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61. 发明申请

WO2006035282A2 MUSCARINIC RECEPTOR ANTAGONISTS 审中-公开
公开(公告)号：WO2006035282A2
公开(公告)日：2006-04-06
申请号：PCT/IB2005/002838
申请日：2005-09-26
申请人： RANBAXY LABORATORIES LIMITED , MEHTA, Anita , SALMAN, Mohammad , SARMA, Pakala, Kumara, Savithru , AERON, Shelley , CHUGH, Anita , GUPTA, Suman
发明人： MEHTA, Anita , SALMAN, Mohammad , SARMA, Pakala, Kumara, Savithru , AERON, Shelley , CHUGH, Anita , GUPTA, Suman
IPC分类号： A61K31/439
CPC分类号： C07D471/08
摘要： This present invention generally relates to muscarinic receptor antagonists, which are useful, among other uses, for the treatment of various diseases of the respiratory, urinary and gastrointestinal systems mediated through muscarinic receptors. The invention also relates to the process for the preparation of disclosed compounds, pharmaceutical compositions containing the disclosed compounds, and the methods for treating diseases mediated through muscarinic receptors.
摘要翻译：本发明总体上涉及毒蕈碱性受体拮抗剂，其可用于治疗通过毒蕈碱性受体介导的呼吸系统，泌尿系统和胃肠系统的各种疾病。本发明还涉及制备公开的化合物的方法，含有所公开的化合物的药物组合物以及治疗通过毒蕈碱受体介导的疾病的方法。

62. 发明申请

WO2006024926A1 MONOSACCHARIDE DERIVATIVES 审中-公开
标题翻译：单糖衍生物
公开(公告)号：WO2006024926A1
公开(公告)日：2006-03-09
申请号：PCT/IB2005/002573
申请日：2005-08-31
申请人： RANBAXY LABORATORIES LIMITED , SATTIGERI, Vishwajanani, Jitendra , ARORA, Sudershan, K. , PALLE, Venkata, P. , SALMAN, Mohammad , RAY, Abhijit , SHIRUMALLA, Raj, Kumar , RAUF, Abdul, Rehman, Abdul
发明人： SATTIGERI, Vishwajanani, Jitendra , ARORA, Sudershan, K. , PALLE, Venkata, P. , SALMAN, Mohammad , RAY, Abhijit , SHIRUMALLA, Raj, Kumar , RAUF, Abdul, Rehman, Abdul
IPC分类号： C07H15/18
CPC分类号： C07H15/18
摘要： The present invention relates to monosaccharide derivatives as anti-inflammatory agents. The compounds disclosed herein can be useful for inhibition and prevention of inflammation and associated pathologies, including inflammatory and autoimmune diseases such as bronchial asthma, rheumatoid arthritis, type I diabetes, multiple sclerosis, allograft rejection, psoriasis, inflammatory bowel disease, ulcerative colitis, acne, atherosclerosis, cancer, pruritis or allergic rhinitis. Pharmacological compositions containing the compounds of the present invention and the methods of treating bronchial asthma, chronic obstructive pulmonary disease, rheumatoid arthritis, multiple sclerosis, type I diabetes, psoriasis, allograft rejection, inflammatory bowel disease, ulcerative colitis, acne, atherosclerosis, cancer, pruritis, allergic rhinitis and other inflammatory and/or autoimmune disorders, using the compounds are also provided.
摘要翻译：本发明涉及作为抗炎剂的单糖衍生物。本文公开的化合物可用于抑制和预防炎症和相关病理学，包括炎症和自身免疫性疾病如支气管哮喘，类风湿性关节炎，I型糖尿病，多发性硬化，同种异体移植排斥，牛皮癣，炎性肠病，溃疡性结肠炎，痤疮，动脉粥样硬化，癌症，瘙痒症或过敏性鼻炎。包含本发明化合物的药物组合物，治疗支气管哮喘，慢性阻塞性肺病，类风湿性关节炎，多发性硬化，I型糖尿病，牛皮癣，同种异体移植排斥，炎性肠病，溃疡性结肠炎，痤疮，动脉粥样硬化，癌症，还提供了使用该化合物的瘙痒症，过敏性鼻炎和其它炎症和/或自身免疫性疾病。

63. 发明申请

WO2006016245A1 MUSCARINIC RECEPTOR ANTAGONISTS 审中-公开
标题翻译：肌肉受体拮抗剂
公开(公告)号：WO2006016245A1
公开(公告)日：2006-02-16
申请号：PCT/IB2005/002306
申请日：2005-08-03
申请人： RANBAXY LABORATORIES LIMITED , SALMAN, Mohammad , SARMA, Pakala, Kumara, Savithru , KONDASKAR, Atul , CHUGH, Anita , GUPTA, Suman
发明人： SALMAN, Mohammad , SARMA, Pakala, Kumara, Savithru , KONDASKAR, Atul , CHUGH, Anita , GUPTA, Suman
IPC分类号： C07D209/52 , A61K31/403 , A61P11/00 , A61P13/00 , A61P1/00
CPC分类号： C07D209/52
摘要： The present invention generally relates to muscarinic receptor antagonists, which are useful in the treatment of various diseases of the respiratory, urinary or gastrointestinal systems mediated through muscarinic receptors. The invention also relates to processes for preparing such muscarinic receptor antagonists and pharmaceutical compositions thereof. The invention further relates to methods of treating diseases mediated through muscarinic receptors.
摘要翻译：本发明一般涉及毒蕈碱受体拮抗剂，其可用于治疗通过毒蕈碱受体介导的呼吸，泌尿或胃肠道系统的各种疾病。本发明还涉及制备这种毒蕈碱受体拮抗剂及其药物组合物的方法。本发明还涉及治疗通过毒蕈碱受体介导的疾病的方法。

64. 发明申请

WO2006013445A2 THIAZOLIDINEDIONE DERIVATIVES 审中-公开
标题翻译：噻唑烷二酮衍生物
公开(公告)号：WO2006013445A2
公开(公告)日：2006-02-09
申请号：PCT/IB2005/002247
申请日：2005-07-28
申请人： RANBAXY LABORATORIES LIMITED , ANAND, Nitya , SALMAN, Mohammad , SHARMA, Somesh , KAPKOTI, Gobind, Singh , CHUGH, Anita , NANDA, Kamna , SARMA, Pakala, Kumara, Savithru
发明人： ANAND, Nitya , SALMAN, Mohammad , SHARMA, Somesh , KAPKOTI, Gobind, Singh , CHUGH, Anita , NANDA, Kamna , SARMA, Pakala, Kumara, Savithru
IPC分类号： C07D277/00
CPC分类号： C07D277/34
摘要： The present invention relates to alpha 1a and/or alpha 1d adrenergic receptor antagonists. Compounds described can function as alpha 1a and/or alpha 1d adrenergic receptor antagonists and can be used to treat diseases or disorders mediated through alpha 1a and/or alpha 1d adrenergic receptors. Compounds described can also be used to treat benign prostatic hyperplasia or related symptoms thereof. Compounds described can also be used to treat lower urinary tract symptoms associated with or without benign prostatic hyperplasia. Also described are processes to prepare the described compounds, as well as pharmaceutical compositions thereof and methods of treating benign prostatic hyperplasia or related symptoms thereof.
摘要翻译：本发明涉及α1a和/或α1d肾上腺素能受体拮抗剂。所描述的化合物可以作为α1a和/或α1d肾上腺素能受体拮抗剂起作用，并且可用于治疗通过α1a和/或α1d肾上腺素能受体介导的疾病或病症。所描述的化合物也可用于治疗良性前列腺增生或其相关症状。所描述的化合物也可用于治疗与或不伴有良性前列腺增生相关的下尿路症状。还描述了制备所述化合物的方法，以及其药物组合物和治疗良性前列腺增生或其相关症状的方法。

65. 发明申请

WO2006005980A1 XANTHINE DERIVATIVES USEFUL AS MUSCARINIC RECEPTOR ANTAGONISTS 审中-公开
标题翻译： XANTHINE衍生物作为MUSCARINIC受体拮抗剂有用
公开(公告)号：WO2006005980A1
公开(公告)日：2006-01-19
申请号：PCT/IB2004/002004
申请日：2004-06-16
申请人： RANBAXY LABORATORIES LIMITED , MEHTA, Anita , SALMAN, Mohammad , SARMA, Pakala, Kumara, Savithru , CHUGH, Anita , GUPTA, Suman
发明人： MEHTA, Anita , SALMAN, Mohammad , SARMA, Pakala, Kumara, Savithru , CHUGH, Anita , GUPTA, Suman
IPC分类号： C07D405/12
CPC分类号： C07D405/12 , C07D405/14
摘要： This present invention generally relates to xanthine derivatives as muscarinic receptor antagonists which are useful, among other uses, for the treatment of various diseases of the respiratory, urinary and gastrointestinal systems mediated through muscarinic receptors. The invention also relates to the process for the preparation of disclosed compounds, pharmaceutical compositions containing the disclosed compounds, and the methods for treating diseases mediated through muscarinic receptors.
摘要翻译：本发明一般涉及作为毒蕈碱受体拮抗剂的黄嘌呤衍生物，其可用于治疗通过毒蕈碱受体介导的呼吸，泌尿和胃肠系统的各种疾病。本发明还涉及制备所公开的化合物的方法，含有所公开的化合物的药物组合物，以及用于治疗通过毒蕈碱受体介导的疾病的方法。

66. 发明申请

WO2005092907A3 MONOSACCHARIDE DERIVATIVES AS ANTI-CANCER AND ANTI-INFLAMMATORY AGENTS 审中-公开
公开(公告)号：WO2005092907A3
公开(公告)日：2005-10-06
申请号：PCT/IB2005/000803
申请日：2005-03-29
申请人： RANBAXY LABORATORIES LIMITED , SATTIGERI, Viswajanani, Jitendra , ARORA, Sudershan, K. , SALMAN, Mohammad , PALLE, Venkata, P. , YADAV, Gyan, Chand , TANWAR, Madan, Pal , MUKHERJEE, Ashis , NARAYANAN, Ramamurthy , RAUF, Abdul, Rehaman, Abdul , NAIK, Keshav, Prabhakar , SONI, Ajay , RAY, Abhijit , SHIRUMALLA, Raj, Kumar , MOOKHTIAR, Kasim Abbas
发明人： SATTIGERI, Viswajanani, Jitendra , ARORA, Sudershan, K. , SALMAN, Mohammad , PALLE, Venkata, P. , YADAV, Gyan, Chand , TANWAR, Madan, Pal , MUKHERJEE, Ashis , NARAYANAN, Ramamurthy , RAUF, Abdul, Rehaman, Abdul , NAIK, Keshav, Prabhakar , SONI, Ajay , RAY, Abhijit , SHIRUMALLA, Raj, Kumar , MOOKHTIAR, Kasim Abbas
IPC分类号： C07H9/04 , C07H15/00 , C07H3/02 , A61K31/70 , A61K31/7028 , A61K31/7042 , A61P37/00 , A61P35/00 , A61P17/00 , A61P11/06
摘要： The present invention relates to monosaccharide derivatives as anti-inflammatory agents. The compounds disorder herein can be useful for inhibition and prevention of inflammation and associated pathologies including inflammatory and autoimmune diseases such as bronchial asthma, rheumatoid arthritis, type I diabetes, multiple sclerosis, allograft rejection or psoriasis. Pharmacological compositions containing compounds disclosed herein and the methods of treating bronchial asthma, chronic obstructive pulmonary disease, rheumatoid arthritis, multiple sclerosis, type I diabetes, psoriasis, allograft rejection, and other inflammatory and/or autoimmune disorders, using the compounds are also provided.

67. 发明申请

WO2005058898A2 PHOSPHODIESTERASE INHIBITORS 审中-公开
标题翻译：磷酸二酯酶抑制剂
公开(公告)号：WO2005058898A2
公开(公告)日：2005-06-30
申请号：PCT/IB2004/004173
申请日：2004-12-16
申请人： RANBAXY LABORATORIES LIMITED , PALLE, Venkata, P. , BALACHANDRAN, Sarala , SALMAN, Mohammad , KUKREJA, Gagan , BAREGAMA, Lalit, Kumar , RAY, Abhijit , DASTIDAR, Sunanda, Ghosh
发明人： PALLE, Venkata, P. , BALACHANDRAN, Sarala , SALMAN, Mohammad , KUKREJA, Gagan , BAREGAMA, Lalit, Kumar , RAY, Abhijit , DASTIDAR, Sunanda, Ghosh
IPC分类号： C07D473/00
CPC分类号： C07D473/00
摘要： The present invention relates to purine derivatives, which can be used as selective phosphodiesterase (PDE) type IV inhibitors. Compounds disclosed herein can be useful in the treatment of asthma, arthritis, bronchitis, chronic obstructive pulmonary disease (COPD), psoriasis, allergic rhinitis, shock, atopic dermatitis, Crohn's disease, adult respiratory distress syndrome (ARDS), eosinophilic granuloma, allergic conjunctivitis, osteoarthritis, ulcerative colitis and other inflammatory diseases especially in humans. Also provided are processes for the preparation of disclosed compounds, pharmaceutical composition containing the disclosed compounds and their use as selective phosphodiesterase (PDE) type IV inhibitors.
摘要翻译：本发明涉及可用作选择性磷酸二酯酶（PDE）IV型抑制剂的嘌呤衍生物。本文公开的化合物可用于治疗哮喘，关节炎，支气管炎，慢性阻塞性肺疾病（COPD），牛皮癣，过敏性鼻炎，休克，特应性皮炎，克罗恩病，成人呼吸窘迫综合征（ARDS），嗜酸性肉芽肿，过敏性结膜炎，骨关节炎，溃疡性结肠炎和其他炎性疾病，特别是人类。还提供了制备所公开化合物的方法，含有所公开化合物的药物组合物及其作为选择性磷酸二酯酶（PDE）IV型抑制剂的用途。

68. 发明申请

WO2005056536A1 ANTIDIABETIC AGENTS WHICH EXHIBIT ACTIVITY AGAINST PPAR 审中-公开
标题翻译：展示PPAR活性的抗菌药物
公开(公告)号：WO2005056536A1
公开(公告)日：2005-06-23
申请号：PCT/IB2004/003861
申请日：2004-11-24
申请人： RANBAXY LABORATORIES LIMITED , SALMAN, Mohammad , SATTIGERI, Jitendra, A.
发明人： SALMAN, Mohammad , SATTIGERI, Jitendra, A.
IPC分类号： C07D263/32
CPC分类号： C07D213/30 , C07D235/30 , C07D239/91 , C07D263/32 , C07D263/58 , C07D265/36 , C07D265/38 , C07D279/16
摘要： The present invention relates to alkanoic acids and their derivatives which exhibit activity against PPARs, and hence can be used as antidiabetic compounds. Compounds disclosed herein can be used as peroxisome proliferation activated receptor (PPAR) activator. Such compounds can be used as therapeutic agents for the treatment of diseases and conditions mediated through any of the isoforms of PPAR, diabetes and diabetes-associated complications, and treatment of diseases and conditions in which insulin resistance is the central pathophysiological mechanism and diseases or conditions such as Type II diabetes, dyslipidaemia, hypertension, coronary heart disease, cardiovascular disease, atherosclerosis, nephrosclerosis, polycystic ovarian syndrome, eating disorders, diabetes nephropathy, glomerulonephritis, glomerularsclerosis, nephrotic syndrome, psoriasis or obesity. Processes for the preparation of the disclosed compounds, pharmaceutical compositions containing the disclosed compounds, and methods for treating diabetes mellitus and the diseases and conditions mediated through insulin resistance are also provided.
摘要翻译：本发明涉及对PPARs具有活性的链烷酸及其衍生物，因此可用作抗糖尿病化合物。本文公开的化合物可用作过氧化物酶体增殖激活受体（PPAR）激活剂。这些化合物可用作治疗通过PPAR，糖尿病和糖尿病相关并发症的任何同种型介导的疾病和病症的治疗剂，以及治疗其中胰岛素抵抗是中枢病理生理机制和疾病或病症的疾病和病症例如II型糖尿病，血脂异常，高血压，冠心病，心血管疾病，动脉粥样硬化，肾硬化，多囊卵巢综合征，进食障碍，糖尿病肾病，肾小球性肾炎，肾小球硬化，肾病综合征，牛皮癣或肥胖症。还提供了制备所公开的化合物的方法，含有所公开的化合物的药物组合物，以及治疗糖尿病的方法以及通过胰岛素抵抗介导的疾病和病症。

69. 发明申请

WO2005037281A1 1-ALKYLPIPERAZINYL-PYRROLIDIN-2, 5-DIONE DERIVATIVES AS ADRENERGIC RECEPTOR ANTAGONIST 审中-公开
标题翻译： 1-ALKYLPIPERAZINYL-PYRROLIDIN-2，5-DONE DERIVATIVES AS ADRENERGIC RECEPTOR ANTAGONIST
公开(公告)号：WO2005037281A1
公开(公告)日：2005-04-28
申请号：PCT/IB2003/004545
申请日：2003-10-15
申请人： RANBAXY LABORATORIES LIMITED , ANAND, Nitya , SALMAN, Mohammad , SHARMA, Somesh , YADAV, Gyan, Chand , CHUGH, Anita
发明人： ANAND, Nitya , SALMAN, Mohammad , SHARMA, Somesh , YADAV, Gyan, Chand , CHUGH, Anita
IPC分类号： A61K31/496
CPC分类号： C07D207/40 , C07D207/408 , C07D207/416 , C07D209/48
摘要： Compounds of formula (I), disclosed herein can function as α 1a and/or α 1d adrenergic receptor antagonists and can be used for the treatment of benign prostatic hyperplasia and related symptoms thereof. Compounds disclosed herein can also be used for the treatment of lower urinary tract symptoms associated with or without benign prostatic hyperplasia. The invention also relates to a process for the preparation of compounds disclosed herein, and pharmaceutical compositions containing these compounds.
摘要翻译：本文公开的式（I）化合物可以用作α1a和/或α1肾上腺素能受体拮抗剂，可用于治疗良性前列腺增生及其相关症状。本文公开的化合物也可用于治疗与或不伴有良性前列腺增生相关的下尿路症状。本发明还涉及制备本文公开的化合物的方法和含有这些化合物的药物组合物。

70. 发明申请

WO2005030735A1 TRIAZINES DERIVATIVES AS CELL ADHESION INHIBITORS 审中-公开
标题翻译： TRIAZINES衍生物作为细胞粘附抑制剂
公开(公告)号：WO2005030735A1
公开(公告)日：2005-04-07
申请号：PCT/IB2004/003115
申请日：2004-09-24
申请人： RANBAXY LABORATORIES LIMITED , SATTIGERI, Viswajanani, J. , SALMAN, Mohammad , NARAYANAN, Ramamurthi , SETH, Subhendu , SARIN, Simi , ABHIJIT, Ray , DASTIDAR, Sunanda, Ghose
发明人： SATTIGERI, Viswajanani, J. , SALMAN, Mohammad , NARAYANAN, Ramamurthi , SETH, Subhendu , SARIN, Simi , ABHIJIT, Ray , DASTIDAR, Sunanda, Ghose
IPC分类号： C07D251/16
CPC分类号： C07D251/52 , C07D251/16 , C07D251/18 , C07D251/50 , C07D251/54 , C07D251/70 , C07D405/12 , C07D409/12
摘要： The present invention relates to triazine derivatives as cell adhesion inhibitors. The compounds of this invention can be useful inter alia, for inhibition and prevention of cell adhesion and cell adhesion-mediated pathologies, including inflammatory and autoimmune diseases such as bronchial asthma, rheumatoid arthritis, type I diabetes, multiple sclerosis, allograft rejection, psoriasis. The compounds can be used to formulate pharmacological compositions, and the methods of treating bronchial asthma, rheumatoid arthritis, multiple sclerosis, type I diabetes, psoriasis, allograft rejection, and other inflammatory and/or autoimmune disorders, using the compounds are also provided herein.
摘要翻译：本发明涉及作为细胞粘附抑制剂的三嗪衍生物。本发明的化合物尤其可用于抑制和预防细胞粘附和细胞粘附介导的病理学，包括炎症和自身免疫性疾病如支气管哮喘，类风湿性关节炎，I型糖尿病，多发性硬化，同种异体移植排斥，牛皮癣。该化合物可用于配制药物组合物，本文还提供了使用该化合物治疗支气管哮喘，类风湿性关节炎，多发性硬化，I型糖尿病，牛皮癣，同种异体移植排斥和其它炎性和/或自身免疫性疾病的方法。

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