专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

61. 发明申请

WO2011153166A1 NATIVE NAD-DEPENDENT GAPDH REPLACED WITH NADP-DEPENDENT GAPDH PLUS NADK 审中-公开
标题翻译： NADP依赖性NADP依赖性GAPDH的NADP依赖性腺苷
公开(公告)号：WO2011153166A1
公开(公告)日：2011-12-08
申请号：PCT/US2011/038619
申请日：2011-05-31
申请人： WILLIAM MARSH RICE UNIVERSITY , SAN, Ka-yiu , BENNETT, George, N. , WANG, Yipeng
发明人： SAN, Ka-yiu , BENNETT, George, N. , WANG, Yipeng
IPC分类号： C12P19/36
CPC分类号： C12N15/70 , C12N9/0008 , C12N9/1205 , C12P5/007 , C12P7/52 , C12P17/08 , C12P19/36 , C12Y101/01008 , C12Y101/01094 , C12Y207/01023
摘要： This invention is metabolically engineered bacterial strains that provides increased intracellular NADPH availability for the purpose of increasing the yield and productivity of NADPH-dependent compounds. In the invention, native NAD-dependent GAPDH is replaced with NAPP-dependent GAPDH plus overexpressed NADK. Uses for the bacteria are also provided.
摘要翻译：本发明是代谢改造的细菌菌株，其提供增加的细胞内NADPH可用性，以提高NADPH依赖化合物的产量和产率。在本发明中，天然NAD依赖性GAPDH被NAPP依赖性GAPDH加上过表达的NADK替代。也提供了细菌的使用。

62. 发明申请

WO2011143592A1 METHODS AND COMPOSITIONS FOR THE RECOMBINANT BIOSYNTHESIS OF PROPANOL 审中-公开
标题翻译：丙二醇重组生物化学的方法和组合物
公开(公告)号：WO2011143592A1
公开(公告)日：2011-11-17
申请号：PCT/US2011/036490
申请日：2011-05-13
申请人： JOULE UNLIMITED TECHNOLOGIES, INC. , SKRALY, Frank, Anthony
发明人： SKRALY, Frank, Anthony
IPC分类号： C12P7/04 , C12N15/74 , C12P1/20
CPC分类号： C12P7/04 , C07C1/20 , C12N9/0006 , C12N9/0008 , C12N9/93 , C12Y101/01002 , C12Y101/01298 , C12Y102/0101 , C12Y602/01017 , C07C11/06
摘要： The invention provides methods for the biosynthesis of propanol using engineered host cells. Genes encoding enzymes for the conversion of metabolic intermediates to propanol, methods for optimizing expression of these enzymes in host cells, and methods for the production of propanol by these host cells are disclosed.
摘要翻译：本发明提供使用工程化宿主细胞生物合成丙醇的方法。编码用于将代谢中间体转化为丙醇的酶的基因，用于优化宿主细胞中这些酶的表达的方法以及由这些宿主细胞产生丙醇的方法。

63. 发明申请

WO2011140088A1 INCREASING BACTERIAL SUCCINATE PRODUCTIVITY INCREASING BACTERIAL SUCCINATE PRODUCTIVITY INCREASING BACTERIAL SUCCINATE PRODUCTIVITY INCREASING BACTERIAL SUCCINATE PRODUCTIVITY INCREASING BACTERIAL SUCCINATE PRODUCTIVITY INCREASING BACTERIAL SUCCINATE PRODUCTIVITY INCREASING BACTERIAL SUCCINATE PRODUCTIVITY INCREASING BACTERIAL SUCCINATE PRODUCTIVITY 审中-公开
标题翻译：增加细菌成功生产力增加细菌成功率生产力增加细菌成功率生产力提高细菌成功率生产力提高细菌成功率提高细菌成功率
公开(公告)号：WO2011140088A1
公开(公告)日：2011-11-10
申请号：PCT/US2011/035001
申请日：2011-05-03
申请人： WILLIAM MARSH RICE UNIVERSITY , SAN, Ka-yiu , BENNETT, George , BALZER, Grant , ZHU, Jiangfeng , THAKKER, Chandresh , SANCHEZ, Ailen
发明人： SAN, Ka-yiu , BENNETT, George , BALZER, Grant , ZHU, Jiangfeng , THAKKER, Chandresh , SANCHEZ, Ailen
IPC分类号： C12P7/62 , C12N1/20
CPC分类号： C12P7/46 , C12N9/0008 , C12N9/93 , C12N15/52 , C12N15/70 , C12Y102/01002 , C12Y604/01001
摘要： Improved bacteria for making succinate and other (4) carbon dicarboxylates from the Krebs cycle have modifications to reduce acetate, lactate, EtOH and formate, as well as turn on the glyoxylate shunt, produce more NADH and overexpress PYC. In one embodiment, the bacteria are ΔadhEΔldhAΔiclRΔack-pta plus PYC + and NAD + -dependant FDH + . Improved bacteria for making succinate and other (4) carbon dicarboxylates from the Krebs cycle have modifications to reduce acetate, lactate, EtOH and formate, as well as turn on the glyoxylate shunt, produce more NADH and overexpress PYC. In one embodiment, the bacteria are ΔadhEΔldhAΔiclRΔack-pta plus PYC + and NAD + -dependant FDH + .Improved bacteria for making succinate and other (4) carbon dicarboxylates from the Krebs cycle have modifications to reduce acetate, lactate, EtOH and formate, as well as turn on the glyoxylate shunt, produce more NADH and overexpress PYC. In one embodiment, the bacteria are ΔadhEΔldhAΔiclRΔack-pta plus PYC + and NAD + -dependant FDH + .
摘要翻译：用于制备琥珀酸盐和来自Krebs循环的其它（4）碳二羧酸盐的细菌具有改变以减少乙酸盐，乳酸盐，EtOH和甲酸盐，以及开启乙醛酸盐分流，产生更多的NADH并过量表达PYC。在一个实施方案中，细菌是ΔAdhEΔldhAΔIl1αΔck-pta加PYC +和NAD +依赖性FDH +。用于制备琥珀酸盐和来自Krebs循环的其它（4）碳二羧酸盐的细菌具有改变以减少乙酸盐，乳酸盐，EtOH和甲酸盐，以及开启乙醛酸盐分流，产生更多的NADH并过量表达PYC。在一个实施方案中，细菌是αadhE1ddAΔIllΔΔck-pta加PYC +和NAD +依赖性FDH +。用于制备来自克雷伯斯循环的琥珀酸盐和其它（4）碳二羧酸盐的改良细菌具有改变以减少乙酸盐，乳酸盐，EtOH 和甲酸盐，以及开启乙醛酸分流，产生更多的NADH和过表达PYC。在一个实施方案中，细菌是ΔAdhEΔldhAΔIl1αΔck-pta加PYC +和NAD +依赖性FDH +。

64. 发明申请

WO2011094457A1 MICROORGANISM PRODUCTION OF HIGH-VALVE CHEMICAL PRODUCTS, AND RELATED COMPOSITIONS, METHODS AND SYSTEMS 审中-公开
标题翻译：微生物生产高效化学产品及相关成分，方法与系统
公开(公告)号：WO2011094457A1
公开(公告)日：2011-08-04
申请号：PCT/US2011/022790
申请日：2011-01-27
申请人： OPX BIOTECHNOLOGIES, INC. , THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE , LYNCH, Michael, D. , GILL, Ryan, T. , WARNECKE-LIPSCOMB, Tanya
发明人： LYNCH, Michael, D. , GILL, Ryan, T. , WARNECKE-LIPSCOMB, Tanya
IPC分类号： C12P7/00
CPC分类号： C12P7/42 , C12N9/0008 , C12N9/0036 , C12N9/88 , C12N9/93 , C12P7/52 , C12P7/66 , C12P17/18 , C12P19/62 , C12P19/623 , C12P21/005 , C12P29/00 , C12Y604/01002
摘要： This invention relates to metabolically engineered microorganism strains, such as bacterial strains, in which there is an increased utilization of malonyl-CoA for production of a chemical product, which includes polyketides and 3-hydroxypropionic acid.
摘要翻译：本发明涉及代谢工程化的微生物菌株，例如细菌菌株，其中丙二酰辅酶A用于生产化学产品的利用率增加，其中包括聚酮化合物和3-羟基丙酸。

65. 发明申请

WO2011005527A3 KETOREDUCTASE-MEDIATED STEREOSELECTIVE ROUTE TO ALPHA CHLOROALCOHOLS 审中-公开
标题翻译： KETOREDUCTASE介导的立体选择性ALPHA CHOLOROALCOHOLS
公开(公告)号：WO2011005527A3
公开(公告)日：2011-05-12
申请号：PCT/US2010039511
申请日：2010-06-22
申请人： CODEXIS INC , BONG YONG KOY , VOGEL MICHAEL , COLLIER STEVEN JAMES , MITCHELL VESNA , MAVINAHALLI JAGADEESH
发明人： BONG YONG KOY , VOGEL MICHAEL , COLLIER STEVEN JAMES , MITCHELL VESNA , MAVINAHALLI JAGADEESH
IPC分类号： C12N9/02 , A61P7/04 , C12N15/53
CPC分类号： C12N9/0006 , C12N9/0008 , C12P7/28 , C12P13/02 , C12P17/02 , C12Y101/01184
摘要： The present disclosure relates to engineered ketoreductase polypeptides and uses thereof for the preparation of a chloroalcohols from a chloroketones. Also provided are polynucleotides encoding the engineered ketoreductase polypeptides and host cells capable of expressing the engineered ketoreductase polypeptides.
摘要翻译：本公开涉及改造的酮还原酶多肽及其用于从氯代酮制备氯代醇的用途。还提供了编码工程化酮还原酶多肽的多核苷酸和能够表达工程化酮还原酶多肽的宿主细胞。

66. 发明申请

WO2011052819A1 글리세롤로부터 3-하이드록시프로피온산을 생산하는 새로운 방법 审中-公开
标题翻译：从甘油生产3-羟基丙酸的新方法
公开(公告)号：WO2011052819A1
公开(公告)日：2011-05-05
申请号：PCT/KR2009/006278
申请日：2009-10-29
申请人： 한국생명공학연구원 , 김철호 , 서정우 , 라련화 , 오백록 , 서필수 , 허선연
发明人： 김철호 , 서정우 , 라련화 , 오백록 , 서필수 , 허선연
IPC分类号： C12P7/18 , C12N1/21 , C12N15/53
CPC分类号： C12P7/42 , C07K14/26 , C12N9/0006 , C12N9/0008 , C12P7/18 , C12P7/52
摘要： 본 발명은 글리세롤을 이용하여 3-하이드록시프로피온산을 제조하는 새로운 방법에 관한 것으로, 더욱 자세하게는 코엔자임 B12 생성능을 가지고, 글리세롤을 탄소원으로하여 3-하이드록시프로피온산을 생산하는 능력을 가지는 미생물에서 알데히드 디하이드로게나아제를 코딩하는 유전자를 증폭시킨 변이 미생물을 글리세롤 함유 배지에서 배양하여 3-하이드록시프로피온산을 제조하는 방법에 관한 것이다. 본 발명에 따르면, 코엔자임 B12를 추가할 필요가 없으며, microaerobic 혹은 aerobic 조건에서도 글리세롤의 발효가 가능하기 때문에 3-하이드록시프로피온산의 대량 생산을 위한 생물 공정 개발에 매우 적합할 것으로 판단된다.
摘要翻译：本发明涉及一种使用甘油制备3-羟基丙酸的新方法，更具体地涉及通过培养突变型微生物制备3-羟基丙酸的方法，其中编码醛脱氢酶的基因在包含在微生物中的含有甘油的培养基中扩增能够使用甘油作为碳源产生3-羟基丙酸，并具有产生腺苷钴胺的能力。公开了大量生产3-羟基丙酸的生物工艺开发，因为甘油可以在微需氧或需氧条件下发酵，并且不需要任何另外的腺苷钴胺。

67. 发明申请

WO2011034031A1 イソプロピルアルコール生産細菌及びイソプロピルアルコール生産方法审中-公开
标题翻译：异丙醇生产细菌和生产异丙醇的方法
公开(公告)号：WO2011034031A1
公开(公告)日：2011-03-24
申请号：PCT/JP2010/065770
申请日：2010-09-13
申请人：三井化学株式会社 , 森重敬 , 高橋均 , 竹林のぞみ , 和田光史
发明人：森重　敬 , 高橋　均 , 竹林　のぞみ , 和田　光史
IPC分类号： C12N1/21 , C12N15/09 , C12P7/04
CPC分类号： C12N9/88 , C12N9/0008 , C12N9/1029 , C12P7/04 , C12Y203/01016 , C12Y401/01004
摘要：　本発明は、スクロース非ＰＴＳ遺伝子群に属するスクロース加水分解酵素遺伝子を少なくとも含むと共にイソプロピルアルコール生産系が付与又は強化されたイソプロピルアルコール生産大腸菌及びこれを用いて、スクロースを含む植物由来原料からイソプロピルアルコールを生産するイソプロピルアルコール生産方法を提供する。
摘要翻译：公开了产生异丙醇的大肠杆菌，其至少含有属于蔗糖非PTS基因组的蔗糖水解酶基因，并且在异丙醇生产系统中提供或增强。还公开了使用产生异丙醇的大肠杆菌生产异丙醇的方法，其中异丙醇由含有蔗糖的植物来源的原料产生。

68. 发明申请

WO2011026913A1 POLYPEPTIDES HAVING OXIDOREDUCTASE ACTIVITY AND THEIR USES 审中-公开
标题翻译：具有氧化还原活性的多肽及其用途
公开(公告)号：WO2011026913A1
公开(公告)日：2011-03-10
申请号：PCT/EP2010/062896
申请日：2010-09-02
申请人： DSM IP ASSETS B.V. , RUIJSSENAARS, Harald Johan , WIERCKX, Nick Johannes Petrus , KOOPMAN, Frank Wouter , STRAATHOF, Adrianus Johannes Jozef , WINDE, DE, Johannes, Hendrik
发明人： RUIJSSENAARS, Harald Johan , WIERCKX, Nick Johannes Petrus , KOOPMAN, Frank Wouter , STRAATHOF, Adrianus Johannes Jozef , WINDE, DE, Johannes, Hendrik
IPC分类号： C07D307/50 , C11D3/386 , C12N9/02 , C12P7/44
CPC分类号： C12P17/04 , C08F124/00 , C12N9/0006 , C12N9/0008 , Y02P20/52
摘要： The invention relates to a polypeptide having oxidoreductase activity which comprises the amino acid sequence set out in SEQ ID NO: 3 or an amino acid sequence encoded by the nucleotide sequence of SEQ ID NO: 4, or a variant polypeptide thereof having 45% or more sequence identity with the sequence of SEQ ID NO: 3. The invention also relates to a process for the production of 2,5-furan-dicarboxylic acid (FDCA) or production of 5-hydroxymethyl-2-furancarboxylic acid (HMF acid).
摘要翻译：本发明涉及具有氧化还原酶活性的多肽，其包含SEQ ID NO：3所示的氨基酸序列或由SEQ ID NO：4的核苷酸序列编码的氨基酸序列，或其变体多肽具有45％以上序列同一性。本发明还涉及生产2,5-呋喃二羧酸（FDCA）或生产5-羟甲基-2-呋喃甲酸（HMF酸）的方法。

69. 发明申请

WO2011008535A1 PRODUCTION OF FATTY ALCOHOLS WITH FATTY ALCOHOL FORMING ACYL-COA REDUCTASES (FAR) 审中-公开
标题翻译：生产脂肪醇与脂肪醇形成ACYA-COA还原剂（FAR）
公开(公告)号：WO2011008535A1
公开(公告)日：2011-01-20
申请号：PCT/US2010/040368
申请日：2010-06-29
申请人： CODEXIS, INC. , MCDANIEL, Robert , BEHROUZIAN, Behnaz , CLARK, Louis , HATTENDORF, Douglas , VALLE, Fernando
发明人： MCDANIEL, Robert , BEHROUZIAN, Behnaz , CLARK, Louis , HATTENDORF, Douglas , VALLE, Fernando
IPC分类号： C12P7/64 , C12N1/00
CPC分类号： C12P7/04 , C10L1/026 , C10L1/04 , C10L1/19 , C12N9/0008 , C12P7/649 , Y02E50/13
摘要： Methods of producing fatty alcohols from recombinant host cells comprising genes encoding heterologous fatty acyl-CoA reductase (FAR) enzymes are described including FAR enzymes and functional fragments thereof derived from marine bacterium and particularly marine gamma proteobacterium such as Marinobacter and Oceanobacter, as well as polynucleotides encoding the FAR enzymes and vectors and host cells comprising the same.
摘要翻译：描述了从包含编码异源脂肪酰辅酶A还原酶（FAR）酶的基因的重组宿主细胞产生脂肪醇的方法，其包括衍生自海洋细菌，特别是海洋γ蛋白质细胞如马里他杆菌和海洋洋细菌的FAR酶及其功能片段，以及多核苷酸编码FAR酶和载体以及包含其的宿主细胞。

70. 发明申请

WO2010127319A3 ORGANISMS FOR THE PRODUCTION OF 1,3-BUTANEDIOL 审中-公开
标题翻译：生产1,3-丁二醇的有机体
公开(公告)号：WO2010127319A3
公开(公告)日：2010-12-23
申请号：PCT/US2010033300
申请日：2010-04-30
申请人： GENOMATICA INC , BURGARD ANTHONY P , BURK MARK J , OSTERHOUT ROBIN E , PHARKYA PRITI
发明人： BURGARD ANTHONY P , BURK MARK J , OSTERHOUT ROBIN E , PHARKYA PRITI
IPC分类号： C12P7/16 , C12N1/20
CPC分类号： C12P7/18 , C07C29/80 , C12N9/0006 , C12N9/0008 , C12N9/1029 , C12N9/1096 , C12N9/88 , C12N15/52 , C12Y101/01 , C12Y101/01157 , C12Y102/01 , C12Y203/01 , C12Y206/01 , C12Y401/01 , C12Y402/01 , C12Y403/01
摘要： A non-naturally occurring microbial organism includes a microbial organism having a 1,3-butanediol (1,3-BDO) pathway having at least one exogenous nucleic acid encoding a 1,3- BDO pathway enzyme expressed in a sufficient amount to produce 1,3-BDO. The pathway includes an enzyme selected from a 2-amino-4-ketopentanoate (AKP) thiolase, an AKP dehydrogenase, a 2-amino-4-hydroxypentanoate aminotransferase, a 2-amino-4- hydroxypentanoate oxidoreductase (deaminating), a 2-oxo-4-hydroxypentanoate decarboxylase, a 3-hydroxybutyraldehyde reductase, an AKP aminotransferase, an AKP oxidoreductase (deaminating), a 2,4-dioxopentanoate decarboxylase, a 3-oxobutyraldehyde reductase (ketone reducing), a 3-oxobutyraldehyde reductase (aldehyde reducing), a 4-hydroxy-2-butanone reductase, an AKP decarboxylase, a 4-aminobutan-2-one aminotransferase, a 4-aminobutan-2- one oxidoreductase (deaminating), a 4-aminobutan-2-one ammonia-lyase, a butenone hydratase, an AKP ammonia-lyase, an acetylacrylate decarboxylase, an acetoacetyl-CoA reductase (CoA- dependent, aldehyde forming), an acetoacetyl-CoA reductase (CoA-dependent, alcohol forming), an acetoacetyl-CoA reductase (ketone reducing), a 3-hydroxybutyryl-CoA reductase (aldehyde forming), a 3-hydroxybutyryl-CoA reductase (alcohol forming), a 4-hydroxybutyryl- CoA dehydratase, and a crotonase. A method for producing 1,3-BDO, includes culturing such microbial organisms under conditions and for a sufficient period of time to produce 1,3-BDO.
摘要翻译：非天然存在的微生物体包括具有1,3-丁二醇（1,3-BDO）途径的微生物生物，其具有至少一种编码1,3-BDO途径酶的外源核酸，所述外源核酸以足够的量表达，以产生1 ，3-BDO。该途径包括选自2-氨基-4-酮戊酸（AKP）硫解酶，AKP脱氢酶，2-氨基-4-羟基戊酸转氨酶，2-氨基-4-羟基戊酸氧化还原酶（脱氨基），2- 4-羟基戊酸脱羧酶，3-羟基丁醛还原酶，AKP氨基转移酶，AKP氧化还原酶（脱氨），2,4-二氧代戊酸脱羧酶，3-氧代丁醛还原酶（还原酮），3-氧代丁醛还原酶），4-羟基-2-丁酮还原酶，AKP脱羧酶，4-氨基丁-2-酮氨基转移酶，4-氨基丁-2-酮氧化还原酶（脱氨基），4-氨基丁-2-酮氨裂解酶乙酰乙酰辅酶A还原酶（CoA依赖性醛形成），乙酰乙酰辅酶A还原酶（CoA依赖性醇形成），乙酰乙酰辅酶A还原酶（酮还原），3-羟基丁酰辅酶A还原酶（醛形成），3-羟基丁基乙酰辅酶A还原酶（醇形成），4-羟基丁酰辅酶A脱水酶和巴豆酸酶。一种生产1,3-BDO的方法包括在条件和足够的时间内培养这些微生物生产1,3-BDO。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式