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81. 发明申请

WO2018058124A1 TREPROSTINIL PRODRUGS 审中-公开
公开(公告)号：WO2018058124A1
公开(公告)日：2018-03-29
申请号：PCT/US2017/053503
申请日：2017-09-26
申请人： UNITED THERAPEUTICS CORPORATION
发明人： PHARES, Ken , BATRA, Hitesh , GUO, Liang , SILVERSTEIN, Adam, Marc
IPC分类号： A61K31/216 , A61K31/222 , A61K31/335 , A61P9/12
摘要： Provided are novel prodrugs of treprostinil, as well as methods of making and methods of using these prodrugs.
摘要翻译：提供了曲前列素的新型前体药物，以及使用这些前体药物的制备方法和使用方法。

82. 发明申请

WO2016077420A1 COMPOSITIONS AND METHODS OF TREATMENT WITH PRODRUGS OF TIZOXANIDE, AN ANALOGUE OR SALT THEREOF 审中-公开
标题翻译：组合物和治疗方法与天竺葵素，其类似物或盐的处理
公开(公告)号：WO2016077420A1
公开(公告)日：2016-05-19
申请号：PCT/US2015/060084
申请日：2015-11-11
申请人： ROMARK LABORATORIES, L.C.
发明人： ROSSIGNOL, Jean-Francois , STACHULSKI, Andrew
IPC分类号： A01N43/78
CPC分类号： C07D277/58 , A61K9/20 , A61K9/48 , A61K31/138 , A61K31/426 , A61K31/506 , A61K31/555 , A61K31/704 , A61K31/7068 , A61K45/06 , A61P31/04 , A61P31/12 , A61P35/00 , C07D277/46 , A61K2300/00
摘要： Prodrugs of tizoxanide, an analogue or salt thereof are disclosed. The prodrugs have an ester moiety comprising an amino acid moiety, and increase the bioavailability of the tizoxanide, an analogue or salt thereof. Compositions and methods of treating an intracellular protozoan infection, a viral infection or a cancer are also disclosed.
摘要翻译：公开了替唑尼特的前药，其类似物或盐。前药具有包含氨基酸部分的酯部分，并且提高了他佐尼特，其类似物或盐的生物利用度。还公开了治疗细胞内原生动物感染，病毒感染或癌症的组合物和方法。

83. 发明申请

WO2014143999A1 ANTIBACTERIAL COMPOUNDS 审中-公开
标题翻译：抗菌化合物
公开(公告)号：WO2014143999A1
公开(公告)日：2014-09-18
申请号：PCT/US2014/028220
申请日：2014-03-14
申请人： UNITHER VIROLOGY, LLC , WARFIELD, Kelly
发明人： WARFIELD, Kelly , RAMSTEDT, Urban
IPC分类号： A61K31/445
CPC分类号： A61K31/445 , A01N43/40 , A61K31/655 , Y02A50/473
摘要： Provided are iminosugars having antibacterial properties and methods of treating and/or preventing bacterial infections with such iminosugars. The present disclosure relates to antibacterial compounds and, in particular, to iminosugars having antibacterial activity. One embodiment is a method of treating or preventing a bacterial infection comprising administering to a subject in need thereof an antibacterial effective amount of a compound of the following formula: or a pharmaceutically acceptable salt thereof.
摘要翻译：提供具有抗菌性的亚氨基糖苷和用这种亚氨基二糖治疗和/或预防细菌感染的方法。本公开涉及抗菌化合物，特别是涉及具有抗菌活性的亚氨基糖。一个实施方案是治疗或预防细菌感染的方法，包括向有需要的受试者施用抗菌有效量的下式化合物或其药学上可接受的盐。

84. 发明申请

WO2014022376A2 TREATMENT OF PULMONARY ARTERIAL HYPERTENSION WITH PROSTACYCLIN-TREATED ENDOTHELIAL PROGENITOR CELLS 审中-公开
标题翻译：用前列腺素治疗的内皮祖细胞治疗肺动脉高压
公开(公告)号：WO2014022376A2
公开(公告)日：2014-02-06
申请号：PCT/US2013/052700
申请日：2013-07-30
申请人： UNITED THERAPEUTICS CORPORATION
发明人： JEFFS, Roger , PETERSEN, Thomas , ILAGAN, Roger M. , WADE, Michael
IPC分类号： A61K35/12 , A61K31/557
CPC分类号： A61K35/44 , A61K31/5585 , A61K35/28 , A61K45/06 , C12N5/0692 , C12N2501/999 , F04C2270/041 , A61K2300/00
摘要： The current application is directed to a method for treating pulmonary arterial hypertension (PAH), comprising: providing isolated endothelial progenitor cells (EPCs); treating the EPCs with prostacyclin, wherein the treated EPCs exhibit a hyperproliferative phenotype with enhanced angiogenic property; and administering a composition comprising the treated EPCs into a subject suffering from PAH.
摘要翻译：目前的应用涉及治疗肺动脉高压（PAH）的方法，其包括：提供分离的内皮祖细胞（EPCs）; 用前列环素处理EPCs，其中经处理的EPC表现出具有增强的血管生成特性的过度增殖表型; 以及将包含所述经处理的EPC的组合物施用于患有PAH的受试者。

85. 发明申请

WO2012012166A1 METHODS OF FORMING A METAL CONTACT ON A SILICON SUBSTRATE 审中-公开
标题翻译：在硅基底上形成金属接触的方法
公开(公告)号：WO2012012166A1
公开(公告)日：2012-01-26
申请号：PCT/US2011/042328
申请日：2011-06-29
申请人： INNOVALIGHT, INC , ABBOTT, Malcolm , KRAY, Daniel
发明人： ABBOTT, Malcolm , KRAY, Daniel
IPC分类号： H01L21/00
CPC分类号： H01L31/022425 , Y02E10/50
摘要： The abstract was not in accordance with PCT Rule 8.1(b) because it was more than 150 words in length. The abstract has been established by this Authority to read as follows: Forming a metal contact on a silicon substrate includes depositing a nanoparticle ink on a substrate surface in a pattern, the nanoparticle ink comprising a set of nanoparticles and a set of solvents. The method also includes heating the substrate to a first temperature for a first time period to create a densified nanoparticle layer with a nanoparticle layer thickness of greater than about 50 nm. The method further includes depositing an SiNx layer on the substrate surface, the SiNx layer having a SiNx layer thickness of between about 50 nm and about 110 nm; exposing the substrate to an etchant that is selective to the densified nanoparticle layer for a second time period and at a second temperature to create a via; and forming a metal contact in the via, wherein an ohmic contact is formed with the silicon substrate.
摘要翻译：摘要与PCT规则第8.1（b）条不符，因为它的长度超过150个字。摘要已经由本局建立，以阅读如下：在硅衬底上形成金属接触包括以图案沉积在衬底表面上的纳米颗粒油墨，纳米颗粒油墨包含一组纳米颗粒和一组溶剂。该方法还包括将基底加热到第一温度第一时间以产生具有大于约50nm的纳米颗粒层厚度的致密的纳米颗粒层。该方法还包括在衬底表面上沉积SiNx层，SiNx层的SiNx层厚度在约50nm至约110nm之间; 将所述衬底暴露于对所述致密纳米颗粒层选择性的蚀刻剂，所述蚀刻剂在第二时间段内和在第二温度下产生通孔; 以及在所述通孔中形成金属接触，其中与所述硅衬底形成欧姆接触。

86. 发明申请

WO2012006273A1 COMBINATION THERAPIES WITH COX-2 INHIBITORS AND TREPROSTINIL 审中-公开
标题翻译：与COX-2抑制剂和TREPROSTINIL的组合治疗
公开(公告)号：WO2012006273A1
公开(公告)日：2012-01-12
申请号：PCT/US2011/042938
申请日：2011-07-05
申请人： UNITED THERAPEUTICS CORPORATION , ROTHBLATT, Martine , AUSTER, Martin
发明人： ROTHBLATT, Martine , AUSTER, Martin
IPC分类号： A01N43/08 , A61K31/34
CPC分类号： A61K45/06 , A61K31/196 , A61K31/216 , A61K31/365 , A61K31/415 , A61K31/42 , A61K31/661 , A61K38/05 , A61K38/06 , A61K38/07 , A61K2300/00
摘要： The present invention is directed to compositions and methods for pain management, and for treating inflammation or an inflammation-associated disorder in a subject comprising administering to the subject a therapeutically effective amount of a COX-2 inhibitor and a therapeutically effective amount of a prostacyclin analog, such as treprostinil, a pharmaceutically acceptable salt thereof, or a treprostinil derivative described herein.
摘要翻译：本发明涉及用于疼痛治疗和用于治疗受试者的炎症或炎症相关疾病的组合物和方法，包括向受试者施用治疗有效量的COX-2抑制剂和治疗有效量的前列环素类似物，例如曲前列素，其药学上可接受的盐或曲前列环素衍生物。

87. 发明申请

WO2012003317A1 LEFT ATRIAL APPENDAGE OCCLUSION DEVICE 审中-公开
标题翻译：左侧ATRIAL APPENDAGE OCCLUSION DEVICE
公开(公告)号：WO2012003317A1
公开(公告)日：2012-01-05
申请号：PCT/US2011/042597
申请日：2011-06-30
申请人： JAVOIS, Alex , FREUDENTHAL, Franz
发明人： JAVOIS, Alex , FREUDENTHAL, Franz
IPC分类号： A61F2/01 , A61B17/12
CPC分类号： A61B17/12122 , A61B17/12172 , A61B2017/12054
摘要： A left atrial appendage occlusion device including an occluder disk configured to substantially prevent blood from at least one of entering and exiting the left atrial appendage, a middle portion including a coiled element and a first anchoring element. The coiled element connects to the occluder disk, has a substantially constant cross section and allows for variable length, variable orientation, and/or varied angles. The first anchoring element connects to the coiled element and includes scalloped edges that are configured to anchor the occlusion device to inner walls of the left atrial appendage and reduce the risk of one of penetration and perforation of walls of the left atrial appendage. The left atrial appendage occlusion device may also include a self-centering element that connects to the occluder disk and middle portion and is configured to center the occlusion device within the orifice of the left atrial appendage.
摘要翻译：一种左心耳闭塞装置，包括封堵器盘，其构造成基本上防止来自进入和离开左心耳中的至少一个的血液，包括盘绕元件和第一锚定元件的中间部分。线圈元件连接到封堵器盘，具有基本上恒定的横截面并且允许可变长度，可变取向和/或变化的角度。第一锚固元件连接到线圈元件并且包括扇形边缘，其被构造成将闭塞装置锚定到左心耳的内壁并且降低左心耳壁的穿透和穿孔之一的风险。左心耳闭塞装置还可以包括连接到封堵器盘和中间部分的自定心元件，并且构造成使闭塞装置在左心耳的孔内居中。

88. 发明申请

WO2011146708A2 RETRACTABLE MULTI-USE CARDIAC MONITOR 审中-公开
标题翻译：可回收多用途监护仪
公开(公告)号：WO2011146708A2
公开(公告)日：2011-11-24
申请号：PCT/US2011/037139
申请日：2011-05-19
申请人： MEDICOMP, INC. , BALDA, Daniel
发明人： BALDA, Daniel
IPC分类号： A61B5/0402
CPC分类号： A61B5/0408 , A61B5/0006 , A61B5/0404 , A61B5/04325 , A61B5/044 , A61B5/6823 , A61B5/6826 , A61B2560/045 , A61B2562/221
摘要： A retractable multi-use cardiac monitor is provided that includes a memory, and a first side that includes a first housing where a first sensing connector is on the outside of the first housing, and where the first sensing connector is configured to collect electrocardiogram (ECG) data and store ECG data onto the memory. The retractable multi-use cardiac monitor also includes a second housing including a wire retractor and a second sensing connector, where the second sensing connector is on the outside of the second housing, and the wire retractor is configured to extend and retract a wire that connects the second and first sides, and where the second sensing connector is configured to collect ECG data and store ECG data onto the memory. The retractable multi-use cardiac monitor further includes a wireless radio configured to transmit a portion of collected ECG data from the memory to a destination.
摘要翻译：提供了一种可伸缩的多用途心脏监测器，其包括存储器，以及第一侧面，其包括第一壳体，其中第一感测连接器位于第一壳体的外部，并且其中第一感测连接器被配置为收集心电图（ECG ）数据并将ECG数据存储到存储器上。可伸缩多用心脏监护仪还包括第二壳体，其包括线牵开器和第二感测连接器，其中第二感测连接器位于第二壳体的外侧，线牵引器构造成延伸和缩回连接的线第二和第一侧，并且其中第二感测连接器被配置为收集ECG数据并将ECG数据存储到存储器中。可伸缩多用心脏监护仪还包括被配置为将收集的ECG数据的一部分从存储器传送到目的地的无线电无线电。

89. 发明申请

WO2011115922A1 TREATMENT FOR PULMONARY HYPERTENSION 审中-公开
标题翻译：治疗肺动脉高压
公开(公告)号：WO2011115922A1
公开(公告)日：2011-09-22
申请号：PCT/US2011/028390
申请日：2011-03-14
申请人： UNITED THERAPEUTICS CORPORATION , ROTHBLATT, Martine, A. , RUBIN, Lewis, J.
发明人： ROTHBLATT, Martine, A. , RUBIN, Lewis, J.
IPC分类号： A61K31/513 , A61K31/522 , A61K31/557 , A61K31/5578 , A61K31/5585 , A61P9/08 , A61P9/10
CPC分类号： A61K31/5585 , A61K31/513 , A61K31/522 , A61K31/557 , A61K31/5575 , A61K31/5578 , A61K2300/00
摘要： One embodiment relates to a method of treating pulmonary hypertension based upon co-administering to a subject in need thereof a pharmaceutically effective amount of an oral therapeutic agent for treating pulmonary hypertension and a pharmaceutically effective amount of an inhaled therapeutic agent for treating pulmonary hypertension. The benefit of the co-administration of these agents is to eliminate or reduce one or more side effects associated with mono-therapy of either agent, as well as one or more side effects associated with other administration routes such as subcutaneous or intravenous administration.
摘要翻译：一个实施方案涉及一种治疗肺动脉高压的方法，其基于与有需要的受试者共同施用药物有效量的用于治疗肺动脉高压的口服治疗剂和药学有效量的用于治疗肺动脉高压的吸入治疗剂。这些试剂的共同给药的益处是消除或减少与任一种药物的单一疗法相关的一种或多种副作用，以及与其它给药途径相关的一种或多种副作用，例如皮下或静脉内给药。

90. 发明申请

WO2011066272A1 METHODS OF USING A SET OF SILICON NANOPARTICLE FLUIDS TO CONTROL IN SITU A SET OF DOPANT DIFFUSION PROFILES 审中-公开
标题翻译：使用一套硅纳米颗粒流体控制在一组痰液扩散型材中的方法
公开(公告)号：WO2011066272A1
公开(公告)日：2011-06-03
申请号：PCT/US2010/057782
申请日：2010-11-23
申请人： INNOVALIGHT, INC. , ROGOJINA, Elena , POPLAVSKYY, Dmitry , KELMAN, Maxim , KRAY, Daniel , SCARDERA, Guiseppe , BURROWS, Michael
发明人： ROGOJINA, Elena , POPLAVSKYY, Dmitry , KELMAN, Maxim , KRAY, Daniel , SCARDERA, Guiseppe , BURROWS, Michael
IPC分类号： H01L31/00
CPC分类号： H01L21/2225 , H01L21/223 , H01L21/2257 , H01L31/022425 , H01L31/068 , H01L31/0682 , H01L31/1804 , Y02E10/547 , Y02P70/521
摘要： A method of forming a multi-doped junction is disclosed. The method includes providing a first substrate and a second substrate. The method also includes depositing a first ink on a first surface of each of the first substrate and the second substrate, the first ink comprising a first set of nanoparticles and a first set of solvents, the first set of nanoparticles comprising a first concentration of a first dopant. The method further includes depositing a second ink on a second surface of each of the first substrate and the second substrate, the second ink comprising a second set of nanoparticles and a second set of solvents, the second set of nanoparticles comprising a second concentration of a second dopant.
摘要翻译：公开了形成多掺杂结的方法。该方法包括提供第一基板和第二基板。该方法还包括在第一基底和第二基底中的每一个的第一表面上沉积第一墨水，第一墨水包括第一组纳米颗粒和第一组溶剂，第一组纳米颗粒包含第一浓度的第一掺杂剂。所述方法还包括在所述第一基底和所述第二基底中的每一个的第二表面上沉积第二墨，所述第二墨包含第二组纳米颗粒和第二组溶剂，所述第二组纳米颗粒包含第二浓度的第二掺杂剂。

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