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61. 发明申请

WO2014152878A3 USE OF DIMERIZATION DOMAINS FOR TEMPERATURE REGULATION OF ENZYME ACTIVITY 审中-公开
标题翻译：修饰域用于温度调节酶活性的研究
公开(公告)号：WO2014152878A3
公开(公告)日：2014-11-13
申请号：PCT/US2014028091
申请日：2014-03-14
申请人： AGRIVIDA INC
发明人： LAZAR GABOR , DONALD JASON , RAAB R MICHAEL
IPC分类号： C07K1/00 , C07K14/00 , C07K17/00 , C12N9/24
CPC分类号： C12N9/2437 , C07K2319/73 , C07K2319/92 , C12N9/2434 , C12N9/2482 , C12Y302/01004 , C12Y302/01008
摘要： Methods for regulating protein activity by fusing dimerization domains to target protein are provided. Chimeric proteins that include dimerization domains fused to target proteins for altering the activity of the target proteins are described. Engineered nucleic acids encoding chimeric proteins and hosts engineered to express engineered nucleic acids are also provided.
摘要翻译：提供了通过将二聚化结构域融合至靶蛋白来调节蛋白质活性的方法。描述了包括与靶蛋白融合以改变靶蛋白活性的二聚化结构域的嵌合蛋白。还提供了编码嵌合蛋白的工程化核酸和工程改造以表达工程化核酸的宿主。

62. 发明申请

WO2014122079A3 IMPROVED PURIFICATION OF PROTEINS VIA A DEGLYCOSYLATION STEP 审中-公开
公开(公告)号：WO2014122079A3
公开(公告)日：2014-08-14
申请号：PCT/EP2014/051931
申请日：2014-01-31
申请人： CHR. HANSEN A/S
发明人： JACOBSEN, Jonas , BISGAARD-FRANTZEN, Hans , VAN DEN BRINK, Johannes Maarten , JENSEN, Jesper Langholm , HANSEN, Sari Charlotte
IPC分类号： C07K1/00 , C07K1/18 , C07K1/20
摘要： A method for purifying a polypeptide of interest by use of a deglycosylation step.

63. 发明申请

WO2014116982A3 METHODS OF MODULATING GABAERGIC INHIBITORY SYNAPSE FORMATION AND FUNCTION 审中-公开
公开(公告)号：WO2014116982A3
公开(公告)日：2014-07-31
申请号：PCT/US2014/012997
申请日：2014-01-24
申请人： BRANDEIS UNIVERSITY , PARADIS, Suzanne , MOORE, Anna, R. , KUZIRIAN, Marissa, S.
发明人： PARADIS, Suzanne , MOORE, Anna, R. , KUZIRIAN, Marissa, S.
IPC分类号： A61K38/00 , A61K38/16 , C07K1/00
摘要： The present technology relates to methods of modulating the number of GABAergic synapses between at least two neurons. These methods include contacting at least one of the neurons with a PlexinB agonist or a nucleic acid molecule encoding a PlexinB agonist, such as a composition including a Sema4D polypeptide or an extracellular fragment thereof, or a nucleic acid molecule encoding the Sema4D polypeptide or extracellular fragment thereof. The present technology also relates to methods of modulating neuronal activity in the central nervous system or peripheral nervous system of a subject in need thereof by modulating the number of GABAergic synapses between at least two neurons. The present technology further relates to methods of treating a neurological disorder that would benefit from modulating neuronal activity in the central nervous system or peripheral nervous system of a subject in need thereof.

64. 发明申请

WO2014088928A1 METHODS FOR MAKING TARGETED PROTEIN TOXINS BY SORTASE-MEDIATED PROTEIN LIGATION 审中-公开
标题翻译：通过蛋白质介导的蛋白质引物制备靶向蛋白质的方法
公开(公告)号：WO2014088928A1
公开(公告)日：2014-06-12
申请号：PCT/US2013/072552
申请日：2013-12-02
申请人： PRESIDENT AND FELLOWS OF HARVARD COLLEGE
发明人： COLLIER, R., John , MCCLUSKEY, Andrew, J.
IPC分类号： C07K1/00 , C07K14/705
CPC分类号： C12P21/00 , A61K47/65 , A61K47/6817 , A61K47/6851 , A61K47/6889 , C07K1/026 , C07K2319/01 , C07K2319/20 , C07K2319/55 , C12N9/52
摘要： We described novel methods for making targeted protein toxins by sortase-mediated protein ligation. The methods allow for a toxin and receptor-binding ligand to be ligated under mild conditions in vitro, following their expression and purification as single entities. The methods also provide a much more efficient way of making functional targeted fusion toxins compared to recombinant or chemical production of these structures.
摘要翻译：我们描述了通过分选酶介导的蛋白质连接制备靶向蛋白质毒素的新方法。这些方法允许毒素和受体结合配体在温和条件下在体外连接，其表达和纯化作为单个实体。与这些结构的重组或化学生产相比，这些方法还提供了更有效的制备功能性靶向融合毒素的方法。

65. 发明申请

WO2012162068A3 DEIMMUNIZED SERUM-BINDING DOMAINS AND THEIR USE FOR EXTENDING SERUM HALF-LIFE 审中-公开
标题翻译：消除血清结合域及其用于延长血清半衰期
公开(公告)号：WO2012162068A3
公开(公告)日：2014-02-20
申请号：PCT/US2012038227
申请日：2012-05-16
申请人： MACROGENICS INC , BONVINI EZIO , BARAT BHASWATI , HUANG LING , JOHNSON LESLIE S
发明人： BONVINI EZIO , BARAT BHASWATI , HUANG LING , JOHNSON LESLIE S
IPC分类号： C07K16/00 , A61K39/00 , C07K1/00
CPC分类号： C07K16/32 , C07K14/315 , C07K16/2803 , C07K16/2809 , C07K16/283 , C07K16/2851 , C07K16/44 , C07K2317/24 , C07K2317/31 , C07K2317/567 , C07K2317/62 , C07K2317/624 , C07K2317/626 , C07K2317/73 , C07K2317/76 , C07K2317/90 , C07K2317/92 , C07K2319/31 , C07K2319/32 , C07K2319/73
摘要： The disclosure is directed to a polypeptide (for example, an antigen-binding molecule) that comprises a polypeptide portion of a deimmunized serum-binding protein capable of binding to said serum protein. The presence of the serum-binding protein extends the serum half-life of the polypeptide, relative to the serum half-life of the polypeptide if lacking the polypeptide portion of the deimmunize serum-binding protein. Further disclosed are methods and uses that employ such molecules.
摘要翻译：本公开涉及包含能够结合所述血清蛋白的解除免疫的血清结合蛋白的多肽部分的多肽（例如，抗原结合分子）。如果缺乏去免疫的血清结合蛋白的多肽部分，则血清结合蛋白的存在相对于多肽的血清半衰期延长了多肽的血清半衰期。进一步公开的是使用这种分子的方法和用途。

66. 发明申请

WO2013188984A1 SYSTEMS AND METHODS FOR IDENTIFYING THERMODYNAMICALLY RELEVANT POLYMER CONFORMATIONS 审中-公开
标题翻译：识别热力学相关聚合物结构的系统和方法
公开(公告)号：WO2013188984A1
公开(公告)日：2013-12-27
申请号：PCT/CA2013/050489
申请日：2013-06-21
申请人： ZYMEWORKS INC.
发明人： LAKATOS, Gregory
IPC分类号： G06F19/16 , G01N33/68 , G06F19/00 , C07K1/00 , C40B30/02
CPC分类号： G06F19/16 , C07K1/00 , C07K2299/00 , G01N33/68 , G06F19/704 , G06F19/707
摘要： Systems, methods and non-transitory computer readable media identify favored polymer conformations. One or more residues are identified and may be replaced in the polymer, or the original primary sequence of the polymer may be retained. The conformations of residues in a subset of residues in a region of the identified one or more residues are altered. This conformational adjustment is repeated for other subsets of residues in the region of the identified one or more residues, and for other conformations, thereby deriving a plurality of polymer structures. A set of clusters is generated for each residue of the polymer using the conformationally adjusted structures, thereby creating sets of clusters. Structures in the plurality of structures are grouped into subgroups when the structures fall into the same clusters across a threshold number of the sets of clusters. One or more physical properties are determined for structures in subgroups, thereby identifying one or more thermodynamically relevant polymer conformations for the polymer.
摘要翻译：系统，方法和非暂时计算机可读介质标识有利的聚合物构象。鉴定出一个或多个残基并且可以在聚合物中被替换，或者可以保留聚合物的原始一级序列。所鉴定的一个或多个残基区域中的残基子集中的残基的构象被改变。在所鉴定的一个或多个残基的区域中的其它子集的残基重复该构象调整，并对其它构型重复，从而导出多个聚合物结构。使用构象调整的结构为聚合物的每个残基生成一组簇，由此产生簇集。当结构通过阈值数量的集群集合落入相同的集群时，多个结构中的结构被分组成子组。确定亚组中的结构的一种或多种物理性质，从而鉴定聚合物的一个或多个热力学相关的聚合物构象。

67. 发明申请

WO2013044265A3 MULTIPLEX MRM ASSAY FOR EVALUATION OF CANCER 审中-公开
标题翻译：多重MRM测定用于评估癌症
公开(公告)号：WO2013044265A3
公开(公告)日：2013-08-29
申请号：PCT/US2012056965
申请日：2012-09-24
申请人： EXPRESSION PATHOLOGY INC
发明人： KRIZMAN DAVID B , HEMBROUGH TODD , THYPARAMBIL SHEENO , LIAO WEI-LIAO
IPC分类号： C40B30/10 , C07K1/00 , C07K14/00
CPC分类号： G01N33/6848 , G01N33/6893 , G01N33/743 , G01N2333/47 , G01N2333/70567 , G01N2800/56 , G01N2800/7028
摘要： The current disclosure provides specific peptides, and derived ionization characteristics of the peptides from the estrogen receptor (ER) proteins that are particularly advantageous for quantifying the ER proteins directly in biological samples that have been fixed in formalin by the method of Selected Reaction Monitoring / Multiple Reaction Monitoring (SRM/MRM) mass spectrometry. These peptides can be quantitated if they reside in a modified or in an unmodified form. An example of a modified form of an ER peptide is phosphorylation of a tyrosine, threonine, serine, and/or other amino acid residues within the peptide sequence.
摘要翻译：目前的公开内容提供特定的肽，并且来自雌激素受体（ER）蛋白质的肽的特异性肽的衍生电离特征，其特别有利于通过选择反应监测/多重方法在福尔马林中固定的生物样品中直接定量ER蛋白质反应监测（SRM / MRM）质谱。如果它们以修饰或未修饰的形式存在，则可定量这些肽。 ER肽的修饰形式的实例是肽序列内的酪氨酸，苏氨酸，丝氨酸和/或其他氨基酸残基的磷酸化。

68. 发明申请

WO2013120060A1 DELIVERY OF THERAPEUTIC AGENTS BY A COLLAGEN BINDING PROTEIN 审中-公开
标题翻译：通过胶原蛋白结合蛋白递送治疗药物
公开(公告)号：WO2013120060A1
公开(公告)日：2013-08-15
申请号：PCT/US2013/025541
申请日：2013-02-11
申请人： THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ARKANSAS , KITASATO UNIVERSITY , MONTEFIORE MEDICAL CENTER
发明人： PONNAPAKKAM, Tulasi , PHILOMINATHAN, Sagaya, Theresa Leena , SAKON, Joshua , KATIKANENI, Ranjitha , KOIDE, Takaki , MATSUSHITA, Osamu , GENSURE, Robert, C.
IPC分类号： A61K38/46 , C07K1/00 , C12N9/14 , A61K38/29
CPC分类号： A61K38/48 , A61K38/29 , A61K47/56 , A61K47/64 , C12Y304/00
摘要： Methods of delivering therapeutic agents by administering compositions including a bacterial collagen-binding polypeptide segment linked to the therapeutic agent to subjects in need of treatment with the therapeutic agent are provided. Methods of treating hyperparathyroidism, and hair loss using compositions comprising a collagen binding polypeptide and a PTH/PTHrP receptor agonist are provided. In addition, methods of reducing hair regrowth by administering a composition including a collagen binding polypeptide and a PTH/PTHrP receptor antagonist are provided.
摘要翻译：提供了通过将包含与治疗剂连接的细菌胶原结合多肽片段的组合物施用于需要用治疗剂治疗的受试者来递送治疗剂的方法。提供了使用包含胶原结合多肽和PTH / PTHrP受体激动剂的组合物治疗甲状旁腺机能亢进和脱发的方法。此外，提供了通过施用包含胶原结合多肽和PTH / PTHrP受体拮抗剂的组合物来减少头发再生的方法。

69. 发明申请

WO2013086430A1 COMPOSITIONS AND METHODS FOR PURIFYING BAX 审中-公开
标题翻译：用于净化BAX的组合物和方法
公开(公告)号：WO2013086430A1
公开(公告)日：2013-06-13
申请号：PCT/US2012/068590
申请日：2012-12-07
申请人： UNIVERSITY OF CENTRAL FLORIDA RESEARCH FOUNDATION, INC.
发明人： KHALED, Annette
IPC分类号： C12N15/12 , C12N15/09 , C07K1/00
CPC分类号： C07K14/4747 , C07K2319/036
摘要： Disclosed are compositions and methods for purifying a Bax protein. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
摘要翻译：公开了用于纯化Bax蛋白质的组合物和方法。该摘要旨在作为用于在特定技术中进行搜索的扫描工具，而不意在限制本发明。

70. 发明申请

WO2013071180A1 LIGNOCELLULOSE PROCESSING METHODS AND RELATED PRODUCTS 审中-公开
标题翻译：木糖醇加工方法及相关产品
公开(公告)号：WO2013071180A1
公开(公告)日：2013-05-16
申请号：PCT/US2012/064541
申请日：2012-11-09
申请人： VIRDIA LTD. , JANSEN, Robert , BANIEL, Eran , EYAL, Aharon , LAPIDOT, Noa , LAWSON, James Alan , BAUER, Timothy Allen , HAR-TAL, Yael Miriam , ELIAHU, Shay , JACOB, Avital
发明人： JANSEN, Robert , BANIEL, Eran , EYAL, Aharon , LAPIDOT, Noa , LAWSON, James Alan , BAUER, Timothy Allen , HAR-TAL, Yael Miriam , ELIAHU, Shay , JACOB, Avital
IPC分类号： C07K1/00
CPC分类号： C13K1/02 , C13K13/002 , C13K13/007 , Y02P20/582
摘要： A method comprising: (a) extracting a lignocellulosic substrate with an aqueous solution to form a first liquid stream comprising hemicellulose sugars and impurities and an extracted substrate; (b) separating said first liquid stream from said extracted substrate; and (c) refining said first liquid stream to form a refined hemicellulose sugars stream; wherein said refining comprises at least one of: (i) liming to form a limed stream; and (ii) concentrating sugars in said first liquid stream to at least 40% and contacting with a water-soluble solvent to form a solvent-comprising refined stream.
摘要翻译：一种方法，包括：（a）用水溶液萃取木质纤维素底物以形成包含半纤维素糖和杂质的第一液体流和提取的底物; （b）从所述提取的基底分离所述第一液体流; 和（c）精炼所述第一液体流以形成精制的半纤维素糖流; 其中所述精炼包括以下中的至少一种：（i）石灰化以形成石灰石流; 和（ii）将所述第一液体流中的糖浓缩至至少40％，并与水溶性溶剂接触以形成含溶剂的精制流。

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