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71. 发明申请

WO0158915A8 HUMAN G-PROTEIN CHEMOKINE RECEPTOR (CCR5) HDGNR10 审中-公开
标题翻译：人类G蛋白趋化因子受体（CCR5）HDGNR10
公开(公告)号：WO0158915A8
公开(公告)日：2002-09-06
申请号：PCT/US0104152
申请日：2001-02-09
申请人： HUMAN GENOME SCIENCES INC , ROSEN CRAIG A , ROSCHKE VIKTOR , LI YI , RUBEN STEVEN M
发明人： ROSEN CRAIG A , ROSCHKE VIKTOR , LI YI , RUBEN STEVEN M
IPC分类号： G01N33/50 , A61K31/7088 , A61K38/00 , A61K39/395 , A61K45/00 , A61K48/00 , A61P11/00 , A61P19/02 , A61P25/00 , A61P29/00 , A61P31/00 , A61P31/12 , A61P31/18 , A61P35/00 , A61P37/00 , C07K14/715 , C07K16/28 , C07K19/00 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/09 , C12P21/02 , C12P21/08 , G01N33/15 , G01N33/53 , G01N33/566 , C12N15/00 , C12N15/11 , C12N15/13
CPC分类号： C07K16/2866 , A01K2217/05 , A01K2217/075 , A61K38/00 , A61K48/00 , C07K14/7158 , C07K2319/00 , C12N2799/026
摘要： The present invention relates to a novel human protein called Human G-protein Chemokine Receptor (CCR5) HDGNR10, and isolated polynucleotides encoding this protein. The invention is also directed to human antibodies that bind Human G-protein Chemokine Receptor (CCR5) HDGNR10 and to polynucleotides encoding those antibodies. Also provided are vectors, host cells, antibodies, and recombinant methods for producing Human G-protein Chemokine Receptor (CCR5) HDGNR10 and human anti-Human G-protein Chemokine Receptor (CCR5) HDGNR10 antibodies. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating diseases, disorders, and/or conditions related to this novel human protein and these novel human antibodies.
摘要翻译：本发明涉及称为人G蛋白趋化因子受体（CCR5）HDGNR10的新型人蛋白质和编码该蛋白质的分离的多核苷酸。本发明还涉及结合人G蛋白趋化因子受体（CCR5）HDGNR10的人抗体和编码那些抗体的多核苷酸。还提供了用于生产人G蛋白趋化因子受体（CCR5）HDGNR10和人抗人G蛋白趋化因子受体（CCR5）HDGNR10抗体的载体，宿主细胞，抗体和重组方法。本发明进一步涉及用于诊断和治疗与这种新型人蛋白质和这些新型人抗体有关的疾病，病症和/或病症的诊断和治疗方法。

72. 发明申请

WO0155304A3 NUCLEIC ACIDS, PROTEINS, AND ANTIBODIES 审中-公开
公开(公告)号：WO0155304A3
公开(公告)日：2002-07-18
申请号：PCT/US0101302
申请日：2001-01-17
申请人： HUMAN GENOME SCIENCES INC , ROSEN CRAIG A , BARASH STEVEN C , RUBEN STEVEN M
发明人： ROSEN CRAIG A , BARASH STEVEN C , RUBEN STEVEN M
IPC分类号： A61K38/00 , A61K48/00 , C07K14/47 , C07K14/705 , C07K16/18 , C12N1/13 , C12N1/15 , C12N1/21 , C12N9/00 , C12N9/64 , C12N15/12 , C12N15/60 , C12Q1/68 , C07K13/00 , C07H21/04
CPC分类号： C12N9/6424 , A01K2217/05 , A61K38/00 , A61K48/00 , A61K2039/505 , C07K14/47 , C07K14/705 , C07K16/18 , C07K2319/30 , C12N9/00 , C12N9/6489 , C12Q1/6883 , G01N2500/00
摘要： The present invention relates to novel proteins. More specifically, isolated nucleic acid molecules are provided encoding novel polypeptides. Novel polypeptides and antibodies that bind to these polypeptides are provided. Also provided are vectors, host cells, and recombinant and synthetic methods for producing human polynucleotides and/or polypeptides, and antibodies. The invention further relates to diagnostic and therapeutic methods useful for diagnosing, treating, preventing and/or prognosing disorders related to these novel polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of polynucleotides and polypeptides of the invention. The present invention further relates to methods and/or compositions for inhibiting or enhancing the production and function of the polypeptides of the present invention.

73. 发明申请

WO0155311A3 NUCLEIC ACIDS, PROTEINS, AND ANTIBODIES 审中-公开
公开(公告)号：WO0155311A3
公开(公告)日：2002-07-04
申请号：PCT/US0101315
申请日：2001-01-17
申请人： HUMAN GENOME SCIENCES INC , ROSEN CRAIG A , BARASH STEVEN C , RUBEN STEVEN M
发明人： ROSEN CRAIG A , BARASH STEVEN C , RUBEN STEVEN M
IPC分类号： A61K38/00 , A61K48/00 , C07K14/47 , C07K14/705 , C07K16/18 , C12N1/13 , C12N1/15 , C12N1/21 , C12N9/00 , C12N9/64 , C12N15/12 , C12N15/60 , C12Q1/68 , C12N15/00 , C07K1/00
CPC分类号： C12N9/6424 , A01K2217/05 , A61K38/00 , A61K48/00 , A61K2039/505 , C07K14/47 , C07K14/705 , C07K16/18 , C07K2319/30 , C12N9/00 , C12N9/6489 , C12Q1/6883 , G01N2500/00
摘要： The present invention relates to novel proteins. More specifically, isolated nucleic acid molecules are provided encoding novel polypeptides. Novel polypeptides and antibodies that bind to these polypeptides are provided. Also provided are vectors, host cells, and recombinant and synthetic methods for producing human polynucleotides and/or polypeptides, and antibodies. The invention further relates to diagnostic and therapeutic methods useful for diagnosing, treating, preventing and/or prognosing disorders related to these novel polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of polynucleotides and polypeptides of the invention. The present invention further relates to methods and/or compositions for inhibiting or enhancing the production and function of the polypeptides of the present invention.

74. 发明申请

WO0053210A9 METHODS OF TREATMENT AND PREVENTION OF RESTENOSIS 审中-公开
标题翻译：治疗方法和预防保留
公开(公告)号：WO0053210A9
公开(公告)日：2002-05-23
申请号：PCT/US0006279
申请日：2000-03-13
申请人： HUMAN GENOME SCIENCES INC , LONG ISLAND JEWISH RES INST , ROSEN CRAIG A , NI JIAN , WANG MINGSHENG , SHI Y ERIC
发明人： ROSEN CRAIG A , NI JIAN , WANG MINGSHENG , SHI Y ERIC
IPC分类号： A61K38/57 , A61K48/00 , A61K38/00 , C07H21/00 , C07H21/04
CPC分类号： A61K38/57 , A61K48/00
摘要： The present invention describes methods of treating or preventing restenosis, vascular injury, and vascular disease in a subject by administering TIMP-4. The inventors have surprisingly found that TIMP-4 has an important role in the accumulation of the extracellular matrix in a vessel wall and as such facilitates the healing process of an injured vessel. Also provided by the present invention is a method of inhibiting migration of smooth muscle cells, such as vascular smooth muscle cells, by introducing to the cell an amount of TIMP-4 effective to inhibit the migration, as well as inhibiting extracellular matrix degradation of a vessel, such as an artery, vein or capillary, by introducing TIMP-4 to the vessel.
摘要翻译：本发明描述了通过施用TIMP-4治疗或预防受试者的再狭窄，血管损伤和血管疾病的方法。发明人惊奇地发现TIMP-4在血管壁中的细胞外基质的积累中具有重要作用，并且因此有助于损伤血管的愈合过程。本发明还提供了一种抑制平滑肌细胞如血管平滑肌细胞迁移的方法，通过向细胞中引入有效抑制迁移的量的TIMP-4，以及抑制细胞外基质降解血管，如动脉，静脉或毛细血管，通过将TIMP-4引入血管。

75. 发明申请

WO0226930A2 NUCLEIC ACIDS, PROTEINS, AND ANTIBODIES 审中-公开
标题翻译：核酸，蛋白质和抗体
公开(公告)号：WO0226930A2
公开(公告)日：2002-04-04
申请号：PCT/US0129838
申请日：2001-09-25
申请人： HUMAN GENOME SCIENCES INC , ROSEN CRAIG A , BIRSE CHARLES E
发明人： ROSEN CRAIG A , BIRSE CHARLES E
IPC分类号： C12N20060101 , C12N
CPC分类号： C12N1/00
摘要： The present invention relates to novel proteins. More specifically, isolated nucleic acid molecules are provided encoding novel polypeptides. Novel polypeptides and antibodies that bind to these polypeptides are provided. Also provided are vectors, host cells, and recombinant and synthetic methods for producing human polynucleotides and/or polypeptides, and antibodies. The invention further relates to diagnostic and thereapeutic methods useful for diagnosing, treating, preventing and/or prognosing disorders related to these novel polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of polynucleotides and polypeptides of the invention. The present invention further relates to methods and/or compositions for inhibiting or enhancing the production and function of the polypeptides of the present invention.
摘要翻译：本发明涉及新型蛋白质。更具体地，提供编码新型多肽的分离的核酸分子。提供结合这些多肽的新型多肽和抗体。还提供了载体，宿主细胞，以及用于产生人多核苷酸和/或多肽的抗体的重组和合成方法。本发明还涉及用于诊断，治疗，预防和/或预测与这些新型多肽相关的疾病的诊断和治疗方法。本发明还涉及用于鉴定本发明的多核苷酸和多肽的激动剂和拮抗剂的筛选方法。本发明还涉及用于抑制或增强本发明多肽的产生和功能的方法和/或组合物。

76. 发明申请

WO0066608A9 TUMOR NECROSIS FACTOR-GAMMA 审中-公开
标题翻译：肿瘤坏死因子-GAMMA
公开(公告)号：WO0066608A9
公开(公告)日：2002-03-14
申请号：PCT/US0011689
申请日：2000-04-28
申请人： HUMAN GENOME SCIENCES INC , ROSEN CRAIG A , NI JIAN , YU GUO LIANG , ZHANG JUN
发明人： ROSEN CRAIG A , NI JIAN , YU GUO-LIANG , ZHANG JUN
IPC分类号： A61K31/713 , A61K38/00 , A61K48/00 , C07K14/525 , C07H21/02 , A01N43/00 , A01N43/04 , A61K31/70 , A61K45/00 , C07H21/04 , C07K1/00 , C07K14/00 , C07K17/00 , C12N15/00 , C12N15/09 , C12N15/63 , C12N15/70 , C12N15/74 , C12P21/02
CPC分类号： A61K31/713 , A61K38/00 , A61K48/00 , C07K14/525
摘要： Human TNF-gamma-alpha and TNF-gamma-beta polypeptides and DNA (RNA) encoding such polypeptides and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptides to inhibit cellular growth, for example in a tumor or cancer, for facilitating wound-healing, to provide resistance against infection, induce inflammatory activities, and stimulating the growth of certain cell types to treat diseases, for example restenosis. Also disclosed are diagnostic methods for detecting a mutation in the TNF-gamma-alpha and TNF-gamma-beta nucleic acid sequences or overexpression of the TNF-gamma-alpha and TNF-gamma-beta polypeptides. Antagonists against such polypeptides and their use as a therapeutic to treat cachexia, septic shock, cerebral malaria, inflammation, arthritis and graft-rejection are also disclosed.
摘要翻译：公开了人TNF-γ-α和TNF-γ-β多肽和编码这种多肽的DNA（RNA）以及通过重组技术产生这种多肽的方法。还公开了利用这些多肽抑制细胞生长的方法，例如在肿瘤或癌症中，用于促进伤口愈合，提供抗感染，诱导炎症活性和刺激某些细胞类型的生长以治疗疾病，示例再狭窄。还公开了用于检测TNF-γ-α和TNF-γ-β核酸序列中的突变或TNF-γ-α和TNF-γ-β多肽的过表达的诊断方法。还公开了抗这些多肽的拮抗剂及其作为治疗性恶病质，败血性休克，脑疟疾，炎症，关节炎和移植排斥的治疗剂的用途。

77. 发明申请

WO0218620A2 NEUTROKINE-ALPHA AND NEUTROKINE-ALPHA SPLICE VARIANT 审中-公开
标题翻译： NEUTROKINE-ALPHA和NEUTROKINE-ALPHA SPLICE变体
公开(公告)号：WO0218620A2
公开(公告)日：2002-03-07
申请号：PCT/US0125549
申请日：2001-08-15
申请人： HUMAN GENOME SCIENCES INC , YU GUO LIANG , EBNER REINHARD , NI JIAN , ROSEN CRAIG A , ULLRICH STEPHEN
发明人： YU GUO-LIANG , EBNER REINHARD , NI JIAN , ROSEN CRAIG A , ULLRICH STEPHEN
IPC分类号： A61K47/48 , A61K49/00 , C07K14/52 , C07K16/24 , C12N15/12 , C12N15/13 , G01N33/564 , C12Q
CPC分类号： C07K14/52 , A61K47/6849 , A61K49/0004 , C07K16/24 , C07K2317/21 , C07K2317/622 , G01N33/564
摘要： The present invention relates to nucleic acid molecules encoding Neutrokine-alpha and/or Neutrokine-alphaSV polypeptides, including soluble forms of the extracellular domain. Neutrokine-alpha and/or Neutrokine-alphaSV polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to antibodies or portions thereof that specifically bind Neutrokine-alpha and/or Neutrokine-alphaSV and diagnostic and therapeutic methods using these antibodies. Also provided are diagnostic methods for detecting immune system-related disorders and therapeutic methods for treating immune system-related disorders using the compositions of the invention.
摘要翻译：本发明涉及编码Neutrokine-α和/或Neutrokine-αSV多肽的核酸分子，包括细胞外结构域的可溶形式。还提供了中和型α和/或中枢神经素αSV多肽，载体，宿主细胞和用于制备它们的重组方法。本发明进一步涉及使用这些抗体特异性结合中枢神经素α和/或中枢神经素-αSV的诊断和治疗方法的抗体或其部分。还提供了用于检测免疫系统相关疾病的诊断方法和使用本发明的组合物治疗免疫系统相关疾病的治疗方法。

78. 发明申请

WO0179258A9 ALBUMIN FUSION PROTEINS 审中-公开
公开(公告)号：WO0179258A9
公开(公告)日：2002-02-28
申请号：PCT/US0112008
申请日：2001-04-12
申请人： HUMAN GENOME SCIENCES INC , PRINCIPIA PHARMACEUTICAL CORP , ROSEN CRAIG A , SADEGHI HOMAYOUN , PRIOR CHRISTOPHER P , TURNER ANDREW JOHN
发明人： ROSEN CRAIG A , SADEGHI HOMAYOUN , PRIOR CHRISTOPHER P , TURNER ANDREW JOHN
IPC分类号： C12N15/09 , A61K35/12 , A61K35/76 , A61K38/00 , A61K38/21 , A61K38/22 , A61K38/23 , A61K38/27 , A61K38/28 , A61K38/43 , A61K38/46 , A61K38/48 , A61K38/55 , A61K39/395 , A61K47/48 , A61K48/00 , A61P1/00 , A61P1/04 , A61P1/16 , A61P1/18 , A61P3/10 , A61P3/14 , A61P5/00 , A61P5/10 , A61P5/14 , A61P5/40 , A61P7/00 , A61P7/04 , A61P7/06 , A61P9/00 , A61P9/06 , A61P9/10 , A61P9/12 , A61P11/00 , A61P11/06 , A61P13/00 , A61P13/02 , A61P13/08 , A61P13/12 , A61P15/00 , A61P15/08 , A61P15/10 , A61P15/18 , A61P17/00 , A61P17/02 , A61P17/06 , A61P17/12 , A61P17/14 , A61P19/00 , A61P19/02 , A61P19/08 , A61P19/10 , A61P21/00 , A61P21/04 , A61P25/00 , A61P25/02 , A61P25/08 , A61P25/16 , A61P25/28 , A61P27/02 , A61P29/00 , A61P31/00 , A61P31/12 , A61P31/14 , A61P31/16 , A61P31/18 , A61P31/20 , A61P31/22 , A61P33/02 , A61P33/06 , A61P33/12 , A61P35/00 , A61P35/02 , A61P35/04 , A61P37/00 , A61P37/02 , A61P37/04 , A61P37/06 , A61P37/08 , A61P39/02 , A61P41/00 , A61P43/00 , C07K14/47 , C07K14/55 , C07K14/56 , C07K14/565 , C07K14/585 , C07K14/60 , C07K14/61 , C07K14/62 , C07K14/635 , C07K14/65 , C07K14/705 , C07K14/715 , C07K14/745 , C07K14/75 , C07K14/76 , C07K14/765 , C07K14/81 , C07K16/00 , C07K19/00 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/02 , C12N5/10 , C12N9/14 , C12N9/74 , C12N9/99 , C12N15/62 , C07K1/00 , A01N37/18
CPC分类号： A61K38/4846 , A01K2217/05 , A61K9/0019 , A61K38/21 , A61K38/212 , A61K38/38 , A61K47/42 , A61K47/65 , A61K48/00 , A61K2039/54 , C07K14/56 , C07K14/61 , C07K14/62 , C07K14/65 , C07K14/705 , C07K14/7151 , C07K14/76 , C07K14/765 , C07K2319/00 , C07K2319/21 , C07K2319/31 , C07K2319/50 , C07K2319/75 , C12N9/96 , C12N15/62
摘要： The present invention encompasses albumin fusion proteins. Nucleic acid molecules encoding the albumin fusion proteins of the invention are also encompassed by the invention, as are vectors containing these nucleic acids, host cells transformed with these nucleic acids vectors, and methods of making the albumin fusion proteins of the invention and using these nucleic acids, vectors, and/or host cells. Additionally the present invention encompasses pharmaceutical compositions comprising albumin fusion proteins and methods of treating, preventing, or ameliorating diseases, disorders or conditions using albumin fusion proteins of the invention.

79. 发明申请

WO0123409A8 38 HUMAN SECRETED PROTEINS 审中-公开
标题翻译： 38人类分泌蛋白
公开(公告)号：WO0123409A8
公开(公告)日：2002-01-24
申请号：PCT/US0026371
申请日：2000-09-26
申请人： HUMAN GENOME SCIENCES INC , ROSEN CRAIG A , RUBEN STEVEN M , KOMATSOULIS GEORGE A
发明人： ROSEN CRAIG A , RUBEN STEVEN M , KOMATSOULIS GEORGE A
IPC分类号： G01N33/50 , A61K31/7088 , A61K38/00 , A61K48/00 , A61P31/00 , A61P37/04 , C07K14/47 , C07K16/18 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/09 , C12P21/02 , C12Q1/02 , C12Q1/68 , G01N33/15 , A01K31/70 , A01N43/04 , C07K14/00 , C07K16/00 , G01N33/566
CPC分类号： C07K14/47 , A61K38/00
摘要： Cette invention se rapporte à de nouvelles protéines sécrétées humaines et à des acides nucléiques isolés contenant les régions codantes des gènes codant ces protéines. Cette invention concerne également des vecteurs, des cellules hôtes et des anticorps et des procédés de recombinaison visant à produire des protéines sécrétées humaines. Cette invention concerne en outre des procédés diagnostiques et thérapeutiques servant à diagnostiquer et à traiter des maladies, des troubles et/ou des états associés à ces nouvelles protéines sécrétées humaines.

80. 发明申请

WO0155300A3 NUCLEIC ACIDS, PROTEINS, AND ANTIBODIES 审中-公开
标题翻译：核酸，蛋白质和抗体
公开(公告)号：WO0155300A3
公开(公告)日：2002-01-03
申请号：PCT/US0101238
申请日：2001-01-17
申请人： HUMAN GENOME SCIENCES INC , ROSEN CRAIG A , BARASH STEVEN C , RUBEN STEVEN M
发明人： ROSEN CRAIG A , BARASH STEVEN C , RUBEN STEVEN M
IPC分类号： C07K14/47 , C12N15/11
CPC分类号： C07K14/47
摘要： The present invention relates to novel lung cancer related polynucleotides and the polypeptides encoded by these polynucleotides herein collectively known as "lung cancer antigens", and the use of such lung cancer antigens for detecting disorders of the lung, particularly the presence of lung cancer and lung cancer metastases. More specifically, isolated lung cancer associated nucleic acid molecules are provided encoding novel lung cancer associated polypeptides. Novel lung cancer polypeptides and antibodies that bind to these polypeptides are provided. Also provided are vectors, host cells, and recombinant and synthetic methods for producing human lung cancer associated polynucleotides and/or polypeptides. The invention further relates to diagnostic and therapeutic methods useful for diagnosing, treating, preventing and/or prognosing disorders related to the lung, including lung cancer, and therapeutic methods for treating such disorders. The invention further relates to screening methods for identifying agonists and antagonists of polynucleotides and polypeptides of the invention. The present invention further relates to methods and/or compositions for inhibiting the production and function of the polypeptides of the present invention.
摘要翻译：本发明涉及新的肺癌相关多核苷酸和由这些多核苷酸编码的多肽本文统称为“肺癌抗原”，以及使用这种肺癌抗原来检测肺部疾病，特别是肺癌和肺癌的存在癌症转移。更具体地，提供分离的肺癌相关核酸分子，其编码新的肺癌相关多肽。提供了与这些多肽结合的新型肺癌多肽和抗体。还提供载体，宿主细胞，以及用于产生人肺癌相关多核苷酸和/或多肽的重组和合成方法。本发明还涉及用于诊断，治疗，预防和/或预后与肺相关的疾病（包括肺癌）和治疗这些疾病的治疗方法的诊断和治疗方法。本发明还涉及用于鉴定本发明的多核苷酸和多肽的激动剂和拮抗剂的筛选方法。本发明还涉及用于抑制本发明多肽的产生和功能的方法和/或组合物。

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