专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

71. 发明申请

WO03009779A3 DELIVERY OF THERAPEUTIC CAPABLE AGENTS 审中-公开
标题翻译：交付治疗药物
公开(公告)号：WO03009779A3
公开(公告)日：2003-10-02
申请号：PCT/US0223922
申请日：2002-07-25
申请人： AVANTEC VASCULAR CORP , SIRHAN MOTASIM , YAN JOHN
发明人： SIRHAN MOTASIM , YAN JOHN
IPC分类号： A61L27/00 , A61F2/00 , A61F2/06 , A61F2/84 , A61F2/90 , A61K31/17 , A61K31/185 , A61K31/192 , A61K31/277 , A61K31/352 , A61K31/365 , A61K31/366 , A61K31/401 , A61K31/404 , A61K31/4353 , A61K31/436 , A61K31/4375 , A61K31/4422 , A61K31/45 , A61K31/453 , A61K31/4545 , A61K31/4709 , A61K31/472 , A61K31/519 , A61K31/52 , A61K31/551 , A61K31/554 , A61K31/565 , A61K31/573 , A61K31/675 , A61K31/7056 , A61K31/7068 , A61K38/00 , A61K39/395 , A61K45/00 , A61L31/00 , A61L31/16 , A61P3/14 , A61P7/02 , A61P7/04 , A61P9/08 , A61P9/10 , A61P29/00 , A61P31/12 , A61P35/00 , A61P37/04 , A61P37/06 , A61P43/00
CPC分类号： A61F2/91 , A61F2/915 , A61F2002/91533 , A61F2002/91558 , A61F2002/91583 , A61F2230/0054 , A61F2250/0067 , A61F2250/0068 , A61L31/16 , A61L2300/416
摘要： The present invention provides improved stents and other prostheses for delivering substances to vascular and other luminal and intracorporeal environments. In particular, the present invention provides for therapeutic capable agent eluting stents (10) with minimized undesirable loss of the therapeutic capable agent during expansion of the stent.
摘要翻译：本发明提供了用于将物质递送到血管和其他腔内和体内环境的改进的支架和其他假体。特别地，本发明提供了治疗能力洗脱支架（10），其在支架扩张期间具有治疗能力的试剂的最小化不期望的损失。

72. 发明申请

WO02066035A3 AZOLES AS MALONYL-COA DECARBOXYLASE INHIBITORS USEFUL AS METABOLIC MODULATORS 审中-公开
标题翻译： AZOLES作为可用作代谢调节剂的丙二酰-CoA脱羧酶抑制剂
公开(公告)号：WO02066035A3
公开(公告)日：2002-10-24
申请号：PCT/US0204777
申请日：2002-02-19
申请人： CHUGAI PHARMACEUTICAL CO LTD , ARRHENIUS THOMAS , CHENG JIE FEI , WILSON MARK , SERAFIMOV ROSSY
发明人： ARRHENIUS THOMAS , CHENG JIE FEI , WILSON MARK , SERAFIMOV ROSSY
IPC分类号： C07D277/72 , A61K31/423 , A61K31/425 , A61K31/426 , A61K31/427 , A61K31/428 , A61K31/4353 , A61K31/4439 , A61K31/454 , A61K31/496 , A61K31/519 , A61K31/5377 , A61K31/541 , A61P3/00 , A61P3/04 , A61P3/06 , A61P3/08 , A61P3/10 , A61P7/00 , A61P9/00 , A61P9/04 , A61P9/10 , A61P35/00 , A61P43/00 , C07D277/20 , C07D277/36 , C07D277/56 , C07D277/70 , C07D277/82 , C07D409/12 , C07D417/12 , C07D513/04
CPC分类号： A61K31/423 , A61K31/425 , A61K31/426 , A61K31/428 , A61K31/454 , A61K31/496 , A61K31/5377 , A61K31/541
摘要： The present invention relates to methods of treatment of certain metabolic diseases, and to novel compounds and their prodrugs, and/or pharmaceutically acceptable salts, pharmaceutical compositions containing such compounds useful in treating such diseases. In particular, this invention relates to the use of novel compounds and compositions for treatment of cardiovascular diseases, diabetes, cancers, acidosis, and obesity through the inhibition of malonyl-CoA decarboxylase (MCD). These compounds have the formulae (I) and (II), wherein Y, C, R1, R2, R6, and R7 are defined herein.
摘要翻译：本发明涉及治疗某些代谢疾病的方法，涉及新化合物及其前药和/或药学上可接受的盐，含有可用于治疗这些疾病的化合物的药物组合物。具体而言，本发明涉及通过抑制丙二酰辅酶A脱羧酶（MCD）来治疗心血管疾病，糖尿病，癌症，酸中毒和肥胖症的新型化合物和组合物的用途。这些化合物具有式（I）和（II），其中Y，C，R 1，R 2，R 6和R 7如本文所定义。

73. 发明申请

WO02055017A2 METHOD OF TREATING AUTOIMMUNE DISEASES 审中-公开
标题翻译：治疗自身免疫性疾病的方法
公开(公告)号：WO02055017A2
公开(公告)日：2002-07-18
申请号：PCT/US2001/043871
申请日：2001-11-19
IPC分类号： A61K31/00 , A61K31/16 , A61K31/165 , A61K31/166 , A61K31/167 , A61K31/17 , A61K31/18 , A61K31/19 , A61K31/192 , A61K31/22 , A61K31/222 , A61K31/336 , A61K31/407 , A61K31/4353 , A61K31/4406 , A61K31/473 , A61K31/70 , A61P17/14 , C12Q1/44 , A61K
CPC分类号： A61K31/70 , A61K31/00 , A61K31/16 , A61K31/165 , A61K31/166 , A61K31/167 , A61K31/17 , A61K31/18 , A61K31/19 , A61K31/192 , A61K31/22 , A61K31/222 , A61K31/336 , A61K31/407 , A61K31/4353 , A61K31/4406 , A61K31/473 , C12Q1/44 , G01N2500/04
摘要： A method of treating an autoimmune disease (for example, Systemic Lupus Erythematosus) comprises administering to the subject a treatment effective amount of a histone hyperacetylating agent, or a pharmaceutically acceptable salt thereof. Methods of screening compounds useful for the treatment of autoimmune disease are also disclosed.
摘要翻译：治疗自身免疫性疾病（例如，系统性红斑狼疮）的方法包括向受试者施用有效量的组蛋白超乙酰化剂或其药学上可接受的盐。还公开了可用于治疗自身免疫疾病的化合物的筛选方法。

74. 发明申请

WO0160345A3 PHARMACEUTICAL COMPOSITION COMPRISING SQUALENE EPOXIDASE INHIBITOR AND MACROLIDE IMMUNOMODULATOR 审中-公开
标题翻译：包含平均环氧化物酶抑制剂和大鼠免疫调节剂的药物组合物
公开(公告)号：WO0160345A3
公开(公告)日：2002-04-18
申请号：PCT/EP0101744
申请日：2001-02-16
申请人： NOVARTIS AG , NOVARTIS ERFIND VERWALT GMBH , RYDER NEIL STEWART , MAYER FRIEDRICH KARL
发明人： RYDER NEIL STEWART , MAYER FRIEDRICH KARL
IPC分类号： A61K45/06 , A61K31/137 , A61K31/35 , A61K31/4353 , A61P31/10 , A61P37/02 , A61P43/00
CPC分类号： A61K31/35 , A61K31/135 , A61K2300/00
摘要： Synergistic combinations of a squalene epoxidase inhibitor such as terbinafine and a macrolide T-cell immunomodulator or immunosuppressant such as 33-epichloro,33-desoxyascomycin are provided, which are useful in particular in the treatment of diseases involving fungal or suspected fungal infection, for immunomodulation or immunosuppression in conditions in which fungal or suspected fungal colonisation of e.g. the skin plays a role, such as atopic dermatitis and seborrhoeic dermatitis, and in situations of fungal resistance.
摘要翻译：提供角鲨烯环氧酶抑制剂如特比萘芬和大环内酯类T细胞免疫调节剂或免疫抑制剂如33-表氯-3-脱氧霉菌素的协同组合，其特别用于治疗涉及真菌或疑似真菌感染的疾病，用于免疫调节或在真菌或疑似真菌定殖的条件下的免疫抑制皮肤发挥作用，如特应性皮炎和脂溢性皮炎，以及真菌感染的情况。

75. 发明申请

WO0228866A2 HYDROXYESTERS OF 7-DESMETHYLRAPAMYCIN 审中-公开
标题翻译： 7-脱乙酰壳多糖的羟基转移酶
公开(公告)号：WO0228866A2
公开(公告)日：2002-04-11
申请号：PCT/US0130592
申请日：2001-09-28
申请人： AMERICAN HOME PROD
发明人： ZHU TIANMIN , ENEVER ROBIN
IPC分类号： C07D493/18 , A61K31/453 , A61P3/10 , A61P9/00 , A61P9/10 , A61P11/00 , A61P11/06 , A61P17/00 , A61P17/02 , A61P17/04 , A61P17/06 , A61P17/08 , A61P19/02 , A61P21/04 , A61P25/28 , A61P27/02 , A61P29/00 , A61P31/10 , A61P31/14 , A61P35/00 , A61P35/02 , A61P37/06 , C07D498/18 , A61K31/4353
CPC分类号： C07D498/18
摘要： This invention provides hydroxyesters of 7-desmethylrapamycin which are useful in inducing immunosuppression and in the treatment of transplantation rejection, autoimmune diseases, solid tumors, fungal infections, and vascular disease.
摘要翻译：本发明提供7-脱甲基雷帕霉素的羟基酯，其可用于诱导免疫抑制和用于治疗移植排斥反应，自身免疫性疾病，实体瘤，真菌感染和血管疾病。

76. 发明申请

WO02017891A2 METHOD FOR DIAGNOSING NEURONAL DISEASES AND FOR TREATING PRIMARY HEMOSTASIS DEFICIENCY 审中-公开
标题翻译：神经疾病的诊断和治疗缺血性原始血液系统的方法
公开(公告)号：WO02017891A2
公开(公告)日：2002-03-07
申请号：PCT/DE2001/003178
申请日：2001-08-27
IPC分类号： A61K45/00 , A61K31/00 , A61K31/198 , A61K31/4045 , A61K31/405 , A61K31/4353 , A61K31/436 , A61K31/7105 , A61K38/13 , A61K45/06 , A61K48/00 , A61K49/00 , A61P3/10 , A61P7/02 , A61P7/04 , A61P9/10 , A61P37/00 , A61P37/02 , A61P37/08 , A61P43/00
CPC分类号： A61K49/0004 , A61K31/00 , A61K31/4353 , A61K31/436 , A61K38/13 , A61K45/06 , A61K2300/00
摘要： The invention relates to a method for diagnosing neuronal diseases and for treating primary hemostasis deficiency. The invention further relates to a method for suppressing the immune system, which is inter alia significant for transplantation medicine and for the treatment of allergies. The invention is used in the field of medicine and in the pharmaceutical industry. The invention is worked according to the claims. The invention is based on the discovery that serotonin is synthesized by TPH isoenzymes that are differently expressed in the neurons in the peripheral tissues. Gene targeting was used to show that an isoform, the peripheral enzyme (referred to in the following as TPH), is responsible for maintaining primary hemostasis and T-cell mediated immune responses. Another isoform, the newly identified neuron-specific TPH (referred to as nTPH) synthesizes serotonin irrespective thereof in the central nervous system. The invention further relates to the newly identified neuronal tryptophane hydroxylase (nTPH) that differs from the TPH known so far in the regulatory domain.
摘要翻译：本发明涉及用于诊断神经元疾病和用于治疗缺陷性原发止血的方法。此外，本发明涉及抑制免疫系统的方法，即i.a. 对移植医学和治疗过敏非常重要。本发明的应用领域是医药和制药工业。本发明是根据Asnprüchen实现的。本发明基于体内血清素由神经元和外周组织中不同表达的TPH同工酶合成的实质性发现。已经通过基因靶向显示，外周酶（仍称为TPH）的同种型负责维持原发性止血和T细胞介导的免疫应答。另一种亚型，即新鉴定的神经元特异性TPH（称为nTPH），在CNS中独立合成5-羟色胺。本发明还涉及新发现的神经元色氨酸羟化酶（nTPH），其与调节域中迄今已知的TPH不同。

77. 发明申请

WO01058869A2 CANNABINOID RECEPTOR MODULATORS, THEIR PROCESSES OF PREPARATION, AND USE OF CANNABINOID RECEPTOR MODULATORS FOR TREATING RESPIRATORY AND NON-RESPIRATORY DISEASES 审中-公开
标题翻译： CANNABINOID受体调节剂，其制备方法和用于治疗呼吸道和非呼吸系统疾病的CANNABINOID受体调节剂的使用
公开(公告)号：WO01058869A2
公开(公告)日：2001-08-16
申请号：PCT/US2001/004131
申请日：2001-02-08
IPC分类号： A61K31/40 , A61K31/404 , A61K31/41 , A61K31/415 , A61K31/4184 , A61K31/421 , A61K31/422 , A61K31/4245 , A61K31/427 , A61K31/428 , A61K31/433 , A61K31/4353 , A61K31/438 , A61K31/44 , A61K31/4439 , A61K31/454 , A61K31/496 , A61K31/506 , A61K31/5377 , A61K31/5383 , A61K31/551 , A61K45/00 , A61P11/00 , A61P11/06 , C07D207/337 , C07D207/40 , C07D207/416 , C07D209/08 , C07D209/42 , C07D231/14 , C07D231/56 , C07D233/90 , C07D257/04 , C07D263/32 , C07D271/06 , C07D401/06 , C07D401/12 , C07D403/06 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/12 , C07D453/02 , C07D471/04 , C07D471/08 , C07D471/10 , C07D498/04 , C07D498/06 , C07D207/34 , C07D401/14 , C07D407/12
CPC分类号： C07D207/416 , A61K31/40 , A61K31/415 , A61K31/44 , C07D209/42 , C07D231/14 , C07D231/56 , C07D233/90 , C07D257/04 , C07D263/32 , C07D271/06 , C07D401/06 , C07D401/12 , C07D403/06 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/12 , C07D471/04 , C07D471/08
摘要： Use of a compound for treating a respiratory disease in a mammal wherein the compound is a cannabinoid receptor modulator is disclosed. Compounds useful as cannabinoid receptor modulators for treating respiratory and non-respiratory leukocyte-activation associated diseases comprise compounds of formula (I), in which A and B are nitrogen or carbon, provided only one of A and B is nitrogen; and R1-R6 are as defined in the specification, wherein R2 with R5 may form a ring, and/or two R4 groups may form a six-membered aryl or heteroaryl ring, optionally having a substituent R6 forming a ring with R3.
摘要翻译：公开了在化合物是大麻素受体调节剂的哺乳动物中用于治疗呼吸系统疾病的化合物的用途。用作治疗呼吸道和非呼吸性白细胞活化相关疾病的大麻素受体调节剂的化合物包括式（I）化合物，其中A和B为氮或碳，只提供A和B之一为氮; 和R 1 -R 6如说明书中所定义，其中R 2与R 5可以形成环，和/或两个R 4基团可以形成六元芳基或杂芳基环，任选地具有与R 3形成环的取代基R 6。

78. 发明申请

WO01029050A2 NEURAMINIDASE INHIBITORS 审中-公开
标题翻译：神经酰胺糖苷酶抑制剂
公开(公告)号：WO01029050A2
公开(公告)日：2001-04-26
申请号：PCT/US2000/026071
申请日：2000-09-22
IPC分类号： A61P31/00 , C07D471/04 , C07D487/04 , C07D498/04 , A61K31/4353 , A61K31/5383
CPC分类号： C07D471/04 , C07D487/04
摘要： The instant invention provides compounds of formula (I) or a pharmaceutically acceptable salt, prodrug, or ester thereof, useful in the inhibition of neuraminidase enzymes from disease-causing microorganisms, especially influenza neuraminidase, pharmaceutical formulations containing same, processes and intermediates for preparing said compounds, as well as methods of using said compounds, including preventing and treating diseases caused by microorganisms having said neuraminidase enzyme.
摘要翻译：本发明提供式（I）化合物或其药学上可接受的盐，前药或酯，其可用于抑制致病微生物，特别是流感神经氨酸酶的神经氨酸酶，含有其的药物制剂，用于制备所述的化合物，以及使用所述化合物的方法，包括预防和治疗由具有所述神经氨酸酶的微生物引起的疾病。

79. 发明申请

WO01019828A2 KINASE INHIBITORS AS THERAPEUTIC AGENTS 审中-公开
标题翻译：激酶抑制剂作为治疗剂
公开(公告)号：WO01019828A2
公开(公告)日：2001-03-22
申请号：PCT/US2000/025357
申请日：2000-09-15
IPC分类号： A61K31/437 , A61K31/5025 , A61K31/519 , A61K31/55 , A61K38/00 , A61P1/18 , A61P3/10 , A61P7/06 , A61P9/00 , A61P9/10 , A61P15/00 , A61P17/02 , A61P17/06 , A61P19/02 , A61P27/02 , A61P29/00 , A61P31/12 , A61P31/18 , A61P33/02 , A61P35/00 , A61P35/02 , A61P37/02 , C07D471/04 , C07D487/04 , C07F9/6561 , A61K31/4353 , A61K31/551 , C07D491/04 , C07D498/04
CPC分类号： C07D471/04 , C07D487/04 , C07F9/6561
摘要： The present invention is directed to a compound of Formula (I) as defined herein which are useful as kinase inhibitors.
摘要翻译：本发明涉及用作激酶抑制剂的对应于本发明定义的式（I）的化合物。

80. 发明申请

WO0038786A3 USE OF CYCLOOXYGENASE 2 INHIBITOR AND AN INTEGRIN ANTAGONIST AS A COMBINATION THERAPY IN THE TREATMENT OF NEOPLASIA 审中-公开
标题翻译： CYCLOOXYGENASE 2抑制剂和INTEGRIN ANTAGONIST作为治疗NEOPLASIA的组合治疗方法的应用
公开(公告)号：WO0038786A3
公开(公告)日：2001-03-08
申请号：PCT/US9930692
申请日：1999-12-22
申请人： SEARLE & CO , MCKEARN JOHN P , GORDON GARY , CUNNINGHAM JAMES J , GATELY STEPHEN T , KOKI ALANE T , MASFERRER JAIME L
发明人： MCKEARN JOHN P , GORDON GARY , CUNNINGHAM JAMES J , GATELY STEPHEN T , KOKI ALANE T , MASFERRER JAIME L
IPC分类号： A61K45/00 , A61K31/00 , A61K31/07 , A61K31/122 , A61K31/135 , A61K31/136 , A61K31/138 , A61K31/16 , A61K31/165 , A61K31/166 , A61K31/18 , A61K31/191 , A61K31/192 , A61K31/197 , A61K31/198 , A61K31/203 , A61K31/255 , A61K31/28 , A61K31/282 , A61K31/337 , A61K31/341 , A61K31/351 , A61K31/353 , A61K31/36 , A61K31/381 , A61K31/402 , A61K31/415 , A61K31/4162 , A61K31/4164 , A61K31/4168 , A61K31/4178 , A61K31/4184 , A61K31/4188 , A61K31/4196 , A61K31/42 , A61K31/421 , A61K31/422 , A61K31/425 , A61K31/427 , A61K31/429 , A61K31/435 , A61K31/4353 , A61K31/437 , A61K31/4375 , A61K31/44 , A61K31/4402 , A61K31/4418 , A61K31/4427 , A61K31/4433 , A61K31/4439 , A61K31/444 , A61K31/445 , A61K31/4453 , A61K31/45 , A61K31/451 , A61K31/4535 , A61K31/4545 , A61K31/4709 , A61K31/4741 , A61K31/4745 , A61K31/475 , A61K31/496 , A61K31/501 , A61K31/505 , A61K31/506 , A61K31/51 , A61K31/519 , A61K31/525 , A61K31/541 , A61K31/55 , A61K31/5513 , A61K31/566 , A61K31/567 , A61K31/569 , A61K31/57 , A61K31/575 , A61K31/66 , A61K31/664 , A61K31/675 , A61K31/704 , A61K31/7048 , A61K31/7068 , A61K33/04 , A61K33/10 , A61K33/24 , A61K38/00 , A61K39/395 , A61K41/00 , A61K45/06 , A61P1/00 , A61P11/00 , A61P13/10 , A61P15/00 , A61P15/14 , A61P17/00 , A61P35/00 , A61P41/00 , A61P43/00 , C07D211/54 , C07D211/66 , C07D211/96 , C07D213/74 , C07D261/18 , C07D309/08 , C07D401/06 , C07D401/12 , C07D403/12 , C07D405/12 , C07D413/12 , C07D417/12 , C07D471/04 , C07K5/023 , C07K5/062 , C07K16/18
CPC分类号： A61K33/24 , A61K31/00 , A61K31/135 , A61K31/335 , A61K31/415 , A61K31/42 , A61K31/445 , A61K31/47 , A61K31/505 , A61K31/506 , A61K31/675 , A61K41/00 , A61K41/0038 , A61K45/06 , A61K2300/00
摘要： The present invention provides methods to treat or prevent neoplasia disorders in a mammal using a combination of a cyclooxygenase-2 inhibitor, an integrin antagonist and an antineoplastic agent.
摘要翻译：本发明提供了使用环氧合酶-2抑制剂，整联蛋白拮抗剂和抗肿瘤剂的组合来治疗或预防哺乳动物中的肿瘤形成障碍的方法。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式