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71. 发明申请

WO1996016014A1 ACTIVE BIO-COMPOUNDS 审中-公开
标题翻译：活性生物化合物
公开(公告)号：WO1996016014A1
公开(公告)日：1996-05-30
申请号：PCT/DK1995000461
申请日：1995-11-21
申请人： NOVO NORDISK A/S , BREINHOLT, Jens , OHMANN, Anders , RASSING, Brigitte, Romer , JENSEN, Georg, W. , MOLLER, Inge
发明人： NOVO NORDISK A/S
IPC分类号： C07C49/747
CPC分类号： C07C69/00 , A01N35/06 , A01N49/00 , A01N63/04 , C07C49/747 , C07C49/753 , C07C2603/00 , C12P29/00 , C12R1/645
摘要： The invention relates to biologically active novel compounds having general formula (I). Also disclosed is a method of preparing said novel compounds, a fungicidal composition comprising, as an active ingredient, said novel compounds, the use of said compounds, and further a method of controlling fungi at a locus infested or liable to be infested therewith. Finally contemplated is an isolated pure culture of the microorganism Hypomyces aurantius A03892 (CBS No. 654.93) or a mutant thereof capable of producing said compounds.
摘要翻译：本发明涉及具有通式（I）的生物活性新型化合物。还公开了一种制备所述新化合物的方法，一种杀真菌组合物，其包含作为活性成分的所述新化合物，所述化合物的用途，以及另外一种在感染或易于侵染的场所控制真菌的方法。最后考虑的是微生物Hypomyces aurantius A03892（CBS No.654.93）或其能够产生所述化合物的突变体的分离的纯培养物。

72. 发明申请

WO1996014066A1 A METHOD OF TREATING URINARY BLADDER DYSFUNCTIONS 审中-公开
标题翻译：一种治疗尿路功能障碍的方法
公开(公告)号：WO1996014066A1
公开(公告)日：1996-05-17
申请号：PCT/DK1995000443
申请日：1995-11-07
申请人： NOVO NORDISK A/S
发明人： NOVO NORDISK A/S , MUHLHAUSER, Mark, A. , SHANNON, Harlan, E. , THOR, Karl, B.
IPC分类号： A61K31/41
CPC分类号： A61K31/4439
摘要： The present invention relates to a novel method for treating a mammal suffering from urinary bladder dysfunctions comprising administering to said subject an effective amount of a compound of formula (I) wherein Z is oxygen or sulphur.
摘要翻译：本发明涉及一种用于治疗患有膀胱功能障碍的哺乳动物的新方法，包括向所述受试者施用有效量的式（I）化合物，其中Z 1为氧或硫。

73. 发明申请

WO1996013632A1 A PROCESS FOR CHEMICAL FINISHING OF INSOLUBLE POLYMERS 审中-公开
标题翻译：一种不溶性聚合物的化学处理方法
公开(公告)号：WO1996013632A1
公开(公告)日：1996-05-09
申请号：PCT/DK1995000428
申请日：1995-10-27
申请人： NOVO NORDISK A/S , LUND, Henrik , KIRK, Ole , MUNK, Niels
发明人： NOVO NORDISK A/S
IPC分类号： D06M16/00
CPC分类号： C12P7/62 , D06M13/184 , D06M13/224 , D06M16/003 , D21H25/02
摘要： A process for enzymatically catalyzing an esterification of insoluble polymer fibres containing free hydroxy groups by reacting the polymer fibres with a carboxylic acid such as a carboxylic acid having the general formula R-COOR , wherein R is linear or branched C1-25alkyl, preferably linear C3-25 alkyl, more preferably linear C8-25alkyl, which optionally is substituted with one or more carboxy, nitro, chloro, bromo, fluoro, amino, hydroxy, keto; and R is hydrogen, C1-4alkyl, or vinyl, preferably methyl, ethyl or vinyl; or an ester thereof, preferably an enolester, in the presence of an enzyme capable of catalyzing esterification, especially a lipase or an esterase, is useful for chemical finishing of yarn, textile, fabric, papermaking pulp, cardboard or paper, the fibre or fabric made therefrom having improved functional properties such as reduced tendency to wrinkling, improved durable softness, anti-static appearance, water repellency, enhanced soil release or flame retardancy.
摘要翻译：通过使聚合物纤维与羧酸如具有通式R-COOR 1的羧酸反应来酶催化含有游离羟基的不溶性聚合物纤维的酯化的方法，其中R是直链或支链C 1-5烷基，优选直链C 3-35烷基，更优选直链C 8-25烷基，其任选被一个或多个羧基，硝基，氯，溴，氟，氨基，羟基，酮基取代; 和R 1是氢，C 1-4烷基或乙烯基，优选甲基，乙基或乙烯基; 或其酯，优选烯醇酯，在能够催化酯化的酶，特别是脂肪酶或酯酶的存在下，可用于纱线，纺织品，织物，造纸纸浆，纸板或纸，纤维或织物的化学整理具有改善的功能性能，例如降低的起皱倾向，改善的耐用柔软性，防静电外观，防水性，增强的污垢释放或阻燃性。

74. 发明申请

WO1996013579A1 NOVEL LIPOLYTIC ENZYME 审中-公开
标题翻译：新鲜的脂肪酶
公开(公告)号：WO1996013579A1
公开(公告)日：1996-05-09
申请号：PCT/DK1995000425
申请日：1995-10-26
申请人： NOVO NORDISK A/S , OXENBOLL, Karen, M. , BORCH, Kim , PATKAR, Shamkant, Anant
发明人： NOVO NORDISK A/S
IPC分类号： C12N09/20
CPC分类号： C12N9/20 , C11D3/38627
摘要： The present invention relates to novel lipolytic enzymes. More specifically the invention provides novel lipolytic enzymes having the properties of a lipase native to the strain Fusarium culmorum CBS 513.94, or has immunochemical properties identical or partially identical to those of a lipase native to the strain Fusarium culmorum CBS 513.94.
摘要翻译：本发明涉及新的脂肪分解酶。更具体地说，本发明提供了具有天然于大肠杆菌CBS 513.94菌株的脂肪酶性质的新型脂肪分解酶，或具有与大肠杆菌CBS 513.94菌株天然的脂肪酶相同或部分相同的免疫化学性质。

75. 发明申请

WO1996011703A1 A PHARMACEUTICAL FORMULATION COMPRISING A GROWTH HORMONE AND ISOLEUCINE 审中-公开
标题翻译：包含生长激素和ISOLEUCINE的药物制剂
公开(公告)号：WO1996011703A1
公开(公告)日：1996-04-25
申请号：PCT/DK1995000409
申请日：1995-10-13
申请人： NOVO NORDISK A/S , SORENSEN, Hans, Holmegaard
发明人： NOVO NORDISK A/S
IPC分类号： A61K38/27
CPC分类号： A61K38/27
摘要： A pharmaceutical formulation comprising a growth hormone and isoleucine as additive or buffering substance shows a very high stability against deamidation, oxidation and cleavage of peptide bonds. The stability of the product allows for the storing and shipment thereof in a lyophilized state or in the form of a dissolved or re-dissolved formulation at ambient temperature.
摘要翻译：包含生长激素和异亮氨酸作为添加剂或缓冲物质的药物制剂显示出非常高的抗磷酸化，氧化和肽键切割的稳定性。产品的稳定性允许在室温下以冻干状态或以溶解或再溶解制剂的形式储存和运输。

76. 发明申请

WO1996006532A1 A BASIC PROTEIN COMPOSITION FOR KILLING OR INHIBITING MICROBIAL CELLS 审中-公开
标题翻译：用于杀死或抑制微生物细胞的基础蛋白质组合物
公开(公告)号：WO1996006532A1
公开(公告)日：1996-03-07
申请号：PCT/DK1995000351
申请日：1995-09-01
申请人： NOVO NORDISK A/S , JOHANSEN, Charlotte
发明人： NOVO NORDISK A/S
IPC分类号： A01N63/00
CPC分类号： A61Q17/005 , A01N63/02 , A23L2/44 , A23L3/3472 , A23L3/3526 , A23L3/3571 , A61K8/64 , A61K8/66 , A61K2800/524 , C11D3/3719 , C11D3/38636 , C11D3/38654 , C11D3/48 , A01N2300/00
摘要： A composition consisting essentially of a basic protein or peptide capable of killing microbial cell, e.g. a protamine or protamine sulphate, in combination with a cell-wall degrading enzyme and/or an oxidoreductase, e.g. an endoglycosidase Type II, a lysozyme, chitinase, peroxidase enzyme system (EC 1.11.1.7) or laccase enzyme (EC 1.10.3.2), has bactericidal, bacteriostatic, fungicidal and/or fungistatic properties and is useful in detergent and hard surface cleaning compositions and in methods for killing microbial cells present on a hard surface, for killing microbial cells or inhibiting growing microbial cells present on laundry, for killing microbial cells present on humain or animal skin, mucous membranes, wounds, bruises or in the eye; and in preservation of food, beverages, cosmetics, contact lens products, food ingredients or enzyme compositions.
摘要翻译：基本上由能够杀死微生物细胞的碱性蛋白质或肽组成的组合物，例如，与细胞壁降解酶和/或氧化还原酶组合的鱼精蛋白或鱼精蛋白硫酸盐。 II型糖苷内切酶，溶菌酶，几丁质酶，过氧化物酶系统（EC 1.11.1.7）或漆酶（EC 1.10.3.2）具有杀菌，抑菌，杀真菌和/或抑制性能，可用于洗涤剂和硬表面清洁组合物以及用于杀死存在于硬表面上的微生物细胞的方法，用于杀死微生物细胞或抑制存在于衣物上的生长中的微生物细胞，以杀死存在于人类或动物皮肤，粘膜，伤口，瘀伤或眼睛中的微生物细胞; 以及食品，饮料，化妆品，隐形眼镜产品，食品成分或酶组合物的保存。

77. 发明申请

WO1996005353A1 A METHOD FOR DESIZING CELLULOSE-CONTAINING FABRIC 审中-公开
标题翻译：一种用于处理含纤维素的织物的方法
公开(公告)号：WO1996005353A1
公开(公告)日：1996-02-22
申请号：PCT/DK1995000328
申请日：1995-08-14
申请人： NOVO NORDISK A/S , LUND, Henrik
发明人： NOVO NORDISK A/S
IPC分类号： D06L01/14
CPC分类号： C12N9/2437 , C12Y302/01004 , D06L1/14
摘要： Cellulose-containing fabrics or textile may be desized without essentially damaging the fabric or textile by subjecting the fabric or textile to a treatment with a certain type of cellulolytic enzyme, e.g. a cellulolytic enzyme having an activity on carboxymethylcellulose (CMC) and a catalytic activity on cellotriose at pH 8.5 corresponding to kcat of at least 0.01 s and preferably being of microbial origin, more preferably being obtainable by or derived from a strain of Humicola, Trichoderma, Myceliophthora, Penicillium, Irpex, Aspergillus, Scytalidium or Fusarium.
摘要翻译：含纤维素的织物或织物可以通过使织物或织物经受某种类型的纤维素分解酶（例如，纤维素分解酶）的处理而不会基本上损坏织物或纺织品。在羧甲基纤维素（CMC）上具有活性的纤维素分解酶和对pH至8.5的对于kcat至少为0.01s -1的纤维三糖的催化活性，并且优选为微生物来源，更优选可由或衍生自腐质霉属，木霉属，霉菌属，青霉属，Irpex，曲霉属，Scytalidium或Fusarium。

78. 发明申请

WO1996005195A1 NOVEL N-SUBSTITUTED NAPHTHOFUSED LACTAMS 审中-公开
标题翻译：新型N取代的萘普生LACTAMS
公开(公告)号：WO1996005195A1
公开(公告)日：1996-02-22
申请号：PCT/DK1995000332
申请日：1995-08-17
申请人： NOVO NORDISK A/S , THOGERSEN, Henning , HANSEN, Birgit, Sehested , PESCHKE, Bernd , HANSEN, Thomas, Kruse , ANDERSEN, Knud, Erik
发明人： NOVO NORDISK A/S
IPC分类号： C07D403/10
CPC分类号： C07D403/10 , C07D223/14 , C07D413/14
摘要： Disclosed are novel N-substituted naphthofused lactams and salts thereof of formula (I). Compounds of general formula (I) possess the ability to stimulate the release of endogenous growth hormone. Thus, these compounds may be used in the treatment of conditions which require stimulation of growth hormone production or secretion such as in humans with growth hormone deficiency or where increased growth hormone plasma levels are desired, for instance in elderly patients or in livestock.
摘要翻译：公开了式（I）的新型N-取代萘并内酰胺及其盐。通式（I）的化合物具有刺激内源性生长激素释放的能力。因此，这些化合物可用于治疗需要刺激生长激素产生或分泌的条件，例如在具有生长激素缺乏的人中或需要增加生长激素血浆水平的情况下，例如在老年患者或家畜中。

79. 发明申请

WO1996003440A1 OXIDASE-PROMOTED GELLING OF PHENOLIC POLYMERS 审中-公开
标题翻译：氧化聚合物的氧化促进凝胶
公开(公告)号：WO1996003440A1
公开(公告)日：1996-02-08
申请号：PCT/DK1995000317
申请日：1995-07-26
申请人： NOVO NORDISK A/S , BUDOLFSEN, Gitte , HELDT-HANSEN, Hans, Peter
发明人： NOVO NORDISK A/S
IPC分类号： C08B37/00
CPC分类号： C08G61/00 , C08B37/0045 , C08B37/0057 , C08L5/00 , C08L5/06 , C12P19/04
摘要： A method for causing gelling or increase of viscosity of an aqueous medium containing a gellable polymeric material having substituents with phenolic hydroxy groups comprises adding an oxidase, particularly a laccase, to the aqueous medium.
摘要翻译：含有具有酚羟基取代基的可胶凝聚合材料的水性介质的胶凝或粘度增加的方法包括向水性介质中加入氧化酶，特别是漆酶。

80. 发明申请

WO1996000290A1 PURIFIED POLYPORUS LACCASES AND NUCLEIC ACIDS ENCODING SAME 审中-公开
标题翻译：纯化多糖类和核酸编码它们
公开(公告)号：WO1996000290A1
公开(公告)日：1996-01-04
申请号：PCT/US1995007536
申请日：1995-06-15
申请人： NOVO NORDISK BIOTECH, INC. , NOVO NORDISK A/S
发明人： NOVO NORDISK BIOTECH, INC. , NOVO NORDISK A/S , YAVER, Debbie, Sue , XU, Feng , DALBOGE, Henrik , SCHNEIDER, Palle , AASLYNG, Dorrit, Anita
IPC分类号： C12N15/53
CPC分类号： D21C5/005 , A61K8/66 , A61Q5/10 , C12N9/0061 , C12N15/80 , D06M16/003 , D06P1/0004 , D06P1/0048 , D06P1/32
摘要： The present invention relates to isolated nucleic acid constructs containing a sequence encoding a Polyporus laccase, and the laccase proteins encoded thereby.
摘要翻译：本发明涉及含有编码多孔菌漆酶的序列的分离的核酸构建体和由其编码的漆酶蛋白质。

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