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    • 62. 发明申请
    • COMPOUNDS AND METHODS FOR CONTROLLING FUNGI
    • 用于控制真菌的化合物和方法
    • WO2010135070A1
    • 2010-11-25
    • PCT/US2010/033327
    • 2010-05-03
    • DOW AGROSCIENCES LLCDAVIS, GeorgeLO, WilliamRENGA, JamesTISDELL, FrancisYAP, MauriceYOUNG, David
    • DAVIS, GeorgeLO, WilliamRENGA, JamesTISDELL, FrancisYAP, MauriceYOUNG, David
    • C07D239/30A01N43/54A01P3/00
    • A61K31/505A01N43/54C07D239/30
    • Various aspects disclosed herein relate to aryl substituted aminopyrimidines according to Formula (I), wherein, X 1 is N or C-R 3 ; X 2 is N or C-R 4 provided that X 1 and X 2 are not both N; R 1 -R 7 are H, CN, CHO, -SCN, NO 2 , F, Cl, Br, I, substituted or unsubstituted C1-C4-alkyl, substituted or unsubstituted halo-C1-C4-alkyl, substituted or unsubstituted C1-C4-alkoxy, substituted or unsubstituted halo-C1-C4-alkoxy, substituted or unsubstituted C1-C4-thioalkyl, substituted or unsubstituted halo-C1-C4-thioalkyl, substituted or unsubstituted C3-C-7-cycloalkyl, substituted or unsubstituted C2-C4-alkenyl, C2-C4-alkynyl, substituted or unsubstituted C1-C4-acylalkyl, C1-C4-acyloxy, C1-C4 alkoxycarbonyl, Cl-C4-alkoxy-amino, C1-C4-alkyl-S(O)=NH, substituted or unsubstituted aryl, substituted or unsubstituted heterocycle, wherein the substituents are one or more of the following F, Cl, Br, OH, CN, NO 2 , CHO, -SCN, S(0)n-C1-C4-alkyl (where n = 0-2), C1-C4-alkyl, halo-C1-C4-alkyl, C1-C4-alkylamine, C1-C4-alkoxy, halo-C1-C4-alkoxy, C1-C4-thioalkyl, halo-C1-C4-thioalkyl, C1-C4-alkylacyl, C1-C4-acyloxy, C1-C4 alkoxycarbonyl, C1-C4-alkoxy-imino, hydroxy- imino; C1-C4-alkyl-S(O)=NH; and Q is a substituted or unsubstituted aryl, substituted or unsubstituted heterocycle wherein the substituents of Q are taken from R 1 -R 7 .
    • 本文公开的各个方面涉及根据式(I)的芳基取代的氨基嘧啶,其中,X 1是N或C-R 3; X2是N或C-R4,条件是X1和X2不同时为N; R 1 -R 7是H,CN,CHO,-SCN,NO 2,F,Cl,Br,I,取代或未取代的C 1 -C 4 - 烷基,取代或未取代的卤代-C 1 -C 4烷基,取代或未取代的C 1 -C 4 - 烷氧基,取代或未取代的卤代-C 1 -C 4 - 烷氧基,取代或未取代的C 1 -C 4 - 硫代烷基,取代或未取代的卤代C 1 -C 4 - 硫代烷基,取代或未取代的C 3 -C 7 - 环烷基,取代或未取代的C 2 -C 4 烯基,C 2 -C 4 - 炔基,取代或未取代的C 1 -C 4酰基烷基,C 1 -C 4酰氧基,C 1 -C 4烷氧基羰基,C 1 -C 4烷氧基 - 氨基,C 1 -C 4烷基-S(O) 取代或未取代的芳基,取代或未取代的杂环,其中取代基是以下F,Cl,Br,OH,CN,NO 2,CHO,-SCN,S(O)n-C 1 -C 4烷基中的一种或多种 n = 0-2),C 1 -C 4 - 烷基,卤代-C 1 -C 4 - 烷基,C 1 -C 4烷基胺,C 1 -C 4 - 烷氧基,卤代-C 1 -C 4 - 烷氧基,C 1 -C 4 - C 1 -C 4烷氧基,C 1 -C 4烷氧基羰基,C 1 -C 4烷氧基亚氨基,羟基亚氨基; C1-C4烷基-S(O)= NH; 并且Q是取代或未取代的芳基,取代或未取代的杂环,其中Q的取代基取自R 1 -R 7。
    • 69. 发明申请
    • CLOSED SUCTION CATHETER ADAPTER WITH FLUSH ARRANGEMENT
    • 封闭式吸尘器适配器带有冲洗装置
    • WO2010014732A1
    • 2010-02-04
    • PCT/US2009/052132
    • 2009-07-29
    • CARDINAL HEALTH 207, INC.STENZLER, AlexHAN, SteveYOUNG, David, Matthew
    • STENZLER, AlexHAN, SteveYOUNG, David, Matthew
    • A61M16/04A61M39/02A61M39/10
    • A61M16/0463A61M16/0066A61M16/0465A61M16/0816A61M16/208A61M39/045A61M2039/1077
    • A respiratory apparatus (20) including an adapter and a catheter assembly (24). The adapter assembly (22) includes ventilator (32), respiratory (34), access, (36) and flush ports (38). The access port (36) includes a conduit (42) defining a passageway (44). The flush port (38) projects from the conduit (42) and is fluidly open to the passageway (44) at an outlet. (56). The catheter assembly (24) includes a fitting (74). The fitting (74) includes a hub (90) and a tube (92), with the tube (92) defining an exterior (106) and interior, surface forming a lumen (94), a circumferential groove (108) in the exterior surface (106), and a plurality of apertures (110) fluidly open to the lumen (94) and the circumferential groove (108). The tube is sized (92) to be slidably received within the passageway (44) such that a fluid pathway is formed between the flush port (38) and a distal end (82) of the catheter (70) via the flush port outlet (56), the circumferential groove (108), the plurality of apertures (110), and the lumen (94).
    • 一种包括适配器和导管组件(24)的呼吸装置(20)。 适配器组件(22)包括呼吸机(32),呼吸(34),通道(36)和冲洗口(38)。 进入端口(36)包括限定通道(44)的导管(42)。 冲洗口38从导管42突出,并在出口处向通路44流体地开放。 (56)。 导管组件(24)包括配件(74)。 配件(74)包括轮毂(90)和管(92),管(92)限定外部(106)和形成内腔(94)的内表面,外部的周向凹槽(108) 表面(106)和朝向内腔(94)和周向槽(108)流体地开放的多个孔(110)。 管的尺寸(92)可滑动地容纳在通道(44)内,使得流体通道经由冲洗口出口(...)形成在冲洗口(38)和导管(70)的远端(82)之间 56),周向槽(108),多个孔(110)和内腔(94)。