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81. 发明申请

WO2012007877A3 N- SULFONYLBENZAMIDES AS INHIBITORS OF VOLTAGE - GATED SODIUM CHANNELS 审中-公开
标题翻译： N-磺酰苯胺作为电压门式通道的抑制剂
公开(公告)号：WO2012007877A3
公开(公告)日：2012-03-08
申请号：PCT/IB2011052998
申请日：2011-07-06
申请人： PFIZER LTD , BELL ANDREW SIMON , BROWN ALAN DANIEL , LEWTHWAITE RUSSELL ANDREW , PEREZ PACHECO MANUEL , RAWSON DAVID JAMES , STORER ROBERT IAN , SWAIN NIGEL ALAN
发明人： BELL ANDREW SIMON , BROWN ALAN DANIEL , LEWTHWAITE RUSSELL ANDREW , PEREZ PACHECO MANUEL , RAWSON DAVID JAMES , STORER ROBERT IAN , SWAIN NIGEL ALAN
IPC分类号： C07D213/64 , A61K31/415 , A61K31/44 , A61K31/444 , A61P25/04 , C07C311/51 , C07D231/12 , C07D401/12
CPC分类号： A61K31/444 , A61K31/18 , A61K31/4164 , A61K31/4418 , A61K45/06 , C07C311/13 , C07C311/51 , C07D213/64 , C07D213/65 , C07D213/69 , C07D231/12 , C07D233/64 , C07D239/26 , C07D239/42 , C07D401/12
摘要： The invention relates to sulfonamide derivatives, to their use in medicine, to compositions containing them, to processes for their preparation and to intermediates used in such processes. More particularly the invention relates to a new sulfonamide Nav1.7 inhibitors of formula 10 (I): (I) or a pharmaceutically acceptable salt thereof, wherein Z, R 1, R2, R3, R4 and R5 are as defined in the description. Nav 1.7 inhibitors are potentially useful in the treatment of a wide range of disorders, particularly pain.
摘要翻译：本发明涉及磺酰胺衍生物，其在医学上的用途，含有它们的组合物，其制备方法以及在这些方法中使用的中间体。更具体地，本发明涉及式10（I）的新型磺酰胺Nav1.7抑制剂：（I）或其药学上可接受的盐，其中Z，R 1，R 2，R 3，R 4和R 5如说明书中所定义。 Nav 1.7抑制剂可用于治疗各种疾病，特别是疼痛。

82. 发明申请

WO2012021963A1 NOVEL SULFONAMIDE COMPOUNDS FOR INHIBITION OF METASTATIC TUMOR GROWTH 审中-公开
标题翻译：用于抑制分泌性肿瘤生长的新型磺酰胺化合物
公开(公告)号：WO2012021963A1
公开(公告)日：2012-02-23
申请号：PCT/CA2011/000727
申请日：2011-06-22
申请人： METASIGNAL THERAPEUTICS INC. , SUPURAN, Claudiu , DEDHAR, Shoukat , MCDONALD, Paul, C. , CARTA, Fabrizio
发明人： SUPURAN, Claudiu , DEDHAR, Shoukat , MCDONALD, Paul, C. , CARTA, Fabrizio
IPC分类号： C07C311/47 , A61K31/18 , A61K31/63 , A61P35/00
CPC分类号： A61K31/63 , A61K31/18 , A61K31/277 , A61K45/06 , C07C311/47 , C07C2601/08 , C07C2602/08 , C07C2603/18 , A61K2300/00
摘要： Therapeutic sulfonamide compounds with the formula R-Q-Ar-SO 2 NH 2 are disclosed, wherein R is an aryl, hetaryl, alkyl or cycloalkyl group, Q is the group -L(CH 2 ) n -, wherein n = 0,1 or 2 and L is the group - NHCXNH-, -NHC(S)SNH-, -NHCONHCSNH- or -SO 2 NH-, X is O or S and Ar is a C 6 -C 10 aromatic or a heteroaromatic group that contains at least one heteroatom of oxygen, nitrogen or sulphur, which compounds selectively inhibit CAIX and CAXII, and which are effective in inhibiting hypoxic tumor growth, suppress metastases, and impair and deplete cancer stem cells in mammals.
摘要翻译：公开了具有式RQ-Ar-SO2NH2的治疗磺酰胺化合物，其中R是芳基，杂芳基，烷基或环烷基，Q是基团-L（CH 2）n - ，其中n = 0,1或2，L是基团-NHCXNH-，-NHC（S）SNH-，-NHCONHCSNH-或-SO2NH-，X是O或S，Ar是包含至少一个氧，氮或杂原子的C 6 -C 10芳族或杂芳族基团硫化合物，其选择性地抑制CAIX和CAXII，并且其有效抑制缺氧性肿瘤生长，抑制转移，并损害和消耗哺乳动物中的癌症干细胞。

83. 发明申请

WO2012018868A1 SUBSTITUTED 2-HYDROXY-4-(2-(PHENYLSULFONAMIDO)ACETAMIDO)BENZOIC ACID ANALOGS AS INHIBITORS OF STAT PROTEINS 审中-公开
标题翻译：取代的2-羟基-4-（2-（苯基磺酰胺）乙酰胺）苯甲酸类似物作为STAT蛋白的抑制剂
公开(公告)号：WO2012018868A1
公开(公告)日：2012-02-09
申请号：PCT/US2011/046340
申请日：2011-08-02
申请人： UNIVERSITY OF CENTRAL FLORIDA RESEARCH FOUNDATION, INC. , UNIVERSITY OF TORONTO MISSISSAUGA , TURKSON, James , GUNNING, Patrick
发明人： TURKSON, James , GUNNING, Patrick
IPC分类号： A61K31/18
CPC分类号： C07D401/04 , A61K31/18 , C07C311/19 , C07C311/29 , C07C311/42 , C07C311/46 , C07C323/49 , C07C2601/14 , C07D207/48 , C07D211/26 , C07D211/34 , C07D211/60 , C07D211/96 , C07D213/42 , C07D215/36 , C07D233/84
摘要： In one aspect, the invention relates to substituted substituted 2-hydroxy-4-(2- (phenylsulfonamido)acetamido)benzoic acid analogs, derivatives thereof, and related compounds, which are useful as inhibitors of STAT protein activity; synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating disorders of uncontrolled cellular proliferation associated with a STAT protein activity dysfunction using the compounds and compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
摘要翻译：一方面，本发明涉及可用作STAT蛋白活性抑制剂的取代的取代的2-羟基-4-（2-（苯基亚磺酰氨基）乙酰氨基）苯甲酸类似物及其衍生物及相关化合物，制备化合物的合成方法; 包含该化合物的药物组合物; 以及使用所述化合物和组合物治疗与STAT蛋白活性功能障碍相关的不受控制的细胞增殖紊乱的方法。该摘要旨在作为用于在特定技术中进行搜索的扫描工具，而不意在限制本发明。

84. 发明申请

WO2012018437A1 ANTIMICROBIAL HYDROCHLORIC ACID CATHETER LOCK SOLUTION AND METHOD OF USE 审中-公开
标题翻译：抗微生物氢氯酸盐导管解决方案及其使用方法
公开(公告)号：WO2012018437A1
公开(公告)日：2012-02-09
申请号：PCT/US2011/040119
申请日：2011-06-13
申请人： TELEFLEX MEDICAL INCORPORATED , GUPTA, Nisha , STEINKE, Elaine , ROSENBLATT, Joel
发明人： GUPTA, Nisha , STEINKE, Elaine , ROSENBLATT, Joel
IPC分类号： A61M25/00
CPC分类号： A01N59/00 , A61K31/18 , A61K31/727 , A61L2/00 , A61L2/18 , A61L29/02 , A61L29/14 , A61L29/16 , A61L2300/104 , A61L2300/106 , A61L2300/204 , A61L2300/404 , A61L2300/42 , A61M25/0017 , A61K2300/00
摘要： A catheter lock solution includes a hydrochloric acid solution having a concentration of 0.3 Molar to 1.0 Molar. This hydrochloric acid solution may be used to lock a catheter and/or salvage an infected catheter.
摘要翻译：导管锁定溶液包括浓度为0.3摩尔至1.0摩尔浓度的盐酸溶液。该盐酸溶液可用于锁定导管和/或挽救受感染的导管。

85. 发明申请

WO2012013331A2 CAPSULES OF ACTIVE PHARMACEUTICAL INGREDIENTS AND POLYUNSATURATED FATTY ACIDS FOR THE TREATMENT OF PROSTATE DISEASES 审中-公开
标题翻译：活性药物成分和多余脂肪酸的治疗前列腺疾病
公开(公告)号：WO2012013331A2
公开(公告)日：2012-02-02
申请号：PCT/EP2011/003737
申请日：2011-07-26
申请人： GP-PHARM, S.A. , PARENTE DUEÑA, Antonio
发明人： PARENTE DUEÑA, Antonio
IPC分类号： A61K9/48
CPC分类号： A61K31/18 , A61K9/1635 , A61K9/1652 , A61K9/4808 , A61K9/4858 , A61K9/5031 , A61K9/5036 , A61K9/5047 , A61K9/5057 , A61K9/5084 , A61K31/00 , A61K31/167 , A61K31/277 , A61K31/517 , A61K31/57 , A61K31/7048 , A61K38/09 , A61K2300/00
摘要： Pharmaceutical composition in capsule form which contains polyunsaturated fatty acids (PUFA) and active pharmaceutical ingredients for the treatment and/or prevention of prostate diseases and/or hyperandrogenic disorders.
摘要翻译：包含多不饱和脂肪酸（PUFA）和用于治疗和/或预防前列腺疾病和/或高雄激素障碍的活性药物成分的胶囊形式的药物组合物。

86. 发明申请

WO2011128407A9 SUBSTITUTED 2,3-DIHYDROIMIDAZO[1,2-C]QUINAZOLINE-CONTAINING COMBINATIONS 审中-公开
标题翻译：取代的2,3-二氢吲哚并[1,2-C]喹唑啉的组合
公开(公告)号：WO2011128407A9
公开(公告)日：2011-12-22
申请号：PCT/EP2011055917
申请日：2011-04-14
申请人： BAYER PHARMA AG , LIU NINGSHU
发明人： LIU NINGSHU
IPC分类号： A61K45/00
CPC分类号： A61K31/519 , A61K31/18 , A61K31/4406 , A61K31/5377 , A61K45/06 , A61K2300/00
摘要： The present invention relates to : * combinations of : component A : one or more 2,3-dihydroimidazo[1,2-c]quinazoline compounds of general formula (A1) or (A2), or a physiologically acceptable salt, solvate, hydrate or stereoisomer thereof; component B : one or more N-(2-arylamino) aryl sulfonamide compounds of general formula (B), or Lapatinib, or Paclitaxel, or a physiologically acceptable salt, solvate, hydrate or stereoisomer thereof; and, optionally, component C : one or more further pharmaceutical agents; in which optionally some or all of the components are in the form of a pharmaceutical formulation which is ready for use to be administered simultaneously, concurrently, separately or sequentially. dependently of one another by the oral, intravenous, topical, local installations, intraperitoneal or nasal route; * use of such combinations for the preparation of a medicament for the treatment or prophylaxis of a cancer; and * a kit comprising such a combination.
摘要翻译：本发明涉及：组合物A：一种或多种通式（A1）或（A2）的2,3-二氢咪唑并[1,2-c]喹唑啉化合物或其生理学上可接受的盐，溶剂合物，水合物或其立体异构体; 组分B：通式（B）的一种或多种N-（2-芳基氨基）芳基磺酰胺化合物或拉帕替尼或紫杉醇或其生理学上可接受的盐，溶剂化物，水合物或立体异构体; 和任选的组分C：一种或多种另外的药剂; 其中任选地，一些或所有组分是药物制剂的形式，其可以同时使用，同时，单独或顺序地使用。通过口服，静脉内，局部，局部装置，腹膜内或鼻道相互依赖; *使用这种组合来制备用于治疗或预防癌症的药物; 和*包含这种组合的试剂盒。

87. 发明申请

WO2011155898A1 NEW ANTIVIRAL COMPOUNDS 审中-公开
标题翻译：新的抗病毒化合物
公开(公告)号：WO2011155898A1
公开(公告)日：2011-12-15
申请号：PCT/SE2011/050724
申请日：2011-06-13
申请人： WADELL, Göran , EDLUND, Karin , STRAND, Mårten , ANDERSSON, Emma , ÖBERG, Christopher , ELOFSSON, Mikael , MEI, Ya-Fang
发明人： WADELL, Göran , EDLUND, Karin , STRAND, Mårten , ANDERSSON, Emma , ÖBERG, Christopher , ELOFSSON, Mikael , MEI, Ya-Fang
IPC分类号： C07C237/40 , A61K31/136 , A61P31/12 , A61P31/18 , A61P31/22
CPC分类号： C07C233/81 , A61K31/167 , A61K31/18 , A61K31/196 , A61K31/245 , C07C237/40 , C07C237/42 , C07C311/08 , C07C311/21 , C07C2601/14 , Y02A50/463 , Y02A50/467
摘要： The present invention provides new antiviral compounds and pharmacological compositions comprising these new compounds and their use in the prophylaxis, prevention and treatment of viral infections, particularly adenovirus and herpes virus infections.
摘要翻译：本发明提供了包含这些新化合物的新的抗病毒化合物和药物组合物及其在预防，预防和治疗病毒感染，特别是腺病毒和疱疹病毒感染中的用途。

88. 发明申请

WO2011151080A1 PHARMACEUTICAL COMPOSITIONS OF CO-CRYSTALS OF TRAMADOL AND COXIBS 审中-公开
标题翻译： TRAMADOL和COXIBS的共晶的药物组合物
公开(公告)号：WO2011151080A1
公开(公告)日：2011-12-08
申请号：PCT/EP2011/002749
申请日：2011-06-03
申请人： LABORATORIOS DEL DR. ESTEVE, S.A. , SOLER RANZANI, Luis , FALIVENE ALDEA, Albert
发明人： SOLER RANZANI, Luis , FALIVENE ALDEA, Albert
IPC分类号： A61K9/20 , C07C59/64 , A61K31/135 , A61K31/415
CPC分类号： A61K47/34 , A61K9/2018 , A61K9/2027 , A61K31/045 , A61K31/05 , A61K31/135 , A61K31/18 , A61K31/415 , A61K31/4162 , A61K31/63 , A61K47/32 , A61K2300/00
摘要： The present invention relates to oral pharmaceutical compositions comprising co-crystals of tramadol and celecoxib, processes for preparation of the same and their use as medicaments, more particularly for the treatment of pain.
摘要翻译：本发明涉及包含曲马多和塞来昔布的共晶体的口服药物组合物，其制备方法及其作为药物的用途，更特别涉及治疗疼痛。

89. 发明申请

WO2011146732A1 METHODS FOR TREATING INFLAMMATORY AUTOIMMUNE DISORDERS 审中-公开
标题翻译：治疗炎症性自身免疫疾病的方法
公开(公告)号：WO2011146732A1
公开(公告)日：2011-11-24
申请号：PCT/US2011/037181
申请日：2011-05-19
申请人： BETH ISRAEL DEACONESS MEDICAL CENTER , TSOKOS, George, C. , JUANG, Yuang-taung
发明人： TSOKOS, George, C. , JUANG, Yuang-taung
IPC分类号： A61K31/255
CPC分类号： C12N15/1137 , A61K31/00 , A61K31/18 , A61K31/713 , A61K45/06 , C12Q1/6883 , C12Q2600/106 , C12Q2600/136 , G01N33/564 , G01N2333/91215 , G01N2500/04 , G01N2800/347 , Y02A50/409 , Y02A50/411 , A61K2300/00
摘要： A method of treating or reducing the likelihood of an inflammatory autoimmune disorder (e.g., systemic lupus erythematosus (SLE) or a kidney disorder (e.g., glomerulonephritis) in a subject by administering an inhibitor of calcium/calmodulin-dependent protein kinase type IV (CaMKIV) is disclosed. Additionally, methods of diagnosing a subject with SLE or a kidney disorder by determining the level or biological activity of a CaMKIV nucleic acid or polypeptide in a sample from a subject are also disclosed. Further included are methods for identifying compounds that inhibit CaMKIV for the treatment of an inflammatory autoimmune disorder (e.g., SLE) or a kidney disorder (e.g., glomerulonephritis).
摘要翻译：通过施用IV型钙/钙调蛋白依赖性蛋白激酶（CaMKIV）的抑制剂来治疗或降低受试者的炎性自身免疫性疾病（例如，系统性红斑狼疮（SLE）或肾脏疾病（例如肾小球性肾炎））的可能性的方法另外，还公开了通过测定来自受试者的样品中CaMKIV核酸或多肽的水平或生物学活性来诊断患有SLE或肾脏疾病的受试者的方法，还包括用于鉴定抑制用于治疗炎症性自身免疫性疾病（例如SLE）或肾脏疾病（例如肾小球性肾炎）的CaMKIV。

90. 发明申请

WO2011143457A2 COMPOSITIONS AND METHODS FOR TREATING OR PREVENTING ATRIAL FIBRILLATION 审中-公开
标题翻译：用于治疗或预防ATRIAL FIBRILLATION的组合物和方法
公开(公告)号：WO2011143457A2
公开(公告)日：2011-11-17
申请号：PCT/US2011/036291
申请日：2011-05-12
申请人： NORTHWESTERN UNIVERSITY , ARORA, Rishi , ZEMBOWER, David, E.
发明人： ARORA, Rishi , ZEMBOWER, David, E.
IPC分类号： A61K31/4704 , A61K31/138 , A61K31/135 , A61K31/535 , A61P9/04
CPC分类号： A61K31/46 , A61K31/132 , A61K31/135 , A61K31/137 , A61K31/138 , A61K31/165 , A61K31/18 , A61K31/215 , A61K31/22 , A61K31/24 , A61K31/352 , A61K31/4025 , A61K31/404 , A61K31/437 , A61K31/44 , A61K31/445 , A61K31/4545 , A61K31/47 , A61K31/4725 , A61K31/522 , A61K31/5377 , A61K31/551 , A61K2300/00
摘要： The present invention provides compositions and methods for treating or preventing atrial fibrillation (AF). In particular, the present invention provides administration of muscarinic receptor antagonists (e.g., M2-selective muscarinic receptor blockers), administered alone or in combination with other therapeutic agents (e.g., beta-adrenergic receptor blockers) to treat and/or prevent atrial fibrillation.
摘要翻译：本发明提供了治疗或预防房颤（AF）的组合物和方法。特别地，本发明提供了单独施用或与其它治疗剂（例如β-肾上腺素能受体阻断剂）组合施用毒蕈碱受体拮抗剂（例如，M2-选择性毒蕈碱受体阻断剂）以治疗和/或预防心房颤动。

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