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81. 发明申请

WO2014006528A2 COMPOSITIONS AND METHODS FOR THE TREATMENT OF NEUROLOGICAL DEGENERATIVE DISORDERS 审中-公开
标题翻译：用于治疗神经衰弱性疾病的组合物和方法
公开(公告)号：WO2014006528A2
公开(公告)日：2014-01-09
申请号：PCT/IB2013/055145
申请日：2013-06-23
申请人： KANDULA, Mahesh
发明人： KANDULA, Mahesh
CPC分类号： C07D339/04 , A61K47/542 , C07C219/26 , C07C229/50 , C07C323/47 , C07C2602/08
摘要： The invention relates to the compounds of formula 1 or its pharmaceutical acceptable salts, as well as polymorphs, solvates, enantiomers, stereoisomers and hydrates thereof The pharmaceutical compositions comprising an effective amount of compounds of formula I; and methods for treating or preventing neurological degenerative disorders, may be formulated for oral, buccal, rectal, topical, transdermal, transmucosal, intravenous, parenteral administration, syrup, or injection. Such compositions may be used to treatment of Alzheimer's disease, Lewy body disease, Huntington's disease, Amyotrophic lateral sclerosis (ALS) and Parkinson's disease.
摘要翻译：本发明涉及式1化合物或其药学上可接受的盐，以及多晶型物，溶剂合物，对映体，立体异构体和水合物。药物组合物包含有效量的式I化合物; 以及用于治疗或预防神经退行性疾病的方法可以配制用于口服，口腔，直肠，局部，透皮，经粘膜，静脉内，肠胃外给药，糖浆或注射。这样的组合物可用于治疗阿尔茨海默氏病，路易体病，亨廷顿病，肌萎缩性侧索硬化（ALS）和帕金森病。

82. 发明申请

WO2013175357A2 COMPOSITIONS AND METHODS FOR THE TREATMENT OF INFLAMMATORY BOWEL DISEASE 审中-公开
标题翻译：用于治疗炎症性皮肤病的组合物和方法
公开(公告)号：WO2013175357A2
公开(公告)日：2013-11-28
申请号：PCT/IB2013/053982
申请日：2013-05-15
申请人： KANDULA, Mahesh
发明人： KANDULA, Mahesh , KANDULA, Mahesh
CPC分类号： A61K31/245 , A61K31/202 , A61K31/235 , A61K31/606 , A61K31/655 , A61K45/06 , A61K47/542 , C07C233/54 , C07C233/55 , C07C235/74 , C07C237/44 , C07C239/22 , C07C243/22 , C07C251/84 , C07C251/86 , C07C2601/14 , C07C2601/16 , A61K2300/00
摘要： The invention relates to the compounds of formula I and formula II or its pharmaceutical acceptable salts, as well as polymorphs, solvates, enantiomers, stereoisomers and hydrates thereof. The pharmaceutical compositions comprising an effective amount of compounds of formula I or formula II; and methods for treating or preventing inflammatory bowel disease may be formulated for oral, buccal, rectal, topical, transdermal, transmucosal, intravenous, parenteral administration, syrup, or injection. Such compositions may be used to treatment of gastrointestinal diseases and inflammation such as inflammatory bowel disease, ulcerative colitis, mild-to-moderate Crohn's disease, rheumatoid arthritis, inflammatory arthritis, psoriatic arthritis, liver cirrhosis and idiopathic urticaria.
摘要翻译：本发明涉及式I和式II化合物或其药学上可接受的盐，以及多晶型物，溶剂合物，对映体，立体异构体和水合物。药物组合物包含有效量的式I或式II化合物; 并且可以配制用于口服，口腔，直肠，局部，透皮，经粘膜，静脉内，肠胃外给药，糖浆或注射的治疗或预防炎性肠病的方法。这样的组合物可用于治疗胃肠道疾病和炎症，例如炎性肠病，溃疡性结肠炎，轻度至中度克罗恩病，类风湿性关节炎，炎症性关节炎，牛皮癣关节炎，肝硬化和特发性荨麻疹。

83. 发明申请

WO2013175347A2 COMPOSITIONS AND METHODS FOR THE TREATMENT OF RESPIRATORY DISORDERS 审中-公开
标题翻译：用于治疗呼吸道疾病的组合物和方法
公开(公告)号：WO2013175347A2
公开(公告)日：2013-11-28
申请号：PCT/IB2013/053930
申请日：2013-05-14
申请人： KANDULA, Mahesh
发明人： KANDULA, Mahesh
CPC分类号： C07D473/04 , A61K47/48038 , A61K47/481 , A61K47/48107 , A61K47/542 , A61K47/55 , A61K47/551 , C07C229/40 , C07C237/20 , C07C237/40 , C07C239/20 , C07C275/40 , C07C2601/14 , C07D213/66 , C07D339/04
摘要： The invention relates to the compounds of formula I or its pharmaceutical acceptable salts, as well as polymorphs, solvates, enantiomers, stereoisomers and hydrates thereof. The pharmaceutical compositions comprising an effective amount of compounds of formula I, and methods for the treatment of respiratory disorders may be formulated for oral, buccal, rectal, topical, transdermal, transmucosal, intravenous, parenteral administration, syrup, or injection. Such compositions may be used to treatment of viscid or excessive mucus, cough, inflammation, redness in sore throat, infection in the throat, sore throat, abnormal mucus secretion, impaired mucus transport, allergic rhinitis, asthma, COPD, respiratory muscular disorders and pain in acute sore throat.
摘要翻译：本发明涉及式I化合物或其药学上可接受的盐，以及其多晶型物，溶剂合物，对映体，立体异构体和水合物。包含有效量的式I化合物和用于治疗呼吸系统疾病的方法的药物组合物可以配制用于口服，口腔，直肠，局部，透皮，经粘膜，静脉内，肠胃外给药，糖浆或注射。这些组合物可用于治疗粘稠或过度粘液，咳嗽，炎症，喉咙发红，咽喉感染，喉咙痛，粘液分泌异常，粘液运输受损，过敏性鼻炎，哮喘，COPD，呼吸肌肉疾病和疼痛在喉咙痛。

84. 发明申请

WO2013168033A1 COMPOSITIONS AND METHODS FOR TREATMENT OF NEUROLOGIC DISEASES 审中-公开
标题翻译：用于治疗神经病变的组合物和方法
公开(公告)号：WO2013168033A1
公开(公告)日：2013-11-14
申请号：PCT/IB2013/053122
申请日：2013-04-19
申请人： KANDULA, Mahesh
发明人： KANDULA, Mahesh
IPC分类号： A61K31/381 , A61P25/16
CPC分类号： C07D409/12 , C07D333/20 , C07D333/24
摘要： Provided are compounds, pharmaceutical acceptable salts, polymorphs, solvates, enantiomers, stereoisomers and hydrates thereof. The pharmaceutical compositions comprising the compounds may be formulated for oral, buccal, rectal, topical, transdermal, transmucosal, intravenous, parenteral administration, syrup or injection, and may be used for the treatment of neurologic diseases, such as depression, Alzheimer's disease, multiple sclerosis, Batten disease, Parkinson's disease and restless legs syndrome.
摘要翻译：提供化合物，药用盐，多晶型物，溶剂合物，对映体，立体异构体和水合物。包含该化合物的药物组合物可以配制用于口服，口腔，直肠，局部，透皮，经粘膜，静脉内，肠胃外给药，糖浆或注射，并可用于治疗神经疾病，例如抑郁症，阿尔茨海默病，多发性硬化症，巴特病，帕金森病和不宁腿综合征。

85. 发明申请

WO2013168022A1 COMPOSITIONS AND METHODS FOR TREATING ATHEROTHROMBOSIS 审中-公开
标题翻译：用于治疗恶性肿瘤的组合物和方法
公开(公告)号：WO2013168022A1
公开(公告)日：2013-11-14
申请号：PCT/IB2013/052246
申请日：2013-03-21
申请人： KANDULA, Mahesh
发明人： KANDULA, Mahesh , KANDULA, Mahesh
IPC分类号： C07D211/72 , A61K31/445 , A61P9/10 , A61P9/14 , A61P9/00
CPC分类号： A61K31/445 , A61K31/202 , A61K31/355 , A61K31/385 , A61K31/616 , A61K31/618 , C07D211/72 , C07D409/12 , A61K2300/00
摘要： Provided are compounds of formula (I), pharmaceutical acceptable salts, polymorphs, solvates, enantiomers, stereoisomers and hydrates thereof. The pharmaceutical compositions comprising the compounds may be formulated for oral, buccal, rectal, topical, transdermal, transmucosal, intravenous, parenteral administration, syrup or injection, and may be used for the treatment or management of ischemia, cerebral thrombosis, arterial thrombosis, thrombotic cerebrovascular, cardiovascular diseases and blood clots.
摘要翻译：提供式（I）的化合物，其药学上可接受的盐，多晶型物，溶剂合物，对映体，立体异构体和水合物。包含这些化合物的药物组合物可以配制用于口服，口腔，直肠，局部，经皮，经粘膜，静脉内，肠胃外给药，糖浆或注射，并可用于治疗或治疗缺血，脑血栓形成，动脉血栓形成，血栓形成脑血管，心血管疾病和血块。

86. 发明申请

WO2013168016A1 COMPOSITIONS AND METHODS FOR THE TREATMENT OF METABOLIC SYNDROME 审中-公开
标题翻译：用于治疗代谢综合征的组合物和方法
公开(公告)号：WO2013168016A1
公开(公告)日：2013-11-14
申请号：PCT/IB2013/051596
申请日：2013-02-28
申请人： KANDULA, Mahesh
发明人： KANDULA, Mahesh
IPC分类号： C07F9/09 , C07C309/63 , A61K31/683 , A61P3/00 , A61P3/10
CPC分类号： C07F9/65586 , C07D339/04 , C07D409/12
摘要： The invention discloses the compounds of formula (I) and formula (II) or its pharmaceutical acceptable salts, as well as polymorphs, solvates, enantiomers, stereoisomers and hydrates thereof. The pharmaceutical compositions comprising an effective amount of compounds of formula (I) or formula (II), and the methods of treating or preventing or modulating metabolic syndrome may be formulated for oral, buccal, rectal, topical, transdermal, transmucosal, intravenous, parenteral administration, syrup or injection. The compositions may be used to treat fasting hyperglycemia, diabetes mellitus type 2, impaired fasting glucose, impaired glucose tolerance, insulin resistance, high blood pressure, central obesity, overweight with fat deposits mainly around the waist, decreased HDL cholesterol, elevated triglycerides, hyperuricemia, fatty liver progressing to NAFLD, polycystic ovarian syndrome, hypophosphatemia, renal diseases, albuminuria, end stage renal disease and acanthosis nigricans.
摘要翻译：本发明公开了式（I）和式（II）的化合物或其药学上可接受的盐，以及其多晶型物，溶剂合物，对映体，立体异构体和水合物。包含有效量的式（I）或式（II）化合物的药物组合物，以及治疗或预防或调节代谢综合征的方法可以配制用于口服，口腔，直肠，局部，透皮，经粘膜，静脉内，肠胃外给药，糖浆或注射。该组合物可用于治疗空腹高血糖，2型糖尿病，空腹血糖受损，葡萄糖耐量降低，胰岛素抵抗，高血压，中枢性肥胖，超重，肥胖主要在腰围周围，HDL胆固醇降低，甘油三酯升高，高尿酸血症，脂肪肝进展到NAFLD，多囊卵巢综合征，低磷血症，肾脏疾病，蛋白尿，终末期肾病和黑棘皮病。

87. 发明申请

WO2013168012A1 COMPOSITIONS AND METHODS FOR THE TREATMENT OF RESPIRATORY DISORDERS 审中-公开
标题翻译：用于治疗呼吸道疾病的组合物和方法
公开(公告)号：WO2013168012A1
公开(公告)日：2013-11-14
申请号：PCT/IB2013/051485
申请日：2013-02-24
申请人： KANDULA, Mahesh
发明人： KANDULA, Mahesh
IPC分类号： C07D471/08 , A61K31/439 , A61P11/14 , A61P11/00
CPC分类号： C07D221/28 , A61K31/485 , A61K47/48038 , A61K47/48061 , A61K47/542 , A61K47/545 , C07D471/08
摘要： The invention relates to the compounds of formula (I) or its pharmaceutical acceptable salts, as well as polymorphs, solvates, enantiomers, stereoisomers and hydrates thereof. The pharmaceutical compositions comprising an effective amount of compounds of formula (I), and methods for the treatment of respiratory disorders may be formulated for oral, buccal, rectal, topical, transdermal, transmucosal, intravenous, parenteral administration, syrup, or injection. Such compositions may be used to treatment of cough caused by minor throat and bronchial irritation (such as commonly accompanies the flu and common cold), as well as those resulting from inhaled particle irritants, upper respiratory infections, (pseudobulbar affect) in patients with amyotrophic lateral sclerosis and multiple sclerosis, neuropathic pain and pain associated with fibromyalgia.
摘要翻译：本发明涉及式（I）化合物或其药学上可接受的盐，以及其多晶型物，溶剂合物，对映体，立体异构体和水合物。包含有效量的式（I）化合物和用于治疗呼吸系统疾病的方法的药物组合物可以配制用于口服，口腔，直肠，局部，透皮，经粘膜，静脉内，肠胃外给药，糖浆或注射。这种组合物可用于治疗由轻微喉咙和支气管刺激引起的咳嗽（如通常伴有流感和感冒），以及由吸入性粒子刺激物引起的咳嗽症状，上呼吸道感染（假性筋感染），肌萎缩症患者侧索硬化和多发性硬化，神经性疼痛和与纤维肌痛相关的疼痛。

88. 发明申请

WO2013168011A1 COMPOSITIONS AND METHODS FOR THE TREATMENT OF CHRONIC PAIN 审中-公开
标题翻译：用于治疗慢性疼痛的组合物和方法
公开(公告)号：WO2013168011A1
公开(公告)日：2013-11-14
申请号：PCT/IB2013/051482
申请日：2013-02-24
申请人： KANDULA, Mahesh
发明人： KANDULA, Mahesh
IPC分类号： C07D489/00 , A61K31/485 , A61K9/02 , A61K9/08 , A61K9/52 , A61K9/70 , A61P25/04 , A61P25/06 , A61P25/12 , A61P25/14 , A61P25/24 , A61P25/28 , A61P25/30
CPC分类号： C07D489/02 , A61K47/48038 , A61K47/48061 , A61K47/542 , A61K47/545 , C07D489/08
摘要： The invention relates to the compounds of formula (I) and formula (II) or its pharmaceutical acceptable salts, as well as polymorphs, solvates, enantiomers, stereoisomers and hydrates thereof. The pharmaceutical compositions comprising an effective amount of compounds of formula 1 or formula II, and methods for treating chronic pain in a disease may be formulated for oral, buccal, rectal, topical, transdermal, transmucosal, intravenous, parenteral administration, syrup, or injection. Such compositions may be used to treatment of acute pain (such as post-operative pain), palliative care to alleviate the severe., chronic, disabling pain of terminal conditions such as cancer, and degenerative conditions such as rheumatoid arthritis, non-malignant chronic pain, chemotherapy induced pain, musculoskeletal pain, sciatica, radiculopathy pain, migraine, neuropathic pain, post herpetic neuralgia, neuralgia pain, multiple sclerosis, multiple sclerosis, restless legs syndrome (R.l,S), cluster headache, depression, fibromyalgia and amyotrophic lateral sclerosis (A.LS).
摘要翻译：本发明涉及式（I）和式（II）化合物或其药学上可接受的盐，以及其多晶型物，溶剂合物，对映异构体，立体异构体和水合物。包含有效量的式1或式II化合物的药物组合物和治疗疾病中的慢性疼痛的方法可以配制用于口服，口腔，直肠，局部，透皮，经粘膜，静脉内，肠胃外给药，糖浆或注射。这些组合物可用于治疗急性疼痛（如手术后疼痛），姑息治疗以缓解严重的慢性，致残性终末恶化的疼痛，如癌症，退行性疾病如类风湿性关节炎，非恶性慢性疼痛，化疗诱发的疼痛，肌肉骨骼疼痛，坐骨神经痛，神经根病痛，偏头痛，神经性疼痛，疱疹后神经痛，神经痛，多发性硬化，多发性硬化，不宁腿综合征（R1，S），丛集性头痛，抑郁，纤维肌痛和肌萎缩侧硬化症（A.LS）。

89. 发明申请

WO2013168010A1 COMPOSITIONS AND METHODS FOR TREATMENT OF SEVERE PAIN 审中-公开
标题翻译：用于治疗严重疼痛的组合物和方法
公开(公告)号：WO2013168010A1
公开(公告)日：2013-11-14
申请号：PCT/IB2013/051471
申请日：2013-02-23
申请人： KANDULA, Mahesh
发明人： KANDULA, Mahesh
IPC分类号： C07C229/28 , C07C229/00 , A61K31/195 , A61P25/00
CPC分类号： C07D401/12 , A61K47/54 , A61K47/542 , A61K47/545 , A61K47/557 , C07D211/32 , C07D409/12
摘要： Compounds or their pharmaceutical acceptable salts, as well as polymorphs, solvates, enantiomers, stereoisomers and hydrates thereof. The pharmaceutical compositions comprising an effective amount of compounds of formula (I), and methods for the treatment of severe pain may be formulated for oral, buccal, rectal, topical, transdermal, transmucosal, intravenous, parenteral administration, syrup, or injection. Such compositions may be used to treatment of postoperative pain, cancer pain, kidney stones pain, fractures, local pain, chronic pain, chemotherapy induced pain, neuropathic pain, post herpetic neuralgia, motor neurone disease, diabetic neuropathy, postherpetic neuralgia, injury, post-operative pain, osteoarthritis, rheumatoid arthritis, multiple sclerosis, spinal cord injury, migraine, HIV related neuropathic pain, cancer pain and lower back pain.
摘要翻译：化合物或其药学上可接受的盐，以及多晶型物，溶剂合物，对映体，立体异构体和水合物。包含有效量的式（I）化合物和用于治疗严重疼痛的方法的药物组合物可以配制用于口服，口腔，直肠，局部，透皮，经粘膜，静脉内，肠胃外给药，糖浆或注射。此类组合物可用于治疗术后疼痛，癌症疼痛，肾结石疼痛，骨折，局部疼痛，慢性疼痛，化学疗法诱导的疼痛，神经性疼痛，疱疹后神经痛，运动神经元疾病，糖尿病性神经病变，带状疱疹后神经痛，损伤，后期手术疼痛，骨关节炎，类风湿性关节炎，多发性硬化症，脊髓损伤，偏头痛，HIV相关神经性疼痛，癌症疼痛和腰痛。

90. 发明申请

WO2013168007A1 COMPOSITIONS AND METHODS FOR THE TREATMENT OF CARDIOVASCULAR AND NEUROLOGICAL DISEASES 审中-公开
标题翻译：用于治疗心血管和神经病的组合物和方法
公开(公告)号：WO2013168007A1
公开(公告)日：2013-11-14
申请号：PCT/IB2013/051272
申请日：2013-02-16
申请人： KANDULA, Mahesh
发明人： KANDULA, Mahesh
IPC分类号： C07H7/02 , A61K31/7028 , A61K31/7042 , A61P9/00 , A61P25/00 , A61P3/10 , A61P3/04
CPC分类号： C07H13/06 , A61K31/7024 , A61K47/48038 , A61K47/48061 , A61K47/542 , A61K47/545 , C07H13/04
摘要： The invention relates to the compounds of formula (I), formula (II) and formula (III) or its pharmaceutical acceptable salts, as well as polymorphs, solvates, enantiomers, stereoisomers and hydrates thereof. The pharmaceutical compositions comprising an effective amount of compounds of formula (I), formula (II) or formula (III) and methods for the treatment of cardiovascular and neurological diseases may be formulated for oral, buccal, rectal, topical, transdermal, transmucosal, intravenous, parenteral administration, syrup, or injection. Such compositions may be used to treatment: of hyperglycemia, insulin resistance, diabetes mellitus, diabetes insipidus, type 1 diabetes, type 2 diabetes, microvascular complications, macrovascular complications, lipid disorders, prediabetes, obesity, arrhythmia, myocardial infarction, stroke, neuropathy, renal complications, hypertriglyceridemia, cardiovascular complications, postprandial hyperglycemia, depression, Alzheimer's disease, Parkinson's disease, Huntington's disease, inflammation, Crohn's disease, inflammatory bowel disease and obesity.
摘要翻译：本发明涉及式（I），式（II）和式（III）的化合物或其药学上可接受的盐，以及其多晶型物，溶剂合物，对映体，立体异构体和水合物。包含有效量的式（I），式（II）或式（III）的化合物和用于治疗心血管和神经疾病的方法的药物组合物可以配制用于口服，口腔，直肠，局部，透皮，经粘膜，静脉内，肠胃外给药，糖浆或注射。此类组合物可用于治疗：高血糖症，胰岛素抵抗，糖尿病，尿崩症，1型糖尿病，2型糖尿病，微血管并发症，大血管并发症，脂质障碍，糖尿病前期，肥胖症，心律失常，心肌梗死，中风，神经病变，肾脏并发症，高甘油三酯血症，心血管并发症，餐后高血糖症，抑郁症，阿尔茨海默病，帕金森病，亨廷顿病，炎症，克罗恩病，炎性肠病和肥胖症。

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