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61. 发明申请

WO2003104416A2 SPLICEOSOME MEDIATED RNA TRANS-SPLICING IN STEM CELLS 审中-公开
标题翻译：干细胞中SPLICEOSOME介导的RNA转移分离
公开(公告)号：WO2003104416A2
公开(公告)日：2003-12-18
申请号：PCT/US2003/017954
申请日：2003-06-05
申请人： INTRONN, INC. , MITCHELL, Lloyd, G. , ENGLEHARDT, John , LIU, Xiao, Ming
发明人： MITCHELL, Lloyd, G. , ENGLEHARDT, John , LIU, Xiao, Ming
IPC分类号： C12N
CPC分类号： C12N5/0688 , A61K48/005 , C12N2510/02
摘要： The present invention provides methods and compositions for generating novel nucleic acid molecules through targeted spliceosomal mediated trans -splicing in stem cells. The compositions of the invention include stem cells engineered to express pre- trans -splicing molecules (PTMs) designed to interact with a target precursor messenger RNA molecule (target pre-mRNA) and mediate a trans -splicing reaction resulting in the generation of novel chimeric RNA molecules (chimeric RNA). In particular, the stem cells of the present invention are genetically engineered to express a PTM that will interact with a specific target pre-mRNA expressed within a stem cell as it differentiates so as to result in correction of a genetic defect responsible for a genetic disorder. The methods of the invention encompass transferring a nucleic acid molecule capable of encoding a PTM of interest into a stem cell followed by transplantation of the PTM modified stem cell into a host. As the stem cell differentiates the target pre-mRNA is expressed thereby providing the substrate for a trans -splicing reaction. The present invention is based on the successful transfer and expression of a nucleic acid molecule encoding a PTM capable of interacting with a cystic fibrosis transmembrane conductance regulator (CFTR) pre-mRNA into primary human surface airway progenitor cells. The methods and compositions of the present invention can be used to correct genetic defects associated with a variety of different disorders such as cystic fibrosis, hemophilia, sickle cell anemia, Tay-Sachs disease, thalassemias, polycystic kidney disease and muscular dystrophy, to name a few.
摘要翻译：本发明提供通过干细胞中的靶向剪接体介导的转接产生新的核酸分子的方法和组合物。本发明的组合物包括工程化以表达设计成与靶前体信使RNA分子（靶前体mRNA）相互作用的预转录分子（PTM）的干细胞，并介导导致产生新型嵌合体 RNA分子（嵌合RNA）。特别地，本发明的干细胞经遗传工程化以表达PTM，其将与干细胞中表达的特异性靶mRNA前体相互作用，因为它会区分，从而导致造成遗传疾病的遗传缺陷的校正。本发明的方法包括将能够编码感兴趣的PTM的核酸分子转移到干细胞中，随后将PTM修饰的干细胞移植到宿主中。当干细胞分化时，靶mRNA前体被表达，从而提供用于转拼反应的底物。本发明基于能够将能够与囊性纤维化跨膜传导调节子（CFTR）前mRNA相互作用的PTM的核酸分子成功转移和表达进入原代人表面气道祖细胞。本发明的方法和组合物可用于纠正与各种不同疾病相关的遗传缺陷，例如囊性纤维化，血友病，镰状细胞性贫血，泰萨氏病，地中海贫血，多囊肾病和肌营养不良症，命名为少数。

62. 发明申请

WO1992020633A1 A METHOD OF STRENGTHENING GLASS 审中-公开
标题翻译：加强玻璃的方法
公开(公告)号：WO1992020633A1
公开(公告)日：1992-11-26
申请号：PCT/GB1992000913
申请日：1992-05-20
申请人： THE UNIVERSITY OF SHEFFIELD , ELLIS, Bryan , CHEN, Xiao, Ming , SEDDON, Angela, Beth
发明人： THE UNIVERSITY OF SHEFFIELD
IPC分类号： C03C17/32
CPC分类号： C03C17/32 , C03C17/30 , C07F7/1804 , C08F290/144
摘要： A method of strengthening glass using a mixture of a silane and a resin, the mixture being applied to the glass surface as an aqueous emulsion which is then cured. The silane is a reaction product of a silane coupling agent, which contains an epoxy group, with an unsaturated carboxylic acid, and the resin is a resin having at least two polymerisable unsaturated groups in the molecule. Preferably the silane and the resin have unsaturated reactive groups of matched reactivity. Advantageously the mixture contains about 20 parts of the silane per hundred parts of the resin. In another embodiment a silane coupling agent is dissolved in a polymerisable resin, the mixture of silane and resin is emulsified in water, the emulsion being applied as a coating, which is then cured.
摘要翻译：使用硅烷和树脂的混合物强化玻璃的方法，将混合物作为水乳液施加到玻璃表面，然后固化。硅烷是含有环氧基的硅烷偶联剂与不饱和羧酸的反应产物，树脂是分子中具有至少两个可聚合的不饱和基团的树脂。优选地，硅烷和树脂具有匹配反应性的不饱和反应性基团。有利地，该混合物每百份树脂含有约20份硅烷。在另一个实施方案中，将硅烷偶联剂溶解在可聚合树脂中，硅烷和树脂的混合物在水中乳化，该乳液作为涂层施涂，然后将其固化。

63. 发明申请

WO2012040328A2 RADON MIGRATION OF ACOUSTIC DATA 审中-公开
标题翻译：声学数据的氡迁移
公开(公告)号：WO2012040328A2
公开(公告)日：2012-03-29
申请号：PCT/US2011/052552
申请日：2011-09-21
申请人： BAKER HUGHES INCORPORATED , BOLSHAKOV, Alexei , TANG, Xiao Ming , PATTERSON, Douglas, J. , DUBINSKY, Vladimir
发明人： BOLSHAKOV, Alexei , TANG, Xiao Ming , PATTERSON, Douglas, J. , DUBINSKY, Vladimir
IPC分类号： G01V1/48 , G01V1/44 , E21B47/00 , G06F19/00
CPC分类号： G01V1/28 , E21B47/0002 , E21B47/101 , G01V2210/244 , G01V2210/40 , G01V2210/46 , G01V2210/51
摘要： Disclosed is a method implemented by a processor for imaging a formation penetrated by a borehole. The method includes: obtaining acoustic data in a depth-time domain using an acoustic downhole tool disposed at a depth in the borehole, the acoustic downhole tool having an acoustic source and an acoustic receiver; transforming the acoustic data in the depth-time domain into a Radon domain using a Radon transform; filtering the acoustic data in the Radon domain to increase a signal of interest in the acoustic data in the Radon domain; determining a location of a point in the formation that reflected acoustic energy emitted from the acoustic source to the acoustic receiver, the location of the point being represented in the Radon domain; and inverting the location of the point represented in the Radon domain into a radius-depth domain to image the formation.
摘要翻译：公开了由处理器执行的用于对钻孔穿透的地层进行成像的方法。该方法包括：使用布置在钻孔深度处的声学井下工具在深度 - 时间域中获得声学数据，声学井下工具具有声源和声学接收器; 使用Radon变换将深度 - 时间域中的声学数据变换成Radon域; 对Radon域中的声学数据进行滤波以增加对Radon域中的声学数据感兴趣的信号; 确定地层中反映从声源发射到声学接收器的声能的点的位置，该点的位置在氡域中表示; 并将Radon域中表示的点的位置倒置到半径深度域中以对地层进行成像。

64. 发明申请

WO2011141292A1 METHOD AND APPARATUS FOR DETECTING WHICH ONE OF SYMBOLS OF WATERMARK DATA IS EMBEDDED IN A RECEIVED SIGNAL 审中-公开
标题翻译：用于检测水印数据符号的接收信号中嵌入的方法和装置
公开(公告)号：WO2011141292A1
公开(公告)日：2011-11-17
申请号：PCT/EP2011/056652
申请日：2011-04-27
申请人： THOMSON LICENSING , CHEN, Xiao-Ming , BAUM, Peter, Georg , ARNOLD, Michael , GRIES, Ulrich
发明人： CHEN, Xiao-Ming , BAUM, Peter, Georg , ARNOLD, Michael , GRIES, Ulrich
IPC分类号： G10L19/00 , G06T1/00
CPC分类号： G10L19/018
摘要： Watermark symbol detection requires a detection metric for deciding at decoder side which candidate symbol is embedded inside the audio or video signal content. The invention provides an improved detection metric processing that achieves a reliable detection of watermarks in the presence of additional noise and echoes, and that is adaptive to signal reception conditions and requires a decreased computational power. This is performed by taking into account the information contained in the echoes of the received audio signal in the decision metric and comparing it with the corresponding metric obtained from decoding a non-marked audio signal, based on recursive calculation of false positive detection rates of peaks in correlation result values. The watermark symbol corresponding to the reference sequence having the lowest false positive error is selected as the embedded one.
摘要翻译：水印符号检测需要用于在解码器侧确定哪个候选符号被嵌入在音频或视频信号内容内的检测度量。本发明提供了一种改进的检测度量处理，其在附加噪声和回波的存在下实现水印的可靠检测，并且其适应于信号接收条件并且需要降低的计算能力。这是通过考虑包含在决定度量中的接收到的音频信号的回波中的信息来进行的，并将其与从解码未标记音频信号获得的相应度量进行比较，基于递归计算峰值的假阳性检测率相关结果值。选择与具有最低假正误差的参考序列相对应的水印符号作为嵌入的。

65. 发明申请

WO2011050147A1 METHODS AND RELATED DEVICES FOR SINGLE MOLECULE WHOLE GENOME ANALYSIS 审中-公开
标题翻译：用于单分子全基因组分析的方法和相关设备
公开(公告)号：WO2011050147A1
公开(公告)日：2011-04-28
申请号：PCT/US2010/053513
申请日：2010-10-21
申请人： BIONANOMATRIX, INC . , XIAO, Ming , DAS, Someskumar
发明人： XIAO, Ming , DAS, Someskumar
IPC分类号： C12Q1/68
CPC分类号： C12Q1/683 , G01N21/6486 , C12Q2563/107 , C12Q2561/109 , C12Q2537/137 , C12Q2563/185 , C12Q2535/131
摘要： Provided are methods of labeling and analyzing features along at least one macro molecule such as a linear biopolymer, including methods of mapping the distribution and frequency of specific sequence motifs or the chemical or proteomic modification state of such sequence motifs along individual unfolded nucleic acid molecules. The present invention also provides methods of identifying signature patterns of sequence or epigenetic variations along such labeled macro molecules for direct massive parallel single molecule level analysis. The present invention also provides systems suitable for high throughput analysis of such labeled macro mo lecules.
摘要翻译：提供了沿着沿着至少一个宏观分子（例如线性生物聚合物）标记和分析特征的方法，包括将特定序列基序的分布和频率或沿着各个未折叠核酸分子的这种序列基序的化学或蛋白质组修饰状态映射的方法。本发明还提供了鉴定用于直接大规模并行单分子水平分析的沿着这种标记的宏分子的序列或表观遗传变异的特征图案的方法。本发明还提供了适用于这种标记的宏观移动体的高通量分析的系统。

66. 发明申请

WO2010054112A2 PLASMA RESISTANT COATINGS FOR PLASMA CHAMBER COMPONENTS 审中-公开
标题翻译：用于等离子体室组分的抗菌涂料
公开(公告)号：WO2010054112A2
公开(公告)日：2010-05-14
申请号：PCT/US2009/063437
申请日：2009-11-05
申请人： APPLIED MATERIALS, INC. , SUN, Jennifer, Y. , HE, Xiao-Ming , THACH, Senh
发明人： SUN, Jennifer, Y. , HE, Xiao-Ming , THACH, Senh
IPC分类号： H05H1/34 , H01L21/3065
CPC分类号： H01J37/32477 , Y10T428/31678
摘要： Plasma resistant coating materials, plasma resistant coatings and methods of forming such coatings on hardware components. In one embodiment, hardware component is an electrostatic chuck (ESC) and the plasma resistant coating is formed on a surface of the ESC. The plasma resistant coatings are formed by methods other than thermal spraying to provide plasma resistant coatings having advantageous material properties.
摘要翻译：等离子体涂层材料，等离子体涂层以及在硬件部件上形成这种涂层的方法。在一个实施例中，硬件部件是静电卡盘（ESC），等离子体涂层形成在ESC的表面上。耐等离子涂层通过热喷涂以外的方法形成，以提供具有有利材料特性的等离子体涂层。

67. 发明申请

WO2010037644A2 METHOD FOR ENCODING, METHOD FOR DECODING, AND METHOD FOR GENERATING A PARITY CHECK MATRIX 审中-公开
标题翻译：编码方法，解码方法和生成奇偶校验矩阵的方法
公开(公告)号：WO2010037644A2
公开(公告)日：2010-04-08
申请号：PCT/EP2009/062120
申请日：2009-09-18
申请人： THOMSON LICENSING , CHEN, Xiao-Ming , THEIS, Oliver , TIMMERMANN, Friedrich
发明人： CHEN, Xiao-Ming , THEIS, Oliver , TIMMERMANN, Friedrich
IPC分类号： G11B20/14
CPC分类号： G11B20/1803 , G11B20/10055 , G11B20/1426 , H03M13/11 , H03M13/1105 , H03M13/1108 , H03M13/116 , H03M13/13 , H03M13/3784 , H03M13/45 , H03M13/451 , H03M13/6325
摘要： The invention proposes a new approach, where on the recording side, after conventional error correction encoding (201), parity-check bits allowing to identify dominant error events are inserted first (202), after which the resulting bitstream is modulation encoded (203). Correspondingly, at the readback side, the parity-based post processing (208) takes place after modulation decoding (207).
摘要翻译：本发明提出了一种新的方法，其中在记录方面，在常规纠错编码（201）之后，首先插入允许识别主要错误事件的奇偶校验位（202），之后所得到的比特流被调制编码（203）。相应地，在回读侧，基于奇偶校验的后处理（208）在调制解码之后进行（207）。

68. 发明申请

WO2010037030A1 EVALUATING LOAN ACCESS USING ONLINE BUSINESS TRANSACTION DATA 审中-公开
标题翻译：使用在线业务交易数据评估贷款访问
公开(公告)号：WO2010037030A1
公开(公告)日：2010-04-01
申请号：PCT/US2009/058621
申请日：2009-09-28
申请人： ALIBABA GROUP HOLDING LIMITED , HU, Xiao, Ming , LI, Feng , PENG, Xin, Yu , GAO, Jing , LU, Wei-yan , ZHANG, Zheng, Wei , ZHANG, Jin, Yin , SHI, Jian , FAN, Guo Dong
发明人： HU, Xiao, Ming , LI, Feng , PENG, Xin, Yu , GAO, Jing , LU, Wei-yan , ZHANG, Zheng, Wei , ZHANG, Jin, Yin , SHI, Jian , FAN, Guo Dong
IPC分类号： G06Q40/00
CPC分类号： G06Q40/025
摘要： A method and a loan access evaluation system use a loan applicant's actual business transaction information received from an online business system on which the loan applicant conducts business. In addition to the information of the loan applicant's owner, other general background business information and historical business information of the loan applicant, the method and the system obtain detailed transaction data of the loan applicant on e-commerce systems or platforms and banks, and thus have access to dynamic business data of the applicant for a more reliable loan access appraisal.
摘要翻译：一种方法和贷款访问评估系统使用贷款申请人从贷款申请人开展业务的在线业务系统收到的实际业务交易信息。除贷款申请人所有者的信息外，贷款申请人的其他一般背景业务信息和历史业务信息，方法和系统还可以获得贷款申请人在电子商务系统或平台和银行上的详细交易数据，因此可以访问申请人的动态业务数据，以获得更可靠的贷款访问评估。

69. 发明申请

WO2009091914A3 IDENTIFICATION OF STRESS IN FORMATIONS USING ANGLES OF FAST AND SLOW DIPOLE WAVES IN BOREHOLE ACOUSTIC LOGGING 审中-公开
标题翻译：使用快速和慢速二极管波形在井眼声学记录中识别形状中的应力
公开(公告)号：WO2009091914A3
公开(公告)日：2009-10-29
申请号：PCT/US2009031139
申请日：2009-01-15
申请人： BAKER HUGHES INC , ZHENG YIBING , MOOS DANIEL , TANG XIAO MING , DUBINSKY VLADIMIR , PATTERSON DOUGLAS J
发明人： ZHENG YIBING , MOOS DANIEL , TANG XIAO MING , DUBINSKY VLADIMIR , PATTERSON DOUGLAS J
IPC分类号： E21B47/00 , G01V1/00
CPC分类号： G01V1/44 , G01V2210/626
摘要： Cross-dipole measurements are obtained in a borehole. By estimating a direction of polarization of the fast shear mode at low and high frequencies and comparing the estimated distances, a cause of anisotropy is established. Formation stresses and directions may be estimated.
摘要翻译：在钻孔中获得交叉偶极子测量。通过估计低频和高频下快速剪切模式的极化方向，并比较估计的距离，建立各向异性的原因。可以估计形成的压力和方向。

70. 发明申请

WO2009103723A1 METHOD FOR CHANNEL ENCODING, METHOD AND APPARATUS FOR CHANNEL DECODING 审中-公开
标题翻译：信道编码方法，信道解码的方法和装置
公开(公告)号：WO2009103723A1
公开(公告)日：2009-08-27
申请号：PCT/EP2009/051896
申请日：2009-02-18
申请人： THOMSON LICENSING , THEIS, Oliver , CHEN, Xiao-Ming , TIMMERMANN, Friedrich
发明人： THEIS, Oliver , CHEN, Xiao-Ming , TIMMERMANN, Friedrich
IPC分类号： H03M5/14
CPC分类号： H03M5/145
摘要： A channel encoding method is disclosed, which comprises dk-encoding and NRZI precoding, the output of which obeys a repeated minimum transition runlength constraint and is FSM decodable with a given lookahead depth. Occurrences of RMTR violating critical bit sequences are replaced by same length replacement sequences containing extended zero runs; and the FSM decodability with a given lookahead depth is achieved by using only those replacement sequences that are decodable with the given lookahead depth. A pertaining FSM channel decoding method and channel decoding apparatus, as well as using the FSM in trellis decoding, are disclosed.
摘要翻译：公开了一种信道编码方法，其包括dk编码和NRZI预编码，其输出服从重复的最小过渡游程长度约束，并且具有给定的前瞻深度可解码的FSM。违反关键位序列的RMTR的发生由包含扩展零运行的相同长度替换序列替换; 并且具有给定的前瞻深度的FSM可解码性通过仅使用可以用给定的前瞻深度解码的替换序列来实现。公开了一种FSM信道解码方法和信道解码装置，以及在网格解码中使用FSM。

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