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    • 77. 发明申请
    • SELECTIVE SERINE/THREONINE KINASE INHIBITORS
    • 选择性丝氨酸/苏氨酸激酶抑制剂
    • WO2007038613A2
    • 2007-04-05
    • PCT/US2006/037699
    • 2006-09-26
    • THE REGENTS OF THE UNIVERSITY OF CALIFORNIATAUNTON, JackCOHEN, MichaelSHOKAT, KevanZHANG, Chao
    • TAUNTON, JackCOHEN, MichaelSHOKAT, KevanZHANG, Chao
    • A61K31/519
    • C07D487/04C07D239/42C07D403/06C07D487/14C07D519/00
    • Inhibition of protein kinases having one or more cysteine residues within the ATP binding site is effected by contacting the kinase, per se or in a cell or subject, with an inhibitory-effective amount of a compound having a heterocyclic core structure comprised of two or more fused rings containing at least one nitrogen ring atom, and an electrophilic substituent that is capable of reacting with a cysteine residue within the ATP binding site of a kinase. Preferred compounds include certain pyrrolopyrimidines and oxindoles having such an electrophilic substituent and optionally an aromatic or heteroaromatic substituent that is capable of interacting with a threonine or smaller residue located in the gatekeeper position of the kinase. Kinases lacking such cysteine residues may be engineered or modified so that they are capable of being inhibited by such compounds by replacing a valine or other amino acid residue within the ATP binding site by a cysteine residue.
    • 在ATP结合位点内具有一个或多个半胱氨酸残基的蛋白激酶的抑制通过使激酶本身或在细胞或受试者中与抑制有效量的具有 由两个或更多个含有至少一个氮环原子的稠环组成的杂环核心结构和能够与激酶的ATP结合位点内的半胱氨酸残基反应的亲电子取代基。 优选的化合物包括某些具有这种亲电子取代基的吡咯并嘧啶和羟吲哚,以及任选的芳族或杂芳族取代基,其能够与位于激酶的守门位置的苏氨酸或更小的残基相互作用。 缺乏这种半胱氨酸残基的激酶可以被改造或修饰,使得它们能够通过用半胱氨酸残基替换ATP结合位点内的缬氨酸或其他氨基酸残基而被这些化合物抑制。
    • 79. 发明申请
    • SYSTEMS AND METHODS FOR ASSIGNING TASKS TO DERIVED TIMERS OF VARIOUS RESOLUTIONS IN REAL-TIME SYSTEMS TO MAXIMIZE TIMER USAGE
    • 用于将任务分配给实时系统中各种分辨率的定时器的系统和方法,以最大限度地延长定时器的使用
    • WO2006026577A2
    • 2006-03-09
    • PCT/US2005/030731
    • 2005-08-31
    • EMC CORPORATIONZHANG, Chao
    • ZHANG, Chao
    • G06F9/46
    • G06F9/4881
    • One or more derived timers based on a source timer are provided to accommodate a plurality of periodic tasks while maintaining the high resolution of the source timer. To accommodate a number of periodic tasks, a number of derived timers can be selected utilizing a novel method based on the number of periodic tasks that are most time-critical, the number of tasks that are less time-critical, and the number of tasks that can be performed during the source timer interval. The interval and start time for each derived timer is selected based the source timer and number of the derived timer. After establishing the derived timers, the most time-critical tasks can be assigned to the source timer and the less time-critical tasks arranged amongst the derived timers.
    • 提供基于源定时器的一个或多个导出定时器,以适应多个周期性任务,同时保持源定时器的高分辨率。 为了适应许多周期性任务,可以使用基于最时间关键的周期性任务的数量,较少时间关键的任务数量和任务数量的新颖方法来选择多个派生定时器 可以在源定时器间隔期间执行。 每个导出定时器的间隔和开始时间是根据源定时器和导出的定时器的数量来选择的。 在建立派生的定时器之后,可以将最时间关键的任务分配给源定时器,并在派生的定时器之间布置更少的时间关键任务。