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81. 发明申请

WO2018141922A1 INTRANASAL COMPOSITION COMPRISING BETAHISTINE 审中-公开
公开(公告)号：WO2018141922A1
公开(公告)日：2018-08-09
申请号：PCT/EP2018/052695
申请日：2018-02-02
申请人： OTOLANUM AG
发明人： WRAIGHT, Christopher John , MEYER, Thomas
IPC分类号： A61K31/4402 , A61P27/16 , A61K47/32 , A61K9/08
摘要： The present disclosure relates to a pharmaceutical composition comprising as active substance betahistine or a pharmaceutically acceptable salt thereof, for use in the treatment of otological or neurological disorders in a human subject by intranasal application.

82. 发明申请

WO2018130670A1 METHODS AND KITS FOR TREATING CARDIOVASCULAR DISEASE 审中-公开
公开(公告)号：WO2018130670A1
公开(公告)日：2018-07-19
申请号：PCT/EP2018/050795
申请日：2018-01-12
申请人： CARDIOFORECAST LTD , INTERLEUKIN GENETICS, INC. , KORNMAN, Kenneth , DOUCETTE-STAMM, Lynn , DUFF, Gordon
发明人： KORNMAN, Kenneth , DOUCETTE-STAMM, Lynn , DUFF, Gordon
IPC分类号： C12Q1/6827 , C12Q1/6883
摘要： The present invention relates to methods and kits for treating cardiovascular disease.

83. 发明申请

WO2018033631A1 MORPHIC FORMS OF MARIZOMIB AND USES THEREOF 审中-公开
标题翻译： MARIZOMIB的形态学表现及其用途
公开(公告)号：WO2018033631A1
公开(公告)日：2018-02-22
申请号：PCT/EP2017/070950
申请日：2017-08-18
申请人： CELGENE INTERNATIONAL II SÀRL
发明人： MANSFIELD, Robert
IPC分类号： C07D491/02 , A61K31/407 , A61P35/00
摘要： The present invention relates to polymorphic forms of marizomib (e.g., Morphic Form I). The morphic forms can be used alone and in pharmaceutical compositions for the treatment of disease.
摘要翻译：本发明涉及marizomib的多晶型形式（例如，形态I型）。形态形式可以单独使用，也可以用于治疗疾病的药物组合物。

84. 发明申请

WO2018011128A1 METABOLIC DRUG LOADING OF EVs 审中-公开
标题翻译：电动车的代谢药物加载
公开(公告)号：WO2018011128A1
公开(公告)日：2018-01-18
申请号：PCT/EP2017/067237
申请日：2017-07-10
申请人： EVOX THERAPEUTICS LTD
发明人： WIKLANDER, Oscar
IPC分类号： A61K9/48 , A61K48/00 , A61K35/13 , A61K35/545 , A61K47/66
CPC分类号： A61K47/66 , A61K9/48 , A61K35/12 , A61K35/13 , A61K35/28 , A61K35/545 , A61K47/543 , A61K47/544 , A61K47/6901 , A61K47/6943 , A61K48/00 , A61P35/00
摘要： The present invention relates to methods for metabolically loading extracellular vesicles (EVs) with a pharmacological agent. The methods comprise culturing EV source cells in the presence of a metabolic component comprising a pharmacological agent, which is thereby incorporated into the EV-producing cells and subsequently into the EV. The invention further relates to medical uses and compositions of such EVs.
摘要翻译：本发明涉及用药理学试剂代谢加载胞外囊泡（EV）的方法。该方法包括在存在包含药理学试剂的代谢组分的情况下培养EV源细胞，其因此被并入EV产生细胞并随后进入EV。本发明还涉及这种EV的医疗用途和组合物。

85. 发明申请

WO2017199017A1 IMPROVEMENTS TO OPEN DISPLAY REFRIGERATORS 审中-公开
标题翻译：改进开放式显示器的冰箱
公开(公告)号：WO2017199017A1
公开(公告)日：2017-11-23
申请号：PCT/GB2017/051366
申请日：2017-05-16
申请人： AEROFOIL ENERGY LIMITED
发明人： MCANDREW, Paul
IPC分类号： A47F3/04
摘要： An open display refrigerator (1) comprises a refrigerated interior space (2, 7), air in the refrigerated interior space (2, 7) being separated from air exterior to the open display refrigerator (1) by an air curtain established by a fan which blows air through an air outlet (4, 7) towards a corresponding air inlet (5) which recovers air from the air curtain for recirculation to the air outlet (4, 7). A distal region of the air outlet (4, 7) is occluded to leave only a region of the air outlet (4, 7) proximal to the interior space (2, 7) open, and an air curtain guide is aligned in a direction of air flow of the air curtain with an edge (11) of the blanking plate (15, 8) proximal to the interior space (2, 7). Alternatively, a proximal region of the air outlet (4, 7) is occluded to leave only a region of the air outlet (4, 7) distal from the interior space (2, 7) open, an air curtain guide aligned in a direction of airflow of the air curtain with an edge (11) of the air outlet (4, 7) distal from the interior space (2, 7). In this alternative, a shelf (14, 9) in the refrigerator (1) is disposed such that a gap between an edge (11) of the shelf (14, 9) adjacent the air curtain guide and the air curtain guide is lower than a predetermined threshold.
摘要翻译：（1）包括冷藏内部空间（2,7），冷藏内部空间（2,7）中的空气与打开的显示冰箱（1）外部的空气分离，通过由风扇形成的空气幕将空气通过空气出口（4,7）朝向相应的空气入口（5）吹送，该空气入口（5）从空气幕回收空气以便再循环至空气出口（4,7）。空气出口（4,7）的远端区域被封闭以仅使空气出口（4,7）的靠近内部空间（2,7）的区域打开，并且空气幕引导件沿着一个方向的空气流与靠近内部空间（2,7）的消隐板（15,8）的边缘（11）接触。或者，空气出口（4,7）的近侧区域被封闭以仅留下远离内部空间（2,7）的空气出口（4,7）的一个区域打开，空气幕导向器在一个方向的空气幕的气流与空气出口（4,7）的远离内部空间（2,7）的边缘（11）接触。在该替代方案中，冰箱（1）中的搁架（14,9）布置成使得邻近空气幕导轨的搁架（14,9）的边缘（11）与空气幕导轨之间的间隙低于一个预定的阈值。

86. 发明申请

WO2017129804A1 METHODS AND APPARATUS FOR USING VIDEO ANALYTICS TO DETECT REGIONS FOR PRIVACY PROTECTION WITHIN IMAGES FROM MOVING CAMERAS 审中-公开
标题翻译：使用视频分析来检测移动相机中的图像中的隐私保护区域的方法和设备
公开(公告)号：WO2017129804A1
公开(公告)日：2017-08-03
申请号：PCT/EP2017/051869
申请日：2017-01-27
申请人： KIWISECURITY SOFTWARE GMBH
发明人： MATUSEK, Florian , KRAUS, Klemens , SUTOR, Stephan , ERDELYI, Adam , ZANKL, Georg
IPC分类号： G08B13/196 , G06K9/00 , H04N21/431 , H04N21/44 , G06T7/194
CPC分类号： G06F21/6245 , G06K9/00288 , G06K9/00718 , G06K9/00771 , G06K9/3233 , G06K9/66 , G06T7/194 , G08B13/19686 , H04N21/4318 , H04N21/44008
摘要： In some embodiments, an apparatus includes a memory and a processor. The processor is configured to receive a set of images associated with a video recorded by a moving or a non-moving camera. The processor is configured to detect a structure of a region of interest from a set of regions of interest in an image from the set of images. The processor is configured to classify the structure into a geometric class from a set of predefined geometric classes using machine learning techniques. The processor is configured to alter the region of interest to generate an altered image when the geometric class is associated with an identity of a person, such that privacy associated with the identity of the person is protected. The processor is configured to send the altered image to a user interface or store the altered image in a standardized format.
摘要翻译：在一些实施例中，一种设备包括存储器和处理器。处理器被配置为接收与由移动或非移动照相机记录的视频相关联的一组图像。处理器被配置为从来自该组图像的图像中的一组感兴趣区域检测感兴趣区域的结构。处理器被配置为使用机器学习技术将结构分类为来自一组预定几何类的几何类。处理器被配置成当几何类与人的身份相关联时改变感兴趣区域以产生变更的图像，使得与人的身份相关联的隐私得到保护。处理器被配置为将改变后的图像发送到用户界面或以标准化格式存储改变后的图像。

87. 发明申请

WO2016146594A1 METHODS OF PURIFYING BISPECIFIC ANTIBODIES 审中-公开
标题翻译：净化双歧杆菌抗体的方法
公开(公告)号：WO2016146594A1
公开(公告)日：2016-09-22
申请号：PCT/EP2016/055474
申请日：2016-03-14
申请人： NOVIMMUNE SA
发明人： FOUQUE, Nicolas , DEPOISIER, Jean François , WILSON, Keith , VAJDA, Judith , MÜLLER, Egbert , DABRE, Romain
IPC分类号： C07K16/00 , C07K16/24 , C07K16/46 , C07K16/28
CPC分类号： C07K16/468 , C07K1/16 , C07K1/165 , C07K1/20 , C07K1/22 , C07K1/36 , C07K16/00 , C07K16/248 , C07K16/249 , C07K16/2866 , C07K2317/31 , C07K2317/32 , C07K2317/52
摘要： The invention relates to the purification of bispecific antibodies carrying a different specificity for each binding site of the immunoglobulin molecule from a mixture of monospecific antibodies. The bispecific antibodies are composed of a single heavy chain and two different light chains, one containing a Kappa constant domain and the other a Lambda constant domain. This invention in particular relates to the isolation of these bispecific antibodies from mixtures that contain monospecific antibodies having two Kappa light chains or portions thereof and monospecific antibodies having two Lambda light chains or portions thereof. The invention also provides the methods of efficiently purifying these bispecific antibodies.
摘要翻译：本发明涉及从单特异性抗体的混合物纯化对免疫球蛋白分子的每个结合位点具有不同特异性的双特异性抗体。双特异性抗体由单个重链和两个不同的轻链组成，一个含有κ恒定结构域，另一个是λ恒定结构域。本发明特别涉及从包含具有两个κ轻链或其部分的单特异性抗体和具有两个λ轻链或其部分的单特异性抗体的混合物中分离出这些双特异性抗体。本发明还提供了有效纯化这些双特异性抗体的方法。

88. 发明申请

WO2016059241A3 LUNG CANCER DIAGNOSTICS AND THERAPEUTICS WITH MIR-660 审中-公开
公开(公告)号：WO2016059241A3
公开(公告)日：2016-04-21
申请号：PCT/EP2015/074068
申请日：2015-10-16
申请人： BIOMIRNA HOLDINGS LTD.
发明人： SOZZI, Gabriella , PASTORINO, Ugo , BOERI, Mattia
IPC分类号： A61K31/713 , A61P35/00 , C12N15/113
摘要： Provided are methods of treating lung cancer in a patient in need thereof. The method includes administration to the patient a composition comprising a therapeutically effective amount of a compound that reduces the expression level of E3 ubiquitin-protein ligase MDM2. The compound in certain instances is a miR-660 miRNA, or a functional variant thereof. The patient in need of treatment in certain instances expresses miR-660 in a lung tissue sample or biological fluid sample at a level lower as compared to a control level derived from a subject or plurality of subjects that do not have lung cancer, or as compared to a control level derived from a lung cancer patient or plurality thereof, that have been given a favorable prognosis; expresses MDM2 at a higher level in a lung tissue sample or biological fluid sample as compared to a control level derived from a subject or plurality of subjects that do not have lung cancer, or as compared to a control level derived from a lung cancer patient or plurality thereof that have been given a favorable prognosis; and/or expresses p53 in a lung tissue sample or a biological fluid sample below a control level derived from a lung tumor tissue sample, or plurality thereof, or a biological fluid sample, or plurality thereof, obtained from a patient that has a favorable lung cancer prognosis; or a control level derived from a healthy subject.

89. 发明申请

WO2016038119A1 METHODS FOR LUNG CANCER DETECTION 审中-公开
标题翻译：肺癌检测方法
公开(公告)号：WO2016038119A1
公开(公告)日：2016-03-17
申请号：PCT/EP2015/070664
申请日：2015-09-09
申请人： ISTITUTO EUROPEO DI ONCOLOGIA S.R.L. , FONDAZIONE ISTITUTO FIRC DI ONCOLOGIA MOLECOLARE , UNIVERSITA DEGLI STUDI DI MILANO
发明人： DI FIORE, Pier, Paolo , BIANCHI, Fabrizio , NICASSIO, Francesco , MARZI, Matteo, Jacopo, Luca, Nicolo , MONTANI, Francesca
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2600/158 , C12Q2600/178 , G06F19/16 , G06F19/18
摘要： The disclosure describes a method for diagnosing lung cancer in a subject by detecting in a biological sample obtained from that patient a miRNA signature, the presence of which provides an earlier indication of cancer than alternative art-recognized methods, including, but not limited to, low-dose computed tomography (LDCT).
摘要翻译：本公开描述了通过在从该患者获得的生物样品中检测miRNA标签来诊断受试者中的肺癌的方法，所述miRNA特征的存在提供了比替代的本领域公认的方法更早的癌症指征，包括但不限于，低剂量计算机断层扫描（LDCT）。

90. 发明申请

WO2022243484A1 NANOPARTICLE DELIVERY SYSTEM FOR PRODUCTION OF ENGINEERED EXTRACELLULAR VESICLES 审中-公开
公开(公告)号：WO2022243484A1
公开(公告)日：2022-11-24
申请号：PCT/EP2022/063655
申请日：2022-05-19
申请人： EVOX THERAPEUTICS LIMITED
发明人： GUPTA, Dhanu , EL ANDALOUSSI, Samir
IPC分类号： C07K14/705 , C12N15/88 , A61K48/0025 , C12N15/87
摘要： The present invention relates to engineered extracellular vesicles (EVs) as a therapeutic modality for the treatment of various severe diseases. More specifically, the invention relates to delivery of nucleic acid cargos by a peptide delivery vector which enables a novel approach to manufacturing engineered EVs which extends their half-life and alters their biodistribution, resulting in a novel therapeutic modality able to carry various types of drugs suitable for application in not only genetic diseases but more broadly across essentially all therapeutic areas.

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