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81. 发明申请

WO2006036655A2 USE OF LOW DOSE CHEMICALLY MODIFIED TETRACYCLINES TO REDUCE INFLAMMATORY MEDIATORS 审中-公开
标题翻译：使用低剂量化学修饰的四环素降低炎症介质
公开(公告)号：WO2006036655A2
公开(公告)日：2006-04-06
申请号：PCT/US2005/033630
申请日：2005-09-21
申请人： RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK , GOLUB, Lorne, M. , RYAN, Maria, Emanuel , LEE, Hsi, Ming
发明人： GOLUB, Lorne, M. , RYAN, Maria, Emanuel , LEE, Hsi, Ming
IPC分类号： A61K31/65
CPC分类号： A61K31/65
摘要： The invention is a method for reducing the production of inflammatory mediators, and/or treating conditions characterized by increased levels of inflammatory mediators, in a mammal in need thereof, by administering a 4-dedimethlarninosancycline to the mammal.
摘要翻译：本发明是一种在需要其的哺乳动物中通过给哺乳动物施用4-去二甲基米诺环素系统来减少炎症介质产生和/或治疗以增加的炎症介质水平为特征的病症的方法。

82. 发明申请

WO2004060074A1 CONTROLLED RELEASE ENCAPSULATED BIOACTIVE SUBSTANCES 审中-公开
标题翻译：控释释放生物活性物质
公开(公告)号：WO2004060074A1
公开(公告)日：2004-07-22
申请号：PCT/US2003/039847
申请日：2003-12-15
申请人： BALCHEM CORPORATION
发明人： LEE, Philip, K. , RICHARDSON, Paul, H.
IPC分类号： A23J1/00
CPC分类号： A21D8/042 , A21D8/047 , A23K40/30 , A23L33/14 , A23P10/35 , A23V2002/00 , Y10T428/12493 , Y10T428/125 , Y10T428/2982 , Y10T428/2984 , Y10T428/2989 , A23V2200/224 , A23V2250/192 , A23V2250/218
摘要： The present invention is a nencapsulated yeast composite a core comprising yeast and a coating containing an emulsifiable lipid. The yeast includes Saccharomyces cerevisiae . The invention also relates to other encapsulated bioactive substance composite. The nature of the coating provides controlled release of the bioactive substance from the encapsulate. The encapsulated composites are useful in the production of food composition, food products, and animal feed products.
摘要翻译：本发明是一种包囊酵母复合材料，其包含酵母和含有可乳化脂质的涂层。酵母包括酿酒酵母（Saccharomyces cerevisiae）。本发明还涉及其它包封的生物活性物质复合物。涂层的性质提供生物活性物质从包封物的控制释放。包封的复合材料可用于生产食品组合物，食品和动物饲料产品。

83. 发明申请

WO2004043228A2 METHOD OF TREATING SEPSIS-INDUCED ARDS 审中-公开
标题翻译：治疗感染性ARDS的方法
公开(公告)号：WO2004043228A2
公开(公告)日：2004-05-27
申请号：PCT/US2003/035531
申请日：2003-11-07
申请人： THE RESEARCH FOUDATION OF STATE UNIVERSITY OF NEW YORK
发明人： SIMON, Sanford, R. , GOLUB, Lorne, M. , LEE, Hsi-Ming , NIEMAN, Gary , STEINBERG, Jay , SCHILLER, Henry , HALTER, Jeff , PICONE, Anthony , MARX, William , GATTO, Louis , LUTZ, Charles
IPC分类号： A61B
CPC分类号： A61K31/65
摘要： The invention is method for preventing sepsis-induced ARDS in a mammal in need thereof, the method comprises administering to the mammal a tetracycline compound in an amount that is effective to prevent sepsis-induced ARDS but has substantially no antibiotic activity.
摘要翻译：本发明是用于预防有需要的哺乳动物中败血症诱导的ARDS的方法，所述方法包括以有效预防败血症诱导的ARDS但基本上没有抗生素活性的量向哺乳动物施用四环素化合物。

84. 发明申请

WO2003059088A1 STABLE HYGROSCOPIC COMPOSITIONS AND METHODS FOR STABILIZING HYGROSCOPIC INGREDIENTS 审中-公开
标题翻译：稳定的HYGROSCOPIC组合物和稳定化学成分的方法
公开(公告)号：WO2003059088A1
公开(公告)日：2003-07-24
申请号：PCT/US2003/000322
申请日：2003-01-06
申请人： BALCHEM CORPORATION
发明人： RICHARDSON, Paul, H.
IPC分类号： A23K1/18
CPC分类号： A23K50/10 , A23K40/35 , Y10S426/807
摘要： The present invention provides methods and compositions for providing controlled protection for hygroscopic ingredients that will be exposed to moist or humid environments for significant periods of time by encapsulating the hygroscopic ingredients with a controlled-protection lipid coating. The methods and compositions are particularly useful for stabilizing a hygroscopic bioactive substance, such as choline or lysine hydrochloride, in an animal feed composition and also providing adequate rumen protection in ruminant feeds.
摘要翻译：本发明提供了用于提供受潮保护成分的受控保护的方法和组合物，所述吸湿成分将通过用受控保护的脂质涂层包封吸湿成分而暴露于潮湿或潮湿的环境中相当长的时间。所述方法和组合物特别可用于在动物饲料组合物中稳定吸湿性生物活性物质，例如胆碱或赖氨酸盐酸盐，并且还在反刍动物饲料中提供适当的瘤胃保护。

85. 发明申请

WO2003020202A2 METHOD FOR REDUCING HYPERTENSION AND HEART FAILURE 审中-公开
标题翻译：降低高血压和心力衰竭的方法
公开(公告)号：WO2003020202A2
公开(公告)日：2003-03-13
申请号：PCT/US2002/023444
申请日：2002-07-23
申请人： THE RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK , SIDDIQUI, M., A., Q. , MASCARENO, Eduardo
发明人： SIDDIQUI, M., A., Q. , MASCARENO, Eduardo
IPC分类号： A61K
CPC分类号： A61K31/277 , A61K31/00
摘要： A method is provided for reducing hypertension and/or heart failure in a mammal. Preferably, the method is used to treat or prevent tissue damage to a human heart. The method includes administering an effective amount of a Jak2 inhibitor, preferably a tyrphostin, such as AG490.
摘要翻译：提供了一种用于降低哺乳动物中的高血压和/或心力衰竭的方法。优选地，该方法用于治疗或预防人体心脏的组织损伤。该方法包括施用有效量的Jak2抑制剂，优选tyrphostin，如AG490。

86. 发明申请

WO2003013259A1 CHEMICAL LEAVENING INGREDIENT 审中-公开
标题翻译：化学成分
公开(公告)号：WO2003013259A1
公开(公告)日：2003-02-20
申请号：PCT/US2002/025041
申请日：2002-08-07
申请人： BALCHEM CORPORATION
发明人： PACIFICO, Carl, J.
IPC分类号： A21D13/00
CPC分类号： A21D2/00 , A23P10/35
摘要： An improved leavening agent and method of baking a bread dough with the improved leavening agent provides a bread dough with physical characteristics and by allowing the release of a leavening acid or base at the optimal time during baking.
摘要翻译：用改进的膨松剂烘烤面包生面团的改进的膨松剂和方法提供具有物理特性的面包生面团，并允许在烘烤期间的最佳时间释放发酵酸或碱。

87. 发明申请

WO2002098417A1 NOVEL METALLOPORPHYRINS AND THEIR USES AS RADIOSENSITIZERS FOR RADIATION THERAPY 审中-公开
标题翻译：新型金属酞菁及其作为放射治疗的放射治疗剂
公开(公告)号：WO2002098417A1
公开(公告)日：2002-12-12
申请号：PCT/US2002/017715
申请日：2002-06-05
申请人： BROOKHAVEN SCIENCE ASSOCIATES , MIURA, Michiko , SLATKIN, Daniel, N.
发明人： MIURA, Michiko , SLATKIN, Daniel, N.
IPC分类号： A61K31/409
CPC分类号： A61K51/0485 , A61K31/409 , A61K41/0038 , A61K41/0095 , C07D487/22
摘要： The present invention covers radiosensitizers containing as an active ingredient halogenated derivatives of boronated porphyrins containing multiple carborane cages which selectively accumulate in neoplastic tissue within the irradiation volume and thus can be used in cancer therapies including, but not limited to, boron neutron-capture therapy and photodynamic therapy. The present invention also covers methods for using these radiosensitizers in tumor imaging and cancer treatment.
摘要翻译：本发明涉及含有作为活性成分的硼化卟啉的卤代衍生物的放射增敏剂，其含有多个碳硼烷笼，其选择性地累积在照射体积内的肿瘤组织中，因此可用于癌症治疗，包括但不限于硼中子捕获治疗和光动力疗法。本发明还涉及在肿瘤成像和癌症治疗中使用这些放射增敏剂的方法。

88. 发明申请

WO2002092888A1 APPARATUS AND METHODS FOR ELECTROSPINNING POLYMERIC FIBERS AND MEMBRANES 审中-公开
标题翻译：用于电聚合纤维和膜的装置和方法
公开(公告)号：WO2002092888A1
公开(公告)日：2002-11-21
申请号：PCT/US2002/015507
申请日：2002-05-15
申请人： THE RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK
发明人： CHU, Benjamin , HSIAO, Benjamin, S. , FANG, Dufei
IPC分类号： D01D5/00
CPC分类号： D01D5/0092 , D04H1/728
摘要： An apparatus and methods for electrospinning polymer fibers and membranes include electrospinning a polymer fiber from a conducting fluid containing the polymer in the presence of a first electric field established between a conducting fluid introduction device (5) and a ground source (9) and modifying the first electric field with a second electric field to form a jet stream of the conducting fluid. The apparatus includes a conducting fluid introduction device (5) containing a plurality of spinnerets (6) for delivering a conducting fluid a ground member (9) positioned adjacent the spinnerets (6), a support member (3) disposed between the spinnerets (6) and the ground member (9) and movable to receive fibers formed from the conducting fluid, and a means (2) for controlling the flow characteristics of conducting fluid from at least one spinneret (6) independently from the flow characteristics of conducting fluid from another spinneret (6).
摘要翻译：用于静电纺丝聚合物纤维和膜的装置和方法包括在存在导电流体引入装置（5）和地源（9）之间建立的第一电场的情况下，从含有聚合物的导电流体静电纺丝聚合物纤维，并修饰具有第二电场的第一电场以形成导电流体的喷射流。该装置包括：导电流体引入装置（5），其包含多个用于输送导电流体的喷丝头（6），位于喷丝板（6）附近定位的接地构件（9）;布置在喷丝头（6）之间的支撑构件）和接地构件（9）并且可移动以接收由导电流体形成的纤维，以及用于独立于导电流体的流动特性独立地控制来自至少一个喷丝头（6）的导电流体的流动特性的装置（2）另一个喷丝头（6）。

89. 发明申请

WO2002092339A1 BIODEGRADABLE AND/OR BIOABSORBABLE FIBROUS ARTICLES AND METHODS FOR USING THE ARTICLES FOR MEDICAL APPLICATIONS 审中-公开
标题翻译：可生物降解和/或生物吸收的纤维制品和用于医疗应用的文章的方法
公开(公告)号：WO2002092339A1
公开(公告)日：2002-11-21
申请号：PCT/US2002/015502
申请日：2002-05-15
申请人： THE RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK
发明人： CHU, Benjamin , HSIAO, Benjamin, S. , FANG, Dufei , BRATHWAITE, Collin
IPC分类号： B32B27/04
CPC分类号： B32B27/12 , A61K9/0024 , A61K9/70 , A61L27/18 , A61L27/58 , A61L31/06 , A61L31/148 , B32B27/18 , B32B27/28 , B32B27/36 , B32B2250/20 , B32B2262/0276 , B32B2307/7163 , B32B2535/00 , Y10T442/2525 , Y10T442/614 , Y10T442/619 , Y10T442/696 , C08L67/04
摘要： Biodegradable and/or bioabsorbable fibrous articles and methods for using the articles in medical applications are disclosed. The biodegradable and/or bioabsorbable fibrous articles, which are formed by electrospinning fibers of biodegradable and/or bioabsorbable fiberizable material, comprise a composite (or asymmetric composite) of different biodegradable and/or bioabsorbable fibers. Articles having specific medical uses include an adhesion-reducing barrier and a controlled delivery system. The methods include methods for reducing surgical adhesions, controlled delivery of a medicinal agent and providing controlled tissue healing.
摘要翻译：公开了可生物降解和/或生物可吸收的纤维制品以及在医疗应用中使用制品的方法。由可生物降解和/或生物可吸收的可纤化材料的静电纺丝形成的可生物降解的和/或生物可吸收的纤维制品包括不同的可生物降解的和/或生物可吸收的纤维的复合材料（或不对称的复合材料）。具有特定医疗用途的制品包括减粘屏障和受控递送系统。所述方法包括减少手术粘连，药物的受控输送和提供受控组织愈合的方法。

90. 发明申请

WO2010093561A1 PARTICULATE COMPOSITION AND THE METHOD OF MAKING THE SAME 审中-公开
标题翻译：颗粒组合物及其制备方法
公开(公告)号：WO2010093561A1
公开(公告)日：2010-08-19
申请号：PCT/US2010/023271
申请日：2010-02-05
申请人： YU, Liangping , BAKER, Carl , DESISTO, Doug, Sr. , RICHARDSON, Paul
发明人： YU, Liangping , BAKER, Carl , DESISTO, Doug, Sr. , RICHARDSON, Paul
IPC分类号： A61K9/00
CPC分类号： A61K9/2018 , A61K9/2095
摘要： A particulate material for delivering an active ingredient and a method for making the same is provided. The particulate material can be included in a solid dosage form to provide both high tablet strength and smooth-dissolving mouth-feel. The particulate material includes at least two low moldability sugars, such as, dextrose and sucrose, in an amount of from about 70% to about 100% of the particulate material and is granulated in the presence of a binding agent.
摘要翻译：提供用于递送活性成分的颗粒材料及其制备方法。颗粒材料可以包含在固体剂型中以提供高的片剂强度和平滑溶解的口感。颗粒材料包括至少两种低成型性糖，例如葡萄糖和蔗糖，其量为颗粒材料的约70％至约100％，并在粘合剂存在下造粒。

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