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71. 发明申请

WO2006076119A2 TREATMENT OF SKIN DISEASES 审中-公开
标题翻译：治疗皮肤病
公开(公告)号：WO2006076119A2
公开(公告)日：2006-07-20
申请号：PCT/US2005/045369
申请日：2005-12-15
申请人： IMMUNEREGEN BIOSCIENCES, INC. , WITTEN, Mark, L.
发明人： WITTEN, Mark, L.
IPC分类号： A61K38/17
CPC分类号： A61K38/046
摘要： Substance P or its analogs are useful for treating certain skin diseases. The active agents can be administered topically. Disease severity is reduced by substance P treatment.
摘要翻译：物质P或其类似物可用于治疗某些皮肤疾病。活性剂可以局部施用。疾病严重程度由物质P治疗减少。

72. 发明申请

WO2006034191A2 TEM17 BINDS TO CORTACTIN 审中-公开
标题翻译： TEM17为CORTACTIN
公开(公告)号：WO2006034191A2
公开(公告)日：2006-03-30
申请号：PCT/US2005/033479
申请日：2005-09-20
申请人： THE JOHNS HOPKINS UNIVERSITY , ST. CROIX, Brad , VOGELSTEIN, Bert , KINZLER, Kenneth, W. , NANDA, Akash , BUCKHAULTS, Philip, W.
发明人： ST. CROIX, Brad , VOGELSTEIN, Bert , KINZLER, Kenneth, W. , NANDA, Akash , BUCKHAULTS, Philip, W.
IPC分类号： C07K14/82
CPC分类号： C07K14/4748
摘要： Tumor Endothelial Marker 17 (TEM17) was recently identified as an mRNA transcript overexpressed in the endothelium of vessels in human solid tumors. We have identified several new variants of TEMI7, derived by alternative splicing, that are intracellular (TEM17-I), secreted (TEM17-S), and on the cell surface membrane (TEM17-M) of tumor endothelium. We identified cortactin as a protein capable of binding to the extracellular region of both TEM17 and its closest homologue, TEM3, which is also expressed in tumor endothelium. The binding domain of cortactin is a 9-amino acid residue region in its plexin-like domain. These provide targets for the delivery of therapeutic and imaging agents to the vessels of solid tumors.
摘要翻译：肿瘤内皮标记17（TEM17）最近被鉴定为人类实体瘤血管内皮中过表达的mRNA转录物。我们已经确定了通过选择性剪接（细胞内（TEM17-I），分泌型（TEM17-S））和肿瘤内皮的细胞表面膜（TEM17-M）衍生的几种新的变体TEMI7。我们鉴定了皮质激素作为能够结合TEM17及其最近同源物TEM3的细胞外区域的蛋白质，TEM3也在肿瘤内皮中表达。皮质激素的结合结构域是其plexin样结构域中的9-氨基酸残基区域。这些为将实施肿瘤的血管递送治疗和显像剂提供了目标。

73. 发明申请

WO2006031689A3 MULTIMERIC CONSTRUCTS 审中-公开
公开(公告)号：WO2006031689A3
公开(公告)日：2006-03-23
申请号：PCT/US2005/032320
申请日：2005-09-13
申请人： GENZYME CORPORATION , SCARIA, Abraham , PECHAN, Peter , WADSWORTH, Samuel
发明人： SCARIA, Abraham , PECHAN, Peter , WADSWORTH, Samuel
IPC分类号： A61K39/395 , C12P21/04 , C12P21/06 , C12N5/00 , C07K14/715 , C07H21/04
摘要： Multimeric fusion proteins of an Ig-like domain of Flt-1 are rendered functional by inclusion or a linker moiety. Vectors encoding the fusion proteins and host cells expressing the fusion proteins can be used therapeutically to block neovascularization in individuals with pathological conditions related to neovascularization. Such conditions include age-related macular degeneration, cancer, psoriasis, proliferative diabetic retinopathy, asthma, uveitis, osteoarthritis, and rheumatoid arthritis. The same means of multimerization used for an Ig-like domain of Flt-1, i.e., a linker and a multimerization domain, can be used for other polypeptides, including extracellular receptors, antibody variable regions, cytokines, chemokines, and growth factors.

74. 发明申请

WO2006004716A2 AMELIORATION OF DRUG-INDUCED TOXICITY 审中-公开
标题翻译：药物诱导毒性的增加
公开(公告)号：WO2006004716A2
公开(公告)日：2006-01-12
申请号：PCT/US2005/022860
申请日：2005-06-29
申请人： THE JOHNS HOPKINS UNIVERSITY , RABB, Hamid
发明人： RABB, Hamid
IPC分类号： A61K39/00
CPC分类号： A61K31/555 , A61K33/24 , A61K39/395 , A61K2300/00
摘要： Kidney toxicity which is induced by cisplatin and other therapeutic and diagnostic agents, limits the effectiveness of the therapy or diagnosis. Modulation or depletion of T cells ameliorates the toxicity, permitting the use of cisplatin at levels and for durations which treat cancers more effectively. Modulation and depletion can be accomplished using antibodies for T cell surface antigens as well as using other molecules which effectively antagonize or down-regulate the cytokines and/or chemokines which T cells elaborate.
摘要翻译：由顺铂和其他治疗剂和诊断剂诱导的肾毒性限制了治疗或诊断的有效性。 T细胞的调节或消耗改善了毒性，允许以更高效地治疗癌症的水平和持续时间使用顺铂。可以使用针对T细胞表面抗原的抗体以及使用有效拮抗或下调T细胞精心设计的细胞因子和/或趋化因子的其他分子来完成调节和消除。

75. 发明申请

WO2005107700A2 ANTI-AGING EFFECTS OF SUBSTANCE P 审中-公开
标题翻译：物质的抗老化作用
公开(公告)号：WO2005107700A2
公开(公告)日：2005-11-17
申请号：PCT/US2005/013113
申请日：2005-04-18
申请人： IMMUNEREGEN BIOSCIENCES, INC. , WITTEN, Mark, L.
发明人： WITTEN, Mark, L.
IPC分类号： A61K8/00
CPC分类号： A61K8/64 , A61Q5/004
摘要： Substance P or its analogs can be administered to humans to reverse or retard the course of various biological processes related to aging in adults. Reversal or retardation can be observed in hair color, muscle or joint pain, memory loss, sleep pattern, and visual accommodation.
摘要翻译：物质P或其类似物可以施用于人以逆转或延缓与成年人老化相关的各种生物过程的过程。可以观察到头发颜色，肌肉或关节疼痛，记忆力丧失，睡眠模式和视觉调节的逆转或延迟。

76. 发明申请

WO2005092033A2 PREVENTING ARRHYTHMIAS ASSOCIATED WITH CELL TRANSPLANTATION 审中-公开
标题翻译：预防与细胞迁移相关的ARRHYTHMIAS
公开(公告)号：WO2005092033A2
公开(公告)日：2005-10-06
申请号：PCT/US2005/009358
申请日：2005-03-22
申请人： THE JOHNS HOPKINS UNIVERSITY , MARBAN, Eduardo , ABRAHAM, Maria, Roselle
发明人： MARBAN, Eduardo , ABRAHAM, Maria, Roselle
IPC分类号： A61K48/00
CPC分类号： A61K48/005 , C12N5/0657 , C12N5/0658 , C12N15/86 , C12N2501/11 , C12N2740/16043
摘要： Skeletal myoblasts are an attractive cell type for transplantation since they are autologous and resistant to ischemia. However, clinical trials of myoblasts transplantation in heart failure have been plagued by ventricular tachy-arrhythmias and sudden cardiac death. The pathogenesis of these arrhythmias is poorly understood, but may be related to the fact that skeletal muscle cells, unlike heart cells, are electrically isolated by the absence of gap junctions. An in vitro model of myoblasts transplantation into cardiomyocyte monolayers can be used to investigate the mechanisms of transplant-associated arrhythmias. Co-cultures of human skeletal myoblasts and rat cardiomyocytes result in reentrant arrhythmias (spiral waves) that reproduce the features of ventricular tachycardia seen in patients receiving myoblasts transplants. These arrhythmias can be terminated by nitrendipine, an L-type calcium channel Mocker, but not by the Na channel blocker lidocaine. Genetic modification of myoblasts to stably express the gap junction protein connexin 43 decreases arrhythmogenicity in co-cultures. It similarly can be used to increase the safety of myoblasts transplantation in patients.
摘要翻译：骨骼肌成肌细胞是一种有吸引力的移植细胞类型，因为它们是自体的，对局部缺血有抗性。然而，成肌细胞移植在心力衰竭中的临床试验一直困扰着心室心律失常和心源性猝死。这些心律失常的发病机制很少被理解，但可能与骨髓肌细胞不同，心肌细胞不通过间隙连接而被电隔离的事实有关。将成肌细胞移植到心肌细胞单层中的体外模型可用于研究移植相关性心律失常的机制。人类骨骼肌成肌细胞和大鼠心肌细胞的共培养物导致再现心律失常（螺旋波），其再现了接受成肌细胞移植的患者中观察到的室性心动过速的特征。这些心律失常可以由尼群地平，一种L型钙通道Mocker，而不是Na通道阻断剂利多卡因终止。成肌细胞的遗传修饰以稳定表达间隙连接蛋白连接蛋白43降低共培养物中的心律失常。它同样可以用于增加患者成肌细胞移植的安全性。

77. 发明申请

WO2005050161A2 CONDUCTIVE MEDIA FOR ELECTROPHORESIS 审中-公开
标题翻译：电导体导电介质
公开(公告)号：WO2005050161A2
公开(公告)日：2005-06-02
申请号：PCT/US2004/037042
申请日：2004-11-08
申请人： FASTER BETTER MEDIA LLC , KERN, Scott E. , BRODY, Jonathan R.
发明人： KERN, Scott E. , BRODY, Jonathan R.
IPC分类号： G01N
CPC分类号： G01N27/44747
摘要： A series of low molarity conductive media based on non-buffering univalent cations, such as sodium chloride-sodium acetate (SCA), sodium boric acid (SB), lithium boric acid, and lithium acetate mitigate the "runaway" positive feedback heating loop produced by conventional media containing biological amine buffers and permit improved DNA electrophoresis under the conditions of low salt concentration. These media serve well in ultra-fast DNA electrophoresis and in high-resolution separations of RNA and DNA fragments.
摘要翻译：一系列基于非缓冲一价阳离子的低摩尔浓度导电介质，如氯化钠 - 乙酸钠（SCA），硼酸（SB），硼酸锂和乙酸锂缓解了“失控”正反馈加热回路产生通过含有生物胺缓冲液的常规培养基，并且在低盐浓度的条件下允许改进的DNA电泳。这些培养基在超快速DNA电泳和RNA和DNA片段的高分辨率分离中起到很好的作用。

78. 发明申请

WO2005017182A2 MULTI-COLOR IN VITRO TRANSLATION 审中-公开
标题翻译：多色翻译
公开(公告)号：WO2005017182A2
公开(公告)日：2005-02-24
申请号：PCT/US2004/019097
申请日：2004-07-21
申请人： THE JOHNS HOPINKS UNIVERSITY SCHOOL OF MEDICINE , TRAVERSO, Carlo, Giovanni , DIEHL, Frank , KINZLER, Kenneth, W. , VOGELSTEIN, Bert
发明人： TRAVERSO, Carlo, Giovanni , DIEHL, Frank , KINZLER, Kenneth, W. , VOGELSTEIN, Bert
IPC分类号： C12Q
CPC分类号： G01N33/6845 , G01N33/542
摘要： In vitro translation is a widely used tool for both analytical and preparative purposes. For analytical purposes, small amounts of proteins are synthesized and visualized through labeled amino acids incorporated during translation. The radioactively labeled amino acids originally used, such as [ 35 S]methionine or [ 14 C]leucine, have been superceded by the addition of antigenic tags or the incorporation of biotin-labeled or fluorescently-labeled amino acids. Such non-radioactive tags are simpler to visualize following translation and do not pose a radiation hazard. Among the non-radioactive tags, fluorescently labeled-lysine is the most convenient, as proteins that have incorporated this amino acid can be directly visualized following gel electrophoresis. Multiple fluorophores introduced into proteins significantly extend their utility, particularly for the comparison of in vitro translated proteins from related sources. This methodology can be employed for several purposes, including the simplified detection of rare truncating mutations in clinical samples from cancer patients.
摘要翻译：体外翻译是用于分析和制备目的的广泛使用的工具。为了分析的目的，通过在翻译过程中并入的标记氨基酸合成少量蛋白质并使其可视化。最初使用的放射性标记的氨基酸，例如[35 S]甲硫氨酸或[[14 C]亮氨酸）已经通过加入抗原标签或引入生物素标记或荧光标记的氨基酸而被替代。这种非放射性标签更容易可视化翻译，并且不会造成辐射危害。在非放射性标签中，荧光标记的赖氨酸是最方便的，因为结合了该氨基酸的蛋白质可以在凝胶电泳后直接显现。引入蛋白质的多种荧光团显着扩展其效用，特别是用于比较来自相关来源的体外翻译蛋白质。该方法可用于多种目的，包括简化检测癌症患者临床样品中罕见的截短突变。

79. 发明申请

WO2005010145A2 METHOD AND COMPOSITIONS FOR DETECTION AND ENUMERATION OF GENETIC VARIATIONS 审中-公开
标题翻译：用于检测和产生遗传变异的方法和组合物
公开(公告)号：WO2005010145A2
公开(公告)日：2005-02-03
申请号：PCT/US2004/015587
申请日：2004-06-09
申请人： THE JOHNS HOPKINS UNIVERSITY , DRESSMAN, Devin , YAN, Hai , KINZLER, Kenneth, W. , VOGELSTEIN, Bert
发明人： DRESSMAN, Devin , YAN, Hai , KINZLER, Kenneth, W. , VOGELSTEIN, Bert
IPC分类号： C12N
CPC分类号： C12Q1/6858 , C07H21/04 , C12N15/1075 , C12Q1/686 , C12Q2565/537 , C12Q2563/149 , C12Q2563/143
摘要： Many areas of biomedical research depend on the analysis of uncommon variations in individual genes or transcripts. Here we describe a method that can quantify such variation at a scale and ease heretofore unattainable. Each DNA molecule in a collection of such molecules is converted into a single particle to which thousands of copies of DNA identical in sequence to the original are bound. This population of beads then corresponds to a one-to-one representation of the starting DNA molecules. Variation within the original population of DNA molecules can then be simply assessed by counting fluorescently-labeled particles via flow cytometry. Millions of individual DNA molecules can be assessed in this fashion with standard laboratory equipment. Moreover, specific variants can be isolated by flow sorting and employed for further experimentation. This approach can be used for the identification and quantification of rare mutations as well as to study variations in gene sequences or transcripts in specific populations or tissues.
摘要翻译：生物医学研究的许多领域取决于对个别基因或转录本中不常见变异的分析。在这里，我们描述一种可以量化这种变化的方法，其规模和容易度迄今为止是无法实现的。将这样的分子的集合中的每个DNA分子转化成单个颗粒，其中与原始序列顺序相同的数千个拷贝的DNA被结合。这种珠子群对应于起始DNA分子的一对一表示。然后可以通过流式细胞术对荧光标记的颗粒进行计数，简单地评估原始DNA分子群体内的变异。可以用标准实验室设备以这种方式评估数百万个单独的DNA分子。此外，可以通过流动分选分离特定的变体并用于进一步的实验。该方法可用于鉴定和定量稀有突变，并研究特定群体或组织中基因序列或转录本的变异。

80. 发明申请

WO2004108087A3 GENE DELIVERY TO ORGANS 审中-公开
公开(公告)号：WO2004108087A3
公开(公告)日：2004-12-16
申请号：PCT/US2004/017702
申请日：2004-06-04
申请人： THE JOHNS HOPKINS UNIVERSITY , DONAHUE, J., Kevin , MCDONALD, Amy, D. , KIKUCHI, Kan
发明人： DONAHUE, J., Kevin , MCDONALD, Amy, D. , KIKUCHI, Kan
IPC分类号： A61K31/70
摘要： Application of a virus with poloxamer alone onto atria results in diffuse epicardial gene transfer with negligible penetration into the myocardium. Progressive increases in protease concentration, however, allow transmural gene transfer. After protease exposure, echocardiographic left atrial diameter does not change. Left atrial ejection fraction decreases on post-operative day 3, but returns to baseline by day 7. At appropriate protease concentrations, tissue tensile strength is unaffected by the procedure. Transmural atrial gene transfer can be effected using this direct "painting" method.

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