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71. 发明申请

WO2020051151A1 METHODS OF TREATING MYCOBACTERIAL INFECTIONS USING TETRACYCLINE COMPOUNDS 审中-公开
公开(公告)号：WO2020051151A1
公开(公告)日：2020-03-12
申请号：PCT/US2019/049368
申请日：2019-09-03
申请人： PARATEK PHARMACEUTICALS, INC. , UNITED STATES GOVERNMENT AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS
发明人： CYNAMON, Michael, Henry , DRAPER, Michael, P. , STEENBERGEN, Judith, N. , TANAKA, S., Ken
IPC分类号： A61K31/427 , A61K31/497 , A61K31/5377
摘要： The present invention provides methods of treating mycobacterial infections or mycobacterial diseases by administering a tetracycline compound, e.g., omadacycline, or a pharmaceutically acceptable salt thereof.

72. 发明申请

WO2019173794A1 ANTI-HIV ANTIBODIES 审中-公开
公开(公告)号：WO2019173794A1
公开(公告)日：2019-09-12
申请号：PCT/US2019/021486
申请日：2019-03-08
申请人： ATRECA, INC. , UNIVERSITY of MARYLAND, BALTIMORE , THE UNITED STATES GOVERNMENT AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS
发明人： SAJADI, Mohammad , LEWIS, George K. , DEVICO, Anthony , LIPPOW, Shaun M. , CAVET, Guy L. , WILLIAMS, Katherine , KIM, Dongkyoon
IPC分类号： A61K39/42 , A61P31/18 , C07K16/00 , C07K16/10 , C12N15/13 , G01N33/569
摘要： Provided herein are anti-HIV antibodies, compositions comprising such antibodies, and methods of producing the antibodies. Additionally provided are methods of treating or preventing HIV infection, or a complication of HIV infection, using the anti-HIV antibodies.

73. 发明申请

WO2019060428A1 BACTERIAL PROTEIN COMPOSITIONS AND USES THEREOF 审中-公开
公开(公告)号：WO2019060428A1
公开(公告)日：2019-03-28
申请号：PCT/US2018/051768
申请日：2018-09-19
申请人： THE UNITED STATES GOVERNMENT AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS , EMORY UNIVERSITY
发明人： RATHER, Philip , WEISS, David , CHIN, Chui-Yoke , TIPTON, Kyle
IPC分类号： A61K35/74 , A61K39/02 , A61K39/04 , A61P31/04 , C07K14/21 , C12N1/20
摘要： Disclosed herein is an attenuated Acinetobacter baumannii comprising an expression vector comprising a nucleic acid encoding the ABUW_1645 protein or a variant thereof. Disclosed herein are methods of treating or preventing colonization, infection, or disease by an Acinetobacter baumannii microbe, the method comprising administering a clinically effective dose of the attenuated Acinetobacter baumannii to a subject in need thereof, wherein the attenuated Acinetobacter baumannii comprises an expression vector expressing the ABUW_1645 protein or variants thereof.

74. 发明申请

WO2019055448A1 SUSPENSION CULTURE DEVICES AND SYSTEMS AND RELATED METHODS 审中-公开
公开(公告)号：WO2019055448A1
公开(公告)日：2019-03-21
申请号：PCT/US2018/050549
申请日：2018-09-12
申请人： DUKE UNIVERSITY , THE UNITED STATES GOVERNMENT AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS
发明人： HAMMOND, Timothy, G. , BIRDSALL, Holly, H.
IPC分类号： B01F3/08 , B01L1/02 , B01L3/00 , B25J9/20 , C12M1/10
CPC分类号： B01F3/08 , B01L1/02 , B01L3/00 , B25J9/20 , C12M1/10
摘要： Suspension culture devices and systems and related methods are disclosed. According to an aspect, a suspension culture device includes a rotatable base having an exterior surface. The base defines an interior space for holding a culture. All or at least a portion of the base may be made of a breathable material extending between the interior space and outside the rotatable base. The suspension culture device includes multiple ports that each permit fluid communication between the interior space and outside the rotatable base.

75. 发明申请

WO2018204893A1 METHODS AND COMPOSITIONS FOR TREATING LIVER DISEASE 审中-公开
公开(公告)号：WO2018204893A1
公开(公告)日：2018-11-08
申请号：PCT/US2018/031261
申请日：2018-05-04
申请人： UNITED STATES GOVERNMENT AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS
发明人： ALPINI, Gianfranco , GLASER, Shannon S. , MENG, Fanyin
IPC分类号： A61K38/00 , A61K38/22 , A61P1/16 , C07K14/575 , C07K14/645 , C07K14/705
摘要： Disclosed is a method of modulating the Sct/SR axis in a mammalian subject in need thereof, including in a subject suffering from a liver disease, such as but not limited to, Early Stage PBC, Primary Sclerosing Cholangitis, Primary Biliary Cholangitis, Biliary Atresia, NASH, NAFLD, or Alcohol induced liver injury. A method of treating Late Stage PBC in a mammalian subject in need thereof is also disclosed; further disclosed is a method of ameliorating PBC-induced biliary damage in a mammalian subject in need thereof. Pharmaceutical compositions for modulating the Sct/SR axis, comprising a SR antagonist or a SR agonist, and a pharmaceutically acceptable carrier or excipient are also disclosed.

76. 发明申请

WO2018071851A1 SENSOR BASED CLEAR PATH ROBOT GUIDE 审中-公开
标题翻译：基于传感器的清除路径机器人指南
公开(公告)号：WO2018071851A1
公开(公告)日：2018-04-19
申请号：PCT/US2017/056640
申请日：2017-10-13
申请人： UNITED STATES GOVERNMENT AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS
发明人： HIGGINS, Brian L.
IPC分类号： A61H3/00 , A61H3/02 , A61H3/04 , A61H3/06
摘要： A guide system is provided that uses a plurality of sensors to identify and determine a clear path for an ambulatory vision impaired person. The system includes one or more wheels that rotate to propel the system, a platform supported by the one or more wheels and housing a processor, a rigid harness with a haptic feedback grip that is positioned to be grasped by an operator, and one or more sensors configured to sense information about the environment. In operation, the processor analyzes information sensed by the sensors to identify object in the path of the guide system and sends messages to the operator to allow the operator to avoid the identified objects. The messages may be sent to the operator via the haptic feedback grip or audibly via a speaker or via a wireless connection to a haptic or audio device being worn by the operator.
摘要翻译：提供了一种引导系统，其使用多个传感器来识别和确定行动不便的视障人士的畅通路径。该系统包括旋转以推进系统的一个或多个轮子，由一个或多个轮子支撑并容纳处理器的平台，具有定位成由操作员抓住的触觉反馈握把的刚性束带以及一个或多个配置成感测关于环境的信息的传感器。在操作中，处理器分析由传感器感测到的信息以识别引导系统的路径中的对象，并向操作员发送消息以允许操作员避开所识别的对象。这些消息可以通过触觉反馈手柄或可听地通过扬声器或通过无线连接被发送给操作员到操作员佩戴的触觉或音频设备。

77. 发明申请

WO2018049269A1 COLLAPSIBLE MANUAL WHEELCHAIR SYSTEM FOR IMPROVED PROPULSION AND TRANSFERS 审中-公开
标题翻译：用于改进推进和转移的可折叠手动轮椅系统
公开(公告)号：WO2018049269A1
公开(公告)日：2018-03-15
申请号：PCT/US2017/050832
申请日：2017-09-08
申请人： UNITED STATES GOVERNMENT AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS
发明人： HANSEN, Andrew H. , GOLDISH, Gary D. , NICKEL, Eric
IPC分类号： A61G5/02 , A61G5/08
摘要： A manual wheelchair including a collapsible frame having a first lateral member that is connected to first and second braces at their respective first ends. A drive wheel axel extends along a first axis of rotation and engages a drive wheel, the first brace, and a portion of a transmission. A push rim axel extends along a second axis of rotation and engages a push rim wheel, the second brace, and a portion of the transmission, which transmits rotation of the push rim to rotation of the drive wheel. The collapsible frame additionally includes a second lateral member that is connected to the first and second braces as their respective second ends. The first and second braces are configured to release the second lateral member to collapse the manual wheelchair.
摘要翻译：包括可折叠框架的手动轮椅，所述可折叠框架具有第一侧向构件，所述第一侧向构件在其各自的第一端处连接到第一支架和第二支架。驱动轮轴沿着第一旋转轴线延伸并且接合驱动轮，第一支架和变速器的一部分。推动轮辋轴沿着第二旋转轴线延伸并且接合推动轮辋轮，第二支架和变速器的一部分，该部分将推动轮辋的旋转传递至驱动轮的旋转。可折叠框架还包括第二横向构件，该第二横向构件作为它们各自的第二端连接到第一支架和第二支架。第一和第二支架构造成释放第二横向构件以折叠手动轮椅。

78. 发明申请

WO2017139794A2 BOWEL CARE USING IONTOPHORESIS 审中-公开
标题翻译：使用IOPOOPHORESIS进行鲍氏护理
公开(公告)号：WO2017139794A2
公开(公告)日：2017-08-17
申请号：PCT/US2017/017717
申请日：2017-02-13
申请人： UNITED STATES GOVERNMENT AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS
发明人： KORSTEN, Mark A. , BAUMAN, William A.
IPC分类号： A61K31/407 , A61K31/4015
CPC分类号： A61K31/40 , A61K31/27 , A61N1/0428 , A61N1/30 , A61N1/36007 , A61K2300/00
摘要： The present disclosure provides compositions and methods for on-going bowel care for persons with chronic intestinal pseudo-obstruction. The compositions and methods can be administered in a non-clinical setting. The compositions comprise acetylcholinesterase inhibitors for stimulating motility of the bowel in combination with anti-cholinergic agents to counteract the potentially dangerous cardiac side effects of the acetylcholinesterase inhibitor. In some examples, the acetylcholinesterase inhibitor, neostigmine, and the anti-cholinergic agent, glycopyrrolate, are combined in a pharmaceutical composition. Certain examples also provide the frequency and duration of administration of the disclosed drug combinations.
摘要翻译：本公开提供了用于慢性肠假性梗阻患者的持续肠内护理的组合物和方法。组合物和方法可以在非临床环境中施用。该组合物包含用于刺激肠动力的乙酰胆碱酯酶抑制剂与抗胆碱能药物联合以抵消乙酰胆碱酯酶抑制剂的潜在危险的心脏副作用。在一些实例中，乙酰胆碱酯酶抑制剂新斯的明和抗胆碱能药物格隆溴铵在药物组合物中组合。某些例子还提供了公开的药物组合的给药频率和持续时间。

79. 发明申请

WO2017070569A1 COMPOUNDS THAT BIND MACROPHAGE MIGRATION INHIBITORY FACTOR 审中-公开
标题翻译：结合巨噬细胞迁移抑制因子的化合物
公开(公告)号：WO2017070569A1
公开(公告)日：2017-04-27
申请号：PCT/US2016/058260
申请日：2016-10-21
申请人： OREGON HEALTH & SCIENCE UNIVERSITY , THE UNITED STATES GOVERNMENT as represented by THE DEPARTMENT OF VETERANS AFFAIRS
发明人： VANDENBARK, Arthur, A. , BENEDEK, Gil , MEZA-ROMERO, Roberto
IPC分类号： C07K14/74
CPC分类号： C07K14/70539 , A61K38/00 , C07K2319/00
摘要： Recombinant polypeptides, pharmaceutical compositions comprising recombinant polypeptides, and methods of treating autoimmune and/or inflammatory diseases using the pharmaceutical compositions are disclosed. The polypeptides are based upon the trimerization and/or MIF binding domains of CD74.
摘要翻译：公开了重组多肽，包含重组多肽的药物组合物，以及使用该药物组合物治疗自身免疫疾病和/或炎性疾病的方法。多肽基于CD74的三聚化和/或MIF结合结构域。

80. 发明申请

WO2017049178A1 METHOD OF MAKING TRABECULAR BONE 审中-公开
标题翻译：制造骨质疏松的方法
公开(公告)号：WO2017049178A1
公开(公告)日：2017-03-23
申请号：PCT/US2016/052277
申请日：2016-09-16
申请人： UNIVERSITY OF PITTSBURGH-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION , THE UNITED STATES GOVERNMENT AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS , UNIVERSITY OF CHICAGO , WASHINGTON UNIVERSITY IN ST. LOUIS
发明人： BLAIR, Harry, Colbert , LARROUTURE, Quitterie , TOURKOVA, Irina, L. , NELSON, Deborah, J. , SCHLESINGER, Paul
IPC分类号： C12N5/071 , C12N5/077 , C12N15/113
CPC分类号： C12N5/0654 , C12N15/1138 , C12N2310/14 , C12N2310/531 , C12N2510/00 , C12N2517/00
摘要： Provided herein are methods of producing trabecular bone material, such as trabecular bone or trabecular bone matrix and cells useful in preparing the trabecular bone material.
摘要翻译：本文提供了生产小梁骨材料的方法，例如小梁骨或小梁骨基质和可用于制备骨小梁骨材料的细胞。

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