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71. 发明申请

WO0033872A2 METHOD OF AND COMPOSITIONS FOR IMMUNIZATION WITH THE PSEUDOMONAS V ANTIGEN 审中-公开
标题翻译：用于免疫PSEUDOMONAS V抗原的方法和组合物
公开(公告)号：WO0033872A2
公开(公告)日：2000-06-15
申请号：PCT/US9927796
申请日：1999-11-23
申请人： MCW RES FOUND INC
发明人： FRANK DARA W , YAHR TIMOTHY L , SAWA TEIJI , WIENER-KRONISH JEANINE
IPC分类号： C12N15/09 , A61K38/00 , A61K39/00 , A61K39/104 , A61K48/00 , A61P11/00 , A61P31/00 , A61P31/04 , C07K14/21 , C12Q1/68 , G01N33/569
CPC分类号： C12Q1/689 , A61K39/00 , A61K39/104 , A61K2039/505 , C07K14/21 , G01N33/56911 , G01N2333/21 , G01N2469/20
摘要： A method of inhibiting, moderating or diagnosing Psuedomonas aeruginosa infection is disclosed. In one embodiment, this method comprises inoculating a patient with an effective amount of PcrV antigen.
摘要翻译：公开了抑制，调节或诊断铜绿假单胞菌感染的方法。在一个实施方案中，该方法包括用有效量的PcrV抗原接种患者。

72. 发明申请

WO9963093A3 BASB027 PROTEINS AND GENES FROM MORAXELLA CATARRHALIS, ANTIGENS, ANTIBODIES, AND USES 审中-公开
标题翻译：来自MORAXELLA CATARRHALIS，抗原，抗体和用途的BASB027蛋白质和基因
公开(公告)号：WO9963093A3
公开(公告)日：2000-03-02
申请号：PCT/EP9903822
申请日：1999-05-31
申请人： SMITHKLINE BEECHAM BIOLOG , VINALS BASSOLS CARLOTA
发明人： VINALS-BASSOLS CARLOTA
IPC分类号： G01N33/53 , A61K39/00 , A61K39/02 , A61K39/395 , A61K39/40 , A61P31/04 , C07K14/21 , C07K16/12 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/09 , C12N15/31 , C12N15/62 , G01N33/50 , G01N33/569
CPC分类号： C07K14/212 , A61K39/00 , C07K2319/00
摘要： The invention provides BASB027 polypeptides and polynucleotides encoding BASB027 polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are diagnostic, prophylactic and therapeutic uses.
摘要翻译：本发明提供BASB027多肽和编码BASB027多肽的多核苷酸以及通过重组技术产生此类多肽的方法。还提供诊断，预防和治疗用途。

73. 发明申请

WO00004170A1 CLEAVAGE OF CAULOBACTER PRODUCED RECOMBINANT FUSION PROTEINS 审中-公开
标题翻译：生产重组蛋白融合蛋白的CAULOBACTER CLEACVAGE
公开(公告)号：WO00004170A1
公开(公告)日：2000-01-27
申请号：PCT/CA1999/000637
申请日：1999-07-14
IPC分类号： C12N15/09 , C07K14/00 , C07K14/08 , C07K14/195 , C07K14/21 , C07K14/245 , C07K19/00 , C12N15/62 , C12P21/02 , C12N15/74
CPC分类号： C07K14/005 , C07K14/001 , C07K14/21 , C07K14/245 , C07K2319/036 , C12N15/625 , C12N2720/10022
摘要： This invention provides a method for cleaving target proteins from Caulobacter S-layer protein under mild acid conditions. A fusion protein secreted by Caulobacter which includes a target protein and a Caulobacter S-layer secretion signal may be cleaved at an aspartate-proline dipeptide without solubilizing the fusion protein. This method may be carried out while the fusion protein is in an insoluble aggregate which facilitates recovery of the protein. This invention also provides a method of preparing a DNA construct for expression of the fusion protein and a method of preparing the fusion protein.
摘要翻译：本发明提供了一种在温和的酸性条件下切割来自无节细胞S层蛋白的靶蛋白的方法。包含目标蛋白质和<！ - SIPO - > S＆lt; S - 层分泌信号的分泌的融合蛋白可以在天冬氨酸 - 脯氨酸二肽处切割，而不溶解融合蛋白。该方法可以在融合蛋白处于促进蛋白质回收的不溶性聚集体中进行。本发明还提供了制备用于表达融合蛋白的DNA构建体的方法和制备融合蛋白的方法。

74. 发明申请

WO9946278A9 VIRAL VECTOR DIRECTED TO PREDETERMINED TARGET CELLS 审中-公开
标题翻译：病毒载体导向预定目标细胞
公开(公告)号：WO9946278A9
公开(公告)日：1999-11-18
申请号：PCT/US9905388
申请日：1999-03-12
申请人： UNIV WAKE FOREST , PARKS GRIFFITH D
发明人： PARKS GRIFFITH D
IPC分类号： C07K14/21 , C07K16/32 , C12N9/12 , C12N9/24 , C07H21/04 , C12P19/34
CPC分类号： C12N9/1211 , A61K2039/505 , C07K14/21 , C07K16/32 , C07K2317/622 , C07K2319/00 , C07K2319/02 , C12N9/2402 , C12Y302/01018
摘要： Disclosed are compositions comprising viral vectors derived from the paramyxovirus, simian virus 5 (SV5). The SV5 vectors of the present invention, as shown in the figure, are designed so that the HN protein that binds to sialic acid is not expressed, and in certain embodiments a foreign membrane bound protein is expressed on the viral surface that targets the virus to particular cells or tissues. The vector then is able to deliver a toxin or cytotoxic agent to the target cell. Also disclosed are nucleic acid segments useful as viral genomes and methods of producing viral vectors.
摘要翻译：公开了包含源自副粘病毒猿病毒5（SV5）的病毒载体的组合物。如图中所示，设计本发明的SV5载体，使得结合唾液酸的HN蛋白不表达，并且在某些实施方案中，外源膜结合蛋白在靶向病毒的病毒表面上表达特定的细胞或组织。然后载体能够将毒素或细胞毒剂递送至靶细胞。还公开了用作病毒基因组的核酸区段和生产病毒载体的方法。

75. 发明申请

WO99052947A2 TRANSFERRIN RECEPTOR GENES OF MORAXELLA 审中-公开
标题翻译： MORAXELLA的转铁蛋白受体基因
公开(公告)号：WO99052947A2
公开(公告)日：1999-10-21
申请号：PCT/CA1999/000307
申请日：1999-04-12
IPC分类号： C12N15/09 , A61K38/00 , A61K39/00 , A61K39/02 , A61K48/00 , C07K14/21 , C07K14/22 , C07K14/705 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/12 , C12N15/31 , C12P21/02 , C12Q1/68 , C12R1/01 , G01N33/68 , C07K14/79
CPC分类号： C07K14/212 , A61K38/00 , A61K39/00 , A61K48/00 , A61K2039/51
摘要： Purified and isolated nucleic acid molecules are provided which encode Tbp2 proteins of M. catarrhalis strains M35, 3 and LES1. The nucleic acid sequence may be used to produce recombinant Tbp2 proteins of the strain of Moraxella free of other proteins of the Moraxella strain for purposes of diagnostics and medical treatment. Furthermore, the nucleic acid molecules may be used in the diagnosis of infection.
摘要翻译：本发明提供了编码粘膜炎莫拉氏菌菌株M35,3和LES1的Tbp2蛋白的纯化和分离的核酸分子。该核酸序列可以用来生产不含莫拉氏菌菌株的其他蛋白质，并用于诊断和医疗的目的，莫拉氏菌菌株的重组Tbp2蛋白。另外，核酸分子可以用于感染的诊断。

76. 发明申请

WO99051643A1 MUTAGENIZED IL13-BASED CHIMERIC MOLECULES 审中-公开
标题翻译：基于IL13的CHIMERIC分子
公开(公告)号：WO99051643A1
公开(公告)日：1999-10-14
申请号：PCT/US1999/007188
申请日：1999-03-31
IPC分类号： C12N15/09 , A61K38/00 , A61P35/00 , C07K14/21 , C07K14/54 , C07K19/00 , A61K38/20 , C12N15/11 , C12N15/24
CPC分类号： C07K14/21 , A61K38/00 , C07K14/5437 , C07K2319/00
摘要： This invention provides mutagenized interleukin 13 molecules that show improved specificity for the restricted (IL4 independent) IL13 receptor and reduced cross reactivity with the IL4/IL4 shared receptor. The mutagenized IL13 molecules include one or more mutations in a domain that interacts with the 140 kDa hIL4R beta or the hIL13R alpha subunit. These mutagenized IL13 molecules provide effective targeting moieties in chimeric molecules (e.g. fusion proteins) that specifically deliver effector molecules (e.g. cytotoxins) to cells overexpressing IL13 receptors (e.g. cancer cells such as gliomas).
摘要翻译：本发明提供了诱导的白细胞介素13分子，其显示对受限（IL4独立）IL13受体的改善的特异性，并降低与IL4 / IL4共享受体的交叉反应性。诱变的IL13分子包括与140kDahIL4Rβ或hIL13Rα1亚基相互作用的结构域中的一个或多个突变。这些诱变的IL13分子在嵌合分子（例如融合蛋白）中提供有效的靶向部分，其特异性地将效应分子（例如细胞毒素）递送到过表达IL13受体的细胞（例如癌细胞如胶质瘤）。

77. 发明申请

WO99046278A1 VIRAL VECTOR DIRECTED TO PREDETERMINED TARGET CELLS 审中-公开
标题翻译：病毒载体转导到预定的靶细胞
公开(公告)号：WO99046278A1
公开(公告)日：1999-09-16
申请号：PCT/US1999/005388
申请日：1999-03-12
IPC分类号： C07K14/21 , C07K16/32 , C12N9/12 , C12N9/24 , C07H21/04 , C12P19/34
CPC分类号： C12N9/1211 , A61K2039/505 , C07K14/21 , C07K16/32 , C07K2317/622 , C07K2319/00 , C07K2319/02 , C12N9/2402 , C12Y302/01018
摘要： Disclosed are compositions comprising viral vectors derived from the paramyxovirus, simian virus 5 (SV5). The SV5 vectors of the present invention, as shown in the figure, are designed so that the HN protein that binds to sialic acid is not expressed, and in certain embodiments a foreign membrane bound protein is expressed on the viral surface that targets the virus to particular cells or tissues. The vector then is able to deliver a toxin or cytotoxic agent to the target cell. Also disclosed are nucleic acid segments useful as viral genomes and methods of producing viral vectors.
摘要翻译：公开了包含衍生自副粘病毒，猿猴病毒5（SV5））的病毒载体的组合物。如图所示，本发明的SV5载体被设计成使得结合唾液酸的HN蛋白质不被表达，并且在某些实施方案中，在靶向病毒的病毒表面上表达外源膜结合蛋白特定的细胞或组织。然后载体能够将毒素或细胞毒性剂递送至靶细胞。还公开了可用作病毒基因组的核酸区段和产生病毒载体的方法。

78. 发明申请

WO99030735A1 UGC (UPSTREAM GENE OF cdsA) 审中-公开
标题翻译： UGC（CDSA上海基因）
公开(公告)号：WO99030735A1
公开(公告)日：1999-06-24
申请号：PCT/US1998/025806
申请日：1998-12-04
IPC分类号： G01N33/50 , A61K38/00 , A61K39/00 , A61K39/104 , A61K45/00 , A61K48/00 , A61P31/04 , A61P31/12 , C07K14/21 , C07K16/12 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/09 , G01N33/15 , G01N33/53 , G01N33/68 , A61K39/02 , A61K39/108 , A61K39/38 , C07H21/02 , C07H21/04
CPC分类号： C07K14/21 , A61K38/00 , A61K39/00
摘要： The invention provides ugc polypeptides and polynucleotides encoding ugc polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing ugc polypeptides to screen for antibacterial compounds.
摘要翻译：本发明提供了编码ugc多肽的ugc多肽和多核苷酸以及通过重组技术产生此类多肽的方法。还提供了利用ugc多肽筛选抗菌化合物的方法。

79. 发明申请

WO99027129A1 VIRULENCE-ASSOCIATED NUCLEIC ACID SEQUENCES AND USES THEREOF 审中-公开
标题翻译：与荧光相关的核酸序列及其用途
公开(公告)号：WO99027129A1
公开(公告)日：1999-06-03
申请号：PCT/US1998/025247
申请日：1998-11-25
IPC分类号： G01N33/50 , A61K45/00 , A61K49/00 , A61P31/04 , C07K14/21 , C12N1/21 , C12N15/09 , C12P21/02 , C12Q1/02 , C12Q1/68 , C12R1/385 , G01N33/15 , C12Q1/00
CPC分类号： C12Q1/18 , A61K49/0004 , C07K14/21 , G01N33/56911 , G01N2333/21 , G01N2500/10
摘要： Disclosed are bacterial virulence polypeptides and nucleic acid sequences (e.g., DNA) encoding such polypeptides, and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing such polypeptides to screen for antibacterial or bacteriostatic compounds
摘要翻译：公开了细菌毒力多肽和编码此类多肽的核酸序列（例如DNA），以及通过重组技术产生此类多肽的方法。还提供了利用这些多肽筛选抗细菌抑菌剂或抑菌剂的方法

80. 发明申请

WO9907207A9 HYPERSENSITIVE RESPONSE ELICITOR FROM PSEUDOMONAS SYRINGAE AND ITS USE 审中-公开
标题翻译： PSEUDOMONAS SYRINGAE及其使用的超声反应指示
公开(公告)号：WO9907207A9
公开(公告)日：1999-05-06
申请号：PCT/US9815501
申请日：1998-07-24
申请人： CORNELL RES FOUNDATION INC
发明人： COLLMER ALAN , CHARKOWSKI AMY , ALFANO JAMES R
IPC分类号： A01H5/00 , A01N63/00 , A01N63/02 , C07K14/21 , C12N1/21 , C12N5/10 , C12N15/09 , C12N15/82 , C12Q1/18 , C12R1/38 , A01G13/00 , A61K35/66 , C12N1/20 , C12R1/18
CPC分类号： C12N15/8281 , A01N63/00 , A01N63/02 , C07K14/21 , C12N15/8261 , C12N15/8286 , Y02A40/146 , Y02A40/162 , Y10S530/825
摘要： The present invention is directed to an isolated protein or polypeptide which elicits a hypersensitive response in plants as well as an isolated DNA molecule which encodes the hypersensitive response eliciting protein or polypeptide. This isolated protein or polypeptide and the isolated DNA molecule can used to impart disease resistance to plants, to enhance plant growth, and/or to control insects on plants. This can be achieved by applying the hypersensitive response elicitor protein or polypeptide in a non-infectious form to plants or plant seeds under conditions effective to impart disease resistance, to enhance plant growth, and/or to control insects on plants or plants grown from the plant seeds. Alternatively, transgenic plants or plant seeds transformed with a DNA molecule encoding a hypersensitive response elicitor protein or polypeptide can be provided and the transgenic plants or plants resulting from the transgenic plant seeds are grown under conditions effective to impart disease resistance, to enhance plant growth, and/or to control insects on plants or plants grown from the plant seeds.
摘要翻译：本发明涉及在植物中引起过敏反应的分离的蛋白质或多肽，以及编码引发蛋白质或多肽的过敏反应的分离的DNA分子。这种分离的蛋白质或多肽和分离的DNA分子可用于赋予植物抗病性，增强植物生长和/或控制植物上的昆虫。这可以通过在有效赋予抗病性，增强植物生长和/或控制昆虫从植物或植物生长的植物或植物上控制昆虫的条件下将植物或植物种子以非传染性形式应用于过敏反应诱发剂蛋白质或多肽植物种子或者，可以提供用编码过敏反应诱发剂蛋白或多肽的DNA分子转化的转基因植物或植物种子，并且将转基因植物种子产生的转基因植物或植物在有效赋予抗病性，增强植物生长，和/或控制来自植物种子生长的植物或植物上的昆虫。

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