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71. 发明申请

WO1995020014A1 MONOAZO DYES CONTAINING A FLUOROSULPHONYL GROUP AND USE THEREOF 审中-公开
标题翻译：含有荧光素团的MONOAZO染料及其用途
公开(公告)号：WO1995020014A1
公开(公告)日：1995-07-27
申请号：PCT/GB1994002831
申请日：1994-12-30
申请人： ZENECA LIMITED , HALL, Nigel
发明人： ZENECA LIMITED
IPC分类号： C09B62/825
CPC分类号： D06P3/8233 , C09B29/0003 , C09B29/0014 , C09B29/0025 , C09B29/0811 , C09B29/0838 , C09B29/095 , C09B29/10 , C09B29/36 , C09B62/825 , D06P3/26
摘要： A process for colouring a synthetic textile material or fibre blend thereof which comprises applying to the synthetic textile material a compound or mixture thereof, which is free from water solubilising groups, of the Formula (1) A-N=N-D, wherein: A and D each independently is an optionally substituted heterocyclic or carbocyclic group and at least one of A or D carries directly at least one -SO2F group or carries a substituent to which at least one -SO2F group is attached except for 4-(4-fluorosulphonylphenylazo)-N,N-dimethylaniline, provided that one of A or D is not 3,5-difluorosulphonylthien-2-yl, optionally substituted 1-phenyl-pyrazol-4-yl-5-one or (a) or that one of A or D does not carry an -NCH2CH(OH)CH2Cl, -NCOCH2Cl or -NCH2CH2SO2F substituent. The presence of one or more -SO2F groups in a dye molecule generally improves the properties of that dye and confers surprisingly good wet fastness and light fastness properties.
摘要翻译：合成纺织材料或其纤维混合物的着色方法，其包括向所述合成纺织品材料施用式（1）AN = ND的无水增溶基团的化合物或其混合物，其中：A和D各自独立地是任选取代的杂环或碳环基团，并且A或D中的至少一个直接携带至少一个-SO 2 F基团或携带至少一个-SO 2 F基团连接的取代基，除了4-（4-氟磺酰基苯基偶氮）-N 的N-二甲基苯胺，条件是A或D中的一个不是3,5-二氟磺酰基噻吩-2-基，任选取代的1-苯基 - 吡唑-4-基-5-酮或（a）或A或D中的一个不携带-NCH 2 CH（OH）CH 2 Cl，-NCOCH 2 Cl或-NCH 2 CH 2 SO 2 F取代基。染料分子中一个或多个-SO 2 F基团的存在通常改善了该染料的性质，并赋予令人惊奇的良好的耐湿牢度和耐光性能。

72. 发明申请

WO1995017435A1 FREE RADICAL POLYMERISATION PROCESS 审中-公开
标题翻译：自由放射聚合过程
公开(公告)号：WO1995017435A1
公开(公告)日：1995-06-29
申请号：PCT/GB1994002769
申请日：1994-12-20
申请人： ZENECA LIMITED , HADDLETON, David, Mark , MUIR, Andrew, Victor, Graham , LEEMING, Stephen, William
发明人： ZENECA LIMITED
IPC分类号： C08F02/38
CPC分类号： C07F5/022 , C08F2/38
摘要： A compound for effecting molecular weight control in polymerisation is a CoII chelate of formula (I), wherein each group R is an organic cyclic group which, independently, is a monovalent group which comprises a cyclic structure or taken together as two adjacent groups provides a divalent group, and wherein further at least one of the groups R includes at least one heteroatom selected from O, N, S, P, halogen and Si, which heteroatom provides a substituent group or part of a substituent group on the cyclic structure, or a heteroatom of a heterocyclic ring of the cyclic structure; and wherein each group Q is independently selected from F, Cl, Br, OH, C1-12 alkoxy and C1-12 alkyl; or being a CoIII analogue of the cobalt II chelate of formula (I) in which the Co atom is additionally covalently bonded to H, a halide or other anion, or a homolytically dissociable organic group. Free-radical polymerisation of at least one ethylenically unsaturated monomer is carried out in the presence of such a compound.
摘要翻译：用于在聚合中进行分子量控制的化合物是式（I）的CoII螯合物，其中每个基团R是有机环状基团，其独立地是包含环状结构的一价基团或两个相邻的基团一起提供一个并且其中所述基团R中的至少一个基团包含至少一个选自O，N，S，P，卤素和Si的杂原子，所述杂原子提供环状结构上的取代基或取代基的一部分，或环状结构的杂环的杂原子; 并且其中每个基团Q独立地选自F，Cl，Br，OH，C 1-12烷氧基和C 1-12烷基; 或者是式（I）的钴II螯合物的CoIII类似物，其中Co原子另外共价键合到H，卤化物或其它阴离子或均分解离的有机基团。至少一种烯键式不饱和单体的自由基聚合在这种化合物的存在下进行。

73. 发明申请

WO1995015961A1 BICYCLIC HETEROCYCLES AS NEUROKININ A ANTAGONISTS 审中-公开
标题翻译：双相异构体作为神经营养因子拮抗剂
公开(公告)号：WO1995015961A1
公开(公告)日：1995-06-15
申请号：PCT/GB1994002646
申请日：1994-12-02
申请人： ZENECA LIMITED
发明人： ZENECA LIMITED , MILLER, Scott, Carson
IPC分类号： C07D401/04
CPC分类号： C07D401/04
摘要： Compounds of formula (I) wherein Q , m and M have any of the meanings given in the specification, their N -oxides, and their pharmaceutically acceptable salts are nonpeptide antagonists of neurokinin A and useful for the treatment of asthma, etc. Also disclosed are pharmaceutical compositions, processes for preparing the compounds of formula (I) and intermediates.
摘要翻译：其中Q 1，m和M具有本说明书中给出的任何含义的其N，N-氧化物及其药学上可接受的盐的式（I）化合物是神经激肽A的非肽拮抗剂，并且是有用的用于治疗哮喘等。还公开了药物组合物，制备式（I）化合物和中间体的方法。

74. 发明申请

WO1995013698A1 MICROCAPSULES CONTAINING SUSPENSIONS OF BIOLOGICALLY ACTIVE COMPOUNDS 审中-公开
标题翻译：含有生物活性化合物悬浮液的微生物
公开(公告)号：WO1995013698A1
公开(公告)日：1995-05-26
申请号：PCT/GB1994002440
申请日：1994-11-07
申请人： ZENECA LIMITED
发明人： ZENECA LIMITED , SCHER, Herbert, Benson , CHEN, Jin, Ling
IPC分类号： A01N25/28
CPC分类号： B01J13/18 , A01N25/04 , A01N25/22 , A01N25/28 , A01N41/10 , A01N43/70 , A01N53/00 , B01J13/02 , B01J13/04 , Y10T428/2989 , A01N37/26 , A01N2300/00
摘要： Microcapsules containing a suspension of a solid, biologically active compound in an organic, water-immiscible liquid and processes for their preparation.
摘要翻译：含有固体，生物活性化合物在有机，水不混溶液体中的悬浮液的微胶囊及其制备方法。

75. 发明申请

WO1995013170A1 PROCESS OF PRODUCING FOODSTUFF PARTICLES 审中-公开
标题翻译：生产食品颗粒的方法
公开(公告)号：WO1995013170A1
公开(公告)日：1995-05-18
申请号：PCT/GB1994002448
申请日：1994-11-08
申请人： ZENECA LIMITED , WRIGGLESWORTH, John, Arthur , REED, John, William, Balaan
发明人： ZENECA LIMITED
IPC分类号： B26F03/02
CPC分类号： A23L5/30 , A21C11/10 , A23L13/46 , A23L13/67 , A23L31/00 , B26D3/22 , B26F3/02 , Y10T83/6542
摘要： Foodstuff particles are produced with ragged ends by tearing them from the ends of strips (2) of the foodstuff by bending the ends.
摘要翻译：食品颗粒通过将端部弯曲而从食品的条带（2）的端部撕开而被制成具有粗糙的端部。

76. 发明申请

WO1995007022A1 FUNGICIDES 审中-公开
标题翻译：杀菌剂
公开(公告)号：WO1995007022A1
公开(公告)日：1995-03-16
申请号：PCT/GB1994001751
申请日：1994-08-11
申请人： ZENECA LIMITED , CROWLEY, Patrick, Jelf , HEANEY, Stephen, Paul , LAWSON, Kevin, Robert , YOULE, David
发明人： ZENECA LIMITED
IPC分类号： A01N37/44
CPC分类号： A01N43/36 , A01N37/44 , A01N37/46 , A01N43/08 , A01N43/10 , A01N47/18 , C07C229/48 , C07C235/54 , C07C237/20 , C07C271/24 , C07C2601/08 , C07D207/16 , C07D307/24 , Y02P20/55
摘要： A method of combating fungi which comprises applying to a plant, to a seed of a plant or to the locus of a seed or plant a compound of formula (I), wherein X is O, S, SO, SO2, NR or CLM; A, B, D, E, L and M are, independently, hydrogen, halogen, alkyl, mono- or di-haloalkyl, benzyl (optionally substituted by halogen or haloalkyl) or hydroxy; A and B or D and E or L and M may together form a =S, =O or =CR R group; B and L or D and L may together form a bond; V is O or NR ; R and R are, independently, hydrogen or an amine protecting group; R , R and R are, independently, hydrogen, alkyl or benzyl; R and R are, independently, hydrogen, halogen, alkyl, phenyl, benzyl, alkoxy or acyloxy; or a salt thereof; provided that when X is CLM, R , R , R , A, M, D and E are all hydrogen, L and B are either both hydrogen or together form a bond, and V is O then the compound of formula (I) is in the form of a salt, but not a hydrochloride salt.
摘要翻译：一种防治真菌的方法，其包括向植物，植物种子或种子或植物的场所施用式（I）化合物，其中X为O，S，SO，SO 2，NR 8，或CLM; A，B，D，E，L和M独立地为氢，卤素，烷基，单 - 或二 - 卤代烷基，苄基（任选被卤素或卤代烷基）或羟基取代; A和B或D和E或L和M可以一起形成= S，= O或= CR 6 R 7组; B和L或D和L可以一起形成键; V是O或NR 4; R 1和R 2独立地是氢或胺保护基; R 3，R 4和R 8独立地是氢，烷基或苄基; R 6和R 7独立地是氢，卤素，烷基，苯基，苄基，烷氧基或酰氧基; 或其盐; 条件是当X为CLM时，R 1，R 2，R 3，A，M，D和E均为氢，L和B均为氢或一起形成键，V为O 那么式（I）的化合物是盐的形式，而不是盐酸盐。

77. 发明申请

WO1995004759A1 FREE RADICAL POLYMERISATION PROCESS 审中-公开
标题翻译：自由放射聚合过程
公开(公告)号：WO1995004759A1
公开(公告)日：1995-02-16
申请号：PCT/GB1994001693
申请日：1994-08-02
申请人： ZENECA LIMITED , HADDLETON, David, Mark , MUIR, Andrew, Victor, Graham
发明人： ZENECA LIMITED
IPC分类号： C08F02/38
CPC分类号： C08F10/00 , C08F2/38
摘要： Process for the free-radical polymerisation of olefinically unsaturated monomer(s) using a free-radical initiator, wherein said polymerisation is performed in the presence of a compound for effecting molecular weight control, said molecular weight control compound being selected from Cobalt II chelates of formulae (I), (II) and (III), wherein: x and y are independently 2 to 5; each R , R , R and R is independently selected from H, C1-C12 alkyl, optionally substituted aryl, OR where R is C1 to C12 alkyl or optionally substituted aryl, CO2R , SO3H, C(=O)R , CO2H, NO2, OH, NR 2, NH2, NHR , SR , SH, CN, SO3R , halogen, 2-furyl and 3-furyl; each X is independently selected from (CR 2)n, (CR 2O)n, optionally substituted o-phenylene, and optionally substituted 1,8-naphthylene, where each R is independently selected from H and C1 to C12 alkyl, and n is 1 to 10; and wherein said cobalt chelates of formulae (I) and (II) possess a positive charge of 2 and are associated with an anion or anions for balancing the positive charge, while that of formula (III) is neutral; and also Co III analogues of said cobalt (II) chelates of formulae (I), (II) and (III) in which the Co atom is additionally covalently bonded, in a direction at right angles to the macrocyclic chelate ring system, to H, a halide ion or other anion, or a homolytically dissociatable organic group.
摘要翻译：使用自由基引发剂使烯属不饱和单体自由基聚合的方法，其中所述聚合在化合物存在下进行以进行分子量控制，所述分子量控制化合物选自钴式（I），（II）和（III），其中：x和y独立地为2至5; 每个R 1，R 2，R 3和R 4独立地选自H，C 1 -C 12烷基，任选取代的芳基，OR 5，其中R 5是C 1至C 12烷基或任选取代的芳基，CO 2 R 5，SO 3 H，C（= O）R 5，CO 2 H，NO 2，OH，NR 5，NH 2，NHR 5，SR 5，SH，CN，SO 3 R 卤素，2-呋喃基和3-呋喃基; 每个X独立地选自（CR 6）n，（CR 6 O）n，任选取代的邻亚苯基和任选取代的1,8-亚萘基，其中每个R 6独立地选自H 和C 1〜C 12烷基，n为1〜10; 并且其中所述式（I）和（II）的钴螯合物具有2的正电荷并且与用于平衡正电荷的阴离子相关联，而式（III）的中性; 以及所述式（I），（II）和（III）的所述钴（II）螯合物的Co III类似物，其中所述Co原子在与大环螯合环体系成直角的方向上额外共价键合至H ，卤化物离子或其它阴离子，或同解离的有机基团。

78. 发明申请

WO1995004754A1 ANTIMICROBIAL PROTEINS 审中-公开
标题翻译：抗微生物蛋白
公开(公告)号：WO1995004754A1
公开(公告)日：1995-02-16
申请号：PCT/GB1994001636
申请日：1994-07-29
申请人： ZENECA LIMITED , BROEKAERT, Willem, Frans , CAMMUE, Bruno, Philippe, Angelo , REES, Sarah, Bronwen
发明人： ZENECA LIMITED
IPC分类号： C07K14/415
CPC分类号： C12N15/8282 , A01N65/42 , C07K14/415 , C12N15/8281
摘要： Antimicrobial proteins capable of isolation from seeds of Allium show a wide range of antifungal activity and some activity against Gram-positive bacteria. DNA encoding the proteins may be isolated and incorporated into vectors. Plants transformed with this DNA may be produced. The proteins find commercial application as antifungal or antibacterial agents; transformed plants will show increased disease resistance.
摘要翻译：能够从葱属种子中分离的抗微生物蛋白质具有广泛的抗真菌活性和一些抗革兰氏阳性菌的活性。编码蛋白质的DNA可以被分离并并入载体中。可以生产用该DNA转化的植物。蛋白质作为抗真菌剂或抗菌剂找到商业应用; 转化的植物将显示增加的抗病性。

79. 发明申请

WO1994029291A1 ANILINE DERIVATIVES 审中-公开
标题翻译：苯胺衍生物
公开(公告)号：WO1994029291A1
公开(公告)日：1994-12-22
申请号：PCT/EP1994001808
申请日：1994-06-03
申请人： ZENECA LIMITED , ZENECA-PHARMA S.A. , EDWARDS, Philip, Neil
发明人： ZENECA LIMITED , ZENECA-PHARMA S.A.
IPC分类号： C07D309/10
CPC分类号： C07D405/12 , C07D309/10
摘要： The invention concerns an aniline derivative of formula (I) wherein R includes hydrogen and (1-4C)alkyl; R includes hydrogen and (1-4C)alkyl; R is hydrogen or (1-4C)alkyl; X includes a group of the formula CR R wherein R is hydrogen or (1-4C)alkyl and R is hydrogen or (1-4C)alkyl; A includes a direct link to X ; X includes thio and sulphonyl; Ar includes phenylene, which may be optionally substituted; R includes hydrogen and (1-4C)alkyl; and R and R together form a ring having 5 to 6 ring atoms including one oxygen atom, and which ring may bear one, two or three substituents, including methyl alpha to the oxygen atom; or a pharmaceutically acceptable salt thereof; processes for their preparation; pharmaceutical compositions containing them and their use as 5-lipoxygenase inhibitors.
摘要翻译：本发明涉及式（I）的苯胺衍生物，其中R 4包括氢和（1-4C）烷基; R 5包括氢和（1-4C）烷基; R 6是氢或（1-4C）烷基; X 3包括式CR 7 R 8的基团，其中R 7是氢或（1-4C）烷基，R 8是氢或（1-4C）烷基; A <1>包括与X <1>的直接链接; X 1包括硫代和磺酰基; Ar包括可以任选取代的亚苯基; R 1包括氢和（1-4C）烷基; 并且R 2和R 3一起形成具有5至6个环原子的环，包括一个氧原子，并且该环可以带有一个，两个或三个取代基，包括氧原子的甲基α; 或其药学上可接受的盐; 其准备过程; 含有它们的药物组合物及其作为5-脂肪氧合酶抑制剂的用途。

80. 发明申请

WO1994028166A1 FLUORESCENCE ENERGY TRANSFER SUBSTRATES 审中-公开
标题翻译：荧光能量转移基板
公开(公告)号：WO1994028166A1
公开(公告)日：1994-12-08
申请号：PCT/GB1994001153
申请日：1994-05-27
申请人： ZENECA LIMITED , GARMAN, Andrew, John
发明人： ZENECA LIMITED
IPC分类号： C12Q01/37
CPC分类号： G01N33/533 , C12Q1/37 , Y10S435/968
摘要： A method for the preparation of a fluorescence resonance energy transfer (FRET) substrate having donor and acceptor species on opposite sides of a proteolytic cleavage site and wherein the donor and/or acceptor species are attached via the side chain(s) of amino acid(s) therein. The method comprises contacting a reactive donor or acceptor species with a polypeptide substrate having the side chain(s) of amino acid(s) therein adapted for reaction with the reactive species and then contacting the substrate so obtained with a corresponding reactive donor or acceptor species. Novel FRET substrates so prepared and their use in assays to identify modulators of protease activity.
摘要翻译：一种用于制备在蛋白水解切割位点的相对侧具有供体和受体物质的荧光共振能量转移（FRET）底物的方法，其中供体和/或受体物质通过氨基酸的侧链（ s）。该方法包括使反应性供体或受体物质与其中具有适于与反应物质反应的氨基酸侧链的多肽底物接触，然后将如此获得的底物与相应的反应性供体或受体物质。新型FRET底物如此制备，并在测定中用于鉴定蛋白酶活性的调节剂。

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