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71. 发明申请

WO2016102227A1 METHOD AND SYSTEM FOR DETERMINING A BLOOD GLUCOSE LEVEL FOR A PATIENT 审中-公开
标题翻译：用于确定患者血液葡萄糖水平的方法和系统
公开(公告)号：WO2016102227A1
公开(公告)日：2016-06-30
申请号：PCT/EP2015/079628
申请日：2015-12-14
申请人： ROCHE DIABETES CARE GMBH , F. HOFFMANN-LA ROCHE AG , ROCHE DIABETES CARE, INC.
发明人： SCHMELZEISEN-REDEKER, Guenther , SCHMITT, Nikolaus , RINGEMANN, Christian
IPC分类号： A61B5/1486 , A61B5/1495 , G06F19/00
CPC分类号： A61B5/14532 , A61B5/002 , A61B5/1451 , A61B5/1473 , A61B5/1495 , A61B5/4839 , A61B5/6801 , A61B5/7221 , A61B5/742 , A61M5/14244 , A61M5/1723 , G06F19/00 , G16H40/63 , G16H50/50
摘要： The present disclosure refers to a method for determining a blood glucose level for a patient, the method comprising, in a system for determining the blood glucose level for the patient, detecting a present sensor signal in a present continuous interstitial blood glucose measurement for a patient; providing measurement data representing the present sensor signal; providing sensor signal correction data representing, for the patient, a patient-specific signal correction, the sensor signal correction data being determined from a former interstitial blood glucose measurement for the patient and comprising at least one of time delay data representing, for the patient, a patient- specific time delay At between a blood glucose value measured in a continuous interstitial blood glucose measurement and a blood glucose reference value measured in a capillary blood glucose measurement, the blood glucose value and the blood glucose reference value referring to the same blood glucose level, sensor offset data representing, for the patient, a patientspecific sensor signal offset for the sensor, and sensor sensitivity data representing, for the patient, a patient- specific sensor sensitivity for the sensor, determining corrected measurement data representing a corrected present sensor signal by applying the sensor signal correction data to the present sensor signal; and determining a blood glucose level for the patient from the corrected measurement data. Furthermore, a system for determining a blood glucose level for a patientis provided.
摘要翻译：本公开涉及一种用于确定患者的血糖水平的方法，所述方法包括在用于确定患者的血糖水平的系统中，检测患者的当前连续间质血糖测量中的当前传感器信号 ; 提供表示当前传感器信号的测量数据; 提供传感器信号校正数据，所述传感器信号校正数据表示对于患者特定于患者的信号校正，所述传感器信号校正数据由用于患者的先前的间质血糖测量确定，并且包括代表患者的时间延迟数据中的至少一个，在连续间质血糖测量中测量的血糖值与在毛细血管血糖测量中测量的血糖参考值之间的患者特异性时间延迟At，参考相同血糖的血糖值和血糖参考值代表针对患者的用于传感器的病人特异性传感器信号偏移的传感器偏移数据，以及针对患者代表传感器的患者特异性传感器灵敏度的传感器灵敏度数据，确定表示校正的当前传感器信号的校正测量数据通过将传感器信号校正数据应用于本传感器信号; 以及从校正的测量数据确定患者的血糖水平。此外，提供了一种用于确定患者的血糖水平的系统。

72. 发明申请

WO2016094433A1 TECHNIQUES FOR POWER SOURCE MANAGEMENT USING A WRIST-WORN DEVICE 审中-公开
标题翻译：使用手写式设备进行电源管理的技术
公开(公告)号：WO2016094433A1
公开(公告)日：2016-06-16
申请号：PCT/US2015/064542
申请日：2015-12-08
申请人： ZHANG, Jack Ke
发明人： ZHANG, Jack Ke
IPC分类号： G06F1/32 , G06F1/26 , A61B5/00 , G06Q50/22
CPC分类号： G06F1/163 , A61B5/0022 , A61B5/02055 , A61B5/02438 , A61B5/14532 , A61B5/486 , A61B5/681 , A61B2560/0209 , A61B2560/0214 , G06F19/00 , G06F19/3418 , G06F19/3456 , G06F19/3481 , G16H40/63 , H02J5/005 , H02J7/0042 , H02J7/0047 , H02J7/025
摘要： A method, apparatus, and/or system for patient wellness monitoring using a wrist-worn device is disclosed. The wrist-worn device may include a faceplate device and a wristband monitoring device. Initially, a sensor of the wrist-worn device may be activated to collect sensor data of a user according to a first regimen. It may be determined that a battery level associated with the wrist-worn may is below a pre-determined threshold. As a result of the batter level, the wrist-worn device may be caused to store a portion of the sensor data in memory. The first regimen may be modified to generate a second regimen. Sensor activation may continue according to the second regimen.
摘要翻译：公开了一种使用腕部佩戴的装置进行患者健康监测的方法，装置和/或系统。腕部佩戴装置可以包括面板装置和腕带监视装置。最初，可以激活腕部佩戴装置的传感器，以根据第一方案收集用户的传感器数据。可以确定与手腕佩戴的相关联的电池电量可能低于预定阈值。作为电平水平的结果，可以使腕部佩戴的装置将传感器数据的一部分存储在存储器中。可以修改第一种方案以产生第二种方案。根据第二种方案，传感器激活可以继续。

73. 发明申请

WO2016085556A1 COATED IMPLANTS, AND CORRESPONDING SYSTEMS AND METHODS 审中-公开
标题翻译：涂层植入物和相应的系统和方法
公开(公告)号：WO2016085556A1
公开(公告)日：2016-06-02
申请号：PCT/US2015/049718
申请日：2015-09-11
申请人： CELL AND MOLECULAR TISSUE ENGINEERING, LLC
发明人： KLUEH, Ulrike, W. , KREUTZER, Donald, L.
IPC分类号： A61B5/145 , A61F2/02 , A61L27/40
CPC分类号： A61F2/0063 , A61B5/14503 , A61B5/14532 , A61B5/686 , Y10T29/49888
摘要： Disclosed herein are medical products with a layer of dehydrated modified basement membrane preparation formed thereon. The basement membrane has been modified before dehydration of remove low molecular weight components. In some embodiments, the basement membrane is crosslinked. Methods of making and using the products also are disclosed.
摘要翻译：本文公开了具有在其上形成的脱水改性基底膜制剂层的医疗产品。在脱水除去低分子量组分之前，基底膜已被修饰。在一些实施方案中，基底膜是交联的。公开了制造和使用产品的方法。

74. 发明申请

WO2016084712A1 計測装置审中-公开
标题翻译：测量装置
公开(公告)号：WO2016084712A1
公开(公告)日：2016-06-02
申请号：PCT/JP2015/082593
申请日：2015-11-19
申请人：富士ゼロックス株式会社
发明人：西崎　早織 , 中山　秀生 , 木下　卓 , 武田　一隆 , 小澤　秀明 , 松下　和征 , 湯川　浩平 , 木村　翔
IPC分类号： A61B3/117
CPC分类号： A61B3/117 , A61B3/10 , A61B5/0059 , A61B5/14532 , A61B5/6821 , A61B5/6835 , A61B5/6843
摘要：　光計測装置（１）は、被計測者の眼球（１０）周辺の皮膚に接触して被計測者の上眼瞼（１８）および下眼瞼（１９）を開いた状態に維持する瞼抑え部（７０）と、瞼抑え部（７０）によって上眼瞼（１８）および下眼瞼（１９）が開かれた状態に維持された眼球（１０）の前眼房を横切るように光を出射する発光系（２１）と、前眼房を横切った光を受光する受光系（２３）とを備える。
摘要翻译：一种装备有：用于使测量对象的眼球周围的皮肤接触并保持上眼睑（18）和下眼睑（19）的眼睑保持部（70）的光测量装置（1）测量科目开放; 用于在眼睑保持部分（70）保持上眼睑（18）和下眼睑（19）打开的同时发光的方式水平地横穿眼球（10）的前房的发光系统（21）以及用于接收水平地横过眼睛前房的光的光接收系统（23）。

75. 发明申请

WO2016014987A3 LONG-TERM IMPLANTABLE MONITORING SYSTEM & METHODS OF USE 审中-公开
标题翻译：长期植入式监测系统及使用方法
公开(公告)号：WO2016014987A3
公开(公告)日：2016-05-26
申请号：PCT/US2015042077
申请日：2015-07-24
申请人： UNIV JEFFERSON
发明人： JOSEPH JEFFREY I , JOSEPH AMANDA L
IPC分类号： A61M37/00 , A61B34/00 , A61N1/372
CPC分类号： A61B5/14528 , A61B5/0031 , A61B5/1451 , A61B5/14532 , A61B5/14552 , A61B5/14556 , A61B5/1459 , A61B5/1473 , A61B5/1495 , A61B5/6852 , A61B5/6876 , A61B5/7282 , A61B5/742 , A61B5/746 , A61B2560/0214 , A61M5/14 , A61M5/14276 , A61M5/1723 , A61M27/002 , A61M2005/1726 , A61M2205/0244 , A61M2205/04
摘要： Methods and systems include a long-term implantable ultra-filtrate monitoring system that uses micro-porous membranes to produce an ultra-filtrate of tissue interstitial fluid or blood plasma. The ultra-filtrate is transported through a sensor to detect a level of analyte in the ultra-filtrate. The long-term implantable fluid monitoring system thus includes a first porous catheter, a second porous catheter, a sensor configured to measure an amount of analyte in fluid, and a pump configured to move fluid through the first porous catheter to the sensor and from the sensor through the second porous catheter.
摘要翻译：方法和系统包括使用微孔膜产生组织间质液或血浆的超滤液的长期可植入超滤液监测系统。超滤液通过传感器传输以检测超滤液中的分析物水平。因此，长期可植入流体监测系统包括第一多孔导管，第二多孔导管，构造成测量流体中分析物的量的传感器以及构造成将流体通过第一多孔导管移动到传感器并从第一多孔导管传感器通过第二多孔导管。

76. 发明申请

WO2015097190A3 DEVICE AND METHOD FOR CHARACTERISATION OF BIOLOGICAL SAMPLES 审中-公开
标题翻译：用于表征生物样品的装置和方法
公开(公告)号：WO2015097190A3
公开(公告)日：2016-05-26
申请号：PCT/EP2014079080
申请日：2014-12-22
申请人： NDM TECHNOLOGIES LTD
发明人： CHOWDHURY DEWAN FAZLUL HOQUE
IPC分类号： A61B5/145 , A61B5/00 , A61B5/1459 , A61B10/00 , A61B17/00 , A61N1/04
CPC分类号： A61B5/14514 , A61B5/0059 , A61B5/14532 , A61B5/1459 , A61B5/683 , A61B5/6846 , A61B10/0045 , A61B2010/0009 , A61B2010/008 , A61N1/0428
摘要： An apparatus for measuring the concentration of an analyte in a sample extracted from the skin (10) of a patient comprises a collection chamber (3) adjacent to the skin; a radiation source (7) configured to irradiate the sample in the collection chamber (3); a reflector (4) configured to reflect incident radiation back through the sample; and a sensor (11) configured to measure the radiation emitted from the sample. The reflector (4) may shield the skin (10) from the incident radiation and have a convoluted or perforated shape to permit sufficient diffusion of the extracted analyte to all parts of the surface of the reflector from its edges. The reflector (4) may be a reflective surface of reverse iontophoresis electrodes (9) used to extract the sample from the skin. In a further apparatus the reflector (4) is implanted beneath an outer layer of the skin (10) so that instead of being extracted, the sample can be measured in vivo. An implanted reflector (4) may be formed from an assemblage of reflective particles. A mask (5) may be provided to prevent the incident radiation bypassing the reflector (4).
摘要翻译：用于测量从患者皮肤（10）提取的样品中的分析物的浓度的装置包括与皮肤相邻的收集室（3）; 辐射源（7），被配置为将样品照射在收集室（3）中; 反射器（4），被配置为将入射的辐射反射回所述样品; 以及被配置为测量从样品发射的辐射的传感器（11）。反射器（4）可以将皮肤（10）从入射的辐射屏蔽起来，并且具有回旋或穿孔的形状，以允许提取的分析物从其边缘向反射器表面的所有部分充分扩散。反射器（4）可以是用于从皮肤提取样品的反向离子电渗电极（9）的反射表面。在另一个装置中，反射器（4）被植入在皮肤（10）的外层之下，使得不是被提取，所以可以在体内测量样品。植入的反射器（4）可以由反射颗粒的组合形成。可以设置掩模（5）以防止旁路反射器（4）的入射辐射。

77. 发明申请

WO2016063190A1 MINIATURE WEARABLE ELECTRONIC DEVICE FOR CONTINOUSLY MONITORING HEALTH THROUGH EAR 审中-公开
标题翻译：通过耳朵持续监测健康的微型可穿戴电子设备
公开(公告)号：WO2016063190A1
公开(公告)日：2016-04-28
申请号：PCT/IB2015/058004
申请日：2015-10-18
申请人： SAINI, Ravinder Pal Singh
发明人： SAINI, Ravinder Pal Singh
IPC分类号： A61B5/00 , A61B1/00 , H05K1/00 , G06F19/00 , G06F1/00
CPC分类号： A61B5/6816 , A61B5/00 , A61B5/0002 , A61B5/01 , A61B5/021 , A61B5/024 , A61B5/14532 , G06F1/163 , G06F19/00 , G16H50/20
摘要： A miniature wearable device, made in the form of an earring or an earring back, is a device which can acquire the physiological parameters like heart rate, blood oxygen level, body temperature, glucose level etc. of a user and, at the same time, it can acquire parameters like ambient temperature, humidity, pollution level etc. of the environment surrounding the user. The smart earring or the smart earring back then processes and transmits these data to a computing device like a smartphone wirelessly. An application provided by the present invention installed in the computing device further processes the acquired data and notifies the user or others as per setting if the parameters exceed recommended threshold values.
摘要翻译：以耳环或耳环形式制造的微型可佩戴装置是能够获取使用者的心率，血氧水平，体温，葡萄糖水平等生理参数的装置，同时，，可以获取用户周围环境的环境温度，湿度，污染等级等参数。智能耳环或智能耳环随后处理并将这些数据无线传输到计算设备，如智能电话。安装在计算装置中的由本发明提供的应用程序进一步处理所获取的数据，并且如果参数超过推荐的阈值，则根据设置通知用户或其他人。

78. 发明申请

WO2016061308A1 HUMAN METABOLIC CONDITION MANAGEMENT 审中-公开
标题翻译：人类代际管理
公开(公告)号：WO2016061308A1
公开(公告)日：2016-04-21
申请号：PCT/US2015/055658
申请日：2015-10-15
申请人： KAHLBAUGH, Bradley E.
发明人： KAHLBAUGH, Bradley E.
IPC分类号： A61B5/145 , G06F19/00
CPC分类号： G16H50/50 , A61B5/14532 , A61B5/7275 , A61M5/14244 , A61M5/1723 , A61M2005/1726 , G06F19/00 , G06F19/3456 , G06F19/3475 , G06F19/3481 , G16H50/30
摘要： Systems and methods for extracting blood glucose patterns and suggesting a behavior may include receiving, at a computing device comprising a processor, temporal data including information regarding glucose readings; identifying, by the computing device, at least one pattern based on metabolite levels extracted from the temporal data the model including variables corresponding to each of the patterns; formulating, by the computing device, a model for predicting a metabolic response; and storing the model on a data storage device. Based on the model, the behavior may be suggested to maintain a blood glucose level within a desired range.
摘要翻译：用于提取血糖图案和提示行为的系统和方法可以包括在包括处理器的计算设备处接收包括关于葡萄糖读数的信息的时间数据; 通过所述计算设备识别基于从所述时间数据提取的代谢物水平的至少一个模式，所述模型包括对应于每个模式的变量; 由计算装置制定用于预测代谢反应的模型; 并将该模型存储在数据存储装置上。基于该模型，可以建议将血糖水平维持在期望范围内的行为。

79. 发明申请

WO2016059635A1 ANALYTE-SENSING DEVICE 审中-公开
标题翻译：分析传感装置
公开(公告)号：WO2016059635A1
公开(公告)日：2016-04-21
申请号：PCT/IL2015/051022
申请日：2015-10-13
申请人： GLUSENSE LTD.
发明人： BRILL, Boaz
IPC分类号： A61B5/00 , A61B5/145 , A61B5/1459 , A61B5/1455 , G01N21/64
CPC分类号： A61B5/14556 , A61B5/0071 , A61B5/14532 , A61B5/1459 , G01N21/6428 , G01N21/6456 , G01N2201/021
摘要： An implantable unit (30) includes fluorescent sensor molecules (40), each of which comprises a binding site for an analyte, and at least one fluorescent moiety configured to emit fluorescent light; and an implantable-unit light source (42) configured to generate light having an illumination peak wavelength appropriate for excitation of the fluorescent moiety. An external system (26) includes an external reading unit (32), which comprises a light sensor (44), which is configured to sense fluorescent light emitted from the fluorescent moiety having an emission peak wavelength, wherein the emission peak wavelength is between 100 and 500 nm greater than the illumination peak wavelength; and one or more processors (60), which are configured to: drive the implantable-unit light source (42) to generate the light; receive, from the light sensor (44), at least one measurement of the fluorescent light emitted from the fluorescent moiety; and calculate the concentration of the analyte in a subject based on the at least one measurement.
摘要翻译：可植入单元（30）包括荧光传感器分子（40），每个荧光传感器分子包括分析物的结合位点和被配置为发射荧光的至少一个荧光部分; 以及被配置为产生具有适合于激发荧光部分的照明峰值波长的光的可植入单元光源（42）。外部系统（26）包括外部读取单元（32），其包括光传感器（44），其被配置为感测从具有发射峰值波长的荧光部分发射的荧光，其中发射峰值波长在100 并且比照明峰值波长大500nm; 以及一个或多个处理器（60），其被配置为：驱动所述可植入单元光源（42）以产生所述光; 从所述光传感器（44）接收从所述荧光部分发射的荧光的至少一个测量值; 并且基于所述至少一个测量来计算受试者中的分析物的浓度。

80. 发明申请

WO2016057343A1 SYSTEM AND METHOD FOR DATA ANALYTICS AND VISUALIZATION 审中-公开
标题翻译：用于数据分析和可视化的系统和方法
公开(公告)号：WO2016057343A1
公开(公告)日：2016-04-14
申请号：PCT/US2015/053854
申请日：2015-10-02
申请人： DEXCOM, INC.
发明人： ZAMANAKOS, Georgios , WIEDEBACK, Daniel, Justin , STEWART, Jeffrey, Grant , REIHMAN, Eli , PRICE, David , MILLER, Lauren, C. , LEONE, Keri , KRAEMER, Dan , KIRBY, Katherine, Eng , KIDA, Greg , KAMATH, Apurv, Ullas , GREENE, Adam, R. , GIMENEZ, Rebecca , ELLI, Sarah, Paige , DRAEGER, Rian , DELMORE, Shane, Philip , BOWMAN, Leif, N.
IPC分类号： G06F19/00
CPC分类号： G06F19/3487 , A61B5/14532 , A61B5/7275 , A61B5/742 , G06F19/00 , G06T11/206 , G16H10/40 , G16H10/60 , G16H15/00 , Y02A90/26
摘要： Systems and methods are described that provide a dynamic reporting functionality that can identify important information and dynamically present a report about the important information that highlights important findings to the user. The described systems and methods are generally described in the field of diabetes management, but are applicable to other medical reports as well. In one implementation, the dynamic reports are based on available data and devices. For example, useless sections of the report, such as those with no populated data, may be removed, minimized in importance, assigned a lower priority, or the like.
摘要翻译：描述了系统和方法，其提供动态报告功能，其可以识别重要信息并且动态地呈现关于向用户突出重要发现的重要信息的报告。所描述的系统和方法通常在糖尿病管理领域中描述，但也适用于其他医疗报告。在一个实现中，动态报告基于可用的数据和设备。例如，报告中的无用部分（例如没有填充数据的部分）可能会被删除，重要性最小化，分配较低优先级等。

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