinaceous plant or bacterial toxins which have one receptor-binding site per molecule. The cytotoxins are cross-linked through the free SH group of their unpaired cysteine residues to binding molecules (including monoclonal antibodies, fragments and other ligands) to form immunotoxins, and these immunotoxins do not bind to the cell surface receptors which are bound by the native cytotoxins. However, when the cross-linker is cleaved and the binding molecule is released, the cytotoxin regains its receptor-binding ability and its cytotoxicity.
摘要翻译：公开了在细胞毒素受体结合位点内或附近具有不配对半胱氨酸残基的位点特异性突变的细胞毒素，并且如果它们不与结合分子缀合，则其保留与天然细胞毒素基本相同的受体结合能力和细胞毒性。适用于本发明的细胞毒素包括假单胞菌外毒素和白喉毒素，以及每分子具有一个受体结合位点的其它蛋白质植物或细菌毒素。细胞毒素通过其未配对的半胱氨酸残基的游离SH基团与结合分子（包括单克隆抗体，片段和其他配体）交联以形成免疫毒素，并且这些免疫毒素不结合到天然的结合的细胞表面受体细胞毒素。然而，当交联剂被切割并且结合分子被释放时，细胞毒素恢复其受体结合能力及其细胞毒性。

82. 发明申请

WO1993000358A1 PSEUDOMONAS EXOENZYME S PEPTIDE COMPOSITION AND METHOD 审中-公开
公开(公告)号：WO1993000358A1
公开(公告)日：1993-01-07
申请号：PCT/CA1992000259
申请日：1992-06-23
申请人： SYNTHETIC PEPTIDES INCORPORATED
发明人： SYNTHETIC PEPTIDES INCORPORATED , HODGES, Robert, S. , IRVIN, Randall, T. , PARANCHYCH, William , SOKOL, Pamela, A. , WOODS, Donald, E.
IPC分类号： C07K07/08
CPC分类号： C07K14/21 , A61K39/00 , C12N9/1077
摘要： A peptide having a sequence corresponding to an antigenic site in the protein exoenzyme S which is antigenically similar to a C-terminal portion of the Pseudomonas aeruginosa pilin protein is disclosed. The peptide is cross-reactive with surface peptides present in certain bacterial and fungal microorganisms, and is effective in inhibiting binding of such organisms to target epithelial cells. The peptide may also be employed in a vaccine composition, for producing immunity against such cross-reactive microorganisms.

83. 发明申请

WO1992016230A1 LIPID A ANALOG/IMMUNOGENIC CARRIER CONJUGATES, THE USE THEREOF AS VACCINES AND POLYVALENT HYPERIMMUNE GAMMAGLOBULINS 审中-公开
标题翻译： LIPID A ANALOG / IMMUNOGENIC CARRIER CONJUGATES，其作为疫苗和多价超高效液相色谱的用途
公开(公告)号：WO1992016230A1
公开(公告)日：1992-10-01
申请号：PCT/US1992002093
申请日：1992-03-16
申请人： UNIVAX BIOLOGICS INCORPORATED , TENG, Nelson , SADOFF, Jerald , BHATTACHARJEE, Apurba
发明人： UNIVAX BIOLOGICS INCORPORATED
IPC分类号： A61K39/116
CPC分类号： C07H13/04 , A61K39/02 , A61K2039/6037 , A61K2039/6081 , C07H13/06 , C07H15/04 , C07K1/1077 , C07K14/21 , C07K14/31 , C07K14/34 , C12P19/44
摘要： The invention relates to lipid A analog/immunogenic carrier conjugates and the use thereof as vaccines for the prophylaxis of septic shock in animals. The invention provides for a polyvalent vaccine which contains the lipid A analog/immunogenic carrier conjugate. The invention also relates to a polyvalent hyperimmune gammaglobulin comprising an effective neutralizing amount of an anti-lipid A gammaglobulin and an effective opsonizing amount of an O antigen specific gammaglobulin. Kits containing these materials are also provided.
摘要翻译：本发明涉及脂质A类似物/免疫原性载体缀合物及其作为用于预防动物感染性休克的疫苗的用途。本发明提供含有脂质A类似物/免疫原性载体缀合物的多价疫苗。本发明还涉及包含有效中和量的抗脂质A丙种球蛋白和有效调理量的O抗原特异性丙种球蛋白的多价超免疫性丙种球蛋白。还提供了含有这些材料的套件。

84. 发明申请

WO1991018018A1 IMPROVED PSEUDOMONAS CHIMERIC PROTEIN CYTOTOXIC TO HUMAN CELLS BEARING IL2 RECEPTORS 审中-公开
标题翻译：改进的PSEUDOMONAS CHIMERIC蛋白细胞因子到承载IL2受体的人类细胞
公开(公告)号：WO1991018018A1
公开(公告)日：1991-11-28
申请号：PCT/US1991003264
申请日：1991-05-09
申请人： THE UNITED STATES OF AMERICA, represented by THE ...
发明人： THE UNITED STATES OF AMERICA, represented by THE ... , PASTAN, Ira , FITZGERALD, David , CHAUDHARY, Vijay , GATELY, Maurice
IPC分类号： C07K13/00
CPC分类号： C07K14/55 , A61K38/00 , C07K14/21
摘要： New chimeric proteins kill human cells expressing IL2 receptors with specificity and toxicity greater than heretofore known chimeric toxins.
摘要翻译：新的嵌合蛋白质杀死表达IL2受体的人细胞，其特异性和毒性大于迄今为止已知的嵌合毒素。

85. 发明申请

WO1991009965A1 AN IMPROVED TOXIN FOR CONSTRUCTION OF IMMUNOTOXINS 审中-公开
标题翻译：改进的毒素构建免疫毒素
公开(公告)号：WO1991009965A1
公开(公告)日：1991-07-11
申请号：PCT/US1990007464
申请日：1990-12-21
申请人： THE UNITED STATES OF AMERICA, represented by THE ...
发明人： THE UNITED STATES OF AMERICA, represented by THE ... , PASTAN, Ira, H. , FITZGERALD, David
IPC分类号： C12P21/00
CPC分类号： C07K14/21 , A61K38/00 , C07K19/00
摘要： The present invention described LysPE40-antibody immunotoxin which selectively kills cells bearing appropriate antigens or receptors.
摘要翻译：本发明描述了LysPE40-抗体免疫毒素，其选择性地杀死具有适当抗原或受体的细胞。

86. 发明申请

WO1990012592A1 RECOMBINANT ANTIBODY-TOXIN FUSION PROTEIN 审中-公开
标题翻译：重组抗体-Toxin融合蛋白
公开(公告)号：WO1990012592A1
公开(公告)日：1990-11-01
申请号：PCT/US1990002097
申请日：1990-04-20
申请人： THE UNITED STATES OF AMERICA, as represented by ... , PROTEIN DESIGN LABORATORIES, INC.
发明人： THE UNITED STATES OF AMERICA, as represented by ... , PROTEIN DESIGN LABORATORIES, INC. , PASTAN, Ira, H. , FITZGERALD, David , QUEEN, Cary, L. , WALDMANN, Thomas, A.
IPC分类号： A61K39/395
CPC分类号： C07K14/21 , A61K38/00 , A61K39/00 , A61K47/68 , A61K47/6829 , A61K47/6849 , C07K14/495 , C07K14/55 , C07K16/2866 , C07K16/2896 , C07K2319/00 , C07K2319/33 , C07K2319/55
摘要： The present invention describes recombinant antibody toxin fusion proteins which selectively kill cells bearing appropriate antigens or receptors. Construction and expression of a single chain antibody toxin fusion protein, anti-Tac(Fv)-PE40, gene and thereby the production of improved toxins utilizing PE are described.
摘要翻译：本发明描述了选择性地杀死携带合适抗原或受体的细胞的重组抗体毒素融合蛋白。描述了单链抗体毒素融合蛋白，抗Tac（Fv）-PE40，基因的构建和表达，从而利用PE生产改进的毒素。

87. 发明申请

WO2017191195A1 UNSATURATED AMINO ACIDS 审中-公开
标题翻译：不饱和氨基酸
公开(公告)号：WO2017191195A1
公开(公告)日：2017-11-09
申请号：PCT/EP2017/060552
申请日：2017-05-03
申请人： EVONIK DEGUSSA GMBH
发明人： HAAS, Thomas , THIESSENHUSEN, Anja , BÜLTER, Thomas , KROUTIL, Wolfgang , FABER, Kurt
IPC分类号： C12P13/04 , C12P13/12 , C07C323/58 , C07C319/02 , C12N9/08 , C12N9/02 , C07K14/21 , C12N15/52 , C12N1/21
CPC分类号： C12P13/04 , C07C319/18 , C07K14/21 , C07K14/33 , C12N9/0008 , C12N9/0065 , C12N9/0071 , C12N9/0095 , C12N15/52 , C12P13/12 , C12Y102/01002 , C12Y111/02004 , C12Y114/14001 , C12Y118/01002 , C12Y118/01005 , C07C323/53
摘要： There is provided a method of producing at least one unsaturated amino acid from at least one amino acid comprising at least two carbonyl groups, the method comprising (a) contacting a recombinant microbial cell with a medium comprising the amino acid comprising the carbonyl groups, wherein the cell is genetically modified to comprise -at least a first genetic mutation that increases the expression relative to the wild type cell of an enzyme (E) selected from the CYP152 10 peroxygenase family, and -at least a second genetic mutation that increases the expression relative to the wild type cell of at least one NAD(P)+ oxidoreductase (E2) and the corresponding mediator protein.
摘要翻译：提供了从包含至少两个羰基的至少一个氨基酸生产至少一个不饱和氨基酸的方法，所述方法包括（a）使重组微生物细胞与包含包含所述羰基的氨基酸，其中所述细胞经遗传修饰以包含 - 至少第一遗传突变，所述第一遗传突变相对于野生型细胞增加选自CYP15210过氧化酶家族的酶（E）的表达，并且 - 至少相对于野生型细胞增加至少一种NAD（P）+氧化还原酶（E2）和相应介体蛋白的表达的第二基因突变。

88. 发明申请

WO2017105987A1 INSECTICIDAL PROTEINS AND METHODS FOR THEIR USE 审中-公开
公开(公告)号：WO2017105987A1
公开(公告)日：2017-06-22
申请号：PCT/US2016/065531
申请日：2016-12-08
申请人： PIONEER HI-BRED INTERNATIONAL, INC. , E I DU PONT DE NEMOURS AND COMPANY
发明人： LIU, Lu , LUM, Amy , ORAL, Jarred Kenneth , PEREZ-ORTEGA, Claudia , ROSEN, Barbara Ann Marie , SCHELLENBERGER, Ute , WEI, Jun-Zhi , XIE, Weiping , ZHONG, Xiaohong , ZHU, Genhai
IPC分类号： C07K14/21 , C12N15/82 , C12R1/38 , A01N63/02
CPC分类号： C07K14/21 , A01N37/42 , A01N63/02 , C12N15/8286 , Y02A40/162
摘要： Compositions and methods for controlling pests are provided. The methods involve transforming organisms with a nucleic acid sequence encoding an insecticidal protein. In particular, the nucleic acid sequences are useful for preparing plants and microorganisms that possess insecticidal activity. Thus, transformed bacteria, plants, plant cells, plant tissues and seeds are provided. Compositions are insecticidal nucleic acids and proteins of bacterial species. The sequences find use in the construction of expression vectors for subsequent transformation into organisms of interest including plants, as probes for the isolation of other homologous (or partially homologous) genes. The pesticidal proteins find use in controlling, inhibiting growth or killing Lepidopteran, Coleopteran, Dipteran, fungal, Hemipteran and nematode pest populations and for producing compositions with insecticidal activity.

89. 发明申请

WO2017066479A1 AXMI554 DELTA-ENDOTOXIN GENE AND METHODS FOR ITS USE 审中-公开
标题翻译： AXMI554 DELTA-内毒素基因及其使用方法
公开(公告)号：WO2017066479A1
公开(公告)日：2017-04-20
申请号：PCT/US2016/056898
申请日：2016-10-13
申请人： BAYER CROPSCIENCE LP , BAYER CROPSCIENCE AG
发明人： RODGERS-VIEIRA, Elyse , SAMPSON, Kimberly , LEHTINEN, Duane , LOESEL, Peter , PORTZ, Daniela
IPC分类号： C07K4/04 , C12N15/82 , C07K14/21
CPC分类号： C12N15/8286 , C07K14/21 , Y02A40/162
摘要： Compositions and methods for conferring pesticidal activity to bacteria, plants, plant cells, tissues and seeds are provided. Compositions comprising a coding sequence for a toxin polypeptide are provided. The coding sequences can be used in DNA constructs or expression cassettes for transformation and expression in plants and bacteria. Compositions also comprise transformed bacteria, plants, plant cells, tissues, and seeds. In particular, isolated toxin nucleic acid molecules are provided. Additionally, amino acid sequences corresponding to the polynucleotides are encompassed, and antibodies specifically binding to those amino acid sequences. In particular, the present invention provides for isolated nucleic acid molecules comprising nucleotide sequences encoding the amino acid sequence shown in SEQ ID NO:4-l l, or the nucleotide sequence set forth in SEQ ID NO: 1-3, as well as variants and fragments thereof.
摘要翻译：提供了赋予细菌，植物，植物细胞，组织和种子杀虫活性的组合物和方法。提供了包含毒素多肽的编码序列的组合物。编码序列可用于DNA构建体或表达盒中用于在植物和细菌中转化和表达。组合物还包含转化的细菌，植物，植物细胞，组织和种子。具体而言，提供了分离的毒素核酸分子。此外，还包括对应于多核苷酸的氨基酸序列，以及与那些氨基酸序列特异性结合的抗体。具体而言，本发明提供了分离的核酸分子，其包含编码SEQ ID NO：4-11所示氨基酸序列或SEQ ID NO：1-3所示核苷酸序列的核苷酸序列，以及变体和片段。

90. 发明申请

WO2016179101A2 TYPE III SECRETION SYSTEM TARGETING MOLECULES 审中-公开
标题翻译：第三类分泌系统分析分子
公开(公告)号：WO2016179101A2
公开(公告)日：2016-11-10
申请号：PCT/US2016/030429
申请日：2016-05-02
申请人： INHIBRX LP
发明人： HOLLANDS, Andrew , TIMMER, John C. , DEVERAUX, Quinn , ECKELMAN, Brendan P.
IPC分类号： C07K16/12 , C07K14/21
CPC分类号： C07K16/1214 , A61K38/00 , C07K14/21 , C07K2317/31 , C07K2317/76
摘要： This invention relates generally to molecules that specifically bind bacterial V-tip proteins of the type III secretion system of Gram negative bacteria such as PcrV from Pseudomonas aeruginosa. More specifically, this invention relates to molecules that block the injection of effector molecules into target cells. This invention also relates to molecules that specifically bind to bacterial lipoproteins, such as Oprl. The molecules of the present invention are monospecific or multispecific and can bind their target antigen in a monovalent or multivalent manner. The invention also relates generally to molecules that specifically bind bacterial cell surface proteins such as Oprl, and to methods of use these molecules in a variety of therapeutic, diagnostic, and/or prophylactic indications.
摘要翻译：本发明一般涉及特异性结合来自绿脓假单胞菌的革兰氏阴性细菌如PcrV的III型分泌系统的细菌V-tip蛋白的分子。更具体地，本发明涉及阻断效应分子注入靶细胞的分子。本发明还涉及特异性结合细菌脂蛋白的分子，例如Opr1。本发明的分子是单特异性或多特异性的并且可以以单价或多价方式结合其靶抗原。本发明一般还涉及特异性结合细菌细胞表面蛋白如Opr1的分子，以及在各种治疗，诊断和/或预防指征中使用这些分子的方法。

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