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61. 发明申请

WO2004002315A3 METHOD FOR CHANGING THE SIGHTING DEVICES OF ISOTOPE SCANNING SENSORS 审中-公开
标题翻译：改变同位素扫描传感器信号设备的方法
公开(公告)号：WO2004002315A3
公开(公告)日：2004-03-18
申请号：PCT/EP0350254
申请日：2003-06-24
申请人： SOPHA MEDICAL VISION INTERNAT , GEAY JEAN-CLAUDE
发明人： GEAY JEAN-CLAUDE
IPC分类号： A61B6/04 , A61G13/04 , G01T1/164 , G01T1/166
CPC分类号： A61B6/04
摘要： In order to facilitate the changing of sighting devices (11) in a nuclear medicine machine (1), a bed (2) is raised in order to bring a patient towards the machine in order to examine said patient. When the bed is raised, a space is easily created between a leg (3) of the bed upon which the bed rests upon the ground and a frame (4) of the machine. This space is used to bring forward the carriage of a sighting device holder and to carry out all necessary maintenance operations.
摘要翻译：为了便于改变核医学机器（1）中的瞄准装置（11），升高床（2）以使患者朝向机器以便检查所述患者。当床升起时，在床上的床脚搁置在地面上的腿部（3）和机器的框架（4）之间容易产生空间。该空间用于提出瞄准装置支架的支架，并执行所有必要的维护操作。

62. 发明申请

WO02092005A3 STABILIZATION OF RADIONUCLIDE-CONTAINING COMPOSITIONS 审中-公开
标题翻译：含有放射性核素的组合物的稳定性
公开(公告)号：WO02092005A3
公开(公告)日：2003-05-01
申请号：PCT/US0215360
申请日：2002-05-16
申请人： BERLEX LAB , MANCHANDA RAJESH
发明人： MANCHANDA RAJESH
IPC分类号： G21G4/08 , A61K51/00 , A61K51/04 , A61K51/08 , G01T1/161 , G01T1/164 , A61M36/14
CPC分类号： A61K51/08 , A61K51/04
摘要： Described are methods for stabilizing radionuclide-containing compositions against degradation caused by free radicals generated from the radionuclide. Iodide ions stabilize the radionuclide-containing compositions by acting as scavengers to generated free radicals, thus, preventing or lessening degradation therefrom. Among the preferred radionuclide-containing compositions to be stabilized are complexes of a complexing agent with a radionuclide complexed therewith, such as a diagnostic agent having a specific binding peptide linked to a metal ion-complexing moiety which is complexed with a radionuclide, such as technetium-99m (Tc-99m). Also included in the invention are compositions of radionuclide-containing compounds or complexes with iodide or an iodide ion-providing component, compositions of compounds or complexing agents that will be associated with a radionuclide and kits containing any combination of radionuclides, radionuclide generators, complexing agents or compounds which are associated with or will be associated with radionuclides and iodide or iodide-providing components.
摘要翻译：描述了稳定含放射性核素的组合物抵抗由放射性核素产生的自由基引起的降解的方法。碘离子通过作为清除剂产生自由基来稳定含放射性核素的组合物，从而防止或减轻其降解。在要稳定的优选的含有放射性核素的组合物中，络合剂与与其络合的放射性核素的复合物，例如具有与放射性核素复合的金属离子络合部分连接的特异性结合肽的诊断剂，例如锝 -99m（Tc-99m）。本发明还包括含有放射性核素的化合物或与碘化物或碘化物离子提供组分的络合物，将与放射性核素相关的化合物或络合剂的组合物和包含放射性核素，放射性核素发生剂，络合剂的任何组合的试剂盒或与放射性核素和碘化物或碘化物提供组分相关或将会相关的化合物。

63. 发明申请

WO2002075358A1 GAMMA CAMERA WITH ROTATING DETECTORS FOR VARIABLE ANGULAR SAMPLING RATE 审中-公开
标题翻译：具有可变角度采样率的旋转探测器的伽马相机
公开(公告)号：WO2002075358A1
公开(公告)日：2002-09-26
申请号：PCT/US2002/007616
申请日：2002-03-14
申请人： KONINKLIJKE PHILIPS ELECTRONICS NV , PHILIPS MEDICAL SYSTEMS (CLEVELAND), INC.
发明人： GAGNON, Daniel , ZENG, Gensheng, L.
IPC分类号： G01T1/164
CPC分类号： G01T1/1644 , A61B6/037
摘要： A subject (10) is disposed adjacent a linear detector array (18) of a nuclear camera. The subject (10) is injected with a radioactive isotope (14) and γ-ray emissions indicative of nuclear decay are detected at the detector array (18) as the detector array rotates about an axis of rotation to collect data over a circular field of view. Detectors farther from the axis of rotation are sampled at a higher sampling rate such that the detectors are sampled after a generally constant arc of rotation to correct for angular aliasing. The detector array (18) rotates about the axis of rotation in a 1/sin θ pattern with angular offset of the detector array from a longitudinal axis of the subject. This corrects for otherwise uneven sampling. A reconstruction processor (46) reconstructs the identifications of the γ-ray receiving detectors, or other indicators of event detection location, and the digital peak values to generate a spherical image representation.
摘要翻译：被摄体（10）设置在核相机的线性检测器阵列（18）附近。被检体（10）注射放射性同位素（14），并且当检测器阵列围绕旋转轴旋转时，在检测器阵列（18）处检测到表示核衰变的γ射线发射，以在圆视图。以更高的采样率采样距离旋转轴更远的检测器，使得检测器在大体上恒定的旋转弧线之后被采样以校正角度混叠。检测器阵列（18）围绕旋转轴线以1 / sin +角度旋转; 图案，其具有来自检测器阵列的纵向轴线的角度偏移。这取决于不均匀采样。重建处理器（46）重建伽马射线接收检测器或事件检测位置的其他指示符的标识，以及数字峰值以产生球形图像表示。

64. 发明申请

WO2002071098A3 HIGH VOLTAGE DISTRIBUTION SYSTEM FOR CZT ARRAYS 审中-公开
公开(公告)号：WO2002071098A3
公开(公告)日：2002-09-12
申请号：PCT/US2001/043390
申请日：2001-11-21
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V.
发明人： GRIESMER, Jerome, J. , KLINE, Barry, D.
IPC分类号： G01T1/164
摘要： A subject (10) is disposed adjacent a detector array (18). The subject (10) is injected with a radioactive isotope (14) and y-ray emissions indicative of nuclear decay are detected at the detector array (18) . The detector array generates electrical signals in response to each y-ray which signals are processed (64) and reconstructed (46) into an image representation of the anatomy of the subject (10). A high voltage bias is applied across the detector array. The bias is applied by a set of bias strips (80) and an electrically isolated common busbar (82) built onto a sheet of flexible circuit material. This flexible circuit (81) is highly transmissive to gamma radiation in the energy range 60-180 keV which is typically used in diagnostic nuclear medicine. Connections between the common busbar (82) and the bias strips (80) are made by resistors (92) on individual detector cards. Each bias strip is capacitively coupled (68) to the local ground on each detector card to form a Faraday shield around each detector array. Bias strips set above groups of detector arrays and electrical pads (86) are disposed along opposite faces. A substantially uniform DC electric field is set up between the strips and pads across the detector array. The strips and pads substantially surround groups of arrays defining Faraday cages. Capacitive filters (68) connected with the strips filter out noise. The capacitor's connection to the P-ASIC ground completes a Faraday Shield aroung the highly sensitive detector array (18). Resistors (92) electrically isolate each of the Faraday cages. Capacitive filters (68) connected with the strips filter out noise. The capacitor's connection to the P-ASIC ground completes a Faraday shield around the highly sensitive detector array (18). Resistors (92) electrically isolate each of the Faraday cages. Additionally, light baffles are added to prevent visible light from generating a signal in the detector array (18). Collimator vanes (16) are supported on a ground layer (100) which is separated from the conductive strips (80) by a resilient foam layer (102).

65. 发明申请

WO02034136A3 NUCLEAR IMAGING SYSTEMS AND METHODS WITH FEATURE-ENHANCED TRANSMISSION IMAGING 审中-公开
标题翻译：核成像系统和方法产生具有改进的性能特征的传输图像
公开(公告)号：WO02034136A3
公开(公告)日：2002-07-11
申请号：PCT/US2001/031650
申请日：2001-10-09
IPC分类号： G01T1/161 , G01T1/164 , G01T1/20
CPC分类号： G01T1/1648 , A61B6/037
摘要： Radiation (32a) having a defined energy spectrum, which is divided into plural subranges is transmitted through radiation are detected (20a-20c) and sorted (48) into the appropriate energy subrange. A transmission image representation is reconstructed (52a-52n) for each data subrange and assigned weighting factors (64a-64n) to provide enhanced images (72, 74, 76) when combined in accordance with the assigned weighting. The multiple transmission images are also combined with equal weighting to generate attenuation correction factors (80) for correcting the emission data (46). The corrected emission image can be combined with one of the feature-enhanced structural images, e.g., for locating the functional emission image with respect to structural features. Also, a feature-enhanced structural image can advantageously be used to register an emission image (86) with an image (100) from another imaging modality such as a computed tomography.
摘要翻译：根据本发明，具有限定能谱的辐射（32a）被分为几个能量子范围，被引导通过受试者。检测透射和透射辐射的路径和能量（20a-20c），并将其分类（48）以置于合适的能量子范围内。为了增强图像产生（72,74,76），对于数据的每个子范围（分配的加权因子（64a-64n））重构传输图像表示（52a-52n）。）当它们按照分配的权重组合时。然后通过相同的加权组合这些传输图像以产生用于校正传输数据（46）的衰减校正因子（80）。校正的发射图像可以与特征增强的结构图像之一组合，例如用于定位关于结构特征的功能发射图像。类似地，可以有利地使用具有改进的性能特征的结构图像，以便用来自另一成像模态的图像（100）记录透射图像（86），例如计算机断层扫描。

66. 发明申请

WO01052269A1 METHOD OF IMAGING BY SPECT 审中-公开
标题翻译： SPECT成像方法
公开(公告)号：WO01052269A1
公开(公告)日：2001-07-19
申请号：PCT/EP2001/000188
申请日：2001-01-10
IPC分类号： G01T1/161 , G01T1/164 , G01T7/00 , G06T1/00 , G21K1/02
CPC分类号： G21K1/025 , G01T1/1648
摘要： The invention relates to a method of imaging a target organ in a patient by SPECT, by using a gamma camera having a gamma detector, and by computer reconstructing the distribution of the radioactivity inside the patient's body from planar images, acquired along at least one linear orbit performed in a transverse direction, wherein said gamma detector is perpendicularly provided on its outer surface with a plurality of collimator septa in a mutually parallel arrangement and with at least one raised wall, extending in the longitudinal direction of the detector, transversely positioned to said septa and with a substantial portion extending beyond said septa, said wall and said septa together forming a so-called rake collimator. The invention further relates to said rake collimator as such and to a combination of a gamma detector and a rake collimator. The invention also relates to an equipment for performing the above method.
摘要翻译：本发明涉及通过使用具有伽马检测器的伽马照相机通过SPECT对患者中的目标器官进行成像的方法，以及通过计算机从平面图像重建平面图像中的放射性分布，沿着至少一个线性轨道，其中所述伽马检测器在其外表面上垂直设置有多个准直器隔片，所述多个准直器隔片具有相互平行的布置，并且至少一个在所述检测器的纵向方向上延伸的凸壁，横向地定位于所述并且具有延伸超过所述隔片的大部分，所述壁和所述隔片一起形成所谓的耙准直器。本发明还涉及这样的所述耙式准直器以及伽马探测器和耙准直器的组合。本发明还涉及一种用于执行上述方法的设备。

67. 发明申请

WO00079301A1 DEVICE FOR DETECTING AND LOCATING A RADIOACTIVE SOURCE EMITTING GAMMA RAYS, USE OF SAME 审中-公开
标题翻译：用于检测和定位放射性源发射游隙的装置，使用它们
公开(公告)号：WO00079301A1
公开(公告)日：2000-12-28
申请号：PCT/FR2000/001746
申请日：2000-06-22
IPC分类号： A61B19/00 , G01T1/161 , G01T1/164
CPC分类号： G01T1/161 , A61B6/4258 , A61B2090/392 , G01T1/1648
摘要： The invention concerns a device for detecting and locating a radioactive source emitting gamma rays, characterised in that it comprises: first means for determining the direction of the gamma radiation emitting source relative to the centre of the detector comprising: gamma radiation sensing means; a plurality of means for evaluating the gamma radiation flux; means analysing the gamma radiation flux for determining the direction of the radiation source; second means for directing the radioactive emitting source comprising mechanical means for causing the device to move, so as to bring its centreline nearer the gamma radiation emitting source; means physically representing the device centreline.
摘要翻译：本发明涉及一种用于检测和定位发射γ射线的放射源的装置，其特征在于，它包括：用于确定伽马射线辐射源相对于检测器中心的方向的第一装置，包括：伽马射线感测装置; 多个用于评估伽马辐射通量的装置; 意味着分析γ辐射通量以确定辐射源的方向; 用于引导放射性发射源的第二装置，包括用于使装置移动的机械装置，以使其中心线更靠近伽马射线辐射源; 表示物理地表示设备中心线。

68. 发明申请

WO00042826A2 VARIABLE RESOLUTION IMAGING SYSTEM 审中-公开
标题翻译：可变分辨率成像系统
公开(公告)号：WO00042826A2
公开(公告)日：2000-07-20
申请号：PCT/US2000/000145
申请日：2000-01-05
IPC分类号： A61B6/03 , G01T1/164 , G01T1/20 , G01T1/29 , H05G
CPC分类号： G01T1/2985 , A61B6/032 , A61B6/4241 , G01T1/1644 , G01T1/2018
摘要： This invention relates to an imaging system useful in medical and industrial X-ray imaging, including classical and digital radiography, and classical CT scanning. The imaging system of the present invention provides an increased spatial resolution over imaging systems of the prior art by angulating an X-ray detector or detector array with respect to a radiation source.
摘要翻译：本发明涉及一种在医学和工业X射线成像中有用的成像系统，包括经典和数字射线照相术，以及经典CT扫描。本发明的成像系统通过使X射线检测器或检测器阵列相对于辐射源成角度地提供超过现有技术的成像系统的空间分辨率。

69. 发明申请

WO0013020A3 CELLULAR TRANSPORT DETECTION SYSTEM 审中-公开
标题翻译：细胞运输检测系统
公开(公告)号：WO0013020A3
公开(公告)日：2000-06-02
申请号：PCT/US9919115
申请日：1999-08-23
申请人： TRELLIS BIOINFORMATICS INC
发明人： KAUVAR LAWRENCE M
IPC分类号： G01N33/50 , G01N33/60 , G01N33/543 , C12Q1/16 , G01N21/63 , G01N33/569 , G01T1/164
CPC分类号： G01N33/5076 , G01N33/5005 , G01N33/5008 , G01N33/502 , G01N33/5035 , G01N33/5044 , G01N33/5058 , G01N33/60
摘要： A method to follow the uptake of labeled materials into scintillant-marked compartments, cells, tissue and organelles in real time by monitoring the location of scintillant-emitted light is disclosed.
摘要翻译：公开了一种通过监测闪烁体发射光的位置来实时追踪标记材料向闪烁体标记的隔室，细胞，组织和细胞器的摄取的方法。

70. 发明申请

WO00013041A1 SEMICONDUCTOR RADIATION DETECTOR WITH DOWNCONVERSION ELEMENT 审中-公开
标题翻译：具有透射元件的半导体辐射探测器
公开(公告)号：WO00013041A1
公开(公告)日：2000-03-09
申请号：PCT/US1999/019644
申请日：1999-08-27
IPC分类号： G01T1/161 , G01T1/164 , G01T1/20 , G01T1/24 , H01L27/14 , H01L27/146 , H01L31/09 , H04N5/32
CPC分类号： G01T1/161 , A61B6/4258 , G01T1/1642 , G01T1/1644 , G01T1/2018 , H01L27/146 , H01L27/14658 , H04N5/32
摘要： A radiation detection device (407) for gamma radiation is disclosed having an array of crystals (410) optically positioned adjacent an optional collimator (402), the crystals emitting visible light upon illumination by the incident gamma radiation. An array of photodetectors (430) is optically positioned adjacent the crystal array (410) on the side of the crystal array (410) opposite that of the collimator (402). A select photodetector in the photodetector array (430) provides an output signal when the select photodetector is illuminated by the visible light. An integrated circuit having an input from the output signals of said array of photodetectors (430) is used to process and output signals indicative of the intensity and position of the gamma radiation.
摘要翻译：公开了一种用于伽马辐射的放射线检测装置（407），其具有邻近可选择准直器（402）光学定位的晶体阵列（410），该晶体在入射的伽马辐射照射时发射可见光。在与晶体阵列（410）的与准直器（402）相反的一侧的晶体阵列（410）附近，光学器件阵列（430）被光学定位。当选择光电检测器被可见光照亮时，光电检测器阵列（430）中的选择光电检测器提供输出信号。使用具有来自所述光电检测器阵列（430）的输出信号的输入的集成电路来处理和输出指示伽马辐射的强度和位置的信号。

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