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81. 发明申请

WO2009055740A2 METHOD OF PREVENTING ADVERSE EFFECTS BY GLP-1 审中-公开
标题翻译：预防GLP-1不良反应的方法
公开(公告)号：WO2009055740A2
公开(公告)日：2009-04-30
申请号：PCT/US2008/081218
申请日：2008-10-24
申请人： MANNKIND CORPORATION , RICHARDSON, Peter , BAUGHMAN, Robert, A. , COSTELLO, Donald
发明人： RICHARDSON, Peter , BAUGHMAN, Robert, A. , COSTELLO, Donald
CPC分类号： A61K45/06 , A61K31/495 , A61K38/26 , A61K38/28 , A61M15/00 , A61K2300/00
摘要： A method for preventing or reducing adverse effects such as profuse sweating, nausea and vomiting, which normally are associated with subcutaneous and intravenous administration of glucagon-like peptide 1 (GLP-1 ) therapy is provided. In particular, the method comprises the rapid administration of a GLP-1 formulation into the pulmonary circulation such as by inhalation, directly into pulmonary alveolar capillaries using a dry powder drug delivery system.
摘要翻译：提供了预防或减少通常与胰高血糖素样肽1（GLP-1）治疗的皮下和静脉内给药相关的不良作用例如大量出汗，恶心和呕吐的方法。特别地，该方法包括使用干粉药物递送系统将GLP-1制剂快速施用到肺循环中，例如通过吸入直接进入肺泡肺毛细血管。

82. 发明申请

WO2008148068A1 MULTICISTRONIC VECTORS AND METHODS FOR THEIR DESIGN 审中-公开
标题翻译：多媒体矢量及其设计方法
公开(公告)号：WO2008148068A1
公开(公告)日：2008-12-04
申请号：PCT/US2008/064801
申请日：2008-05-23
申请人： MANNKIND CORPORATION , BOT, Adrian, Ion , QIU, Zhiyong
发明人： BOT, Adrian, Ion , QIU, Zhiyong
IPC分类号： C12N15/85 , A61K38/00
CPC分类号： C12N15/111 , A61K39/00 , C12N15/1135 , C12N15/85 , C12N2310/111 , C12N2310/14 , C12N2310/53 , C12N2330/30 , C12N2840/20
摘要： The invention disclosed herein generally relates to multicistronic vectors and methods for their design and construction for use as immunotherapeutics capable of inducing an immune response in a subject or capable of suppressing a gene or target expressing an antigen.
摘要翻译：本文公开的本发明通常涉及用于其设计和构建的多顺反子载体和方法，其用作能够诱导受试者中的免疫应答或能够抑制表达抗原的基因或靶的免疫治疗剂。

83. 发明申请

WO2008100598A2 A METHOD FOR ENHANCING T CELL RESPONSE 审中-公开
标题翻译：一种增强细胞应答的方法
公开(公告)号：WO2008100598A2
公开(公告)日：2008-08-21
申请号：PCT/US2008/002044
申请日：2008-02-15
申请人： MANNKIND CORPORATION , KUNDIG, Thomas , BOT, Adrian , SMITH, Kent, Andrew , QIU, Zhiyong
发明人： KUNDIG, Thomas , BOT, Adrian , SMITH, Kent, Andrew , QIU, Zhiyong
IPC分类号： A61K39/00 , A61P37/00 , A61P35/00
CPC分类号： A61K39/39 , A61K2039/5152 , A61K2039/5154 , A61K2039/55516 , A61K2039/55522 , A61K2039/55561 , A61K2039/55577
摘要： Embodiments of the invention disclosed herein relate to methods and compositions for exponentially increasing antigenic stimulation of class I MHC CD8 + T cell responses over that based in the art. Some embodiments relate to an immunogenic composition that enhances an immune response in a subject. In some embodiments, the immunogenic composition comprises an antigen in combination with an immunopotentiator or a biological response modifier (BRM). Overall, the invention disclosed herein demonstrates that increasing antigenic stimulation in a manner independent of the dose of the antigen enhances immunogenicity.
摘要翻译：本文公开的本发明的实施方案涉及用于指数增加I类MHC CD8 + T细胞应答的抗原性刺激的方法和组合。一些实施方案涉及增强受试者的免疫应答的免疫原性组合物。在一些实施方案中，免疫原性组合物包含与免疫增强剂或生物反应调节剂（BRM）组合的抗原。总的来说，本文公开的发明证明以与抗原剂量无关的方式增加抗原刺激增强了免疫原性。

84. 发明申请

WO2007061987A2 POWDER DISPENSING AND SENSING APPARATUS AND METHODS 审中-公开
标题翻译：粉末分配和感测装置及方法
公开(公告)号：WO2007061987A2
公开(公告)日：2007-05-31
申请号：PCT/US2006/044972
申请日：2006-11-20
申请人： MANNKIND CORPORATION , POOLE, Trent, A. , BONNEAU, David, F. , FOG, Per, B.
发明人： POOLE, Trent, A. , BONNEAU, David, F. , FOG, Per, B.
IPC分类号： B65B1/30
CPC分类号： G01G13/24 , B65B1/12 , B65B1/30 , B65B1/32 , B65B57/145 , G01G17/00 , G01G21/23

85. 发明申请

WO2006105501A2 SUPERIOR CONTROL OF BLOOD GLUCOSE IN DIABETES TREATMENT 审中-公开
标题翻译：血糖控制在糖尿病治疗中的优势
公开(公告)号：WO2006105501A2
公开(公告)日：2006-10-05
申请号：PCT/US2006/012366
申请日：2006-03-31
申请人： MANNKIND CORPORATION , CHEATHAM, Wayman, Wendell , BOSS, Anders
发明人： CHEATHAM, Wayman, Wendell , BOSS, Anders
CPC分类号： A61K38/28 , A61K9/007 , A61K9/0073 , A61K9/0075 , A61K31/495 , A61K47/545 , Y10S514/866
摘要： Methods related to the treatment of diabetes and improving the control of blood glucose levels are provided. In particular, methods are provided for effectively reducing postprandial glucose excursions while reducing the incidence of clinically significant late postprandial hypoglycemia by administered an insulin composition in a form suitable for pulmonary administration. Additionally, methods for effectively reducing post-prandial glucose excursions while reducing the incidence of clinically significant late postprandial hypoglycemia by administered an insulin composition in a form suitable for pulmonary administration along with a long-acting basal insulin.
摘要翻译：提供了与治疗糖尿病和改善血糖水平控制有关的方法。特别地，提供了通过以适合于肺部给药的形式施用胰岛素组合物来有效减少餐后葡萄糖偏移同时降低临床上晚期餐后低血糖发生率的方法。另外，通过以与长效基础胰岛素一起施用适合于肺部给药的形式的胰岛素组合物，有效减少餐后葡萄糖偏移的方法同时降低临床上显着晚期餐后低血糖的发生率。

86. 发明申请

WO2006071990A3 METHODS TO BYPASS CD+4 CELLS IN THE INDUCTION OF AN IMMUNE RESPONSE 审中-公开
公开(公告)号：WO2006071990A3
公开(公告)日：2006-07-06
申请号：PCT/US2005/047442
申请日：2005-12-29
申请人： MANNKIND CORPORATION , DIAMOND, David C. , BOT, Adrian Ion
发明人： DIAMOND, David C. , BOT, Adrian Ion
IPC分类号： A61K39/12 , A61K39/29 , A61K39/39 , A61P35/00
摘要： Embodiments of the invention disclosed herein relate to methods and compositions for bypassing the involvement of CD4+ cells when generating antibody and MHC class I-restricted immune responses, controlling the nature and magnitude of the response, and promoting effective immunologic intervention in viral pathogenesis. More specifically, embodiments relate to immunogenic compositions for vaccination particularly therapeutic vaccination, against HIV and other microbial pathogens that impact functioning of the immune system, their nature, and the order, timing, and route of administration by which they are effectively used.

87. 发明申请

WO2005067964A1 A METHOD OF REDUCING SERUM PROINSULIN LEVELS IN TYPE 2 DIABETICS 审中-公开
标题翻译：降低2型糖尿病血清胰蛋白酶水平的方法
公开(公告)号：WO2005067964A1
公开(公告)日：2005-07-28
申请号：PCT/US2005/000596
申请日：2005-01-10
申请人： MANNKIND CORPORATION , CHEATHAM, Wayman, Wendell , PFUETZNER, Andreas , BOSS, ANders Hasager
发明人： CHEATHAM, Wayman, Wendell , PFUETZNER, Andreas , BOSS, ANders Hasager
IPC分类号： A61K38/28
CPC分类号： A61K38/28
摘要： Methods are provided for reducing serum proinsulin levels, lessening post-prandial pancreatic stress, and reducing risk factors for atherosclerosis in subjects with diabetes mellitus, type 2. The method includes administration of insulin in a manner that mimics the meal-related first phase insulin response, using a dose sufficient to reduce serum levels of proinsulin. In some embodiments of the method insulin administration is commenced early in the course of the disease. Mimicking first phase kinetics, peak serum insulin levels can be reached within about 18 minutes of administration. In increasingly preferred embodiments peak serum insulin levels can be reached within about 15, 12, or 10 minutes of administration. Serum insulin levels return to baseline within about two hours of administration.
摘要翻译：提供了用于降低血清胰岛素原水平，减轻餐后胰腺压力并降低患有糖尿病2型的受试者的动脉粥样硬化的危险因素的方法。该方法包括以模拟与膳食相关的第一阶段胰岛素反应的方式施用胰岛素，使用足以降低胰岛素原血清水平的剂量。在该方法的一些实施方案中，胰岛素给药在疾病过程的早期开始。模拟第一相动力学，可在约18分钟内达到峰值血清胰岛素水平。在越来越优选的实施方案中，可以在给药的约15,12或10分钟内达到峰值血清胰岛素水平。血清胰岛素水平在约2小时内恢复至基线。

88. 发明申请

WO2005023348A3 UNIT DOSE CARTRIDGE AND DRY POWDER INHALER 审中-公开
公开(公告)号：WO2005023348A3
公开(公告)日：2005-03-17
申请号：PCT/US2004/028699
申请日：2004-09-03
申请人： MANNKIND CORPORATION , STEINER, Solomon, S. , POOLE, Trent, A. , FOG, Per, B. , POHL, Roderike , CRICK, Michael , FELDSTEIN, Robert
发明人： STEINER, Solomon, S. , POOLE, Trent, A. , FOG, Per, B. , POHL, Roderike , CRICK, Michael , FELDSTEIN, Robert
IPC分类号： A61M15/00
摘要： A dry powder inhaler having improved aerodynamic properties for diluting, dispersing, and metering drug particles for increasing the efficiency of pulmonary drug delivery to a patient is described. The inhaler comprises, in general, a housing (20) having an air intake (15), an air flow-control/check-valve (180), a mixing section (30) and a mouthpiece (40). A cartridge loaded with a single dose of medicament can be installed in the mixing section.

89. 发明申请

WO2004112825A2 COMBINATIONS OF TUMOR-ASSOCIATED ANTIGENS IN COMPOSITIONS FOR VARIOUS TYPES OF CANCERS 审中-公开
标题翻译：肿瘤相关抗原在各种类型癌组织中的组合
公开(公告)号：WO2004112825A2
公开(公告)日：2004-12-29
申请号：PCT/US2004/019571
申请日：2004-06-17
申请人： MANNKIND CORPORATION , CHIANG, Chih-Sheng , BOT, Adrian , SIMARD, John, J., L. , DIAMOND, David, C.
发明人： CHIANG, Chih-Sheng , BOT, Adrian , SIMARD, John, J., L. , DIAMOND, David, C.
IPC分类号： A61K38/17
CPC分类号： A61K39/0011 , A61K48/00 , A61K2039/53 , A61K2039/545
摘要： Disclosed herein are methods and compositions for inducing an immune response against various combinations of tumor-associated antigens, which can promote effective immunologic intervention in pathogenic processes. Embodiments of the invention disclosed herein are directed to the use of effective combinations of TuAAs for the immunotherapy of patients with various types of cancer. Both immunogenic compositions for inducing an immune response to these combinations of antigens and methods for their use are disclosed.
摘要翻译：本文公开了用于诱导针对肿瘤相关抗原的各种组合的免疫应答的方法和组合物，其可以促进对病原性过程的有效的免疫介入。本文公开的本发明的实施方案涉及使用TuAAs的有效组合用于患有各种类型的癌症的患者的免疫治疗。公开了用于诱导针对这些抗原组合的免疫应答的免疫原性组合物及其使用方法。

90. 发明申请

WO2004012672A2 CELL TRANSPORT COMPOSITIONS AND USES THEREOF 审中-公开
标题翻译：细胞运输组合物及其用途
公开(公告)号：WO2004012672A2
公开(公告)日：2004-02-12
申请号：PCT/US2003/024323
申请日：2003-08-01
申请人： MANNKIND CORPORATION
发明人： GELBER, Cohava , ROUSSEAU, Kathleen
IPC分类号： A61K
CPC分类号： A61K9/0075 , A61K9/1641 , A61K9/167 , A61K9/1676 , A61K47/545 , A61K47/6927
摘要： Compositions and methods have been developed for transporting compounds across membranes with little or no toxicity and, when targeted through the appropriate routes of administration (i.e., lung, gastrointestinal (GI) tract), little or no immune stimulation. The compositions can mediate cellular delivery of compounds that would otherwise not enter cells and enhance the intracellular delivery of compounds that would otherwise enter cells inefficiently. The methods are carried out by contacting a proximal face of a lipid bilayer or membrane (e.g. the surface of an intact cell) with a complex containing a compound (e.g., a therapeutic agent) and a diketopiperazine (DKP). DKP and the compound are non-covalently associated with each other or covalently bound to each other .
摘要翻译：开发了用于将化合物跨越膜转运而几乎没有或没有毒性的组合物和方法，并且当通过适当的给药途径（即肺，胃肠道（GI）道）靶向时，很少或没有免疫刺激。所述组合物可以介导化合物的细胞递送，否则所述化合物不会进入细胞并且增强化合物的细胞内递送，否则所述化合物将无效地进入细胞。通过使脂质双分子层或膜的近侧面（例如完整细胞的表面）与含有化合物（例如治疗剂）和二酮哌嗪（DKP）的复合物接触来进行所述方法。 DKP和化合物彼此非共价缔合或彼此共价结合。

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