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61. 发明申请

WO2015118547A1 METHOD OF MAINTAINING DISEASE STABILITY IN A SUBJECT HAVING GAUCHER'S DISEASE 审中-公开
标题翻译：维持病原体病原体疾病稳定性的方法
公开(公告)号：WO2015118547A1
公开(公告)日：2015-08-13
申请号：PCT/IL2015/050145
申请日：2015-02-09
申请人： PROTALIX LTD.
发明人： SHAALTIEL, Yoseph , ALMON, Einat
IPC分类号： A61K38/47 , C12N9/24 , C12N15/82 , A61K36/23 , A61P43/00
CPC分类号： C12N9/2434 , A61K38/00 , A61K38/47 , C12N9/2402 , C12N15/8257 , C12Y302/01045
摘要： A method of maintaining disease stability in a subject having Gaucher's disease following switch from enzyme replacement therapy (ERT) is provided. The method comprising orally administering to the subject a therapeutically effective amount of recombinant glucocerebrosidase (GCD) comprised in plant cells, thereby maintaining disease stability following switch.
摘要翻译：提供了一种在从酶替代疗法（ERT）切换到患有戈谢氏病的受试者中维持疾病稳定性的方法。该方法包括向受试者口服给予植物细胞中包含的治疗有效量的重组葡糖脑苷脂酶（GCD），从而保持切换后的疾病稳定性。

62. 发明申请

WO2015032302A1 卵黏蛋白液体制剂及其制备方法审中-公开
公开(公告)号：WO2015032302A1
公开(公告)日：2015-03-12
申请号：PCT/CN2014/085737
申请日：2014-09-02
申请人：华中农业大学
发明人：马美湖 , 单媛媛 , 黄茜
IPC分类号： A61K38/57 , A61K38/40 , A61K38/47 , A61K47/26 , A61K47/34 , A61K47/18 , A61K47/04 , A61P31/04 , A61P31/12
CPC分类号： A61K38/40 , A01N63/02 , A61K9/12 , A61K35/57 , A61K36/899 , A61K38/47 , A01N25/02 , A61K2300/00
摘要：一种卵黏蛋白液体制剂，含有下述重量百分比的成分：卵黏蛋白0.01~0.1%、辅助蛋白0.001~0.01%、氨基酸1.5~4%、多元醇0.5~5%，余量为pH值6~8的缓冲液或水，所述辅助蛋白为溶菌酶和/或卵转铁蛋白。所述卵黏蛋白液体制剂中还含有50~500mmol/L钙离子或10~500mmol/L镁离子。本发明的卵黏蛋白液体制剂能抵御微生物入侵、降低病毒活性与毒力，可喷涂于食品表面、动物或人的口鼻、创伤伤口等处。

63. 发明申请

WO2014201027A2 TREATMENT OF MERKEL CELL POLYOMAVIRUS INFECTION 审中-公开
标题翻译：梅克尔细胞多发性骨髓瘤感染的治疗
公开(公告)号：WO2014201027A2
公开(公告)日：2014-12-18
申请号：PCT/US2014/041753
申请日：2014-06-10
申请人： ANSUN BIOPHARMA, INC.
发明人： MOSS, Ronald, D.
IPC分类号： A61K38/47
CPC分类号： A61K38/47 , A61K38/164 , C12Y302/01 , Y02A50/467 , Y02A50/471
摘要： The present disclosure provides novel compositions and methods for treating an infection of the skin resulting from an infection of a member of the Orthopolyomavirus virus family. In particular, the present disclosure provides compounds having an anchoring domain that anchors the compound to the surface of a target cell, and a sialidase domain that can act extracellularly to inhibit infection of a target cell by a pathogen, such as a virus. The present disclosure also comprises therapeutic compositions having sialidase activity, including protein based compounds having sialidase catalytic domains. Compounds of the disclosure can be used for treating pathogenic infection to the skin.
摘要翻译：本公开提供了用于治疗由正性多瘤病毒病毒病毒家族的成员的感染导致的皮肤感染的新型组合物和方法。特别地，本公开提供具有将化合物锚定到靶细胞表面的锚定结构域的化合物，以及可以在细胞外作用以抑制病原体如病毒感染靶细胞的唾液酸酶结构域。本公开还包括具有唾液酸酶活性的治疗组合物，包括具有唾液酸酶催化结构域的蛋白质基化合物。本公开的化合物可用于治疗对皮肤的致病性感染。

64. 发明申请

WO2013130963A8 COMPOSITIONS AND METHODS FOR TREATING TYPE III GAUCHER DISEASE 审中-公开
公开(公告)号：WO2013130963A8
公开(公告)日：2014-10-09
申请号：PCT/US2013028608
申请日：2013-03-01
申请人： SHIRE HUMAN GENETIC THERAPIES
发明人： CROMBEZ ERIC , BHIRANG KIRAN , COHN GABRIEL MARTIN
IPC分类号： A61K38/46 , A61K38/47
CPC分类号： A61K38/47 , A61K9/0019 , C12Y302/01045 , G01N33/538 , G01N33/6854 , G01N2333/924 , G01N2800/044 , G01N2800/52
摘要： Methods and compositions for treating Gaucher disease are described.

65. 发明申请

WO2014144288A1 USING RNA-GUIDED FOKI NUCLEASES (RFNS) TO INCREASE SPECIFICITY FOR RNA-GUIDED GENOME EDITING 审中-公开
标题翻译：使用RNA引导的FOKI核（RFNS）增加RNA指导基因组编辑的特异性
公开(公告)号：WO2014144288A1
公开(公告)日：2014-09-18
申请号：PCT/US2014/028630
申请日：2014-03-14
申请人： THE GENERAL HOSPITAL CORPORATION
发明人： JOUNG, J. Keith , TSAI, Shengdar
IPC分类号： C12P21/06 , C12P19/34 , A61K38/43 , A61K38/47
CPC分类号： C12N15/102 , C07K14/005 , C07K14/195 , C07K2319/00 , C07K2319/01 , C07K2319/80 , C12N9/0071 , C12N9/1007 , C12N9/16 , C12N9/22 , C12N9/96 , C12N15/01 , C12N15/1031 , C12N15/11 , C12N15/63 , C12N15/85 , C12N2310/20 , C12N2710/00033 , C12N2770/00033 , C12N2800/80 , C12Y114/11 , C12Y201/01 , C12Y301/00 , C12Y301/21004
摘要： Methods for increasing specificity of RNA-guided genome editing, e.g., editing using CRISPR/Cas9 systems.
摘要翻译：提高RNA指导基因组编辑特异性的方法，例如使用CRISPR / Cas9系统进行编辑。

66. 发明申请

WO2014130722A1 METHODS AND COMPOSITIONS FOR TREATMENT OF FORBES-CORI DISEASE 审中-公开
标题翻译：用于治疗福尔马林病的方法和组合物
公开(公告)号：WO2014130722A1
公开(公告)日：2014-08-28
申请号：PCT/US2014/017478
申请日：2014-02-20
申请人： VALERION THERAPEUTICS, LLC , ARMSTRONG, Dustin, D.
发明人： ARMSTRONG, Dustin, D.
IPC分类号： C07K14/47 , C07K19/00 , A61K38/47 , A61K39/395 , A61P43/00
CPC分类号： A61K47/64 , A61K38/00 , A61K38/45 , A61K38/47 , A61K47/6849 , C07K16/28 , C07K16/44 , C07K2317/565 , C07K2317/622 , C07K2317/77 , C07K2319/00 , C07K2319/06 , C07K2319/10 , C07K2319/30 , C07K2319/33 , C12N9/1051 , C12N9/2428 , C12N9/2451 , C12Y204/01025 , C12Y204/01125 , C12Y302/01003 , C12Y302/01033
摘要： The present invention is directed to chimeric polypeptides comprising an amytoglucasklase (AGL) polypeptide mid an internalizing moiety, or chimeric polypeptides comprising a mature acid-alpha glucosidase (GAA) and an internalizing moiety. The chimeric polypeptides of the invention are used to increase the activity of She enzyme in cells, decrease glycogen accumulation in cells and treat Forbes-Cori disease.
摘要翻译：本发明涉及在内化部分中间包含淀粉样葡聚糖酶（AGL）多肽的嵌合多肽，或包含成熟酸-α葡糖苷酶（GAA）和内化部分的嵌合多肽。本发明的嵌合多肽用于增加细胞中She酶的活性，减少细胞中的糖原积累并治疗福布斯 - 柯利病。

67. 发明申请

WO2014113641A1 SELECTIVE GLYCOSIDASE REGIMEN FOR IMMUNE PROGRAMMING AND TREATMENT OF CANCER 审中-公开
标题翻译：选择性糖苷酶方案免疫编程和治疗癌症
公开(公告)号：WO2014113641A1
公开(公告)日：2014-07-24
申请号：PCT/US2014/011995
申请日：2014-01-17
申请人： KLINE, Ellis
发明人： KLINE, Ellis
IPC分类号： A61K38/47
CPC分类号： A61K38/47 , A61K9/006 , A61K31/404 , A61K31/506 , A61K31/517 , A61K31/5377 , A61K45/06 , C12Y302/01018 , C12Y302/01023 , C12Y302/01049 , C12Y302/0105 , C12Y302/01051 , A61K2300/00
摘要： The present invention relates to treatment and prevention of cancer with glycosidase(s). In various aspects the invention relates to the treatment and management of cancer to prevent metastasis or recurrence, or to improve outcome and rate of successful treatment with conventional therapeutic regimens. An enormous level of research and pharmaceutical development focuses on the treatment of cancer. Cancer remains one of the top targets of pharmaceutical pipelines. Products under development range from kinase inhibitors, to angiogenesis inhibitors, monoclonal antibodies against tumor targets, apoptosis inducers, anti-tumor vaccination, and conventional chemotherapeutic agents against various tumor targets and with various cytotoxic effects.
摘要翻译：本发明涉及用糖苷酶治疗和预防癌症。在各个方面，本发明涉及治疗和控制癌症以预防转移或复发，或改善用常规治疗方案成功治疗的结果和速率。巨大的研究和药物开发水平集中在治疗癌症。癌症仍然是药物管道的首要目标之一。正在开发的产品范围从激酶抑制剂，血管生成抑制剂，针对肿瘤靶标的单克隆抗体，细胞凋亡诱导剂，抗肿瘤疫苗接种和针对各种肿瘤靶标的常规化学治疗剂以及各种细胞毒性作用。

68. 发明申请

WO2012106725A3 METHODS AND COMPOSITIONS FOR TREATING OCCULAR DISORDERS 审中-公开
标题翻译：治疗阴道疾病的方法和组合
公开(公告)号：WO2012106725A3
公开(公告)日：2014-04-17
申请号：PCT/US2012024013
申请日：2012-02-06
申请人： SANGAMO BIOSCIENCES INC , ZHANG H STEVE
发明人： ZHANG H STEVE
IPC分类号： A01K67/027 , A61K35/12 , A61K38/16 , A61K38/47 , A61P27/02 , C07H21/04 , C07K14/00 , C12N9/96
CPC分类号： C12N9/22 , A01K67/0275 , A01K2217/072 , A01K2227/105 , A01K2267/0306 , A61K38/00 , C07K14/4703 , C07K14/4705 , C07K14/705 , C07K2319/80 , C07K2319/81
摘要： Disclosed herein are methods and compositions for treating ocular disorders which include a fusion protein which targets a rhodopsin gene. The fusion protein includes an engineered DNA binding domain and a functional domain.
摘要翻译：本文公开了用于治疗眼部疾病的方法和组合物，其包括靶向视紫红质基因的融合蛋白。融合蛋白包括工程化的DNA结合结构域和功能结构域。

69. 发明申请

WO2014055672A1 CLAY PRODUCT AND USES THEREOF 审中-公开
标题翻译：粘土产品及其用途
公开(公告)号：WO2014055672A1
公开(公告)日：2014-04-10
申请号：PCT/US2013/063102
申请日：2013-10-02
申请人： OIL-DRI CORPORATION OF AMERICA , BROOMHEAD, Jonathan , CHI, Fang , CRAVENS, Ron , GOSS, George, Robert , JAFFEE, Richard , JOHNSTON, Sara, LeAnn , McPHERSON, Michael , WILLIAMS, Ronda, Jean
发明人： BROOMHEAD, Jonathan , CHI, Fang , CRAVENS, Ron , GOSS, George, Robert , JAFFEE, Richard , JOHNSTON, Sara, LeAnn , McPHERSON, Michael , WILLIAMS, Ronda, Jean
IPC分类号： A61K38/47 , A61K31/11 , A01N35/00
CPC分类号： A61K33/06 , A61K31/198 , A61K33/12 , A61K35/02 , A61K35/66 , A61K36/06 , A61K2300/00
摘要： The present invention relates to a combination of an anti-toxin, The present invention relates to a combination of an anti-toxin, an immunomodulator and a component that provides energy to mucosal cells, which may be useful for decreasing effects of Clostridia sp. or coccidia sp based diseases or other enteric diseases or by generally improving gastro intestinal health or function
摘要翻译：本发明涉及抗毒素的组合。本发明涉及抗毒素，免疫调节剂和向粘膜细胞提供能量的成分的组合，其可用于降低Clostridia sp的作用。或球虫类疾病或其他肠道疾病或通常改善胃肠健康或功能

70. 发明申请

WO2013136069A3 ANIMAL FEED SUPPLEMENT AND ASSAY METHOD 审中-公开
标题翻译：动物饲料补充和测定方法
公开(公告)号：WO2013136069A3
公开(公告)日：2014-01-30
申请号：PCT/GB2013050616
申请日：2013-03-13
申请人： UNIV BIRMINGHAM
发明人： WARING ROSEMARY , HUNTER JOHN
IPC分类号： A23K1/165 , A23K1/18 , A61K38/43 , A61K38/47
CPC分类号： A61K38/47 , A23K10/30 , A23K20/189 , A23K50/20 , C12Y302/00 , C12Y302/01001 , C12Y302/01002 , G01N33/0004
摘要： An animal feed additive comprising a plurality of enzymatically active enzymes, the enzymes comprising a plurality of carbohydrases, for example one or one amylases and optionally one or more fructanases. This is typically used for equines and may be combined with oats or hay. This mixture has been found to be especially useful to prevent intestinal disease such as colic, acidosis and laminitis. The application also describes methods of monitoring the health of an equine, comprising measuring the concentration of one or more volatile organic compounds from the faeces of an animal selected from acetic acid, butanoic acid, propanoic acid, 2-methyl propanoic acid and 3-methyl butanoic acid.
摘要翻译：包含多种酶活性酶的动物饲料添加剂，所述酶包含多个糖酶，例如一个或一个淀粉酶和任选的一种或多种果糖酶。这通常用于马，并可与燕麦或干草结合使用。已经发现该混合物特别有用于预防肠道疾病如绞痛，酸中毒和扁桃体炎。本申请还描述了监测马的健康的方法，包括从动物的粪便中测量一种或多种挥发性有机化合物的浓度，所述动物选自乙酸，丁酸，丙酸，2-甲基丙酸和3-甲基丁酸。

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