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81. 发明申请

WO1994025606A2 RECOMBINANT ALANINE RACEMASE AND GAPDH FROM TOLYPOCLADIUM 审中-公开
标题翻译：重组丙氨酸消旋酶和关机GAPDH弯颈Niveum
公开(公告)号：WO1994025606A2
公开(公告)日：1994-11-10
申请号：PCT/EP1994001272
申请日：1994-04-23
申请人： SANDOZ-ERFINDUNGEN VERWALTUNGSGESELLSCHAFT MBH , SANDOZ-PATENT-GMBH , SANDOZ LTD. , KOCHER, Hans, Peter , SCHNEIDER-SCHERZER, Elisabeth , SCHOERGENDORFER, Kurt , WEBER, Gerhard
发明人： SANDOZ-ERFINDUNGEN VERWALTUNGSGESELLSCHAFT MBH , SANDOZ-PATENT-GMBH , SANDOZ LTD.
IPC分类号： C12N15/61
CPC分类号： C12N9/0008 , C07K7/645 , C12N9/90 , C12Y102/01009
摘要： The invention concerns nucleotide suquences coding for enzymes which exhibit an alanine racemase activity, plus methods of preparing alanine racemase which use these sequences. The invention also concerns methods of preparing cyclosporin and cyclosporin derivatives. The invention further relates to DNA fragments with part or all of the gene for glycerinaldehyde-3-phosphate dehydrogenase (GAPDH) from Tolypocladium niveum, its promotor and termination region, and the use thereof. Another aspect of the invention relates to vectors, and cells transformed by these vectors.

82. 发明申请

WO1994024293A1 GENETIC STABILIZING ELEMENTS 审中-公开
标题翻译：遗传稳定元素
公开(公告)号：WO1994024293A1
公开(公告)日：1994-10-27
申请号：PCT/EP1994001193
申请日：1994-04-18
申请人： SANDOZ-ERFINDUNGEN-VERWALTUNGSGESELLSCHAFT MBH , SANDOZ-PATENT-GMBH , SANDOZ LTD.
发明人： SANDOZ-ERFINDUNGEN-VERWALTUNGSGESELLSCHAFT MBH , SANDOZ-PATENT-GMBH , SANDOZ LTD. , DIETRICH, Paul, Shartzer , VAN GRINSVEN, Marinus, Quirinus, Joseph, Marie , GIELEN, Johannes, Jacobus, Ludgerus , DE HAAS, Johannes, Maria , VAN DRIEL, Roeland
IPC分类号： C12N15/82
CPC分类号： C12N15/822
摘要： A stabilized gene for transforming a host plant cell, said gene comprising a gene exogenous to the plant cell, and at least one stabilizing DNA segment in a 3'- or 5'-flanking region of said gene. The gene may comprise a stabilizing DNA segment in a 3'-flanking region and a second stabilizing DNA segment in a 5'-flanking region of said gene. The invention further includes vectors and transgenic plants comprising the said stabilized gene.
摘要翻译：用于转化宿主植物细胞的稳定基因，所述基因包含对所述植物细胞外源的基因，以及所述基因的3'-或5'-侧翼区中的至少一个稳定的DNA片段。所述基因可以包含在所述基因的5'-侧翼区域中的3'-侧翼区域中的稳定化DNA区段和第2稳定化DNA区段。本发明还包括载体和包含所述稳定基因的转基因植物。

83. 发明申请

WO1994006852A1 SPRAY-STABLE AQUEOUS FOAM, ITS PRODUCTION AND USE 审中-公开
标题翻译： SPRAY耐含水泡沫及其制备方法和用途
公开(公告)号：WO1994006852A1
公开(公告)日：1994-03-31
申请号：PCT/EP1993002498
申请日：1993-09-15
申请人： SANDOZ-PATENT-GMBH , SANDOZ LTD. , HELBER, Rudolf , HUBER, Hartmuth , KNOCH, Hans , PISCHEL, Thomas , REUSCH, Thomas , WALTHER, Werner
发明人： SANDOZ-PATENT-GMBH , SANDOZ LTD.
IPC分类号： C08J09/30
CPC分类号： C08J9/30 , C08J2375/04 , C14C11/006
摘要： Spray-stable and castable aqueous foams (S) produced by the mechanical foaming of suitable aqueous preparations (W), in which the aqueous phase contains (A) a curable polymer system consisting of (U) an ionomeric polyurethane or a mixture of ionomeric polyurethanes and possibly (P) one or more further polymers which are at leat curable with (U), and (B) at least one foam stabiliser, having a weight per litre of (S) at 20 C and normal pressure is in the range of 400 to 700 g, are eminently suitable for foam-coating corresponding substrates, especially leather.

84. 发明申请

WO1994002677A1 SOIL-REPELLENT FINISHING AGENT 审中-公开
标题翻译：防尘剂设备
公开(公告)号：WO1994002677A1
公开(公告)日：1994-02-03
申请号：PCT/CH1993000183
申请日：1993-07-19
申请人： SANDOZ-PATENT-GMBH , SANDOZ LTD. , BAUMANN, Hans-Peter , WEIBLE, Karl-Heinz
发明人： SANDOZ-PATENT-GMBH , SANDOZ LTD.
IPC分类号： D06M15/41
CPC分类号： D06M13/358 , D06L4/621 , D06M15/263 , D06M15/277 , D06M15/41 , D06M15/412
摘要： The defined condensation products (P) - salts at least in some cases - from dihydroxydiphenylsulphone, formaldehyde and the defined aromatic compounds (A) in defined molar ratios make for excellent soil-repellent finishing of polyamide fiber materials, especially in combination with a fiber-reactive, colorless compound and possibly using in addition other soil-repellent finishing agents, to provide highly effective, long-lasting finishes that do not produce a distracting yellowing either upon application or with extended use.

85. 发明申请

WO1993018222A1 WAX DISPERSIONS, THEIR PREPARATION AND USE 审中-公开
标题翻译： WAX分散剂，其制备和使用
公开(公告)号：WO1993018222A1
公开(公告)日：1993-09-16
申请号：PCT/CH1993000050
申请日：1993-03-01
申请人： SANDOZ-PATENT-GMBH , SANDOZ LTD.
发明人： SANDOZ-PATENT-GMBH , SANDOZ LTD. , DANNER, Bernard
IPC分类号： D06M13/02
CPC分类号： D06M15/227 , C08L91/08 , D06M7/00 , D06M13/02 , D06M13/342 , D06M13/463 , D06M13/467 , D06M2200/40 , D06M2200/50
摘要： Aqueous wax dispersions (G) are characterized by containing (A) a wax mixture of (A1) at least a non-oxidized paraffin wax with 20 dmm needle penetration or less (according to ASTM-D 1321) and a melting range above 65 °C; (A2) at least an oxidized hydrocarbon wax with 4 dmm needle penetration or less (according to ASTM-D 1321), and possibly (A3) at least a non-oxidized paraffin wax with 55 dmm needle penetration or less (according to ASTM-1321) and a melting range lower or equal to 65 °C; and/or (A4) at least a cationically modified oxidized hydrocarbon wax; (B) a cationic dispersent system, possibly (C) at least a softening and/or antistatic auxiliary and/or (D) a preservative agent and/or an anti-foaming agent and/or (E) at least an amphoteric surface-active agent. These wax dispersions are remarquably suitable as brightening and are used in particular for brightening yarns.

86. 发明申请

WO1993001166A1 4-AMINO-3-HYDROXYCARBOXYLIC ACID DERIVATIVES 审中-公开
标题翻译： 4-氨基-3-羟基羧酸衍生物
公开(公告)号：WO1993001166A1
公开(公告)日：1993-01-21
申请号：PCT/EP1992001471
申请日：1992-06-30
申请人： SANDOZ LTD. , SANDOZ-PATENT-GMBH , BILLICH, Andreas , CHARPIOT, Brigitte , LEHR, Philip , SCHOLZ, Dieter
发明人： SANDOZ LTD. , SANDOZ-PATENT-GMBH
IPC分类号： C07C271/22
CPC分类号： C07D213/30 , A61K38/00 , C07C271/22 , C07C323/59 , C07C323/60 , C07D209/16 , C07D209/20 , C07D213/38 , C07D213/40 , C07D215/36 , C07D233/64 , C07D235/12 , C07D235/14 , C07K5/0205 , Y02P20/55
摘要： The invention concerns the compounds of formula (I) wherein A and B independently are a bond or optionally substituted aminoacyl; R1 is hydrogen; an amino protecting group; or a group of formula R6Y- wherein R6 is hydrogen or an optionally substituted alkyl, alkenyl, alkinyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, heterocyclyl or heterocyclylalkyl group; and Y is -CO-; -NHCO-; NHCS-; -SO2-; -O-CO-; or -O-CS-; R2 is the side chain of a natural amino acid; an alkyl, arylalkyl, heteroarylalkyl or cycloalkylalkyl group; or trimethylsilylmethyl, 2-thienylmethyl or styrylmethyl; R3 is an optionally substituted alkyl, alkenyl, alkinyl, cyloalkyl, aryl, arylalkyl, heteroaryl or heteroarylalkyl group; R4 is a group of formula -OR7 or -NHR7 wherein R7 has the significance indicated above for R6; and X is -S- or -NR5- wherein R5 is hydrogen, methyl, formyl or acetyl; in free form and, where such forms exist, in salt form. They can be obtained by a process comprising epoxide ring opening, appropriate substitution and/or deprotection or saponification. They have antiviral activity, particularly HIV-1 proteinase inhibiting activity, and are thus indicated for use in the treatment of retroviral diseases.
摘要翻译：本发明涉及式（I）的化合物，其中A和B独立地是一个键或任选取代的氨酰基; R1是氢; 氨基保护基; 烯基，炔基，芳基，芳基烷基，杂芳基，杂芳基烷基，杂环基或杂环基烷基;或其中R 6为氢或任选取代的烷基，烯基，炔基，芳基， Y为-CO-; -NHCO-; NHCS-; -SO2-; -O-CO-; 或-O-CS-; R2是天然氨基酸的侧链; 烷基，芳基烷基，杂芳基烷基或环烷基烷基; 或三甲基甲硅烷基甲基，2-噻吩基甲基或苯乙烯基甲基; 链烯基，炔基，环烷基，芳基，芳基烷基，杂芳基或杂芳基烷基; R4是式-OR7或-NHR7的基团，其中R7具有上面对R6表示的含义; 并且X是-S-或-NR 5 - ，其中R 5是氢，甲基，甲酰基或乙酰基; 以形式存在，且以盐形式存在。它们可以通过包括环氧化物开环，适当取代和/或去保护或皂化的方法获得。它们具有抗病毒活性，特别是HIV-1蛋白酶抑制活性，因此被指示用于治疗逆转录病毒疾病。

87. 发明申请

WO1997018208A1 QUINOLINE DERIVATIVES AS TYPE IV PHOSPHODIESTERASE INHIBITORS 审中-公开
标题翻译：喹啉衍生物作为IV型磷酸酯酶抑制剂
公开(公告)号：WO1997018208A1
公开(公告)日：1997-05-22
申请号：PCT/EP1996004978
申请日：1996-11-13
申请人： SANDOZ LTD. , SANDOZ-PATENT-GMBH , NOVARTIS-ERFINDUNGEN VERWALTUNGSGESELLSCHAFT M.B.H. , LÜÖND, Rainer , POMBO VILLAR, Esteban
发明人： SANDOZ LTD. , SANDOZ-PATENT-GMBH , NOVARTIS-ERFINDUNGEN VERWALTUNGSGESELLSCHAFT M.B.H.
IPC分类号： C07D413/14
CPC分类号： C07D401/14 , C07D413/14 , C07D417/14
摘要： 8-(Benzo[c]thiadiazolyl, benzo[c]furazanyl, or 2-methyl-2H-benzo[d]triazolyl)-quinolines, in free or N-oxide or acid addition or ammonium salt form, are novel and found to be useful as pharmaceuticals, e.g., as PDEIV inhibitors, for example in the treatment of asthma. Novel methods of treatment using the compounds, processes for making the compounds, and pharmaceutical compositions comprising the compounds are also provided. For example, compounds of formula (1), wherein X is -O-, -S-, or -N(CH3)-, R1 is hydrogen or (C1-4)alkyl, and R2 is (C1-4)alkyl or pyridyl, in free or N-oxide or pharmaceutically acceptable acid addition or ammonium salt form.
摘要翻译： 8-（苯并[c]噻二唑基，苯并[c]呋咱基，或2-甲基-2H-苯并[d]三唑基） - 喹啉，为游离或N-氧化物或酸加成或铵盐形式，可用作药物，例如作为PDEIV抑制剂，例如用于治疗哮喘。还提供了使用该化合物的治疗新方法，制备该化合物的方法和包含该化合物的药物组合物。例如，式（1）的化合物，其中X是-O - ， - S-或-N（CH 3） - ，R 1是氢或（C 1-4）烷基，R 2是（C 1-4）烷基或吡啶基，游离或N-氧化物或药学上可接受的酸加成盐或铵盐形式。

88. 发明申请

WO1996041807A1 RAPAMYCIN DERIVATIVES 审中-公开
标题翻译： RAPAMYCIN衍生物
公开(公告)号：WO1996041807A1
公开(公告)日：1996-12-27
申请号：PCT/EP1996002441
申请日：1996-06-05
申请人： SANDOZ LTD. , SANDOZ-PATENT-GMBH , SANDOZ-ERFINDUNGEN VERWALTUNGSGESELLSCHAFT MBH , COTTENS, Sylvain , SEDRANI, Richard
发明人： SANDOZ LTD. , SANDOZ-PATENT-GMBH , SANDOZ-ERFINDUNGEN VERWALTUNGSGESELLSCHAFT MBH
IPC分类号： C07D498/18
CPC分类号： C07D498/18 , C07F7/1804
摘要： Compounds of Formula (I), wherein R2 is selected from formula (II) or formula (III), and X is OH or H show immunosuppressant activity.
摘要翻译：式（I）化合物，其中R 2选自式（II）或式（III），X是OH或H表示免疫抑制剂活性。

89. 发明申请

WO1996015227A1 METHODS OF INDUCING CELL DEATH OF PRIMITIVE HEMATOPOIETIC CELLS AND COMPOSITIONS FOR INDUCTION THEREOF 审中-公开
标题翻译：诱导原代细胞凋亡细胞死亡的方法及其诱导组合物
公开(公告)号：WO1996015227A1
公开(公告)日：1996-05-23
申请号：PCT/EP1995004479
申请日：1995-11-14
申请人： SANDOZ LTD. , SANDOZ-PATENT-GMBH , SANDOZ-ERFINDUNGEN VERWALTUNGSGESELLSCHAFT MBH , SYSTEMIX, INC.
发明人： SANDOZ LTD. , SANDOZ-PATENT-GMBH , SANDOZ-ERFINDUNGEN VERWALTUNGSGESELLSCHAFT MBH , SYSTEMIX, INC. , BRANDT, John , TSUKAMOTO, Ann, S. , HOFFMAN, Ronald, H. , BAZIL, Vladimir
IPC分类号： C12N05/08
CPC分类号： C12N5/0647 , A61K38/00 , C07K16/2896 , C12N2501/125 , C12N2501/23 , C12N2501/48 , C12N2501/599
摘要： The present invention encompasses methods for inducing cell death in hematopoietic cells expressing CD43. The methods can be used in conjunction with therapeutic treatments such as chemotherapy and hematopoietic stem cell transplantation. The method is also useful in obtaining a highly enriched population of hematopoietic stem cells.
摘要翻译：本发明包括在表达CD43的造血细胞中诱导细胞死亡的方法。这些方法可以与化疗和造血干细胞移植等治疗性治疗结合使用。该方法在获得高度富集的造血干细胞群体中也是有用的。

90. 发明申请

WO1996013273A1 PHARMACEUTICAL COMPOSITIONS 审中-公开
标题翻译：药物组合物
公开(公告)号：WO1996013273A1
公开(公告)日：1996-05-09
申请号：PCT/EP1995004187
申请日：1995-10-25
申请人： SANDOZ LTD. , SANDOZ-PATENT-GMBH , SANDOZ-ERFINDUNGEN VERWALTUNGSGESELLSCHAFT MBH , COTTENS, Sylvain , HAEBERLIN, Barbara , SEDRANI, Richard , VONDERSCHER, Jacky
发明人： SANDOZ LTD. , SANDOZ-PATENT-GMBH , SANDOZ-ERFINDUNGEN VERWALTUNGSGESELLSCHAFT MBH
IPC分类号： A61K38/13
CPC分类号： A61K9/0019 , A61K9/1075 , A61K9/4858 , A61K31/436 , A61K38/13 , A61K47/12
摘要： This invention provides a microemulsion pre-concentrate comprising a difficultly soluble active agent and a carrier medium comprising: 1) a hydrophilic phase which comprises dimethylisosorbide and/or a lower alkyl alkanoic ester, 2) a lipophilic phase, and 3) a surfactant. The active agent may be a cyclosporin or a macrolide. In another aspect, this invention provides a pharmaceutical composition for enteral or parenteral administration comprising a macrolide and an acid.
摘要翻译：本发明提供了包含难溶性活性剂和载体介质的微乳液预浓缩物，其包含：1）亲水相，其包含二甲基异山梨醇酯和/或低级烷基链烷酸酯，2）亲油相，和3）表面活性剂。活性剂可以是环孢菌素或大环内酯。另一方面，本发明提供了包含大环内酯和酸的肠内或肠胃外给药的药物组合物。

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