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71. 发明申请

WO1994022878A1 ALKYLATING AGENT AND 1,4-ADDITION PROCESS OF AN ALKYL GROUP ONTO AN ALPHA, BETA-UNSATURATED KETONE COMPOUND 审中-公开
标题翻译：烷基化AND METHOD FOR 1,4-加成的烷基，以α，β-不饱和酮化合物
公开(公告)号：WO1994022878A1
公开(公告)日：1994-10-13
申请号：PCT/EP1994001001
申请日：1994-03-30
申请人： SCHERING AKTIENGESELLSCHAFT , WESTERMANN, Jürgen , NICKISCH, Klaus
发明人： SCHERING AKTIENGESELLSCHAFT
IPC分类号： C07F07/12
CPC分类号： C07B37/02 , C07F7/12 , C07F7/1804 , C07J1/0011 , C07J1/0025 , C07J1/0059
摘要： An alkylating agent contains an aluminium reagent Alk3-mAlLm, in which Alk stands for a methyl, ethyl, n- or i-propyl, n-, i- or tert.-butyl, pentyl, hexyl, heptyl or octyl group, which may all also be branched, L stands for an ethoxy group, for a chlorine or bromine atom and m equals 1 or 2, as alkyl source. The alkylating agent may also contain zinc dimethyl as methyl source, as well as catalytic amounts of one or several copper-I and/or copper-II compounds and one or several silyl reagents having the general formula (III), in which R , R and R may be the same or different and stand for a straight- or branched-chain alkyl residue with 1 carbon atom, or when they have a branched chain with 3 to 10 carbon atom, an alkyl residue if required substituted by 1 to 3 chlorine atoms or by 1 to 3 straight- or branched-chain alkoxy or alkyl residues with 1 carbon atom, or when they have a branched chain with 3 to 6 carbon atoms; Z stands for a chlorine, bromine or iodine atom, cyano-, perfluoroalkylsulfonyloxi residue [(CnF2n+1SO2O-), in which n = 1, 2, 3 ou 4], the mesylate residue CH3SO2O-, the tosyl residue p-CH3-C6H4-SO2O or another leaving group. This alkylating agent is used for 1,4-adding an alkyl group onto a alpha , beta -unsaturated or to an alpha , beta -biunsaturated ketone or to a alpha , beta -unsaturated aldehyde. This alkylating agent supplies biologically active compounds in extraordinarily high yields and because the reaction medium is free from chlorinated hydrocarbons, the new alkylating agent process are characterized by their environmental compatibility.

72. 发明申请

WO1994012186A1 PROSTAGLANDIN DERIVATIVE HAVING RADIOPROTECTIVE EFFECTS 审中-公开
标题翻译： PROSTAGLANDIN衍生物具有放射性保护作用
公开(公告)号：WO1994012186A1
公开(公告)日：1994-06-09
申请号：PCT/EP1993003359
申请日：1993-11-30
申请人： SCHERING AKTIENGESELLSCHAFT , ZAFFARONI, Nadia , VILLA, Raffaella , ORLANDI, Linda , DE PASCALE, Antonella , DEL MASTRO, Sonia , SILVESTRINI, Rosella
发明人： SCHERING AKTIENGESELLSCHAFT
IPC分类号： A61K31/557
CPC分类号： A61K31/557
摘要： The present invention relates to a composition having radioprotective action in human cells which contains nocloprost as active ingredient.
摘要翻译：本发明涉及一种具有放射防护作用的组合物，其含有作为活性成分的诺卡洛前列素的人细胞。

73. 发明申请

WO1994007864A1 CYANOPHENYLPYRAZOLINES AS PESTICIDES 审中-公开
标题翻译：作为杀虫剂的氰基戊二酰胺
公开(公告)号：WO1994007864A1
公开(公告)日：1994-04-14
申请号：PCT/EP1993002714
申请日：1993-10-04
申请人： SCHERING AKTIENGESELLSCHAFT , VAN ALMSICK, Andreas , HOFFMANN, Holger , BOSUM-DYBUS, Annegrit , WEGMANN, Thomas , JOPPIEN, Hartmut , VON KEYSERLINGK, Harald
发明人： SCHERING AKTIENGESELLSCHAFT
IPC分类号： C07D231/06
CPC分类号： C07D231/06 , A01N47/38
摘要： Pyrazoline derivatives of general formula (I), in which R1 and R2 are phenyl, optionally substituted by one or more of the same or different groups selected from cyano, halogen, nitro, C1-6-alkyl, C1-6-alkoxy, halo-C1-6-alkyl or halo-C1-6-alkoxy, in which at least one of the phenyl groups is substituted by cyano; R3 is phenyl or cyclohexyl, each of which is optionally substituted by one or more of the same or different groups selected from halogen, nitro, cyano, C1-6-alkyl, C1-6-alkoxy, halo-C1-6-alkyl, halo-C1-6-alkoxy, C1-6-alkylsulfonyl, halo-C1-6-alkylsulfonyl or C1-6-alkoxycarbonyl; and R4 is hydrogen, C1-6-alkyl, halo-C1-6-alkyl, C1-6-acyl, C1-6-alkoxycarbonyl or halo-C1-6-alkoxycarbonyl, have insecticidal and acaricidal activity.
摘要翻译：通式（I）的吡唑啉衍生物，其中R 1和R 2为苯基，任选被一个或多个相同或不同的选自氰基，卤素，硝基，C 1-6 - 烷基，C 1-6 - 烷氧基，卤代 C 1-6 - 烷基或卤代C 1-6 - 烷氧基，其中至少一个苯基被氰基取代; R3是苯基或环己基，其各自任选被一个或多个相同或不同的选自卤素，硝基，氰基，C 1-6 - 烷基，C 1-6 - 烷氧基，卤代C 1-6 - 烷基，卤代C 1-6 - 烷氧基，C 1-6 - 烷基磺酰基，卤代C 1-6 - 烷基磺酰基或C 1-6 - 烷氧基羰基; 和R 4是氢，C 1-6 - 烷基，卤代C 1-6 - 烷基，C 1-6 - 酰基，C 1-6 - 烷氧基羰基或卤代-C 1-6 - 烷氧基羰基具有杀虫和杀螨活性。

74. 发明申请

WO1994005631A1 9-CHLOROPROSTAGLANDIN ESTERS AND AMIDES AND THEIR USE IN THE PREPARATION OF DRUGS 审中-公开
标题翻译： 9-氯前列腺素的酯和酰胺和它们用于药物的生产
公开(公告)号：WO1994005631A1
公开(公告)日：1994-03-17
申请号：PCT/DE1993000809
申请日：1993-08-31
申请人： SCHERING AKTIENGESELLSCHAFT , BUCHMANN, Bernd , SKUBALLA, Werner , EKERDT, Roland , McDONALD, Fiona , THIERAUCH, Karl-Heinz
发明人： SCHERING AKTIENGESELLSCHAFT
IPC分类号： C07C405/00
CPC分类号： B82Y5/00 , A61K31/557 , A61K47/6951 , C07C405/00 , C07C405/0041
摘要： The invention concerns 9-chloroprostaglandin esters and amides of general formula (I), methods of preparing them and their use as drugs.

75. 发明申请

WO1994004157A1 TRANSDERMAL APPLICATION AGENT CONTAINING 3-KETO-DESOGESTREL 审中-公开
标题翻译：手段透皮应用含有3-酮 - 去氧孕烯
公开(公告)号：WO1994004157A1
公开(公告)日：1994-03-03
申请号：PCT/EP1993002224
申请日：1993-08-19
申请人： SCHERING AKTIENGESELLSCHAFT , LIPP, Ralph , GÜNTHER, Clemens , RIEDL, Jutta , TÄUBER, Ulrich
发明人： SCHERING AKTIENGESELLSCHAFT
IPC分类号： A61K31/565
CPC分类号： A61K9/7061 , A61K9/7069 , A61K9/7084 , A61K31/565 , A61K2300/00
摘要： A transdermal application agent is characterized in that it contains 3-keto-desogestrel, if required combined with one or two estrogens.

76. 发明申请

WO1993012527A1 METHOD OF MANUFACTURING HIGHLY CONDUCTING COMPOSITES CONTAINING ONLY SMALL PROPORTIONS OF ELECTRON CONDUCTORS 审中-公开
标题翻译：制造仅包含电子导体的小比例的高导电复合材料的方法
公开(公告)号：WO1993012527A1
公开(公告)日：1993-06-24
申请号：PCT/DE1992000787
申请日：1992-09-11
申请人： SCHERING AKTIENGESELLSCHAFT , BESENHARD, Jürgen, Otto , MEYER, Heinrich , CLAUSSEN, Olaf , KÜHLKAMP, Michael
发明人： SCHERING AKTIENGESELLSCHAFT
IPC分类号： H01B01/24
CPC分类号： B05D7/5483 , B05D1/18 , B05D3/005 , B05D5/12 , B05D7/142 , C23C18/1635 , C23C18/1844 , C23C18/2086 , C25D5/54 , H01B1/22 , H01B1/24 , H05K3/424 , H05K2201/0323
摘要： The invention concerns a method of manufacturing highly conducting composites, the method being characterized by the following steps: a) contacting a powder or fibres with an aqueous solution containing an appreciably water-soluble high-molecular substance, b) optionally washing with water, c) contacting with a dispersion containing finely particulate electrically conducting material, wetting agents (surfactants) and an ionogenic metal compound, d) optionally washing with water and e) moulding to the required shape.
摘要翻译：本发明涉及一种制备高导电性复合材料的方法，该方法的特征在于以下步骤：a）使粉末或纤维与含有明显水溶性高分子物质的水溶液接触，b）任选地用水洗涤，c ）与含有细颗粒导电材料，润湿剂（表面活性剂）和离子型金属化合物的分散体接触，d）任选地用水洗涤和e）模制成所需形状。

77. 发明申请

WO1993008173A1 QUINOXALINE DERIVATES WITH AFFINITY FOR QUISQUALATE-RECEPTORS 审中-公开
标题翻译：喹诺酮衍生物具有适应症的受体受体
公开(公告)号：WO1993008173A1
公开(公告)日：1993-04-29
申请号：PCT/DE1992000895
申请日：1992-10-25
申请人： SCHERING AKTIENGESELLSCHAFT
发明人： SCHERING AKTIENGESELLSCHAFT , HUTH, Andreas , SCHMIECHEN, Ralph , BEETZ, Ilse , SCHUMANN, Ingrid , TURSKI, Lechoslaw , LÖSCHMANN, Peter, Andreas , STEPHENS, David, Norman , SEIDELMANN, Dieter , KRÜGER, Martin , RAHTZ, Dieter , HÖLSCHER, Peter
IPC分类号： C07D241/44
CPC分类号： C07F9/650994 , C07D241/44
摘要： Quinoxaline derivates have the formula (I), in which R is C1-12-alkyl substituted by R , C2-12-alkenyl substituted by R , C2-12-alkinyl substituted by R , C3-7-cycloalkyl substituted by R , -(CH2)n-C6-12-aryl substituted by R in the aryl or alkyl residue or -(CH2)n-hetaryl substituted by R in the hetaryl or alkyl residue; R is hydrogen, C1-12-alkyl substituted by R , C2-12-alkenyl substituted by R , C2-12-alkinyl substituted by R , (CH2)n-C6-12-aryl substituted by R in the aryl or alkyl residue, or -(CH2)n-hetaryl substituted by R in the hetaryl or alkyl residue; R , R , R and R are the same or different and represent hydrogen, halogen, nitro, NR R , NHCOR , SO2R , C3-7-cycloalkyloxy, COR , cyano, CF3, C1-6-alkyl, C1-4-alkoxy or imidazole possibly substituted by cyano, C1-4-alkyl or -COO-C1-6-alkyl or R and R or R and R represent a condensated benzene ring, and R stands for -CO-R , or -PO-XY and is present once or twice in the same or a different form. Also disclosed are the preparation of these derivates and their use in medicaments.
摘要翻译：喹喔啉衍生物具有式（I），其中R 1是被R 2取代的C 1-12 - 烷基，被R 2取代的C 2-12链烯基，被R 2取代的C 2-12 - 炔基被R 2取代的C 3-7 - 环烷基， - 被芳基或烷基残基取代的 - （CH 2）n -C 6-12芳基或被R 2取代的 - （CH 2）n - 杂芳基在杂芳基或烷基残基中; R 4为氢，被R 2取代的C 1-12 - 烷基，被R 2取代的C2-12链烯基，被R 2取代的C2-12-炔基，（CH2）n-C6- 或在芳基或烷基残基中被R 2取代的12-芳基或在杂芳基或烷基残基中被R 2取代的 - （CH 2）n - 杂芳基; R 5，R 6，R 7和R 8相同或不同，表示氢，卤素，硝基，NR 9 R 10，NHCOR 11，SO 2 R 12， C 3-7 - 环烷氧基，COR 13，氰基，CF 3，C 1-6 - 烷基，C 1-4 - 烷氧基或咪唑，其可被氰基，C 1-4 - 烷基或-COO-C 1-6 - 烷基或R <5>和R 6或R 7和R 8表示缩合苯环，R 2表示-CO-R 3或-PO-XY，并且存在一次或两次以相同或不同的形式。还公开了这些衍生物的制备及其在药物中的用途。

78. 发明申请

WO1993005785A1 COMBINATION PHARMACEUTICAL PREPARATIONS CONTAINING A NON-STEROIDAL ANTI-INFLAMMATORY AGENT AND NOCLOPROST 审中-公开
标题翻译：含有非甾体抗炎药物和药物的组合药物制剂
公开(公告)号：WO1993005785A1
公开(公告)日：1993-04-01
申请号：PCT/EP1992001994
申请日：1992-08-28
申请人： SCHERING AKTIENGESELLSCHAFT , VORBRÜGGEN, Helmut , TÄUBER, Ulrich , TACK, Johannes , AMON, Ingrid , WABNITZ, Rudolf
发明人： SCHERING AKTIENGESELLSCHAFT
IPC分类号： A61K31/557
CPC分类号： A61K31/557 , A61K9/209 , A61K9/5084 , A61K31/60 , A61K31/19 , A61K31/195 , A61K31/405 , A61K2300/00
摘要： Pharmaceutical preparation contain as active substance a combination of a non-steroidal anti-inflammatory agent with nocloprost.

79. 发明申请

WO1993004116A1 PROCESS FOR TREATING MATERIALS ADHESIVELY SECURED TOGETHER BY AN ADHESIVE AGENT 审中-公开
标题翻译：处理由粘合剂固化的材料进行处理的方法
公开(公告)号：WO1993004116A1
公开(公告)日：1993-03-04
申请号：PCT/EP1992001767
申请日：1992-08-04
申请人： SCHERING AKTIENGESELLSCHAFT , GARTZEN, Johannes , HEIL, Günter , MANG, Thomas
发明人： SCHERING AKTIENGESELLSCHAFT
IPC分类号： C08J11/08
CPC分类号： B03B9/061 , B03B5/28 , C08J11/08 , Y02W30/524 , Y02W30/701
摘要： The invention relates to a process for treating at least two materials which are secured together by an adhesive agent. Once such materials have served their purpose they are dumped or burned. The proposal is for a process by means of which one reduces the need for dumping and avoids the problems of incineration. This is achieved in that the adhesive is dissolved by a solvent which does not dissolve the materials themselves so that the adhesively secured materials can be separated and recycled on their own.

80. 发明申请

WO1992021679A1 NEW HETERO-ARYLOXY-'beta'-CARBOLINES, THEIR PREPARATION AND THEIR USE IN MEDICAMENTS 审中-公开
标题翻译：新型异戊烯-α-羧酸纤维蛋白酶，其制备及其在药物中的应用
公开(公告)号：WO1992021679A1
公开(公告)日：1992-12-10
申请号：PCT/DE1992000465
申请日：1992-06-04
申请人： SCHERING AKTIENGESELLSCHAFT
发明人： SCHERING AKTIENGESELLSCHAFT , KRÜGER, Martin , HUTH, Andreas , SEIDELMANN, Dieter , SCHNEIDER, Herbert , TURSKI, Lecboslaw , STEPHENS, David, Norman
IPC分类号： C07D471/04
CPC分类号： C07D471/04
摘要： Described are hetero-aryloxy-β-carbolines of the formula (I), in which RA is a triazine-condensed or benzo-condensed heteroaryl entity with 1-2 nitrogen atoms, which may optionally be substituted by halogen, C¿1-6?alkyl, C1-6alkoxy, C1-6alkylthio, trifluoromethyl or SO2-R?1¿, or a 5 or 6-membered hetero-aryl entity with 1-2 nitrogen atoms, substituted by halogen, C¿1-6?alkyl, C1-6alkoxy, C1-6alkylthio, trifluoromethyl or SO2-R?1¿. Also described is the preparation of these compounds and their use in medicaments.

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