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61. 发明申请

WO1997048815A2 METHOD FOR ENHANCING GENE TRANSFER 审中-公开
标题翻译：增强基因转移的方法
公开(公告)号：WO1997048815A2
公开(公告)日：1997-12-24
申请号：PCT/EP1997003152
申请日：1997-06-17
申请人： NOVARTIS AG , SYSTEMIX, INC. , UCHIDA, Nobuko , TSUKAMOTO, Ann , WEISSMAN, Irving
发明人： NOVARTIS AG , SYSTEMIX, INC.
IPC分类号： C12N15/87
CPC分类号： C12N15/87 , A61K48/00
摘要： The present invention provides a method for optimising gene transfer into hematopoietic stem cells (HSCs) by contacting the cells with hydroxyurea prior to gene transfer to induce HSCs in G0 into active cell cycle. This method is useful for treating patients suffering from a disease that is suitably treated by gene therapy or involves hematopoietic cells. A method is also provided for enhancing the efficacy of bone marrow transplantation by administering hydroxyurea to increase HSC yields.
摘要翻译：本发明提供了通过在基因转移之前使细胞与羟基脲接触以在G0中诱导HSC进入活性细胞周期来优化基因转移到造血干细胞（HSC）中的方法。该方法可用于治疗患有通过基因治疗适当治疗或涉及造血细胞的疾病的患者。还提供了一种通过施用羟基脲来提高HSC产量来增强骨髓移植功效的方法。

62. 发明申请

WO1997048410A1 CYCLOSPORIN-CONTAINING SOFT CAPSULE PREPARATIONS 审中-公开
标题翻译：含CYPOSPORIN的软胶囊制剂
公开(公告)号：WO1997048410A1
公开(公告)日：1997-12-24
申请号：PCT/EP1997003213
申请日：1997-06-19
申请人： NOVARTIS AG , WOO, Jong, Soo
发明人： NOVARTIS AG
IPC分类号： A61K38/13
CPC分类号： A61K9/4858 , A61K9/1075 , A61K38/13
摘要： The present invention relates to a cyclosporin-containing soft capsule preparation which comprises a composition containing cyclosporin as an active ingredient; a hydrophilic component polyethylene glycol or a non-hydrophilic component propylene carbonate or their mixture, a mixture of an esterified compound of fatty acid and primary alcohol, medium chain fatty acid triglyceride and fatty acid monoglyceride as an oil component; and a surfactant having an HLB (Hydrophilic Lipophilic Balance) value of 8 to 17, in a gelatin shell containing polyethylene glycol and propylene glycol as a plasticizer.
摘要翻译：本发明涉及含有环孢菌素的软胶囊制剂，其包含含有环孢菌素作为活性成分的组合物; 亲水性成分聚乙二醇或非亲水性成分的碳酸亚丙酯或它们的混合物，脂肪酸和伯醇的酯化化合物，中链脂肪酸甘油三酯和作为油成分的脂肪酸单甘油酯的混合物; 和在含有聚乙二醇和丙二醇作为增塑剂的明胶壳中具有8-17的HLB（亲水亲油平衡）值的表面活性剂。

63. 发明申请

WO1997047966A1 OPTICAL SENSOR SYSTEM FOR pH DETERMINATION INDEPENDENTLY OF THE ION STRENGTH USING FLUORESCEIN BOUND TO A POLYMER VIA A URETHANE AND/OR UREA GROUP 审中-公开
标题翻译：光学传感器系统，用于独立于使用荧光素与通过尿素和/或尿素组合聚合物的离子强度进行pH测定
公开(公告)号：WO1997047966A1
公开(公告)日：1997-12-18
申请号：PCT/EP1997003037
申请日：1997-06-11
申请人： NOVARTIS AG , BARNARD, Steven, Mark , BECKELMANN, Dirk , BERGER, Joseph , ROUILLY, Marizel , WALDNER, Adrian
发明人： NOVARTIS AG
IPC分类号： G01N31/22
CPC分类号： G01J3/4406 , G01N31/221 , G01N33/84
摘要： The invention relates to an optical sensor for pH determination independent of the ion strength which comprises a solid polyurethane, polyurea-urethane or polyurea composition containing pH-sensitive fluorescein bound via a urea or urethane group in the form of a membrane on a transparent support material. The invention also relates to an optical fluorescence method which permits high-accuracy pH determination independent of the ion strength of the measurement solution. The method is particularly suitable for determining the pH of physiological solutions, in particular for determining the pH of blood.
摘要翻译：本发明涉及一种用于独立于离子强度的pH测定的光学传感器，其包含固体聚氨酯，聚脲 - 聚氨酯或聚脲组合物，其含有通过透明支撑材料上的膜形式的脲或氨基甲酸酯基团结合的pH敏感荧光素。本发明还涉及一种允许独立于测量溶液的离子强度的高精度pH测定的光学荧光方法。该方法特别适用于测定生理溶液的pH，特别是用于测定血液的pH值。

64. 发明申请

WO1997047636A2 INTERMEDIATES FOR OLIGONUCLEOTIDE SYNTHESIS 审中-公开
标题翻译：寡核苷酸合成的中间体
公开(公告)号：WO1997047636A2
公开(公告)日：1997-12-18
申请号：PCT/GB1997001490
申请日：1997-06-03
申请人： NOVARTIS AG , COLLINGWOOD, Stephen, Paul , MOSER, Heinz, Ernst , ALTMANN, Karl-Heinz , DOUGLAS, Mark, Edward
发明人： NOVARTIS AG
IPC分类号： C07H19/04
CPC分类号： C07H19/04 , Y02P20/55
摘要： A compound of formula (I) where B is a radical of a nucleoside base, R is hydrogen or a hydroxy-protecting group, R is hydrogen, hydroxy or a 2' nucleoside-modifying atom or group, R is an unsubstituted or substituted C1 to C10 alkyl, C2 to C10 alkenyl, C4 to C10 cycloalkylalkyl, C6 to C10 aryl or C7 to C13 aralkyl group, and Z is halogen or a group of formula (II) where R and R are each independently an unsubstituted or substituted C1 to C10 alkyl, C2 to C10 alkenyl, C4 to C10 cycloalkylalkyl, C6 to C10 aryl or C7 to C13 aralkyl group, or R is said group and R is hydrogen, or R and R together with the nitrogen atom to which they are attached denote a five- to thirteen-membered heterocyclic ring, or Z is a group of formula (III): Nuc-O-, where Nuc is the residue of a natural or synthetic nucleoside or oligonucleotide after removal of a 5'-hydroxyl group therefrom attached through a 5' methylene thereof to the indicated oxygen atom.
摘要翻译：式（I）的化合物，其中B 1是核苷碱基，R 1是氢或羟基保护基，R 2是氢，羟基或2'核苷修饰原子或基团，R 3是未取代或取代的C1至C10烷基，C2至C10烯基，C4至C10环烷基烷基，C6至C10芳基或C7至C13芳烷基，Z为卤素或式（II） R 4和R 5各自独立地为未取代或取代的C 1至C 10烷基，C 2至C 10烯基，C 4至C 10环烷基烷基，C 6至C 10芳基或C 7至C 13芳烷基，或R 4为所述基团和R 5是氢，或者R 4和R 5与它们所连接的氮原子一起表示5至13元杂环，或Z是式（III）的基团： Nuc-O-，其中Nuc是去除通过其5'亚甲基连接到指定氧原子上的5'-羟基后天然或合成核苷或寡核苷酸的残基。

65. 发明申请

WO1997047610A1 BENZAZOLE DERIVATIVES 审中-公开
标题翻译：苯并唑衍生物
公开(公告)号：WO1997047610A1
公开(公告)日：1997-12-18
申请号：PCT/EP1997002731
申请日：1997-05-27
申请人： NOVARTIS AG , TINEMBART, Olivier , BEVIERRE, Marc-Olivier , WADSWORTH, David, John , HILDENBRAND, Christof
发明人： NOVARTIS AG
IPC分类号： C07D263/56
CPC分类号： C07D263/56 , A01N47/20 , C07D277/64
摘要： Compounds of formula (I) wherein n, X, R1, R2, R3, R4, R5 and R6 are as defined in claim 1, and where appropriate tautomers thereof, in each case in free form or in agrochemically acceptable salt form, can be used as agrochemical active ingredients and can be prepared in a manner known per se.
摘要翻译：其中n，X，R 1，R 2，R 3，R 4，R 5和R 6如权利要求1中所定义的式（I）化合物，并且其中适当的互变异构体在每种情况下以游离形式或以农业化学上可接受的盐形式可以是用作农业化学活性成分，并且可以以本身已知的方式制备。

66. 发明申请

WO1997046553A1 THROMBIN INHIBITORS 审中-公开
标题翻译：冷冻抑制剂
公开(公告)号：WO1997046553A1
公开(公告)日：1997-12-11
申请号：PCT/GB1997001385
申请日：1997-05-21
申请人： NOVARTIS AG , BRUNDISH, Derek, Edward , BROWN, Lyndon, Nigel , LE GRAND, Darren, Mark , MENEAR, Keith, Allan , SMITH, Garrick, Paul , ALLEN, Mark, Christopher , BUTLER, Paul, Ian , COCKROFT, Xiao-Ling , MATTHEWS, Ian, Timothy, William , WALKER, Clive, Victor , WATHEY, William, Bernard
发明人： NOVARTIS AG
IPC分类号： C07D401/12
CPC分类号： C07D213/74 , C07D401/12 , C07D401/14 , C07D405/14 , C07D413/14 , C07D417/14
摘要： The present invention provides a compound of general formula (I) in which Y is a primary or secondary amino group; R2 is the residue of a natural or synthetic amino acid; R3 is hydrogen or a C1-C8 alkyl chain which may be substituted by hydroxy or halogen; and X is (CH2)n where n is 1, 2, or 3, or is CH2N or represents a fused phenyl ring which is optionally substituted by one or two methoxy groups or a salt thereof.
摘要翻译：本发明提供通式（I）的化合物，其中Y为伯或仲氨基; R2是天然或合成氨基酸的残基; R3是氢或可被羟基或卤素取代的C1-C8烷基链; 并且X是（CH 2）n，其中n是1,2或3，或是CH 2 N，或表示任选被一个或两个甲氧基取代的稠合苯环或其盐。

67. 发明申请

WO1997046514A1 PROCESS FOR THE PREPARATION OF HYDRAZINE DERIVATIVES USEFUL AS INTERMEDIATES FOR THE PREPARATION OF PEPTIDE ANALOGUES 审中-公开
标题翻译：制备氢化衍生物的方法有助于制备肽类似物的中间体
公开(公告)号：WO1997046514A1
公开(公告)日：1997-12-11
申请号：PCT/EP1997002604
申请日：1997-05-22
申请人： NOVARTIS AG
发明人： NOVARTIS AG , FÄSSLER, Alexander , BOLD, Guido , CAPRARO, Hans-Georg , STEINER, Heinz
IPC分类号： C07C241/02
CPC分类号： C07D213/42 , C07B2200/07 , C07C253/16 , C07C255/44 , C07C281/02 , C07C281/04 , C07D213/54 , C07D213/55 , C07D257/04 , C07D277/30 , Y02P20/55
摘要： The invention relates to a novel process for the preparation of compounds of formula (I) wherein R1 is hydrogen or a suitable amino-protecting group, R2 is unsubstituted or substituted alkyl, R3 is hydrogen, aryl, heterocyclyl, unsubstituted or substituted alkyl or unsubstituted or substituted cycloalkyl, R4, independently of R1, is hydrogen or a suitable amino-protecting group and m is a number from 1 to 7; and wherein further suitable protecting groups for functional groups may be present; which compounds are antivirally active or can be used as starting materials for pharmaceutically active, especially antiviral compounds. The precursor is an oxo compound, which is in turn prepared by hydrogenation with a suitable complex hydride or with hydrogen in the presence of a suitable catalyst and acyl migration starting from a hydrazone, which is in turn preferably prepared from a nitrile via an imino compound by means of hydrogenation and reaction with a hydrazine derivative, which is prepared from an aldehyde by reaction with a reactive derivative of a carboxylic acid in the presence of a cyanide salt; and the novel intermediates required therefor.
摘要翻译：本发明涉及一种制备式（I）化合物的新方法，其中R 1为氢或适当的氨基保护基，R 2为未取代或取代的烷基，R 3为氢，芳基，杂环基，未取代或取代的烷基或未取代的或取代的环烷基，R 4，独立地R 1为氢或适宜的氨基保护基，m为1至7的数; 并且其中可以存在其它合适的官能团保护基团; 哪些化合物是抗病毒活性的或可以用作药物活性的起始原料，特别是抗病毒化合物。前体是氧代化合物，其又通过在合适的催化剂存在下用合适的络合氢化物或氢气氢化制备，并且从腙开始进行酰基迁移，其又优选通过亚氨基化合物由腈制备通过氢化和与肼衍生物反应，肼衍生物通过与氰化物的存在下与羧酸的反应性衍生物反应而由醛制备; 和所需的新型中间体。

68. 发明申请

WO1997045718A1 OPTICAL DETECTION APPARATUS FOR CHEMICAL ANALYSES OF SMALL VOLUMES OF SAMPLES 审中-公开
标题翻译：用于样品小容量化学分析的光学检测装置
公开(公告)号：WO1997045718A1
公开(公告)日：1997-12-04
申请号：PCT/EP1997002745
申请日：1997-05-27
申请人： NOVARTIS AG , BRUNO, Alfredo, Emilio , BARNARD, Steven, Mark , EHRAT, Markus , VÖLKEL, Reinhard , NUSSBAUM, Philippe , HERZIG, Hans, Peter
发明人： NOVARTIS AG
IPC分类号： G01N21/03
CPC分类号： G01N21/03 , G01N2021/0346
摘要： Optical detection apparatus for chemical analyses of small volumes of samples with light sources (21) to emit induction light, a measuring cell (7) for the sample, phoelectric sensing elements (22) to receive light coming from the sample in the measuring cell (7), as well as beam-conducting means for the induction light or the light from the sample. In the apparatus, several essentially planar, laminar components (2-7) are arranged in a sandwich structure, whereby the components (2-7) contain the light sources (21), the measuring cell (7), the photoelectric sensing elements (22), and also the beam-conducting means.
摘要翻译：用于化学分析用于发射感光的光源（21）的样本的光学检测装置，用于样品的测量单元（7），用于接收来自测量单元中的样品的光的光电传感元件（22） 7），以及用于感应光或来自样品的光的光束传导装置。在该设备中，几个基本上平面的层状部件（2-7）被布置成夹层结构，由此部件（2-7）包含光源（21），测量单元（7），光电感测元件 22），以及光束传导装置。

69. 发明申请

WO1997045018A1 PLANT IMMUNIZATION COMPOSITIONS 审中-公开
标题翻译：植物免疫组合物
公开(公告)号：WO1997045018A1
公开(公告)日：1997-12-04
申请号：PCT/EP1997002744
申请日：1997-05-27
申请人： NOVARTIS AG , MOESINGER, Egon
发明人： NOVARTIS AG
IPC分类号： A01N63/04
CPC分类号： A01N63/02 , A01N63/04
摘要： The present invention provides an agent for inducing resistance against phytopathogenic microorganisms in plants wherein the agent is an extract of biomass from non-plant-pathogenic microorganisms obtainable by the following process: a) resuspending 50g to 200g (dry weight) of biomass from non-plant-pathogenic microorganisms per liter of inorganic or organic solvent; b) stirring at room temperature for 1 to 12 hours; c) incubating; d) resuspending; e) allowing to cool to room temperature; and f) optionally filtering.
摘要翻译：本发明提供了一种用于在植物中诱导对植物病原微生物的抗性的试剂，其中所述试剂是可通过以下方法获得的非植物病原微生物的生物提取物：a）将50g至200g（干重）的生物质从非 - 植物病原微生物每升无机或有机溶剂; b）在室温下搅拌1〜12小时; c）孵化; d）重新悬挂; e）允许冷却至室温; 和f）可选地过滤。

70. 发明申请

WO1997043427A1 PRODUCTION OF APOMICTIC SEED 审中-公开
标题翻译：生产种子
公开(公告)号：WO1997043427A1
公开(公告)日：1997-11-20
申请号：PCT/EP1997002443
申请日：1997-05-13
申请人： NOVARTIS AG , DE VRIES, Sape, Cornelis , SCHMIDT, Eduard, Daniel, Leendert , VAN HOLST, Gerrit, Jan , HECHT, Valerie, France, Gabrielle
发明人： NOVARTIS AG
IPC分类号： C12N15/82
CPC分类号： C12N9/12 , C07K14/415 , C12N15/8287
摘要： The present invention provides, inter alia, a method of producing apomictic seeds comprising the steps of: (i) transforming plant material with a nucleotide sequence encoding a protein the presence of which in a cell, or membrane thereof, renders said cell embryogenic, (ii) regenerating the thus transformed material into plants, or carpel containing parts thereof, and (iii) expressing the sequence in the vicinity of the embryo sac. The protein may be a leucine repeat rich receptor kinase which preferably is modified to the extent that the ligand binding domain is deleted or functionally inactivated.
摘要翻译：本发明尤其提供了一种产生无覆盖种子的方法，包括以下步骤：（i）用编码蛋白质的核苷酸序列转化植物材料，所述核苷酸序列在细胞或其膜中的存在使得所述细胞胚发生（（ ii）将如此转化的材料再生成植物，或其包含其部分的心皮，和（iii）在胚囊附近表达序列。蛋白质可以是亮氨酸重复富含受体激酶，其优选被修饰到配体结合结构域被缺失或功能失活的程度。

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