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71. 发明申请

WO1997012982A1 DNA SEQUENCES CODING FOR A CINNAMOYL CoA REDUCTASE, AND APPLICATIONS THEREOF IN THE CONTROL OF LIGNIN CONTENTS IN PLANTS 审中-公开
标题翻译： CINNAMOYL CoA还原酶的DNA序列编码及其在植物控制中的应用
公开(公告)号：WO1997012982A1
公开(公告)日：1997-04-10
申请号：PCT/FR1996001544
申请日：1996-10-03
申请人： CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE , INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE , BOUDET, Alain-Michel , PICHON, Magalie , GRIMA-PETTENATI, Jacqueline , BECKERT, Michel , GAMAS, Pascal , BRIAT, Jean-François
发明人： CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE , INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE
IPC分类号： C12N15/53
CPC分类号： C12N9/0008 , C12N15/8255
摘要： The present invention relates to any DNA sequence comprising as a coding region all or part of the nucleotidic sequence coding for a mRNA coding coding for a cinnamoyl CoA reductase (CCR) in lucern and/or corn, or all or part of the nucleotide sequence complementary of the latter and coding for an antisense mRNA susceptible of hybridizing with said mRNA. The invention also relates to the use of said sequences for implementing processes for the regulation of lignin biosynthesis in plants.
摘要翻译：本发明涉及包含编码区的全部或部分编码在编码赖氨酸和/或玉米中的肉桂酰辅酶A还原酶（CCR）的mRNA编码的核苷酸序列的全部或部分，或全部或部分互补的核苷酸序列并编码易于与所述mRNA杂交的反义mRNA。本发明还涉及所述序列用于实施植物中木质素生物合成调节方法的用途。

72. 发明申请

WO1997008988A1 ELECTROPHYSIOLOGICAL DEVICE 审中-公开
标题翻译：电生理装置
公开(公告)号：WO1997008988A1
公开(公告)日：1997-03-13
申请号：PCT/FR1996001351
申请日：1996-09-04
申请人： CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE , RIPOCHE, André , BAUDONNIERE, Pierre-Marie
发明人： CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
IPC分类号： A61B05/04
CPC分类号： A61B5/04004 , A61B5/0428
摘要： A sensor equipment (1) to be fitted to a subject has a set of electrodes (2-4) for detecting electromagnetic signals and delivering them as output signals to processing means (6) for shaping said signals prior to the storage thereof. The set of electrodes includes working electrodes having one or more acquisition electrodes (3) as well as a secondary electrode (4) to be connected to the processing means as a floating mass. The output of at least each working electrode is provided with an impedance adapter means (AO2, AO3). The device further comprises a common power supply (10) for said impedance adapter means, as well as a circuit (14) for maintaining an intermediate electric potential, connected to said supply (10), at the electric potential of the secondary electrode (E4).
摘要翻译：要安装到被摄体的传感器设备（1）具有用于检测电磁信号的一组电极（2-4），并将它们作为输出信号传送到处理装置（6），用于在存储之前对所述信号进行整形。电极组包括具有一个或多个采集电极（3）的工作电极以及作为浮动质量块连接到处理装置的次级电极（4）。至少每个工作电极的输出端设有阻抗适配器装置（AO2，AO3）。该装置还包括用于所述阻抗适配器装置的公共电源（10），以及用于在辅助电极（E4）的电位处连接到所述电源（10）的用于维持中间电位的电路（14））。

73. 发明申请

WO1997006119A1 PROCESS FOR PRODUCING DENSE PRODUCTS BASED ON SILICON CARBIDE, AND COMPOSITE PRODUCTS THUS OBTAINED 审中-公开
标题翻译：基于碳化硅生产密封产品的方法和获得的复合产品
公开(公告)号：WO1997006119A1
公开(公告)日：1997-02-20
申请号：PCT/FR1996001219
申请日：1996-08-01
申请人： CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE , CENTRE DE RECHERCHES DE L'INDUSTRIE BELGE DE LA CERAMIQUE , LIHRMANN, Jean-Marc , TIRLOCQ, Jacques
发明人： CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE , CENTRE DE RECHERCHES DE L'INDUSTRIE BELGE DE LA CERAMIQUE
IPC分类号： C04B35/575
CPC分类号： C04B35/565 , C04B35/575
摘要： The invention relates to a process for the fabrication of dense ceramic products based on silicon carbide, wherein a mixture of powders of SiC, Al3C4, AlN and Al2O3 is sintered with or without pressure by continuously raising the temperature with or without isothermal stage. During sintering, the densification is reached at a maximal temperature of 2020 DEG C, preferably a maximum temperature lower than or equal to 1950 DEG C. The composite ceramic product thus obtained has an original biphased structure which is comprised of a first SiC phase and a second cristalline phase consisting of a solid solution of AlN and Al2OC, the two phases being perfectly structurally compatible. The resulting ceramic products are usable particularly as thermomechanical ceramics or as binding phase for refractory material.
摘要翻译：本发明涉及一种用于制造基于碳化硅的致密陶瓷产品的方法，其中通过在有或无等温阶段连续升高温度，在有或没有压力下烧结SiC，Al 3 C 4，AlN和Al 2 O 3的粉末的混合物。在烧结期间，在2020℃的最高温度，优选最低温度低于或等于1950℃达到致密化。由此获得的复合陶瓷产品具有原始的双相结构，其由第一SiC相和第二结晶相由AlN和Al2OC的固溶体组成，两相完全结构相容。得到的陶瓷产品可以特别用作热机械陶瓷或作为耐火材料的结合相。

74. 发明申请

WO1997004335A1 TRANSPARENT POSITION-SENSITIVE PARTICLE DETECTOR 审中-公开
标题翻译：透明位置敏感颗粒检测器
公开(公告)号：WO1997004335A1
公开(公告)日：1997-02-06
申请号：PCT/FR1996001100
申请日：1996-07-16
申请人： CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE , BLAVETTE, Didier, Christian, Adrien , BOSTEL, Alain , DECONIHOUT, Bernard
发明人： CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
IPC分类号： G01T01/28
CPC分类号： H01J37/244 , G01T1/28 , H01J49/025 , H01J2237/24435
摘要： A particle detector including electron multiplying means (14) generating a spray of electrons in response to the impact of each particle (2), a layer (6) extending through said spray and interacting therewith to emit a light pulse, and transparent electron detecting means (8) for determining the moment of impact of the particle and producing data on the impact positions for each determined moment, whereby said positions may be determined and correlated with the moments determined by the detecting means. Said detector may be used in atomic probes.
摘要翻译：一种颗粒检测器，包括响应于每个颗粒（2）的冲击产生电子喷射的电子倍增装置（14），延伸穿过所述喷雾并与其相互作用以发射光脉冲的层（6）和透明电子检测装置（8），用于确定颗粒的冲击力矩并产生每个确定力矩的冲击位置数据，由此可以确定所述位置并与由检测装置确定的力矩相关联。所述检测器可用于原子探针。

75. 发明申请

WO1997004093A1 NUCLEOTIDE AND PEPTIDE SEQUENCES FOR TREATING MYASTHENIA 审中-公开
标题翻译：用于治疗MYASTHENIA的核苷酸和肽段序列
公开(公告)号：WO1997004093A1
公开(公告)日：1997-02-06
申请号：PCT/FR1996001131
申请日：1996-07-18
申请人： CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE , COHEN-KAMINSKY, Sylvia , BERRIH-AKNIN, Sonia
发明人： CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
IPC分类号： C12N15/12
CPC分类号： C07K16/2809 , A61K39/00 , A61K2039/51 , C07K14/7051
摘要： The use of nucleotide or peptide sequences for preparing drugs suitable for treating or preventing acquired auto-immune myasthenia is disclosed. Said nucleotide sequences are selected from sequences capable of coding for a peptide sequence that is in turn capable of causing the formation of antibodies that recognise and form an immunological complex with all or part of the amino acid sequence of human T cell receptor segment V beta 5.1; or sequences capable of coding for a peptide sequence that itself represents an antibody capable of recognising and forming an immunological complex with all or part of the amino acid sequence of said segment V beta 5.1; sequences capable of coding for an anti-sense RNA that is in turn capable of hybridising with all or part of the mRNA coded for by the DNA sequence coding for the amino acid sequence of said segment V beta 5.1; or sequences capable of hybridising with all or part of the DNA sequence coding for the amino acid sequence of said segment V beta 5.1, or with all or part of the mRNA coded for by said DNA sequence. Said peptide sequences are selected from sequences capable of causing the formation of antibodies that recognise and form an immunological complex with human T cell receptor segment V beta 5.1; or sequences corresponding to antibodies capable of recognising and forming an immunological complex with all or part of the amino acid sequence of T cell receptor segment V beta 5.1.
摘要翻译：公开了使用核苷酸或肽序列制备适于治疗或预防所获得的自身免疫性重症肌无力的药物。所述核苷酸序列选自能够编码肽序列的序列，所述肽序列又能够导致形成识别并与人T细胞受体区段Vβ15.1的全部或部分氨基酸序列形成免疫复合物的抗体 ; 或能够编码肽序列的序列，其本身表示能够识别并与所述片段Vβ15.1的全部或部分氨基酸序列形成免疫复合物的抗体; 能够编码反义RNA的序列，其又能够与编码所述片段Vβ15.1的氨基酸序列的DNA序列编码的全部或部分mRNA杂交; 或能够与编码所述区段V beta 5.1的氨基酸序列的全部或部分DNA序列杂交的序列，或与所述DNA序列编码的全部或部分mRNA相互杂交的序列。所述肽序列选自能够形成识别并与人T细胞受体区段Vβ15.1形成免疫复合物的抗体的序列; 或对应于能够识别T细胞受体区段V beta 5.1的全部或部分氨基酸序列的免疫复合物的抗体的序列。

76. 发明申请

WO1996022993A1 POLYMERISABLE OR POLYCONDENSABLE PHOSPHINE OXIDE, POLYMERS OBTAINED THEREFROM, AND USE THEREOF IN NON-LINEAR OPTICS AND ELECTRO-OPTICS 审中-公开
标题翻译：可聚合或多环氧磷氧化物，其获得的聚合物及其在非线性光学和电光学领域的应用
公开(公告)号：WO1996022993A1
公开(公告)日：1996-08-01
申请号：PCT/FR1996000107
申请日：1996-01-23
申请人： COMMISSARIAT A L'ENERGIE ATOMIQUE , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE , LEQUAN, Minh , CHANE CHING, Kathleen , KAJZAR, François
发明人： COMMISSARIAT A L'ENERGIE ATOMIQUE , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
IPC分类号： C07F09/53
CPC分类号： G02F1/3611 , C07F9/5325 , C07F9/650952 , C07F9/6552 , C08F30/02
摘要： Polymerisable or polycondensable phosphine oxides of formula (I), wherein R and R are aryl groups, R is N or CH and R and R are hydrocarbon groups optionally forming a heterocyclic ring and comprising an ethylenically unsaturated group or hydroxyl groups. Said phosphine oxides may be polymerised or polycondensed to form an optically active polymer for use in non-linear optics and electro-optics.
摘要翻译：式（I）的可聚合或可缩聚的氧化膦，其中R 1和R 2为芳基，R 3为N或CH，R 4和R 5为任选形成杂环的烃基并且包含烯键式不饱和基团或羟基。所述膦氧化物可以聚合或缩聚以形成用于非线性光学和电光学的旋光聚合物。

77. 发明申请

WO1996017373A1 IONISING RADIATION DETECTOR HAVING PROPORTIONAL MICROCOUNTERS 审中-公开
标题翻译：具有比例微球的离子辐射检测器
公开(公告)号：WO1996017373A1
公开(公告)日：1996-06-06
申请号：PCT/FR1995001548
申请日：1995-11-23
申请人： CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE , LEMONNIER, Marc , BUCAILLE, Thierry, Claude , CHARLET, Joël, Robert , BORDESSOULE, Michel , BARTOL, François , MEGTERT, Stephan
发明人： CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
IPC分类号： H01J47/06
CPC分类号： H01J47/06
摘要： An ionising radiation detector comprising a chamber (1) filled with a noble gas and provided with an internal proportional counter (2) defining, between itself and an upper wall of the chamber, an absorption region (A) in which the radiation is ionised. The proportional counter comprises at least one anode (6) and at least one cathode (5) that are parallel to one another and separated by a layer of insulating material (7). Both the cathode and the layer of insulating material include at least one through-hole (8) in which a substantially uniform electric field is provided to form a region where electrons produced by the ionisation of the radiation are multiplied. Said detector is useful in medical imaging, biology, crystallography and particle physics.
摘要翻译：一种电离辐射检测器，包括填充有惰性气体并设置有内部比例计数器（2）的室（1），所述内部比例计数器（2）在其与腔室的上壁之间限定辐射被电离的吸收区域（A）。比例计数器包括至少一个阳极（6）和至少一个阴极（5），它们彼此平行并且被绝缘材料层（7）隔开。阴极和绝缘材料层都包括至少一个通孔（8），其中提供基本均匀的电场以形成通过辐射的电离产生的电子相乘的区域。所述检测器可用于医学成像，生物学，晶体学和粒子物理学。

78. 发明申请

WO1995031927A1 DEVICE FOR CONTROLLING EYE MOVEMENT 审中-公开
标题翻译：用于控制眼睛运动的装置
公开(公告)号：WO1995031927A1
公开(公告)日：1995-11-30
申请号：PCT/FR1995000627
申请日：1995-05-15
申请人： CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE , JOUEN, François , BAUDONNIERE, Pierre-Marie
发明人： CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
IPC分类号： A61B03/113
CPC分类号： A61B3/113
摘要： A support (12) for a living being, controllably movable in three directions, defines an area (29-I) for the eyes (30-I). A frame (1) comprises two light sources (14), supplying, at the level of the area (29-I) for the eyes (30-I), two infrared light beams (37-I), two cameras (13-I), each for capturing an image derived from the reflection of said light beam (37-I) on an eye (30-I) and processing means for digitalizing the eye images and processing them in real time to calculate the center coordinates of the corneal point (42-I) with reference to the pupil center (41-I). The processing means further control the movement of the support (12) to position the eyes (30-I) precisely in the axis of the cameras (13-I), according to the coordinates of the pupil contour. A mass memory in the microcomputer (2) stores the data relating to a plurality of basic visual tests comprising a selected sequence of visual stimulation images. The response of the eyes to an image provides a gaze direction which is analyzed by processing means.
摘要翻译：用于生物体的支撑件（12）可在三个方向上可控地移动，限定了眼睛（30-I）的区域（29-I）。框架（1）包括两个光源（14），在眼睛（30-I）的区域（29-I）的水平处提供两个红外光束（37-I），两个照相机 I），每个用于捕获从眼睛（30-I）上的所述光束（37-I）的反射导出的图像和用于数字化眼睛图像并且实时处理它们的处理装置，以计算中心坐标参照瞳孔中心（41-I）的角膜点（42-I）。处理装置还根据瞳孔轮廓的坐标进一步控制支撑件（12）的移动以将眼睛（30-I）精确地定位在照相机（13-I）的轴线上。微型计算机（2）中的大容量存储器存储与包括所选择的视觉刺激图像序列的多个基本视觉测试有关的数据。眼睛对图像的响应提供了通过处理手段分析的注视方向。

79. 发明申请

WO1995008110A1 ENZYME IMMUNOASSAY METHOD, METHOD FOR ENZYME IMMUNOASSAYING AN ANTIGEN USING A MODIFIED ELECTRODE AND ASSAY KIT 审中-公开
标题翻译：酶免疫方法，使用改性电极和测定试剂盒免疫抗原的酶的方法
公开(公告)号：WO1995008110A1
公开(公告)日：1995-03-23
申请号：PCT/FR1994001082
申请日：1994-09-15
申请人： CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE , DEGRAND, Chantal , LIMOGES, Benoît , LEGAL LASALLE, Annie , RAPICAULT, Stéphane , BROSSIER, Pierre
发明人： CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
IPC分类号： G01N27/327
CPC分类号： C12Q1/42 , C12Q1/004 , G01N33/581
摘要： Enzyme immunoassay method, method for enzyme immunoassaying an antigen by electrochemical detection, and assay kit used. The object of the invention is to develop assay methods, in which the detection sensitivity of the product formed during the enzymatic reaction is increased. The object is attained using a method consisting in reacting an enzyme (E) with a substrate (S), collecting the ionic or pro-ionic electroactive product obtained at the end of the enzymatic reaction on an electrode (3) with a polyionic compound (1) of opposite charge and measuring the signal produced by said electrode (3).
摘要翻译：酶免疫测定方法，通过电化学检测酶免疫测定抗原的方法和使用的测定试剂盒。本发明的目的是开发测定方法，其中在酶促反应期间形成的产物的检测灵敏度增加。目的是使用包括使酶（E）与底物（S）反应的方法，将在酶反应结束时获得的离子或前离子电活性产物收集在具有聚离子化合物的电极（3）上的方法 1），并测量由所述电极（3）产生的信号。

80. 发明申请

WO1994026100A1 GENETICALLY ENGINEERED MICE CONTAINING ALTERATIONS IN THE GENES ENCODING RETINOIC ACID RECEPTOR PROTEINS 审中-公开
标题翻译：在基因中编码重要酸性受体蛋白质的遗传工程化小鼠
公开(公告)号：WO1994026100A1
公开(公告)日：1994-11-24
申请号：PCT/US1994005746
申请日：1994-05-18
申请人： INSTITUTE NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE , UNIVERSITE LOUIS PASTEUR, STRASBOURG I , E.R. SQUIBBS & SONS, INC. , MENDELSOHN, Cathy , CHAMBON, Pierre , LUFKIN, Thomas , LOHNES, David , MARK, Manuel , DIERICH, Andrée , GORRY, Philippe , KASTNER, Philippe , LEMEUR, Marianne
发明人： INSTITUTE NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE , UNIVERSITE LOUIS PASTEUR, STRASBOURG I , E.R. SQUIBBS & SONS, INC.
IPC分类号： A01K67/00
CPC分类号： C12N15/8509 , A01K67/0276 , A01K2217/05 , A01K2217/075 , A01K2267/03 , C07K14/70567
摘要： The present invention provides mice which are deficient in the normal expression of one or more members of the RAR or RXR class of receptors, to mice heterozygous for such deficiency, and to cell lines, preferably pluripotent or totipotent cell lines, which are heterozygous or homozygous for such deficiency. The present invention further provides the use of any of the above mice and cell lines in situations where the absence of at least one RAR or RXR receptors, or the normal expression thereof, is desirable.
摘要翻译：本发明提供缺乏RAR或RXR类受体的一种或多种成员的正常表达的小鼠，对于这种缺陷杂合的小鼠以及杂合或纯合的细胞系，优选多能或全能细胞系的小鼠对于这种缺陷。在不需要至少一种RAR或RXR受体或其正常表达的情况下，本发明进一步提供了上述任何一种小鼠和细胞系的用途。

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