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61. 发明申请

WO2006119121A3 CELL-SURFACE DECORATION WITH ACTIVE AGENTS 审中-公开
公开(公告)号：WO2006119121A3
公开(公告)日：2006-11-09
申请号：PCT/US2006/016480
申请日：2006-05-01
申请人： UNIVERSITY OF LOUISVILLE RESEARCH FOUNDATION, INC. , MALDONADO, Claudio , GROSSI, Federico, V. , PEREZ-ABADIA, Gustavo , EHRINGER, William, D.
发明人： MALDONADO, Claudio , GROSSI, Federico, V. , PEREZ-ABADIA, Gustavo , EHRINGER, William, D.
IPC分类号： A61K9/127 , A61K38/12
摘要： A lipid vesicle comprising a functionalized lipid comprising a tether moiety having binding affinity for a ligand portion of an active agent and the active agent are provided. Methods of decorating endothelial cells, tissues, and organs with active agents utilizing the disclosed lipid vesicles are also provided.

62. 发明申请

WO2006104964A2 INHIBITION OF WET TYPE AGE RELATED MACULAR DEGENERATION (AMD) BY ADIPONECTIN OR ACRP 30 审中-公开
标题翻译：通过ADIPONECTIN或ACRP 30抑制湿型年龄相关的微粒变性（AMD）
公开(公告)号：WO2006104964A2
公开(公告)日：2006-10-05
申请号：PCT/US2006/011008
申请日：2006-03-22
申请人： UNIVERSITY OF LOUISVILLE RESEARCH FOUNDATION, INC. , BORA, Puran S. , BORA, Nalini S. , KAPLAN, Henry J.
发明人： BORA, Puran S. , BORA, Nalini S. , KAPLAN, Henry J.
IPC分类号： A61K38/17
CPC分类号： A61K38/2264
摘要： The present invention provides new methods of treating wet type of age related macular degeneration by administering adiponectin (APN) or a functional fragment derived therefrom. One of the pathological complications of age related macular degeneration (AMD) is choroidal angiogenesis or choroidal neovascularization (CNV). The inventors discovered that the level of APN expression is significantly lower in the choroids of the laser-induced mouse model of choroidal angiogenesis or choroidal neovascularization (CNV) than that of the control mice and that administration of recombinant adiponectin (rAPN) or a peptide derived from the globular domain of the intact APN protein to the mouse model of CNV reduced the size of CNV significantly. These studies are the first to demonstrate the inhibitory effect of adiponectin on choroidal angiogenesis and thus provide the basis for treating a condition or disease involving angiogenesis, particularly age related macular degeneration, with administration of adiponectin.
摘要翻译：本发明提供了通过施用脂联素（APN）或其衍生的功能性片段治疗湿性年龄相关性黄斑变性的新方法。年龄相关性黄斑变性（AMD）的病理并发症之一是脉络膜血管生成或脉络膜新生血管形成（CNV）。发明人发现激光诱导的脉络膜血管生成或脉络膜新血管形成（CNV）小鼠模型的脉络膜的APN表达水平显着低于对照小鼠，并且施用重组脂联素（rAPN）或肽衍生物从完整的APN蛋白的球状结构域到CNV的小鼠模型显着降低了CNV的大小。这些研究首先证明脂联素对脉络膜血管生成的抑制作用，从而提供了通过给予脂联素治疗涉及血管生成，特别是年龄相关性黄斑变性的病症或疾病的基础。

63. 发明申请

WO2006102307A2 TARGET SPECIFIC NANOPARTICLES FOR ENHANCING OPTICAL CONTRAST ENHANCEMENT AND INDUCING TARGET-SPECIFIC HYPERTHERMIA 审中-公开
标题翻译：目标特异性纳米粒子，用于增强光学对比度增强和诱导目标特异性高分子
公开(公告)号：WO2006102307A2
公开(公告)日：2006-09-28
申请号：PCT/US2006/010191
申请日：2006-03-21
申请人： UNIVERSITY OF LOUISVILLE RESEARCH FOUNDATION, INC. , KANG, Kyung, Aih , SHI, Donglu
发明人： KANG, Kyung, Aih , SHI, Donglu
IPC分类号： A61K49/00
CPC分类号： A61K49/0065 , A61K41/0052 , A61K49/0034 , A61K49/0041 , A61K49/0043 , A61K49/0058 , A61K49/0093
摘要： A particle for introduction into a biological or physiological system for enhancing optical contrast between target cells and surrounding tissue, and for inducing cell death in the target cells while minimizing effects on surrounding healthy tissue, where the particle includes a magnetic core, a metal nanolayer surrounding the magnetic core and a surfactant layer surrounding the metal nanolayer. Bound to the metal nanolayer is at least one specificity biomolecule having an affinity for the target cells is bound to the metal nanolayer and a therapeutic agent. The particle may be introduced into a biological or physiological system, and exposed to an electromagnetic field to induce hyperthermia in the target cells.
摘要翻译：用于引入生物或生理系统的用于增强靶细胞和周围组织之间的光学对比度的颗粒，并用于在靶细胞中诱导细胞死亡，同时最小化对周围健康组织的影响，其中颗粒包括磁芯，金属纳米层周围磁芯和围绕金属纳米层的表面活性剂层。与金属纳米层结合是至少一种对靶细胞具有亲和力的特异性生物分子与金属纳米层和治疗剂结合。可将该颗粒引入生物或生理系统中，并暴露于电磁场以诱导靶细胞中的高热。

64. 发明申请

WO2006036858A2 MEMS CAPACITIVE CANTILEVER STRAIN SENSOR, DEVICES, AND FORMATION METHODS 审中-公开
标题翻译： MEMS电容式CANTILEVER应变传感器，器件和形成方法
公开(公告)号：WO2006036858A2
公开(公告)日：2006-04-06
申请号：PCT/US2005/034333
申请日：2005-09-23
申请人： UNIVERSITY OF LOUISVILLE RESEARCH FOUNDATION, INC. , WALSH, Kevin , CRAIN, Mark , HNAT, William , JACKSON, Douglas , LIN, Ji-Tzuoh , NABER, John
发明人： WALSH, Kevin , CRAIN, Mark , HNAT, William , JACKSON, Douglas , LIN, Ji-Tzuoh , NABER, John
IPC分类号： G01B7/16
CPC分类号： A61B5/103 , A61B5/076 , A61B2562/0261 , A61B2562/028 , G01B7/22
摘要： An embodiment of the invention provides a MEMS cantilever strain sensor. Capacitor plates in a MEMS device of the invention are carried on cantilevered opposing micro-scale plates (12, 14) separated by a micro-scale gap (18) under an unstrained condition. At least one of the micro-scale plates may be attached to a substrate or forms a substrate, which may be part of a monitored system. When a load is applied to the substrate, distal ends of the opposing cantilevered micro-scale plates become further separated, resulting in a change of capacitance. The change of capacitance is proportional to a load and therefore is an indication of the strain. Electrodes (30, 32) may be integrated into the strain sensor to provide a connection to measurement circuitry, for example. Sensors of the invention also provide for telemetric communication using radio frequency (RF) energy and can be interrogated without a power supply to the sensor.
摘要翻译：本发明的实施例提供一种MEMS悬臂应变传感器。在本发明的MEMS器件中的电容器板被承载在悬臂式相对的微尺度板（12,14）上，在微小尺度间隙（18）处于无限制条件下分开。微尺度板中的至少一个可以附接到基底或形成基底，其可以是被监测系统的一部分。当负载施加到基板时，相对的悬臂微型刻度板的远端进一步分离，导致电容的变化。电容的变化与负载成比例，因此是应变的指示。电极（30,32）可以集成到应变传感器中以提供例如与测量电路的连接。本发明的传感器还提供使用射频（RF）能量的遥测通信，并且可以在没有向传感器供电的情况下被询问。

65. 发明申请

WO2006020567A2 METHOD FOR DIAGNOSING OBSTRUCTIVE SLEEP APNEA 审中-公开
标题翻译：诊断障碍性APNEA的方法
公开(公告)号：WO2006020567A2
公开(公告)日：2006-02-23
申请号：PCT/US2005/028121
申请日：2005-08-09
申请人： UNIVERSITY OF LOUISVILLE RESEARCH FOUNDATION, INC. , GOZAL, David , JORTANI, Saeed, A. , VALDES, Roland, Jr.
发明人： GOZAL, David , JORTANI, Saeed, A. , VALDES, Roland, Jr.
IPC分类号： G01N33/53
CPC分类号： G01N33/6848 , G01N2333/4728 , G01N2333/723 , G01N2333/78 , G01N2333/96455 , G01N2550/00 , G01N2800/2864
摘要： A method for diagnosing obstructive sleep apnea in a patient comprises identifying at least one protein biomarker for obstructive sleep apnea; obtaining a sample from the patient; and testing the sample for presence of the at least one protein biomarker. The protein biomarkers may include alpha- lB-glycoprotein; kallikrein, laminin, aldosterone-binding protein and/or urocortin-2 precursor. The presence of the protein biomarkers may be detected using antibodies. These antibodies may be provided in an array for detecting the presence of the at least one protein biomarker or a pattern of protein biomarkers.
摘要翻译：用于诊断患者阻塞性睡眠呼吸暂停的方法包括鉴定至少一种用于阻塞性睡眠呼吸暂停的蛋白质生物标志物; 从患者身上获取样本; 并测试所述样品以存在所述至少一种蛋白质生物标志物。蛋白质生物标志物可以包括α-1B-糖蛋白; 激肽释放酶，层粘连蛋白，醛固酮结合蛋白和/或尿皮质素2前体。可以使用抗体检测蛋白质生物标志物的存在。这些抗体可以以用于检测至少一种蛋白质生物标志物的存在或蛋白质生物标记物的形式的阵列提供。

66. 发明申请

WO2004030613A2 CANCER THERAPY USING BETA GLUCAN AND ANTIBODIES 审中-公开
标题翻译：癌症治疗使用BETA GLUCAN和抗体
公开(公告)号：WO2004030613A2
公开(公告)日：2004-04-15
申请号：PCT/US2003/027975
申请日：2003-09-04
申请人： UNIVERSITY OF LOUISVILLE RESEARCH FOUNDATION, INC. , ROSS, Gordon, D.
发明人： ROSS, Gordon, D.
IPC分类号： A61K
CPC分类号： A61K31/716 , A61K31/47 , A61K31/715 , A61K39/39558 , A61K2039/505 , A61K2039/545 , C07K16/18 , C07K2317/732 , C07K2317/75 , C07K2317/76 , A61K2300/00
摘要： The present invention relates to methods of using neutral soluble glucan and monoclonal antibodies for antitumor therapy. Neutral soluble Beta (1,3; 1,6) glucan (NSG) enhances the tumoricidal activity of the innate immune system by binding to the C3 complement protein receptor CR3. The glucan does not stimulate the induction of inflammatory cytokines. Also described are methods of using whole glucan particles (WGP) as an immunomodulator by inducing a shift from a Th2 response to the Thl response, leading to an enhanced antitumor cytotoxic T-cell response.
摘要翻译：本发明涉及使用中性可溶性葡聚糖和单克隆抗体进行抗肿瘤治疗的方法。中性可溶性β（1,3; 1,6）葡聚糖（NSG）通过结合C3补体蛋白受体CR3增强先天免疫系统的杀肿瘤活性。葡聚糖不刺激炎性细胞因子的诱导。还描述了通过诱导从Th2应答向Th1应答的转移来使用全葡聚糖颗粒（WGP）作为免疫调节剂的方法，导致增强的抗肿瘤细胞毒性T细胞应答。

67. 发明申请

WO2023018941A1 INDUCTION OF TRAINED IMMUNITY FOR THE TREATMENT OF HYPERPROLIFERATIVE DISORDERS 审中-公开
公开(公告)号：WO2023018941A1
公开(公告)日：2023-02-16
申请号：PCT/US2022/040169
申请日：2022-08-12
申请人： UNIVERSITY OF LOUISVILLE RESEARCH FOUNDATION, INC.
发明人： YAN, Jun
IPC分类号： A61K31/716 , A61K36/06 , A61K31/715 , A61K31/70
摘要： In certain embodiments, the present invention provides a method of treating a pancreatic disorder comprising administering a β-glucan. In certain embodiments, the present invention provides a method inducing influx of immune cells to a pancreas comprising administering a yeast-derived particulate β-glucan. In certain embodiments, the present invention provides a method of reducing tumor in a pancreas comprising administering a β-glucan. In certain embodiments, the present invention provides a method of recruiting anti-tumor, innate immune cells comprising administering a β-glucan. In certain embodiments, the present invention provides a method of inducing whole β-Glucan particles trained immunity in a cancer. In certain embodiments, the present invention provides a method of inhibiting cancer metastasis comprising administering WGP. In certain embodiments, the present invention provides a method of developing trained innate immune cells as an adoptive cell therapy in cancer. In certain embodiments, the present invention provides isolated or purified beta-glucan-trained innate immune cells.

68. 发明申请

WO2023288204A1 DIAGNOSTICS FOR PORPHYROMONAS GINGIVALIS 审中-公开
公开(公告)号：WO2023288204A1
公开(公告)日：2023-01-19
申请号：PCT/US2022/073614
申请日：2022-07-11
申请人： KEYSTONE BIO, INC. , UNIVERSITY OF LOUISVILLE RESEARCH FOUNDATION, INC.
发明人： NARA, Peter L. , SINDELAR, Daniel L. , TOBIN, John Knox , WIGGINS, Taralyn Janette , TOBIN, Gregory John , POTEMPA, Jan Stanislaw
IPC分类号： G01N33/554 , G01N33/53 , G01N33/00 , C07K14/00 , C12N1/20 , C07H21/04
摘要： Antigen-binding molecules (ABMs) that bind to Porphyromonas gingivalis are described. The ABMs may be human or humanized ABMs. The ABMs find use in treating infections involving P. gingivalis, such as periodontal disease. Also provided are methods of treating or preventing a disorder or disease by administering the ABM.

69. 发明申请

WO2022159413A1 ACTINOHIVIN VARIANT POLYPEPTIDES AND RELATED METHODS 审中-公开
公开(公告)号：WO2022159413A1
公开(公告)日：2022-07-28
申请号：PCT/US2022/012853
申请日：2022-01-19
申请人： UNIVERSITY OF LOUISVILLE RESEARCH FOUNDATION, INC.
发明人： MATOBA, Nobuyuki
IPC分类号： A61K38/00 , A61K39/395 , A61P35/00 , C07K16/28 , G01N33/574
摘要： The treatment of growth factor receptor-mediated cancers, such as epidermal growth factor receptor- (EGFR-) and/or insulin-like growth factor 1 receptor- (IGF1R-) mediated cancers, e.g., lung cancer such as non-small cell lung cancer, which is sensitive to polypeptides specifically binds a high-mannose-type glycan epitope, is described. Methods for reducing activation of EGFR and/or IGF1R in cancer cells, inhibiting cancer cell migration, treatment of cancer and/or reduction of tumor growth in subjects (e.g, human patients) are provided.

70. 发明申请

WO2021236672A2 COMPOSITIONS AND METHODS FOR PREVENTION OF CORONAVIRUS INFECTION 审中-公开
公开(公告)号：WO2021236672A2
公开(公告)日：2021-11-25
申请号：PCT/US2021/033009
申请日：2021-05-18
申请人： UNIVERSITY OF LOUISVILLE RESEARCH FOUNDATION, INC. , UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION
发明人： PALMER, Kenneth E. , FUQUA, Joshua L. , ROHAN, Lisa Cencia , WANG, Lin , O'KEEFE, Barry R.
IPC分类号： C07K14/00 , A61P31/12 , A61P11/00 , A61K47/38 , A61P11/02 , A61M11/00 , A61K36/04 , A61K38/00 , C07K14/405
摘要： The present invention relates to griffithsin polypeptides and methods of using the same in inhibition of viral infection. Certain embodiments of the present invention relate to modified griffithsin polypeptides and methods of inhibiting coronavirus infection in a host by administering modified griffithsin polypeptides to the upper respiratory tract of the host. Further embodiments relate to an intranasal spray formulation including griffithsin polypeptides in a composition including a preservative and a viscosity modifier.

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