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81. 发明申请

WO2022177230A1 A COMPOSITION FOR TREATMENT OF HEPATITIS B COMPRISING HBV SPECIFIC ANTIBODY FOR COMBINATION WITH VACCINE COMPOSITION 审中-公开
公开(公告)号：WO2022177230A1
公开(公告)日：2022-08-25
申请号：PCT/KR2022/002034
申请日：2022-02-10
申请人： GREEN CROSS CORPORATION
发明人： JUNG, Jaesung , KIM, Woohyun , KIM, Tae-Hee , INCHAUSPE, Genevieve , MARTON, Perrine
IPC分类号： A61K39/42
摘要： The present invention relates to a pharmaceutical composition for treating, or for use for treating hepatitis B comprising an HBV-specific antibody for use in combination with a vaccine composition, and more particularly a pharmaceutical composition for treating hepatitis B comprising an HBV-specific antibody having a specific amino acid sequence for use in treating hepatitis B in combination with an adenovirus-based therapeutic vaccine composition having a nucleotide sequence encoding a hepatitis B virus-specific antigen, and a method for treating hepatitis B using a combination of the pharmaceutical composition and the vaccine composition. According to the present invention, co-administration of the HBV vaccine therapeutic agent "TG1050" and the antibody "GC1102" capable of binding to the HBV surface antigen (HBsAg), which have different mechanisms of action, is very effective in preventing or treating hepatitis B caused by HBV infection, compared to single administration of TG1050 or GC1102.

82. 发明申请

WO2017116066A1 METHODS AND COMPOSITIONS FOR TREATING HUNTER SYNDROME 审中-公开
标题翻译：治疗亨特综合征的方法和组合物
公开(公告)号：WO2017116066A1
公开(公告)日：2017-07-06
申请号：PCT/KR2016/015060
申请日：2016-12-21
申请人： GREEN CROSS CORPORATION , MEDIGENEBIO CORPORATION
发明人： OKUYAMA, Torayuki , JIN, Thong-Gyu , BYUN, Han-Yeul , SEO, Jin-Wook , LEE, Byoung-Ju , KIM, Yong-Chul , JANG, In-Young
IPC分类号： A61K38/43 , A61K9/00
CPC分类号： A61K47/26 , A61K9/0085 , A61K38/43
摘要： The present invention provides, among other things, compositions and methods for CNS delivery of Idursulfase-beta, a human recombinant iduronate-2-sulfatase protein, for effective treatment of Hunter Syndrome. The compositions and methods provided by the present invention effectively reduce symptoms not only in brain and spinal cord but also in peripheral tissues including heart, liver, spleen, lung, and kidney.
摘要翻译：本发明尤其提供用于有效治疗亨特综合征的Idursulfase-β（一种人重组艾杜糖醛酸-2-硫酸酯酶蛋白）的CNS递送的组合物和方法。本发明提供的组合物和方法不仅在脑和脊髓中而且在包括心脏，肝脏，脾脏，肺和肾的外周组织中都有效地减轻了症状。

83. 发明申请

WO2016117883A8 PHARMACEUTICAL FORMULATION COMPRISING ANTI-EGFR ANTIBODY 审中-公开
公开(公告)号：WO2016117883A8
公开(公告)日：2016-07-28
申请号：PCT/KR2016/000472
申请日：2016-01-15
申请人： GREEN CROSS CORPORATION
发明人： CHOI, Yong Woon , KIM, Yoo Hoon , CHOI, Jungsub
IPC分类号： A61K39/395 , A61K47/34
摘要： The present invention provides a pharmaceutical formulation comprising an anti- epidermal growth factor receptor (EGFR) antibody. The pharmaceutical formulation has low turbidity, without showing aggregation or particle formation, even under accelerated conditions, and exhibits good stability. Therefore, the pharmaceutical formulation can be effectively used for the treatment of disorders such as cancer.

84. 发明申请

WO2016117883A3 PHARMACEUTICAL FORMULATION COMPRISING ANTI-EGFR ANTIBODY 审中-公开
标题翻译：包含抗EGFR抗体的药物制剂
公开(公告)号：WO2016117883A3
公开(公告)日：2016-07-28
申请号：PCT/KR2016/000472
申请日：2016-01-15
申请人： GREEN CROSS CORPORATION
发明人： CHOI, Yong Woon , KIM, Yong Hoon , CHOI, Jungsub
IPC分类号： A61K39/395 , A61K47/34
摘要： The present invention provides a pharmaceutical formulation comprising an anti- epidermal growth factor receptor (EGFR) antibody. The pharmaceutical formulation has low turbidity, without showing aggregation or particle formation, even under accelerated conditions, and exhibits good stability. Therefore, the pharmaceutical formulation can be effectively used for the treatment of disorders such as cancer.
摘要翻译：本发明提供了包含抗表皮生长因子受体（EGFR）抗体的药物制剂。该药物制剂具有低浊度，即使在加速条件下也不显示聚集或颗粒形成，并且表现出良好的稳定性。因此，该药物制剂可以有效地用于治疗诸如癌症的疾病。

85. 发明申请

WO2013062305A1 METHOD FOR PREPARING HIGHLY CONCENTRATED FIBRINOGEN SOLUTION AND METHOD FOR PREPARING FIBRIN SEALANT BY USING THEREOF 审中-公开
标题翻译：制备高浓度纤维蛋白溶液的方法及使用它制备纤维素密封剂的方法
公开(公告)号：WO2013062305A1
公开(公告)日：2013-05-02
申请号：PCT/KR2012/008755
申请日：2012-10-24
申请人： GREEN CROSS CORPORATION
发明人： KIM, Jun Sic , LEE, Gun Sul , KIM, Ki-Yong , KANG, Yong , SON, Ki Hwan
IPC分类号： A61K38/36 , A61K38/37 , A61P7/02 , A61P7/00
CPC分类号： A61K38/363 , A61K38/45 , A61L24/106 , C07K14/75
摘要： Provided are a method for preparing a highly concentrated fibrinogen solution, and a method for preparing a fibrin sealant component 1 containing the highly concentrated fibrinogen solution and Factor ΧIII. More particularly, the method for preparing a highly concentrated fibrinogen solution according to the present invention can be prepared by adding amino acid or amino acid derivatives, and/or salts, etc. to a lowly concentrated fibrinogen solution separated from blood plasma and highly concentrating fibrinogen using an ultra filtration method, and a fibrin sealant component 1 in order to be used in a fibrin sealant product can be prepared by adding Factor ΧIII before or after the ultra filtration in the method for preparing the highly concentrated fibrinogen. The fibrin sealant component 1 prepared by the method according to the present invention may be cryopreserved in a liquid state, be preserved for a long time at room temperature, and be immediately applied to treatment without performing a reconstitution process. In addition, the present invention relates to a fibrin sealant product configured of the fibrin sealant component 1 and a fibrin sealant component 2 which is a solution containing thrombin and calcium chloride filled in a separate container. The fibrin sealant product according to the present invention may be provided in a vial type in which the fibrin sealant component 1 and the fibrin sealant component 2 are filled in separate vials, respectively, or a pre-filled type in which the fibrin sealant component 1 and the fibrin sealant component 2 are filled in separate syringes connected with each other to thereby be immediately used.
摘要翻译：本发明提供了制备高度浓缩的纤维蛋白原溶液的方法，以及制备含有高度浓缩的纤维蛋白原溶液和因子ChiIII的纤维蛋白密封剂组分1的方法。更具体地，根据本发明的制备高度浓缩的纤维蛋白原溶液的方法可以通过将氨基酸或氨基酸衍生物和/或盐等添加到从血浆和高浓度纤维蛋白原分离的低浓度纤维蛋白原溶液中来制备使用超滤方法和纤维蛋白密封剂组分1以在纤维蛋白密封剂产品中使用可以通过在制备高度浓缩的纤维蛋白原的方法中在超滤之前或之后加入因子ChiIII来制备。通过根据本发明的方法制备的纤维蛋白密封剂组分1可以液体冷冻保存，在室温下长时间保存，并且立即施用于治疗而不进行重构过程。此外，本发明涉及由纤维蛋白密封剂组分1和纤维蛋白密封剂组分2构成的纤维蛋白密封剂产品，纤维蛋白密封剂组分2是填充在单独的容器中的含有凝血酶和氯化钙的溶液。根据本发明的纤维蛋白密封剂产品可以以小瓶型提供，其中纤维蛋白密封剂组分1和纤维蛋白密封剂组分2分别填充在分开的小瓶中，或预填充型，其中纤维蛋白密封剂组分1 并且将纤维蛋白密封剂组分2填充在彼此连接的分开的注射器中，从而立即使用。

86. 发明申请

WO2012070890A3 PHARMACEUTICAL COMPOSITION COMPRISING EXTRACT OF LONICERA JAPONICA FOR PREVENTION AND TREATMENT OF GASTROESOPHAGEAL REFLUX DISEASE 审中-公开
公开(公告)号：WO2012070890A3
公开(公告)日：2012-05-31
申请号：PCT/KR2011/009027
申请日：2011-11-24
申请人： GREEN CROSS HERB & PHARMACEUTICAL CO., LTD. , Green Cross Corporation , YOO, Young-Hyo , KIM, Jeom Yong , KIM, Sun Ok , KIM, Joo Young , PARK, Sun Kyu , JANG, Min Jung
发明人： YOO, Young-Hyo , KIM, Jeom Yong , KIM, Sun Ok , KIM, Joo Young , PARK, Sun Kyu , JANG, Min Jung
IPC分类号： A61K36/355 , A61K31/19 , A61K31/185 , A61P1/08
摘要： Disclosed is a composition for treating or preventing gastroesophageal reflux disease, which includes an organic solvent extract of Lonicerae Flos Thunberg. A fraction of the disclosed extract can be very effectively used for treating, preventing, or improving gastroesophageal reflux disease without side effects.

87. 发明申请

WO2011136400A1 TUMOR-SPECIFIC PROMOTER AND ONCOLYTIC VIRUS VECTOR COMPRISING THE SAME 审中-公开
标题翻译：肿瘤特异性促进剂和包含其的肿瘤病毒载体
公开(公告)号：WO2011136400A1
公开(公告)日：2011-11-03
申请号：PCT/KR2010/002608
申请日：2010-04-26
申请人： GREEN CROSS CORPORATION , MOGAM BIOTECHNOLOGY RESEARCH INSTITUTE , INDUSTRY-ACADEMIC COOPERATION FOUNDATION, YONSEI UNIVERSITY , KOH, Daekyung , YUN, Seongtae , LEE, Kyuhyun , LEE, Hong-Kyu , HWANG, Mihee , YUN, Chae-Ok , JO, Eui-Cheol
发明人： KOH, Daekyung , YUN, Seongtae , LEE, Kyuhyun , LEE, Hong-Kyu , HWANG, Mihee , YUN, Chae-Ok , JO, Eui-Cheol
IPC分类号： C12N15/11 , C12N15/85 , C12N15/67 , A61P35/00
CPC分类号： A61K35/76 , A61K35/13 , A61K35/761 , C12N2830/008
摘要： Provided are tumor-specific promoters, oncolytic virus vectors and a pharmaceutical composition comprising the virus vector. The virus vector comprising the novel tumor-specific promoter shows excellent oncolytic effects on tumor cells, and thus it is useful for treating a cancer.
摘要翻译：提供肿瘤特异性启动子，溶瘤病毒载体和包含病毒载体的药物组合物。包含新型肿瘤特异性启动子的病毒载体对肿瘤细胞显示出优异的溶瘤作用，因此可用于治疗癌症。

88. 发明申请

WO2010035915A1 SULFUR CONTAINING PYRAZOLE-HETEROCYCLE DERIVATIVES AS CANNABINOID CB1 RECEPTOR ANTAGONISTS 审中-公开
标题翻译：作为CANNABINOID CB1受体拮抗剂的含硫吡唑杂交衍生物
公开(公告)号：WO2010035915A1
公开(公告)日：2010-04-01
申请号：PCT/KR2008/005689
申请日：2008-09-25
申请人： GREEN CROSS CORPORATION , LEE, Jinhwa , SEO, Hee Jeong , KIM, Min-Ah , KIM, Jeongmin , LEE, Sung-Han , JUNG, Myung Eun , KIM, Mi-Soon
发明人： LEE, Jinhwa , SEO, Hee Jeong , KIM, Min-Ah , KIM, Jeongmin , LEE, Sung-Han , JUNG, Myung Eun , KIM, Mi-Soon
IPC分类号： C07D265/30 , C07D233/54 , A61K51/04 , A61K31/4164
CPC分类号： C07D417/04 , C07D413/04
摘要： A novel sulfur containing heteroaryl-pyrazole compound of formula (I) or a pharmaceutically acceptable salt thereof is effective as a cannabinoid CB1 receptor inverse agonist or antagonist, which is useful for preventing or treating obesity and obesity-related metabolic disorders. The prevention also provide a method for preparing same, a pharmaceutical composition containing same, and a method for preventing or treating obesity and obesity-related metabolic disorders.
摘要翻译：式（I）的新型含硫杂芳基 - 吡唑化合物或其药学上可接受的盐作为大麻素CB1受体反向激动剂或拮抗剂是有效的，其可用于预防或治疗肥胖症和与肥胖相关的代谢紊乱。预防还提供其制备方法，含有该组合物的药物组合物，以及预防或治疗肥胖症和与肥胖有关的代谢紊乱的方法。

89. 发明申请

WO2009088255A2 METHOD FOR PREPARING ANTIGEN EFFECTIVE FOR PREVENTING ANTHRAX INFECTION 审中-公开
标题翻译：用于预防抗原感染的抗生素的方法
公开(公告)号：WO2009088255A2
公开(公告)日：2009-07-16
申请号：PCT/KR2009/000134
申请日：2009-01-09
申请人： KOREA CENTER FOR DISEASE CONTROL AND PREVENTION , GREEN CROSS CORPORATION , OH, Hee-Bok , KIM, Bong-Su , RHIE, Gi-Eun , CHUN, Jeong-Hoon , KIM, Hun , YEO, SinKoo , PARK, MahnHoon , CHANG, Chong-Hwan, Jonathan , AHN, Mi Sun
发明人： OH, Hee-Bok , KIM, Bong-Su , RHIE, Gi-Eun , CHUN, Jeong-Hoon , KIM, Hun , YEO, SinKoo , PARK, MahnHoon , CHANG, Chong-Hwan, Jonathan , AHN, Mi Sun
IPC分类号： A61K39/00
CPC分类号： C07K14/32 , A61K39/00
摘要： The method of the present invention comprising successive column chromatography processes for the purification of an anthrax protective antigen can achieve an improved purity of the anthrax protective antigen product by effectively removing impurities (e.g., cellular residual proteins in the culture solution) without the loss of anthrax protective antigen. Therefore, the method of the present invention can be advantageously used for economically producing the anthrax protective antigen on a large scale.
摘要翻译：包含用于纯化炭疽保护性抗原的连续柱层析方法的本发明的方法可以通过有效地除去杂质（例如培养液中的细胞残留蛋白质）而不损失炭疽来实现改善的炭疽保护性抗原产物的纯度保护性抗原。因此，本发明的方法可有利地用于大规模经济地生产炭疽保护抗原。

90. 发明申请

WO2009078498A1 BIARYLPYRAZOLE 4-CARBOXAMIDES AS CANNABINOID CB1 RECEPTOR LIGANDS 审中-公开
标题翻译：作为CANNABINOID的二亚氨基四羧酸CB1受体配体
公开(公告)号：WO2009078498A1
公开(公告)日：2009-06-25
申请号：PCT/KR2007/006590
申请日：2007-12-17
申请人： GREEN CROSS CORPORATION , LEE, Sung-Han , SEO, Hee Jeong , LEE, Jinhwa , KIM, Min-ah , KIM, Jeong Min , KANG, Suk Youn , AHN, Kwang-Woo , LEE, Suk Ho
发明人： LEE, Sung-Han , SEO, Hee Jeong , LEE, Jinhwa , KIM, Min-ah , KIM, Jeong Min , KANG, Suk Youn , AHN, Kwang-Woo , LEE, Suk Ho
IPC分类号： C07D417/04 , C07D413/04 , C07D419/04 , C07D249/08 , C07D269/02 , C07D285/02 , A61K31/415 , A61K31/4155 , A61P3/04
CPC分类号： C07D413/04 , C07D417/04 , C07D419/04 , C07D471/04 , C07D487/04
摘要： A novel biarylpyrazole 4-carboxamide compound of formula (I) or a pharmaceutically acceptable salt thereof is effective as a cannabinoid CB1 receptor ligand, which is useful for preventing or treating obesity and obesity-related metabolic disorders. The present invention also provide a method for preparing same, a pharmaceutical composition containing same, and a method for preventing or treating obesity and obesity-related metabolic disorders.
摘要翻译：式（I）的新型双芳基吡唑4-甲酰胺化合物或其药学上可接受的盐作为大麻素CB1受体配体是有效的，其可用于预防或治疗肥胖症和与肥胖有关的代谢紊乱。本发明还提供其制备方法，含有该组合物的药物组合物，以及预防或治疗肥胖症和肥胖相关的代谢紊乱的方法。

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