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61. 发明申请

WO2003022007A1 ORGANIC LIGHT EMITTING DEVICES HAVING CARRIER BLOCKING LAYERS COMPRISING METAL COMPLEXES 审中-公开
标题翻译：具有包含金属复合物的载体阻挡层的有机发光装置
公开(公告)号：WO2003022007A1
公开(公告)日：2003-03-13
申请号：PCT/US2002/026819
申请日：2002-08-23
申请人： THE TRUSTEES OF PRINCETON UNIVERSITY , THE UNIVERSITY OF SOUTHERN CALIFORNIA , THOMPSON, Mark , REN, Xiaofan , ADAMOVICH, Vadim , CORDERO, Steven , D'HANDRADE, Brian, Wendell , ALLEYNE, Bert , FORREST, Stephen
发明人： THOMPSON, Mark , REN, Xiaofan , ADAMOVICH, Vadim , CORDERO, Steven , D'HANDRADE, Brian, Wendell , ALLEYNE, Bert , FORREST, Stephen
IPC分类号： H05B33/00
CPC分类号： H01L51/5096 , H01L51/0034 , H01L51/0035 , H01L51/0037 , H01L51/005 , H01L51/0059 , H01L51/0062 , H01L51/007 , H01L51/0077 , H01L51/0079 , H01L51/0081 , H01L51/0082 , H01L51/0084 , H01L51/0085 , H01L51/5016 , H01L51/5048 , Y10S428/917 , Y10T428/24942
摘要： Light emitting devices having blocking layers comprising one or more metal complexes are provided. The blocking layers may serve to block electrons, holes, and/or excitons. Preferably, the devices further comprise a separate emissive layer in which charge and/or excitons are confined. Metal complexes suitable for blocking layers can be selected by comparison ofHOMO and LUMO energy levels ofmaterials comprising adjacent layers in devices of the present invention.
摘要翻译：提供具有包含一种或多种金属络合物的阻挡层的发光器件。阻挡层可用于阻挡电子，空穴和/或激子。优选地，所述器件还包括单独的发射层，其中电荷和/或激子被限制在其中。可以通过比较本发明装置中包含相邻层的材料的HOMO和LUMO能级来选择适于阻挡层的金属络合物。

62. 发明申请

WO2002091814A3 HIGH EFFICIENCY MULTI-COLOR ELECTRO-PHOSPHORESCENT OLEDS 审中-公开
公开(公告)号：WO2002091814A3
公开(公告)日：2002-11-21
申请号：PCT/US2002/014956
申请日：2002-05-13
申请人： THE TRUSTEES OF PRINCETON UNIVERSITY , THE UNIVERSITY OF SOUTHERN CALIFORNIA
发明人： D'ANDRADE, Brian , THOMPSON, Mark, E. , FORREST, Stephen, R.
IPC分类号： H01J1/62
摘要： The present invention relates to efficient organic light emitting devices (OLEDs) doped with multiple light-emitting dopants, at least one dopant comprising a phosphorescent emitter, in a thin film emissive layer or layers. The present invention is directed to an efficient phosphorescent organic light emitting device utilizing a plurality of emissive dopants in an emissive region, wherein at least one of the dopants is a phosphorescent material. Thus, the present invention provides an organic light emitting device comprising an emissive region, wherein the emissive region comprises a host material, and a plurality of emissive dopants, wherein the emissive region is comprised of a plurality of bands and each emissive dopant is doped into a separate band within the emissive region, and wherein at least one of the emissive dopants emits light by phosphorescence.

63. 发明申请

WO2002074015A2 MATERIALS AND DEVICES FOR BLUE PHOSPHORESCENCE BASED ORGANIC LIGHT EMITTING DIODES 审中-公开
标题翻译：基于蓝色荧光的有机发光二极管的材料和器件
公开(公告)号：WO2002074015A2
公开(公告)日：2002-09-19
申请号：PCT/US2002/007492
申请日：2002-03-13
申请人： THE TRUSTEES OF PRINCETON UNIVERSITY , THE UNIVERSITY OF SOUTHERN CALIFORNIA , THOMPSON, Mark, E. , FORREST, Stephen, R.
发明人： THOMPSON, Mark, E. , FORREST, Stephen, R.
IPC分类号： H05B
CPC分类号： H01L51/5016 , H01L51/002 , H01L51/005 , H01L51/007 , H01L51/0085 , H01L51/0087 , H01L2251/552
摘要： An OLED includes a wide gap inert host material doped with two dopants. One of the dopants is an emissive phosphorescent material that can transport either electrons or holes. The other dopant is a charge carrying material that can transport whichever of the electrons and holes that is not transported by the phosphorescent dopant. The materials are selected so that the lowest triplet energy level of the host material and the lowest triplet energy level of the charge carrying dopant material are each at a higher energy level than the lowest triplet state energy level of the phosphorescent dopant material. The device is capable, in particular, of efficiently emitting light in the blue region of the visible spectrum.
摘要翻译： OLED包括掺杂有两种掺杂剂的宽间隙惰性主体材料。一种掺杂剂是可以传输电子或空穴的发射磷光材料。另一种掺杂剂是可以输送未被磷光掺杂剂传输的电子和空穴中的哪个电荷携带材料。选择这些材料使得主体材料的最低三重态能级和电荷携带掺杂剂材料的最低三重态能级分别处于比磷光掺杂剂材料的最低三线态状态能级更高的能级。该装置特别能够在可见光谱的蓝色区域中有效地发射光。

64. 发明申请

WO2002032499A1 METHOD AND APPARATUS TO TREAT DISORDERS OF GASTROINTESTINAL PERISTALSIS 审中-公开
标题翻译：治疗胃肠疾病的方法和装置
公开(公告)号：WO2002032499A1
公开(公告)日：2002-04-25
申请号：PCT/US2001/028715
申请日：2001-09-14
申请人： ALFRED E. MANN INSTITUTE FOR BIOMEDICAL ENGINEERING AT THE UNIVERSITY OF SOUTHERN CALIFORNIA
发明人： LOEB, Gerald, E. , RICHMOND, Frances, J., R.
IPC分类号： A61N1/05
CPC分类号： A61N1/36007 , A61N1/37205 , A61N1/3756
摘要： The present invention provides electrical stimulation to the gastrointestinal viscera (2) to trigger or alter muscle contractility by implanting leadless microstimulators (10) in or near the walls of the viscera (2) that can be programmed or controlled from a source outside the body.
摘要翻译：本发明通过将无引导微刺激器（10）植入在可以从身体外部的源编程或控制的内脏（2）的壁中或附近，来向胃肠内脏（2）提供电刺激以触发或改变肌肉收缩性。

65. 发明申请

WO1997037622A1 METHOD AND APPARATUS FOR USING LASER-INDUCED FLUORESCENCE DURING PHOTORETRACTIVE KERATECTOMY 审中-公开
标题翻译：在光电转换过程中使用激光诱导荧光的方法和装置
公开(公告)号：WO1997037622A1
公开(公告)日：1997-10-16
申请号：PCT/US1996011667
申请日：1996-07-15
申请人： THE UNIVERSITY OF SOUTHERN CALIFORNIA , McDONNELL, Peter, J. , PHILLIPS, Andrew, F.
发明人： THE UNIVERSITY OF SOUTHERN CALIFORNIA
IPC分类号： A61F09/00
CPC分类号： A61F9/008 , A61B2017/00057 , A61B2017/00061 , A61F9/00804 , A61F2009/00844 , A61F2009/00872
摘要： Laser-induced fluorescence is generated during ablation of corneal tissue with the argon-fluoride 193nm excimer laser. An intensified charge-coupled device is used to achieve fast per-pulse temporal resolution of laser-induced fluorescence. The epithelium and stroma of a human cornea are subjected to 193nm excimer laser keratectomy. During the procedure, laser-induced fluorescence is measured. Changes in laser-induced fluorescence are detected and used to control the epithelial removal. In each layer two peaks predominated, one at about 405nm and the other at about 346nm. There is a rapid three-fold reduction in the 346nm ultraviolet peak at the transition from epithelium to stroma. By monitoring real-time changes in the measured intensity of laser-induced fluorescence during ablation of corneal tissue by the excimer laser, the transition from phototherapeutic removal of the epithelium to photorefractive reshaping of the stroma may be accurately controlled.
摘要翻译：用氩氟化物193nm准分子激光器在角膜组织消融期间产生激光诱导的荧光。使用强化的电荷耦合器件实现激光诱导荧光的快速每脉冲时间分辨率。对人角膜的上皮和基质进行193nm准分子激光角膜切除术。在该过程中，测量激光诱导的荧光。检测激光诱导荧光的变化并用于控制上皮移除。在每个层中，两个峰占主导，一个在约405nm，另一个在约346nm。在从上皮到基质的过渡中，346nm紫外峰的峰速度急剧下降3倍。通过监测准分子激光在角膜组织消融期间激光诱导荧光的测量强度的实时变化，可以准确地控制从上皮的光治疗去除到基质的光折射整形的过渡。

66. 发明申请

WO1994003556A1 ASYMMETRICAL NONPOLAR DIPHENYL-DIACETYLENE LIQUID CRYSTALS AND EUTECTIC MIXTURES 审中-公开
标题翻译：非对称非对苯二甲酸二乙酯液晶和保护性混合物
公开(公告)号：WO1994003556A1
公开(公告)日：1994-02-17
申请号：PCT/US1993007486
申请日：1993-08-09
申请人： HUGHES AIRCRAFT COMPANY , THE UNIVERSITY OF SOUTHERN CALIFORNIA
发明人： HUGHES AIRCRAFT COMPANY , THE UNIVERSITY OF SOUTHERN CALIFORNIA , WU, Shin-Tson , MARGERUM, J., David , MENG, Hsiang-Hui , DALTON, Larry, R.
IPC分类号： C09K19/18
CPC分类号： C09K19/18
摘要： A new class of asymmetrical diphenyl-diacetylene liquid crystal compounds exhibit ideal properties for formulating eutectic mixtures suitable for infrared and microwave applications. The new class of liquid crystal compounds comprise asymmetrical nonpolar end groups. These compounds exhibit low melting points, wide nematic temperature range and low heat fusion enthalpy. Eutectic mixtures containing entirely diphenyl-diacetylene homologs using the new compounds have high birefringence, low viscosity and wide nematic range. These unique properties are especially advantageous when these mixtures are used in infrared spatial light modulators, high speed liquid crystal modulators and polymer dispersed liquid crystals shutters. The new asymmetrical diphenyl-diacetylene liquid crystal compounds comprise the following basic structure: R1-C6H4-C=C-C=C-C6H4-R2 wherein R1 and R2 are nonpolar end groups and R1 does not equal R2. R1 is selected from the group consisting of alkyl, alkoxy, alkenyl and alkenyloxy end groups and R2 is selected from the group consisting of alkyl, alkenyl and alkenyloxy. In another embodiment, the liquid crystal compound can comprise an alkenyl group having the general formula: CxH2x+1CH=CH-(CH2)n-2-x in either the R1 or R2 location. Moreover, the liquid crystal compound can comprise such an alkenyl group in both R1 and R2 locations, so long as R1 does not equal R2. Eutectic mixtures for infrared and microwave applications comprise at least one asymmetrical nonpolar diphenyl diacetylene liquid crystal compound having the general structures described above.
摘要翻译：一类新的非对称二苯基 - 乙炔液晶化合物显示出适用于红外和微波应用的共晶混合物的理想特性。新型液晶化合物包括非对称非极性端基。这些化合物显示低熔点，宽向列温度范围和低热熔融焓。使用新化合物的含有完全二苯基 - 乙炔同系物的共晶混合物具有高双折射，低粘度和宽向列范围。当这些混合物用于红外空间光调制器，高速液晶调制器和聚合物分散的液晶快门时，这些独特的性质是特别有利的。新的不对称二苯基 - 乙炔液晶化合物包括以下基本结构：R1-C6H4-C = C-C = C-C6H4-R2，其中R1和R2是非极性端基，R1不等于R2。 R1选自烷基，烷氧基，烯基和烯氧基端基，R2选自烷基，烯基和烯氧基。在另一个实施方案中，液晶化合物可以包含在R1或R2位置具有通式CxH2x + 1CH = CH-（CH2）n-2-x的烯基。此外，只要R1不等于R2，液晶化合物可以在R1和R2两个位置都可以包含这样的烯基。用于红外和微波应用的共晶混合物包含至少一种具有上述一般结构的非对称非极性二苯基二乙炔液晶化合物。

67. 发明申请

WO2023081149A1 PROPHYLACTIC USES OF THETA DEFENSINS 审中-公开
公开(公告)号：WO2023081149A1
公开(公告)日：2023-05-11
申请号：PCT/US2022/048569
申请日：2022-11-01
申请人： THE UNIVERSITY OF SOUTHERN CALIFORNIA
发明人： SELSTED, Michael E. , SCHAAL, Justin B. , TRAN, Patti , TRAN, Dat Q.
IPC分类号： A61K38/17 , A61P31/04 , A61P31/14 , A61P33/02
摘要： Compositions and methods that provide safe and effective prophylactic treatment of a wide range of microbial pathogens are described. Such compositions and methods incorporate θ defensins and analogs of θ defensins, which have broad antimicrobial effects, have been found to maintain effective concentrations in the blood stream for extended periods of time, and are safe to administer at high doses.

68. 发明申请

WO2022251254A1 PHARMACOLOGICAL INTERVENTION OF THE ARACHIDONIC ACID PATHWAY TO CURE AMYOTROPHIC LATERAL SCLEROSIS 审中-公开
公开(公告)号：WO2022251254A1
公开(公告)日：2022-12-01
申请号：PCT/US2022/030773
申请日：2022-05-24
申请人： THE JOHNS HOPKINS UNIVERSITY , THE UNIVERSITY OF SOUTHERN CALIFORNIA
发明人： LEE, Gabsang , EOH, Hyungjin , LEE, Hojae , LLOYD, Thomas , MARAGAKIS, Nicholas J.
IPC分类号： A61K31/192 , A61K31/352 , A61K31/415 , A61K31/05 , A61P25/28 , C12N5/0793 , C12Q1/6883
摘要： Embodiments disclosed relate to methods of treating amyotrophic lateral sclerosis (ALS), including: selecting a therapeutic compound; treating an aberrant arachidonic acid (AA) metabolic pathway in an ALS cell.

69. 发明申请

WO2021263126A1 COMPOSITIONS AND METHODS FOR TREATMENT OF FUNGAL INFECTIONS 审中-公开
公开(公告)号：WO2021263126A1
公开(公告)日：2021-12-30
申请号：PCT/US2021/039129
申请日：2021-06-25
申请人： THE UNIVERSITY OF SOUTHERN CALIFORNIA
发明人： SELSTED, Michael E. , TRAN, Dat Q. , SCHAAL, Justin B. , BASSO, Virginia
IPC分类号： C07K7/64 , A61P31/10 , A61P29/00 , C07K14/47 , A61K38/00 , C07K14/4723
摘要： Peptide analogs of a θ-defensin have been developed that provide a biphasic effect in treating disseminated fungal disease and/or associated septic shock. These analogs are active at concentrations below those needed to provide a fungicidal effect, and function by initially mobilizing effector cells of the immune system to address the infective organism followed by regulation of the immune system to down regulate the inflammatory response. These θ-defensin analogs are protective at concentrations where naturally occurring θ-defensins have no apparent effect, and include a core set of structural and sequence features not found in native θ-defensins.

70. 发明申请

WO2019191672A1 A HEPATOCYTE-MIMICKING ANTIDOTE FOR ALCOHOL INTOXICATION 审中-公开
公开(公告)号：WO2019191672A1
公开(公告)日：2019-10-03
申请号：PCT/US2019/024983
申请日：2019-03-29
申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA , THE UNIVERSITY OF SOUTHERN CALIFORNIA
发明人： LU, Yunfeng , JI, Cheng , XU, Duo , HAN, Hui
IPC分类号： A61K38/44 , A61K47/54 , A61K47/64 , B82Y5/00 , C12N9/02 , C12N9/08 , C12N11/18
摘要： Alcohol intoxication causes serious diseases, whereas current treatments are mostly supportive and unable to remove alcohol efficiently. Upon alcohol consumption, alcohol is sequentially oxidized to acetaldehyde and acetate by the endogenous alcohol dehydrogenase and aldehyde dehydrogenase, respectively. We disclose a hepatocyte-mimicking antidote for alcohol intoxication through the co-delivery of the nanocapsules of alcohol oxidase (AOx), catalase (CAT), and aldehyde dehydrogenase (ALDH) to the liver, where AOx and CAT catalyze the oxidation of alcohol to acetaldehyde, while ALDH catalyzes the oxidation of acetaldehyde to acetate. Administered to alcohol-intoxicated mice, the antidote rapidly accumulates in the liver and enables a significant reduction of the blood alcohol concentration. Moreover, blood acetaldehyde concentration is maintained at an extremely low level, significantly contributing to liver protection. Such an antidote, which can eliminate alcohol and acetaldehyde simultaneously, holds great promise for the treatment of alcohol intoxication and poisoning.

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