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81. 发明申请

WO2005031358A3 DIAGNOSTICS AND THERAPEUTICS FOR DISEASES ASSOCIATED WITH ARGINYL AMINOPEPTIDASE RNPEP-LIKE (RNPEP-LIKE) 审中-公开
标题翻译：与ARGINYL氨基酸类RNPEP相似的疾病的诊断和治疗（RNPEP-LIKE）
公开(公告)号：WO2005031358A3
公开(公告)日：2006-11-16
申请号：PCT/EP2004010385
申请日：2004-09-16
申请人： BAYER HEALTHCARE AG , GOLZ STEFAN , BRUEGGEMEIER ULF , GEERTS ANDREAS , POLEJ STEFANIE
发明人： GOLZ STEFAN , BRUEGGEMEIER ULF , GEERTS ANDREAS , POLEJ STEFANIE
IPC分类号： G01N33/573
CPC分类号： G01N33/573 , G01N2333/948
摘要： The invention provides a human RNPEP-like which is associated with the cardiovascular diseases, dermatological diseases, endocrinological diseases, metabolic diseases, cancer, gastroenterological diseases, inflammation, hematological diseases, neurological diseases and urological diseases. The invention also provides assays for the identification of compounds useful in the treatment or prevention of cardiovascular diseases, dermatological diseases, endocrinological diseases, metabolic diseases, cancer, gastroenterological diseases, inflammation, hematological diseases, neurological diseases and urological diseases. The invention also features compounds which bind to and/or activate or inhibit the activity of RNPEP-like as well as pharmaceutical compositions comprising such compounds.
摘要翻译：本发明提供了与心血管疾病，皮肤病，内分泌疾病，代谢疾病，癌症，胃肠疾病，炎症，血液疾病，神经疾病和泌尿系疾病相关的人类RNPEP。本发明还提供了用于鉴定可用于治疗或预防心血管疾病，皮肤病，内分泌疾病，代谢疾病，癌症，胃肠疾病，炎症，血液疾病，神经疾病和泌尿疾病的化合物的测定。本发明还涉及结合和/或活化或抑制RNPEP样活性的化合物以及包含这些化合物的药物组合物。

82. 发明申请

WO2005108993A3 DIAGNOSTICS AND THERAPEUTICS FOR DISEASES ASSOCIATED WITH MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 6 (MAP3K6) 审中-公开
标题翻译：与激素激活蛋白激酶激酶6激酶（MAP3K6）相关的疾病的诊断和治疗方法
公开(公告)号：WO2005108993A3
公开(公告)日：2006-06-15
申请号：PCT/EP2005004553
申请日：2005-04-28
申请人： BAYER HEALTHCARE AG , GOLZ STEFAN , BRUEGGEMEIER ULF , GEERTS ANDREAS
发明人： GOLZ STEFAN , BRUEGGEMEIER ULF , GEERTS ANDREAS
IPC分类号： C12Q1/48 , C12Q1/68 , G01N33/574 , G01N33/68
CPC分类号： G01N33/6893 , C12Q1/485 , G01N33/574
摘要： The invention provides a human MAP3K6 which is associated with cardiovascular diseases, (eg. Myocardial infarction) infections, (eg. Monocytes HIV-1 infected) dermatological diseases, endocrinological diseases, metabolic diseases, cancer, (eg. Thyroid, esophagus, stomach, colon, ileum, rectum, liver, uterus, ovary, breast, prostate, kidney tumor) gastroenterological diseases, inflammation, (eg. Liver cirrhosis, bening prostatic hyperplasia) hematological diseases, muscle skeleton diseases, neurological diseases, urological diseases and respiratory diseases. The invention also provides assays for the identification of compounds useful in the treatment or prevention of cardiovascular diseases, infections, dermatological diseases, endocrinological diseases, metabolic diseases, cancer, gastroenterological diseases, inflammation, hematological diseases, muscle skeleton diseases, neurological diseases, urological diseases and respiratory diseases. The invention also features compounds which bind to and/or activate or inhibit the activity of MAP3K6 as well as pharmaceutical compositions comprising such compounds.
摘要翻译：本发明提供了与心血管疾病（例如心肌梗死）感染（例如感染的单核细胞HIV-1）皮肤病，内分泌疾病，代谢疾病，癌症（例如甲状腺，食管，胃，结肠，回肠，直肠，肝，子宫，卵巢，乳腺，前列腺，肾肿瘤）胃肠疾病，炎症（如肝硬化，勃林前列腺增生）血液病，肌肉骨骼疾病，神经系统疾病，泌尿科疾病和呼吸系统疾病。本发明还提供了用于鉴定可用于治疗或预防心血管疾病，感染，皮肤病，内分泌疾病，代谢疾病，癌症，胃肠疾病，炎症，血液疾病，肌肉骨骼疾病，神经系统疾病，泌尿系疾病和呼吸系统疾病。本发明还涉及结合和/或活化或抑制MAP3K6活性的化合物以及包含这些化合物的药物组合物。

83. 发明申请

WO2005113787A3 DIAGNOSTICS AND THERAPEUTICS FOR DISEASES ASSOCIATED WITH G PROTEIN-DEPENDENT RECEPTOR KINASE 1 (GRK1) 审中-公开
标题翻译：与G蛋白依赖性受体激酶1（GRK1）相关的疾病的诊断和治疗
公开(公告)号：WO2005113787A3
公开(公告)日：2006-05-18
申请号：PCT/EP2005004898
申请日：2005-05-06
申请人： BAYER HEALTHCARE AG , GOLZ STEFAN , BRUEGGEMEIER ULF , GEERTS ANDREAS
发明人： GOLZ STEFAN , BRUEGGEMEIER ULF , GEERTS ANDREAS
IPC分类号： G01N33/574 , C12Q1/48 , G01N33/68
CPC分类号： C12Q1/485 , G01N2500/04
摘要： The invention provides a human GRK1 which is associated with cardiovasular diseases, endocrinological diseases, metabolic diseases, cancer, gastroenterological diseases, inflammation, hematological diseases, muscle skeleton diseases, neurological diseases and urological diseases. The invention also provides assays for the identification of compounds useful in the treatment or prevention of cardiovasular diseases, endocrinological diseases, metabolic diseases, cancer, gastroenterological diseases, inflammation, hematological diseases, muscle skeleton diseases, neurological diseases and urological diseases. The invention also features compounds which bind to and/or activate or inhibit the activity of GRK1 as well as pharmaceutical compositions comprising such compounds.
摘要翻译：本发明提供了与心血管疾病，内分泌疾病，代谢疾病，癌症，胃肠疾病，炎症，血液疾病，肌肉骨骼疾病，神经系统疾病和泌尿系疾病有关的人类GRK1。本发明还提供了用于鉴定可用于治疗或预防心血管疾病，内分泌疾病，代谢疾病，癌症，胃肠疾病，炎症，血液疾病，肌肉骨骼疾病，神经疾病和泌尿疾病的化合物的测定。本发明还涉及结合和/或活化或抑制GRK1的活性的化合物以及包含这些化合物的药物组合物。

84. 发明申请

WO2006040047A2 DIAGNOSTICS AND THERAPEUTICS FOR DISEASES ASSOCIATED WITH RHO/RAC-INTERACTING CITRON KINASE (CIT) 审中-公开
标题翻译：与RHO / RAC相互作用的CITRON激酶（CIT）有关的疾病的诊断和治疗
公开(公告)号：WO2006040047A2
公开(公告)日：2006-04-20
申请号：PCT/EP2005010700
申请日：2005-10-05
申请人： BAYER HEALTHCARE AG , GOLZ STEFAN , BRUEGGEMEIER ULF , GEERTS ANDREAS
发明人： GOLZ STEFAN , BRUEGGEMEIER ULF , GEERTS ANDREAS
IPC分类号： G01N33/68 , A61K31/70 , A61K38/45 , A61K39/395 , A61K47/46 , A61P1/00 , A61P3/00 , A61P5/00 , A61P11/00 , A61P25/00 , A61P33/00 , A61P35/00 , C07K14/47 , C12Q1/68 , G01N33/574
CPC分类号： C12Q1/485 , G01N2500/04
摘要： The invention provides a human CIT which is associated with cardiovascular diseases, respiratory diseases, dermatological diseases, endocrinological diseases, metabolic diseases, inflammation, gastroenterological diseases, cancer, hematological diseases, muscle skeleton diseases, neurological diseases, urological diseases. The invention also provides assays for the identification of compounds useful in the treatment or prevention of cardiovascular diseases, respiratory diseases, dermatological diseases, endocrinological diseases, metabolic diseases, inflammation, gastroenterological diseases, cancer, hematological diseases, muscle skeleton diseases, neurological diseases, urological diseases. The invention also features compounds which bind to and/or activate or inhibit the activity of CIT as well as pharmaceutical compositions comprising such compounds.
摘要翻译：本发明提供了与心血管疾病，呼吸系统疾病，皮肤病，内分泌疾病，代谢疾病，炎症，胃肠疾病，癌症，血液病，肌肉骨骼疾病，神经系统疾病，泌尿科疾病有关的人类CIT。本发明还提供了用于鉴定可用于治疗或预防心血管疾病，呼吸系统疾病，皮肤病，内分泌疾病，代谢疾病，炎症，胃肠疾病，癌症，血液疾病，肌肉骨骼疾病，神经系统疾病，泌尿科疾病。本发明还涉及结合和/或激活或抑制CIT活性的化合物以及包含这些化合物的药物组合物。

85. 发明申请

WO2006013015A3 DIAGNOSTICS AND THERAPEUTICS FOR DISEASES ASSOCIATED WITH MARAPSIN (MPN) 审中-公开
标题翻译：与马拉辛有关的疾病的诊断和治疗（MPN）
公开(公告)号：WO2006013015A3
公开(公告)日：2006-03-30
申请号：PCT/EP2005007954
申请日：2005-07-21
申请人： BAYER HEALTHCARE AG , GOLZ STEFAN , BRUEGGEMEIER ULF , GEERTS ANDREAS
发明人： GOLZ STEFAN , BRUEGGEMEIER ULF , GEERTS ANDREAS
IPC分类号： G01N33/573 , C12N9/64 , C12Q1/37 , G01N33/574
CPC分类号： C12N9/6424 , C12Q1/37 , G01N2500/04
摘要： The invention provides a human MPN which is associated with the cardiovascular diseases, infections, gastroenterological diseases, cancer, hematological diseases, respiratory diseases, inflammation, metabolic diseases, muscle skeleton diseases, neurological diseases, and urological diseases. The invention also provides assays for the identification of compounds useful in the treatment or prevention of cardiovascular diseases, infections, gastroenterological diseases, cancer, hematological diseases, respiratory diseases, inflammation, metabolic diseases, muscle skeleton diseases, neurological diseases, and urological diseases. The invention also features compounds which bind to and/or activate or inhibit the activity of MPN as well as pharmaceutical compositions comprising such compounds.
摘要翻译：本发明提供了与心血管疾病，感染，胃肠疾病，癌症，血液病，呼吸系统疾病，炎症，代谢疾病，肌肉骨骼疾病，神经系统疾病和泌尿系统疾病有关的人MPN。本发明还提供了用于鉴定可用于治疗或预防心血管疾病，感染，胃肠疾病，癌症，血液疾病，呼吸系统疾病，炎症，代谢疾病，肌肉骨骼疾病，神经系统疾病和泌尿系统疾病的化合物的测定法。本发明还涉及结合和/或激活或抑制MPN活性的化合物以及包含此类化合物的药物组合物。

86. 发明申请

WO2006013014A3 DIAGNOSTICS AND THERAPEUTICS FOR DISEASES ASSOCIATED WITH PROSTATE-SPECIFIC MEMBRANE ANTIGEN-LIKE PROTEIN (PSMAL) 审中-公开
标题翻译：与前列腺特异性膜抗原蛋白（PSMAL）相关的疾病的诊断和治疗
公开(公告)号：WO2006013014A3
公开(公告)日：2006-03-30
申请号：PCT/EP2005007953
申请日：2005-07-21
申请人： BAYER HEALTHCARE AG , GOLZ STEFAN , BRUEGGEMEIER ULF , GEERTS ANDREAS
发明人： GOLZ STEFAN , BRUEGGEMEIER ULF , GEERTS ANDREAS
IPC分类号： G01N33/68 , C07K14/705
CPC分类号： C07K14/705 , C12Q1/37 , G01N2500/04
摘要： The invention provides a human PSMAL which is associated with the cardiovascular diseases, cancer, endocrinological diseases, metabolic diseases, gastroenterological diseases, inflammation, hematological diseases, respiratory diseases, muscle skeleton diseases, neurological diseases, urological diseases. The invention also provides assays for the identification of compounds useful in the treatment or prevention of cardiovascular diseases, cancer, endocrinological diseases, metabolic diseases, gastroenterological diseases, inflammation, hematological diseases, respiratory diseases, muscle skeleton diseases, neurological diseases, urological diseases. The invention also features compounds which bind to and/or activate or inhibit the activity of PSMAL as well as pharmaceutical compositions comprising such compounds.
摘要翻译：本发明提供了与心血管疾病，癌症，内分泌疾病，代谢疾病，胃肠疾病，炎症，血液疾病，呼吸系统疾病，肌肉骨骼疾病，神经系统疾病，泌尿系疾病有关的人类PSMAL。本发明还提供了用于鉴定可用于治疗或预防心血管疾病，癌症，内分泌疾病，代谢疾病，胃肠疾病，炎症，血液疾病，呼吸系统疾病，肌肉骨骼疾病，神经系统疾病，泌尿系疾病的化合物的测定。本发明还涉及结合和/或活化或抑制PSMAL活性的化合物以及包含这些化合物的药物组合物。

87. 发明申请

WO2005113786A3 DIAGNOSTICS AND THERAPEUTICS FOR DISEASES ASSOCIATED WITH CHYMASE (CMA1) 审中-公开
标题翻译：与CHYMASE相关的疾病诊断和治疗（CMA1）
公开(公告)号：WO2005113786A3
公开(公告)日：2006-02-09
申请号：PCT/EP2005004897
申请日：2005-05-06
申请人： BAYER HEALTHCARE AG , GOLZ STEFAN , BRUEGGEMEIER ULF , GEERTS ANDREAS
发明人： GOLZ STEFAN , BRUEGGEMEIER ULF , GEERTS ANDREAS
IPC分类号： A61K38/48 , A61K38/55 , A61K39/00 , A61K39/395 , A61K48/00 , A61K49/00 , C07K16/40 , C12N9/64 , C12Q1/37 , G01N33/50 , G01N33/574 , G01N33/68
CPC分类号： A61K48/00 , A61K38/00 , A61K49/0008 , A61K2039/505 , C07K16/40 , C12N9/6424 , C12Q1/37 , C12Y304/21039 , G01N33/574 , G01N2500/00
摘要： The invention provides a human CMA1 which is associated with the cardiovascular diseases, infections, metabolic diseases, dermatological diseases, gastroenterological diseases, cancer, inflammation, hematological diseases, respiratory diseases, muscle skeleton diseases, neurological diseases and urological diseases. The invention also provides assays for the identification of compounds useful in the treatment or prevention of cardiovascular diseases, infections, metabolic diseases, dermatological diseases, gastroenterological diseases, cancer, inflammation, hematological diseases, respiratory diseases, muscle skeleton diseases, neurological diseases and urological diseases. The invention also features compounds which bind to and/or activate or inhibit the activity of CMA1 as well as pharmaceutical compositions comprising such compounds.
摘要翻译：本发明提供了与心血管疾病，感染，代谢疾病，皮肤病，胃肠疾病，癌症，炎症，血液疾病，呼吸系统疾病，肌肉骨骼疾病，神经系统疾病和泌尿系疾病相关的人CMA1。本发明还提供了用于鉴定可用于治疗或预防心血管疾病，感染，代谢疾病，皮肤病，胃肠疾病，癌症，炎症，血液疾病，呼吸系统疾病，肌肉骨骼疾病，神经系统疾病和泌尿疾病的化合物的化合物。本发明还涉及结合和/或活化或抑制CMA1的活性的化合物以及包含这些化合物的药物组合物。

88. 发明申请

WO2005101022A3 DIAGNOSTICS AND THERAPEUTICS FOR DISEASES ASSOCIATED WITH VITAMIN D (1,25-DIHYDROXYVITAMIN D3) RECEPTOR 1 (VDR1) 审中-公开
标题翻译：与维生素D（1,25-二羟基维生素D3）受体1（VDR1）相关的疾病的诊断和治疗
公开(公告)号：WO2005101022A3
公开(公告)日：2006-02-09
申请号：PCT/EP2005003471
申请日：2005-04-02
申请人： BAYER HEALTHCARE AG , GOLZ STEFAN , BRUEGGEMEIER ULF , GEERTS ANDREAS
发明人： GOLZ STEFAN , BRUEGGEMEIER ULF , GEERTS ANDREAS
IPC分类号： G01N33/574 , G01N33/82
CPC分类号： G01N33/82 , G01N33/57484
摘要： The invention provides a human VDR1 which is associated with the infections, cardiovascular diseases, respiratory diseases, dermatological diseases, endocrinological diseases, metabolic diseases, cancer, gastroenterological diseases, inflammation, hematological diseases, muscle skeleton disorders and urological diseases. The invention also provides assays for the identification of compounds useful in the treatment or prevention of infections cardiovascular diseases, respiratory diseases, dermatological diseases, endocrinological deiseases, metabolic diseases, cancer, gastroenterological diseases, inflammation, hematological diseases, muscle skeleton disorders and urological diseases. The invention also features compounds which bind to and/or activate or inhibit the activity of VDR1 as well as pharmaceutical compositions comprising such compounds.
摘要翻译：本发明提供了与感染，心血管疾病，呼吸系统疾病，皮肤病，内分泌疾病，代谢疾病，癌症，胃肠疾病，炎症，血液疾病，肌肉骨骼疾病和泌尿系疾病有关的人类VDR1。本发明还提供了用于鉴定可用于治疗或预防感染心血管疾病，呼吸系统疾病，皮肤病，内分泌疾病，代谢疾病，癌症，肠胃疾病，炎症，血液疾病，肌肉骨骼疾病和泌尿系统疾病的化合物的测定。本发明还涉及结合和/或活化或抑制VDR1的活性的化合物以及包含这些化合物的药物组合物。

89. 发明申请

WO2006008003A2 DIAGNOSTICS AND THERAPEUTICS FOR DISEASES ASSOCIATED WITH VASOACTIVE INTESTINAL PEPTIDE RECEPTOR 1 (VPAC1) 审中-公开
标题翻译：与VASOACTIVE INTESTINAL PEPTIDE RECEPTOR 1（VPAC1）相关的疾病的诊断和治疗方法
公开(公告)号：WO2006008003A2
公开(公告)日：2006-01-26
申请号：PCT/EP2005007441
申请日：2005-07-09
申请人： BAYER HEALTHCARE AG , GOLZ STEFAN , BRUEGGEMEIER ULF , GEERTS ANDREAS
发明人： GOLZ STEFAN , BRUEGGEMEIER ULF , GEERTS ANDREAS
IPC分类号： G01N33/68
CPC分类号： G01N33/566 , G01N33/74 , G01N2333/726 , G01N2500/04
摘要： The invention provides a human VPAC1 which is associated with the cardiovascular diseases, cancer, dermatological diseases, endocrinological diseases, metabolic diseases, inflammation, gastroenterological diseases, hematological diseases, respiratory diseases, muscle skeleton diseases, neurological diseases and urological diseases. The invention also provides assays for the identification of compounds useful in the treatment or prevention of cardiovascular diseases, cancer, dermatological diseases, endocrinological diseases, metabolic diseases, inflammation, gastroenterological diseases, hematological diseases, respiratory diseases, muscle skeleton diseases, neurological diseases and urological diseases. The invention also features compounds which bind to and/or activate or inhibit the activity of VPAC1 as well as pharmaceutical compositions comprising such compounds.
摘要翻译：本发明提供了与心血管疾病，癌症，皮肤病，内分泌疾病，代谢疾病，炎症，胃肠疾病，血液疾病，呼吸系统疾病，肌肉骨骼疾病，神经系统疾病和泌尿系疾病有关的人VPAC1。本发明还提供了用于鉴定可用于治疗或预防心血管疾病，癌症，皮肤病，内分泌疾病，代谢疾病，炎症，胃肠疾病，血液疾病，呼吸系统疾病，肌肉骨骼疾病，神经系统疾病和泌尿系统疾病疾病。本发明还涉及结合和/或活化或抑制VPAC1的活性的化合物以及包含这些化合物的药物组合物。

90. 发明申请

WO2005085865A3 DIAGNOSTICS AND THERAPEUTICS FOR DISEASES ASSOCIATED WITH THYROID HORMONE RECEPTOR BETA (THRB) 审中-公开
标题翻译：与THYROID HORMONE RECEPTOR BETA（THRB）相关疾病的诊断和治疗方法
公开(公告)号：WO2005085865A3
公开(公告)日：2006-01-26
申请号：PCT/EP2005001918
申请日：2005-02-24
申请人： BAYER HEALTHCARE AG , GOLZ STEFAN , BRUEGGEMEIER ULF , GEERTS ANDREAS
发明人： GOLZ STEFAN , BRUEGGEMEIER ULF , GEERTS ANDREAS
IPC分类号： G01N33/78 , G01N33/74 , A61K31/70 , A61K38/00 , A61K39/395 , A61K47/46 , A61P1/00 , A61P3/00 , A61P7/00 , A61P9/00 , A61P13/00 , A61P29/00 , A61P31/00 , C07K14/72 , C12Q1/68 , G01N33/574
CPC分类号： G01N33/78 , G01N2500/00
摘要： The invention provides a human THRB which is associated with the cardiovascular diseases, infections, respiratory diseases, dermatological diseases, gastroenterological diseases, cancer, inflammation, metabolic diseases, hematological diseases, muscle-skeleton diseases, neurological diseases and urological diseases. The invention also provides assays for the identification of compounds useful in the treatment or prevention of cardiovascular diseases, infections, respiratory diseases, dermatological diseases, gastroenterological diseases, cancer, inflammation, metabolic diseases, hematological diseases, muscle-skeleton diseases, neurological diseases and urological diseases. The invention also features compounds which bind to and/or activate or inhibit the activity of THRB as well as pharmaceutical compositions comprising such compounds.
摘要翻译：本发明提供了与心血管疾病，感染，呼吸系统疾病，皮肤病，胃肠疾病，癌症，炎症，代谢疾病，血液病，肌肉骨骼疾病，神经系统疾病和泌尿系疾病有关的人THRB。本发明还提供了用于鉴定可用于治疗或预防心血管疾病，感染，呼吸系统疾病，皮肤病，胃肠疾病，癌症，炎症，代谢疾病，血液疾病，肌肉骨骼疾病，神经系统疾病和泌尿系统疾病疾病。本发明还涉及结合和/或活化或抑制THRB活性的化合物以及包含这些化合物的药物组合物。

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