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71. 发明申请

WO2005071407A3 METHODS OF DIAGNOSING ACUTE CORONARY SYNDROME BY MEASURING UROTENSIN II 审中-公开
公开(公告)号：WO2005071407A3
公开(公告)日：2005-08-04
申请号：PCT/GB2005/000182
申请日：2005-01-19
申请人： INVERNESS MEDICAL SWITZERLAND GMBH , NG, Leong
发明人： NG, Leong
IPC分类号： G01N33/68
摘要： The present invention provides a method for screening, diagnosis or prognosis of acute coronary syndrome (ACS) in a mammalian subject, for determining the stage or severity of ACS in a mammalian subject, for identifying a mammalian subject at risk of developing ACS, or for monitoring the effect of therapy administered to a mammalian subject having ACS. The method comprises measuring the level of Urotensin II (UTN) in a sample of bodily fluid from the mammalian subject. The invention also provides a kit, immunoassay or device for carrying out the method.

72. 发明申请

WO2005071407A2 METHODS OF DIAGNOSING ACUTE CORONARY SYNDROME BY MEASURING UROTENSIN II 审中-公开
标题翻译：通过测量UROTENSIN II诊断急性冠状动脉综合征的方法II
公开(公告)号：WO2005071407A2
公开(公告)日：2005-08-04
申请号：PCT/GB2005000182
申请日：2005-01-19
申请人： INVERNESS MEDICAL SWITZERLAND , NG LEONG
发明人： NG LEONG
IPC分类号： G01N33/68 , G01N33/53
CPC分类号： G01N33/6893 , G01N2800/32 , G01N2800/324
摘要： The present invention provides a method for screening, diagnosis or prognosis of acute coronary syndrome (ACS) in a mammalian subject, for determining the stage or severity of ACS in a mammalian subject, for identifying a mammalian subject at risk of developing ACS, or for monitoring the effect of therapy administered to a mammalian subject having ACS. The method comprises measuring the level of Urotensin II (UTN) in a sample of bodily fluid from the mammalian subject. The invention also provides a kit, immunoassay or device for carrying out the method.
摘要翻译：本发明提供了用于确定哺乳动物受试者中ACS的阶段或严重程度的哺乳动物受试者的急性冠脉综合征（ACS）的筛选，诊断或预后的方法，用于鉴定具有发展ACS风险的哺乳动物受试者，或用于监测施用于具有ACS的哺乳动物受试者的治疗效果。该方法包括测量来自哺乳动物受试者的体液样品中的促肾上腺素II（UTN）的水平。本发明还提供了用于实施该方法的试剂盒，免疫测定或装置。

73. 发明申请

WO2005058500A1 SYSTEM 审中-公开
标题翻译：系统
公开(公告)号：WO2005058500A1
公开(公告)日：2005-06-30
申请号：PCT/GB2004/005334
申请日：2004-12-17
申请人： INVERNESS MEDICAL SWITZERLAND GMBH , BURNELL, Simon , MANNEH, Victor
发明人： BURNELL, Simon , MANNEH, Victor
IPC分类号： B01L3/00
CPC分类号： G01N1/34 , B01L3/502746 , B01L3/502753 , B01L2200/0647 , B01L2300/0681 , B01L2300/0816 , B01L2400/0406 , B01L2400/0487 , B01L2400/086 , G01N2015/0073
摘要： A microfluidic separation system (1) for separating fluid sample medium from cells provided in a sample, for example, a sample of bodily fluid which is to be subjected to further analysis. The system may include a microfluidic structure (2) and a cell aggregation agent. The microfluidic structure may include one or more microfluidic channels (3, 4, 5) operable to separate aggregated cells from fluid sample medium by size exclusion.
摘要翻译：一种微流体分离系统（1），用于从样品中提供的细胞中分离流体样品介质，例如待进一步分析的体液样品。该系统可以包括微流体结构（2）和细胞聚集剂。微流体结构可以包括一个或多个微流体通道（3,4,5），其可操作以通过尺寸排除将聚集的细胞与流体样品介质分离。

74. 发明申请

WO2005043156A1 COAGULATION DETECTION 审中-公开
标题翻译：凝血检测
公开(公告)号：WO2005043156A1
公开(公告)日：2005-05-12
申请号：PCT/GB2004/004462
申请日：2004-10-21
申请人： INVERNESS MEDICAL SWITZERLAND GMBH , DAVIES, Robert, John , HOWELL, Steven , WILLIAMS, David, Edward
发明人： DAVIES, Robert, John , HOWELL, Steven , WILLIAMS, David, Edward
IPC分类号： G01N33/49
CPC分类号： G01N33/4905
摘要： A coagulation detecting apparatus has a structure defining a container for a fluid, and containing particles for movement through the container under the influence of a magnetic field. A magnetic arrangement provides sequential magnetic fields to the container such as to cause the particles to move. A light source illuminates the container and a detector detects optical radiation of the light source after passing through the container, the detector being arranged for optically detecting at least one of presence of the particles at a predetermined location in the fluid and movement of the particles through a predetermined location in the fluid.
摘要翻译：凝固检测装置具有限定用于流体的容器的结构，并且在磁场的影响下容纳用于移动通过容器的颗粒。磁性装置向容器提供顺序的磁场，以使颗粒移动。光源照亮容器并且检测器检测到在通过容器之后光源的光辐射，检测器被布置用于光学检测在流体中的预定位置处的颗粒的存在和颗粒的运动中的至少一种流体中的预定位置。

75. 发明申请

WO2005003787A1 PARTICLE AGGLUTINATION DETECTION METHOD AND DEVICE 审中-公开
标题翻译：粒子分离检测方法和装置
公开(公告)号：WO2005003787A1
公开(公告)日：2005-01-13
申请号：PCT/IL2004/000618
申请日：2004-07-08
申请人： INVERNESS MEDICAL SWITZERLAND GMBH , ROTT, Gennady , SAMUELS, Fred , FISH, Falk
发明人： ROTT, Gennady , SAMUELS, Fred , FISH, Falk
IPC分类号： G01N33/80
CPC分类号： G01N33/80
摘要： Abstract A method for the detection and/or visualization of particle agglutination, comprising: placing a volume of a suspension of the particles on a filter, the filter being constructed so as to permit passage of individual particles; placing a volume of a solution or suspension containing an agglutinating agent at the location of the particle suspension; optionally placing a wash solution at the location of the agglutinating agent; and observing the surface at the location for the presence of particles, such presence indicating that agglutination of the particles occurred. There is also provided a method for detection of agglutination reactions in general and hemagglutination reactions, such as used in blood grouping and cross-matching, in particular. The method is comprised of successive vertical additions of whole blood, blood grouping reagent and wash to a filter. In case of hemagglutination a colored, preferably red or reddish dot becomes visible after washing. A device and a kit based on the invention is also claimed and facilitates blood grouping and matching in non-laboratory environment without the need for laboratory instruments.
摘要翻译：摘要一种用于检测和/或可视化颗粒凝集的方法，包括：将一定体积的颗粒悬浮液放置在过滤器上，所述过滤器构造成允许单个颗粒通过; 将一定体积的含有凝集剂的溶液或悬浮液放置在颗粒悬浮液的位置; 任选地将洗涤溶液置于凝集剂的位置; 并且在该位置处观察颗粒存在的表面，这种存在表明颗粒发生凝集。还提供了一般检测凝集反应的方法，特别是用于血液分组和交叉匹配的血细胞凝集反应。该方法包括连续垂直添加全血，血液分组试剂和洗涤过滤器。在血细胞凝集的情况下，洗涤后可见有色的，优选的红色或微红色点。还要求一种基于本发明的装置和试剂盒，并且在非实验室环境中便于血液分组和匹配，而不需要实验室仪器。

76. 发明申请

WO2004046729A2 BODILY FLUID MARKERS OF TISSUE HYPOXIA 审中-公开
标题翻译：组织缺氧的体液标记物
公开(公告)号：WO2004046729A2
公开(公告)日：2004-06-03
申请号：PCT/GB2003/005113
申请日：2003-11-21
申请人： THE UNIVERSITY OF LEICESTER , INVERNESS MEDICAL SWITZERLAND GMBH , NG, Leong
发明人： NG, Leong
IPC分类号： G01N33/68
CPC分类号： G01N33/6893
摘要： The present invention provides a method and kit for screening, diagnosis or prognosis of tissue hypoxia or of a clinical syndrome indicative of tissue hypoxia in a mammalian subject, for determining the stage or severity of tissue hypoxia or of a clinical syndrome indicative of tissue hypoxia in a mammalian subject, for identifying a mammalian subject at risk of developing tissue hypoxia or a clinical syndrome indicative of tissue hypoxia, or for monitoring the effect of therapy administered to a mammalian subject having tissue hypoxia or a clinical syndrome indicative of tissue hypoxia. The level of oxygen regulated protein (ORP150) or a fragment thereof in a sample of bodily fluid from said mammalian subject is measured to provide information as regards the tissue hypoxia or clinical syndrome indicative of tissue hypoxia.
摘要翻译：本发明提供了用于筛选，诊断或预后哺乳动物受试者的组织缺氧或指示组织缺氧的临床综合征的方法和试剂盒，用于确定组织缺氧或者组织缺氧的阶段或严重程度指示哺乳动物受试者中组织缺氧的临床综合征，用于鉴定处于发展中组织缺氧或指示组织缺氧的临床综合征的风险中的哺乳动物受试者，或用于监测施用于具有组织缺氧或临床的哺乳动物受试者的疗法的效果综合征指示组织缺氧。测量来自所述哺乳动物受试者的体液样品中氧调节蛋白（ORP150）或其片段的水平以提供关于组织缺氧或指示组织缺氧的临床综合征的信息。

77. 发明申请

WO2004008140A3 PLASMA UROTENSIN IN HUMAN HEART FAILURE 审中-公开
公开(公告)号：WO2004008140A3
公开(公告)日：2004-01-22
申请号：PCT/GB2003/003011
申请日：2003-07-11
申请人： INVERNESS MEDICAL SWITZERLAND GMBH , NG, Leong
发明人： NG, Leong
IPC分类号： G01N33/68
摘要： The present invention provides a method for the diagnosis of heart failure in a mammalian subject. The level of urotensin in a sample of bodily fluid from the subject is measured and compared to reference levels typically found in the said bodily fluid of a subject which are indicative of the absence of heart failure. An elevated level of urotensin is indicative of heart failure.

78. 发明申请

WO2003025582A1 IMPROVEMENTS IN OR RELATING TO DETECTION OF IMPAIRED FERTILITY 审中-公开
标题翻译：改善或相关检测有害肥料
公开(公告)号：WO2003025582A1
公开(公告)日：2003-03-27
申请号：PCT/GB2002/004235
申请日：2002-09-18
申请人： INVERNESS MEDICAL SWITZERLAND GMBH , COLEY, John , MIRO, Fernado , ASPINALL, Laurence, John , MURRAY, Peter, George , DADD, Anthony, William , ZHANG, Zhi, Gang , MUNDILL, Paul
发明人： COLEY, John , MIRO, Fernado , ASPINALL, Laurence, John , MURRAY, Peter, George , DADD, Anthony, William , ZHANG, Zhi, Gang , MUNDILL, Paul
IPC分类号： G01N33/76
CPC分类号： G01N33/74 , G01N33/76
摘要： Disclosed is a method of detecting a retarded cycle in a human female subject experiencing same, the method comprising the steps of: obtaining a sample of body fluid from the subject on each of a plurality of, but not less than three, days; testing each of the plurality of samples to determine the concentration therein of at least one analyte of significance in the ovulatory cycle; comparing a result determined from said testing with a predetermined threshold value; and, if said determined result is different from the threshold value; declaring the cycle, during which the samples were taken, to be a retarded cycle.
摘要翻译：本发明公开了一种在经历了这种疾病的人类女性受试者中检测延迟循环的方法，该方法包括以下步骤：在多个但不少于三天的每一天中从对象获得体液样本; 测试所述多个样品中的每一个以确定在排卵周期中至少一种有意义的分析物的浓度; 将从所述测试确定的结果与预定阈值进行比较; 并且如果所述确定结果不同于所述阈值; 宣布将采样的周期作为延迟周期。

79. 发明申请

WO2008155756A2 A DIAGNOSTIC THIMBLE 审中-公开
标题翻译：诊断性THIMBLE
公开(公告)号：WO2008155756A2
公开(公告)日：2008-12-24
申请号：PCT/IL2008/000795
申请日：2008-06-12
申请人： Inverness Medical Switzerland GmbH , KEREN, Tomer
发明人： KEREN, Tomer
IPC分类号： A61B5/00
CPC分类号： A61B5/15144 , A61B5/150022 , A61B5/150358 , A61B5/150412 , A61B5/150503 , A61B5/150564 , A61B5/150572 , A61B5/150748 , A61B5/15105 , A61B5/157 , A61B5/6826 , A61B5/6838
摘要： A diagnostic device for performing a diagnostic blood test of a subject comprising a thimble-like element adapted to be engaged with the subject's finger, a puncturing unit for producing a blood sample from the subject's finger, and an at least one test element in flow communication with said blood sample.
摘要翻译：一种诊断装置，用于执行对象的诊断血液测试，所述诊断装置包括适于与被检者的手指接合的套管状元件，用于从受检者的手指产生血液样本的穿刺单元以及流动连通的至少一个测试元件与血液样本。

80. 发明申请

WO2008139324A2 FLUID SAMPLE COLLECTION DEVICE 审中-公开
标题翻译：流体样品收集装置
公开(公告)号：WO2008139324A2
公开(公告)日：2008-11-20
申请号：PCT/IB2008/001831
申请日：2008-05-12
申请人： INVERNESS MEDICAL SWITZERLAND GMBH , DAI, Jielin , GOU, Lijian , HU, Haipeng , WU, Xin
发明人： DAI, Jielin , GOU, Lijian , HU, Haipeng , WU, Xin
IPC分类号： A61B10/00
CPC分类号： A61B10/0051 , A61B2010/0006
摘要： Disclosed are devices, kits for fluid sample collection, and methods of using them. The subject devices and kits are particularly useful for collection of biological samples, particularly bodily fluids.
摘要翻译：公开了用于流体样品收集的装置，套件以及使用它们的方法。主题装置和试剂盒特别适用于收集生物样品，特别是体液。

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