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61. 发明申请

WO2012006593A2 DISPLAY SUPPORT APPARATUS 审中-公开
标题翻译：显示支持设备
公开(公告)号：WO2012006593A2
公开(公告)日：2012-01-12
申请号：PCT/US2011/043458
申请日：2011-07-08
申请人： SOUTHCO, INC. , BENNETT, Nicholas Paul , BUCKLAND, Stuart Kevan
发明人： BENNETT, Nicholas Paul , BUCKLAND, Stuart Kevan
IPC分类号： G06F1/16
CPC分类号： F16M13/02 , A47B81/00 , F16M11/02 , F16M11/08 , F16M11/10 , F16M11/12 , F16M11/126 , F16M11/18 , F16M11/2014 , F16M11/2092 , F16M11/24 , F16M11/42 , F16M2200/028 , F16M2200/041 , F16M2200/044 , F16M2200/063 , F16M2200/068 , G09F7/18 , G09F21/00
摘要： The display supporting apparatus includes a base, a first arm, a second arm, and a display attachment bracket designed to be fixedly securable or attachable to a display. The display support apparatus further includes a mechanism for providing a constant orientation in relation to the base for the plane bisecting the range of rotation of the second arm about the pivot axis between the first arm and the second arm even as the first arm moves pivotally relative to the base.
摘要翻译：显示器支撑装置包括底座，第一臂，第二臂和设计成可固定地固定或附接到显示器的显示器附件支架。所述显示支持装置还包括一个机构，用于相对于所述基座提供恒定的取向，所述平面将所述第二臂的旋转范围与所述第一臂和所述第二臂之间的所述枢转轴线平分，即使当所述第一臂枢转相对运动时到基地

62. 发明申请

WO2011101624A1 INDICATOR SYSTEM FOR FIBRE OPTIC SENSOR 审中-公开
标题翻译：光纤传感器指示灯系统
公开(公告)号：WO2011101624A1
公开(公告)日：2011-08-25
申请号：PCT/GB2011/000207
申请日：2011-02-15
申请人： GLYSURE LTD , CRANE, Barry, Colin , JAMES, Tony , FOSSEY, John , BARWELL, Nicholas, Paul
发明人： CRANE, Barry, Colin , JAMES, Tony , FOSSEY, John , BARWELL, Nicholas, Paul
IPC分类号： G01N33/66 , G01N21/64 , A61B5/145
CPC分类号： G01N33/66 , A61B5/14532 , A61B5/1459 , A61B5/1473 , G01N21/6428 , G01N2021/6434 , G01N2021/6484 , Y10T29/49826 , Y10T436/144444
摘要： The invention provides an optical sensor, e.g a fibre optic sensor, for determining the presence or amount of an analyte in a medium, the sensor having an indicator provided in the form of a fluid. In one aspect, the sensor contains either a solution of the indicator itself, or a solution of a support material which is bonded to the indicator. Dendrimers are examples of suitable support materials.
摘要翻译：本发明提供了一种用于确定介质中分析物的存在或量的光学传感器，例如光纤传感器，该传感器具有以流体形式提供的指示器。在一个方面，传感器包含指示剂本身的溶液或粘合到指示剂的支撑材料的溶液。树枝状聚合物是合适的支撑材料的例子。

63. 发明申请

WO2010135366A1 SYSTEM FOR TREATMENT OF BIOMASS TO FACILITATE THE PRODUCTION OF ETHANOL 审中-公开
标题翻译：用于处理生物量以促进乙醇生产的系统
公开(公告)号：WO2010135366A1
公开(公告)日：2010-11-25
申请号：PCT/US2010/035316
申请日：2010-05-18
申请人： POET RESEARCH INCORPORATED , MCDONALD, William, F. , STUTZMAN, Nicholas, Paul , CARLSON, David, Charles
发明人： MCDONALD, William, F. , STUTZMAN, Nicholas, Paul , CARLSON, David, Charles
IPC分类号： C12P7/06 , C12P7/10
CPC分类号： C12P7/10 , Y02E50/16 , Y02E50/17
摘要： A method for treating fermented lignocellulosic biomass to be supplied to a distillation system for production of ethanol is provided. The method includes pre- treating lignocellulosic biomass into pre-treated biomass and separating the pre-treated biomass into a liquid component comprising sugars and a solids component comprising cellulose and lignin. The method also includes hydrolysing the solids component of the pre-treated biomass into a hydrolysed biomass comprising sugars and lignin and fermenting the hydrolysed solids component of the pre-treated biomass into a fermentation product comprising ethanol and lignin. The method also includes treating the fermentation product and distilling the treated fermentation product to recover the ethanol. The lignocellulosic biomass comprises cellulose, hemi-cellulose and lignin.
摘要翻译：提供了一种用于处理供应到用于生产乙醇的蒸馏系统的发酵木质纤维素生物质的方法。该方法包括将木质纤维素生物质预处理成预处理的生物质并将预处理的生物质分离成包含糖和包含纤维素和木质素的固体组分的液体组分。该方法还包括将预处理的生物质的固体组分水解成包含糖和木质素的水解生物质，并将预处理的生物质的水解固体组分发酵成包含乙醇和木质素的发酵产物。该方法还包括处理发酵产物并蒸馏经处理的发酵产物以回收乙醇。木质纤维素生物质包括纤维素，半纤维素和木质素。

64. 发明申请

WO2010065733A1 LOW FORCE LOW OIL TRIP MECHANISM 审中-公开
标题翻译：低强度低油层机械
公开(公告)号：WO2010065733A1
公开(公告)日：2010-06-10
申请号：PCT/US2009/066573
申请日：2009-12-03
申请人： COOPER TECHNOLOGIES COMPANY , BRUSKY, Nicholas, Paul
发明人： BRUSKY, Nicholas, Paul
IPC分类号： H01H75/00
CPC分类号： H01H33/555
摘要： A circuit breaker for a transformer includes means for interrupting circuitry in the transformer upon a fault condition in the transformer (the "fault interruption means"). The circuit breaker also includes means for interrupting the circuitry when a level of dielectric fluid in a tank of the transformer is unacceptably low (the "low oil trip means"). The fault interruption means includes a magnet, metal element, and first actuator. Upon the fault condition, the magnet and metal element separate, moving the first actuator to cause the electrical circuitry to open. The low oil trip means includes a float, insulating rod, and second actuator. When the dielectric fluid level drops to an unacceptably low level, the float and insulating rod drop, moving the second actuator to cause the circuitry to open. The low oil trip means operates independently of the fault interruption means, opening the circuitry without separating the magnet and metal element.
摘要翻译：用于变压器的断路器包括用于在变压器的故障状态（“故障中断装置”）中断变压器中的电路的装置。断路器还包括当变压器的箱中的介电流体的水位不可接受地低（“低油脱扣装置”）时中断电路的装置。故障中断装置包括磁体，金属元件和第一致动器。在故障状态下，磁体和金属元件分离，移动第一致动器以使电路打开。低油脱扣装置包括浮子，绝缘杆和第二致动器。当介质流体液位下降到不可接受的低水平时，浮子和绝缘杆下降，移动第二个致动器以使电路打开。低油脱扣装置独立于故障中断装置工作，打开电路而不分离磁体和金属元件。

65. 发明申请

WO2007130429A3 HISTONE DEACETYLASE AND TUBULIN DEACETYLASE INHIBITORS 审中-公开
公开(公告)号：WO2007130429A3
公开(公告)日：2007-11-15
申请号：PCT/US2007/010587
申请日：2007-05-02
申请人： THE PRESIDENT AND FELLOWS OF HARVARD COLLEGE , MAZITSCHEK, Ralph , KWIATKOWSKI, Nicholas, Paul , BRADNER, James, Elliott
发明人： MAZITSCHEK, Ralph , KWIATKOWSKI, Nicholas, Paul , BRADNER, James, Elliott
IPC分类号： A61K31/33 , A61K31/47 , A61K31/44 , A61K31/415 , A61K31/335 , C07D215/00 , C07D233/00 , C07D263/00 , C07D277/68 , C07D403/00 , C07D405/00 , C07D413/00
摘要： In recognition of the need to develop novel therapeutic agents and efficient methods for the synthesis thereof, the present invention provides novel inhibitors of histone deacetylases, tubulin deacetylases, and/or aggresome inhibitors, and pharmaceutically acceptable salts and derivatives thereof. The inventive compounds fall into two classes — "isorubacin" class and "isoisotubacin" class- — all of which include a 1,3-dioxane core. The present invention further provides methods for treating disorders regulated by histone deacetylase activity, tubulin deacetylase activity, and/or the aggresome (e.g., proliferative diseases, cancer, inflammatory diseases, protozoal infections, protein degradation disorders, protein deposition disorders, etc.) comprising administering a therapeutically effective amount of an inventive compound to a subject in need thereof. The present invention also provides methods for preparing compounds of the invention.

66. 发明申请

WO2007130429A2 HISTONE DEACETYLASE AND TUBULIN DEACETYLASE INHIBITORS 审中-公开
标题翻译： HISTONE脱乙酰壳多糖酶和管状体脱乙酰酶抑制剂
公开(公告)号：WO2007130429A2
公开(公告)日：2007-11-15
申请号：PCT/US2007010587
申请日：2007-05-02
申请人： HARVARD COLLEGE , MAZITSCHEK RALPH , KWIATKOWSKI NICHOLAS PAUL , BRADNER JAMES ELLIOTT
发明人： MAZITSCHEK RALPH , KWIATKOWSKI NICHOLAS PAUL , BRADNER JAMES ELLIOTT
IPC分类号： A61K31/357
CPC分类号： C07D413/12 , C07D319/06 , C07D405/12 , C07D417/12
摘要： In recognition of the need to develop novel therapeutic agents and efficient methods for the synthesis thereof, the present invention provides novel inhibitors of histone deacetylases, tubulin deacetylases, and/or aggresome inhibitors, and pharmaceutically acceptable salts and derivatives thereof. The inventive compounds fall into two classes - "isorubacin" class and "isoisotubacin" class- - all of which include a 1,3-dioxane core. The present invention further provides methods for treating disorders regulated by histone deacetylase activity, tubulin deacetylase activity, and/or the aggresome (e.g., proliferative diseases, cancer, inflammatory diseases, protozoal infections, protein degradation disorders, protein deposition disorders, etc.) comprising administering a therapeutically effective amount of an inventive compound to a subject in need thereof. The present invention also provides methods for preparing compounds of the invention.
摘要翻译：鉴于需要开发新的治疗剂及其有效的合成方法，本发明提供组蛋白脱乙酰酶，微管蛋白脱乙酰酶和/或聚集抑制剂的新型抑制剂及其药学上可接受的盐和衍生物。本发明的化合物分为两类 - “异霍巴康”类和“异倍他康”类，其中全部包括1,3-二恶烷核。本发明进一步提供了用于治疗由组蛋白脱乙酰酶活性，微管蛋白脱乙酰酶活性和/或聚集物（例如增殖性疾病，癌症，炎性疾病，原生动物感染，蛋白质降解紊乱，蛋白沉积病症等）调节的病症的方法，其包括向有需要的受试者施用治疗有效量的本发明化合物。本发明还提供了制备本发明化合物的方法。

67. 发明申请

WO2006103393A1 PREDICTING BEHAVIOUR OF DYNAMIC SYSTEMS 审中-公开
标题翻译：动态系统的预测行为
公开(公告)号：WO2006103393A1
公开(公告)日：2006-10-05
申请号：PCT/GB2006/000980
申请日：2006-03-16
申请人： BRITISH TELECOMMUNICATIONS PUBLIC LIMITED COMPANY , MAJEED, Basim , CLARKE, Nicholas, Paul
发明人： MAJEED, Basim , CLARKE, Nicholas, Paul
IPC分类号： H04L12/24 , G06F21/00
CPC分类号： H04L41/147 , H04L41/142 , H04L63/1408 , H04L63/1441
摘要： Methods and systems for establishing predictions relating to the behaviour of a system by: deriving, from data relating to previously-observed behaviour of a system, event data indicative of events that have occurred; deriving, from said event data, sequence data indicative of sequences of events that have occurred; deriving, from said sequence data, a measure of probability in respect of each of a plurality of said sequences of events; storing said measures of probability in respect of said plurality of sequences; receiving subsequent-event data relating to subsequently-observed behaviour of a system; deriving, from said subsequent-event data, subsequent-sequence data; and establishing, with reference to said stored measures of probability, a measure of the likelihood of said subsequent sequence being followed by a predetermined event-of-interest or sequence-of-interest, or by one of a set of predetermined events-of-interest or sequences-of-interest, or by an unknown event or sequence of events.
摘要翻译：用于通过以下方式建立与系统行为相关的预测的方法和系统：从与先前观察到的系统行为有关的数据中导出指示发生的事件的事件数据; 从所述事件数据中导出指示发生的事件序列的序列数据; 从所述序列数据中导出关于多个所述事件序列中的每一个的概率的度量; 存储关于所述多个序列的所述概率测量; 接收与随后观察到的系统行为有关的后续事件数据; 从所述后续事件数据中导出后续序列数据; 以及参考所述存储的概率测度来建立所述后续序列的可能性的度量，所述随后序列的可能性之后是预定的兴趣事件或兴趣序列，或通过一组预定的事件中的一个，兴趣或兴趣序列，或未知事件或事件顺序。

68. 发明申请

WO2006102557A3 TREATMENT OF PROTEIN DEGRADATION DISORDERS 审中-公开
公开(公告)号：WO2006102557A3
公开(公告)日：2006-09-28
申请号：PCT/US2006/010676
申请日：2006-03-22
申请人： THE PRESIDENT AND FELLOWS OF HARVARD COLLEGE , DANA-FARBER CANCER INSTITUTE, INC. , ANDERSON, Kenneth, C. , BRADNER, James, Elliott , GREENBERG, Edward, Franklin , HIDESHIMA, Teru , KWIATKOWSKI, Nicholas, Paul , MAZITSCHEK, Ralph , SCHREIBER, Stuart, L. , SHAW, Jared
发明人： ANDERSON, Kenneth, C. , BRADNER, James, Elliott , GREENBERG, Edward, Franklin , HIDESHIMA, Teru , KWIATKOWSKI, Nicholas, Paul , MAZITSCHEK, Ralph , SCHREIBER, Stuart, L. , SHAW, Jared
IPC分类号： A61K31/42 , A61K31/335
摘要： The invention relates to methods of treating protein degradation disorders, such cellular proliferative disorders (e.g., cancer) and protein deposition disorders (e.g., neurodegenerative disorders). The invention provides methods and pharmaceutical compositions for treating these diseases using aggresome inhibitors or combinations of aggresome inhibitors and proteasome inhibitors. The invention further relates to methods and pharmaceutical compositions for treating multiple myeloma. New HDAC/TDAC inhibitors and aggresome inhibitors are also provided as well as synthetic methodologies for preparing these compounds.

69. 发明申请

WO2004096773A1 QUINOLONE DERIVATIVES 审中-公开
标题翻译：喹诺酮衍生物
公开(公告)号：WO2004096773A1
公开(公告)日：2004-11-11
申请号：PCT/US2004/009290
申请日：2004-04-16
申请人： ELI LILLY AND COMPANY , CAMP, Nicholas, Paul , PENARIOL, Roberta , BEADLE, Christopher, David
发明人： CAMP, Nicholas, Paul , PENARIOL, Roberta , BEADLE, Christopher, David
IPC分类号： C07D215/22
CPC分类号： C07D215/227 , C07D409/04
摘要： This invention relates to compounds of formula (I) where -X-, n, R 1 , R 3 and Ar- have the values defined herein, their preparation and use as norepinephrine reuptake inhibitors useful for the treatment of nervous system disorders
摘要翻译：本发明涉及式（I）化合物，其中-X-，n，R 1，R 3和Ar-具有本文定义的值，其作为去甲肾上腺素再摄取抑制剂的用途可用于治疗神经系统障碍

70. 发明申请

WO2004006268A3 STORAGE OF HAZARDOUS MATERIALS 审中-公开
标题翻译：存储危险材料
公开(公告)号：WO2004006268A3
公开(公告)日：2004-03-18
申请号：PCT/GB0302870
申请日：2003-07-03
申请人： BRITISH NUCLEAR FUELS PLC , HOLLICK ADELE CHARMAINE , HANIGAN NICHOLAS PAUL
发明人： HOLLICK ADELE CHARMAINE , HANIGAN NICHOLAS PAUL
IPC分类号： G21F9/00 , G21F9/16 , G21F9/30 , G21F9/34
CPC分类号： G21F9/304 , C04B28/04 , C04B2111/00767 , G21Y2002/206 , G21Y2002/304 , G21Y2002/60 , G21Y2004/40 , G21Y2004/601 , Y02W30/91 , Y02W30/92 , Y02W30/94 , C04B14/06 , C04B14/28 , C04B18/0463 , C04B18/08 , C04B18/141 , C04B2103/30
摘要： The invention provides a method for the encapsulation of a nuclear material, which comprises treating the material with an encapsulant, which comprises a cementitious material, such as Portland Cement, and curing, said cementitious material. The method is particularly suitable for the treatment of nuclear fuel materials such as uranium metal, complete Magnox fuel elements, or fuel element debris, for which encapsulation treatments have never previously been known. Such materials may be treated by the method of the invention in order to obtain products which remains stable and monolithic for many hundreds of years, and the invention thereby offers a safe and convenient alternative means of handling other than nuclear fuel reprocessing.
摘要翻译：本发明提供了一种用于封装核材料的方法，其包括用包含水泥材料（例如波特兰水泥）的密封剂处理材料，并固化所述水泥材料。该方法特别适用于处理诸如铀金属，完整的Magnox燃料元件或燃料元件碎片等核燃料材料，对此封装处理从未公知过。这种材料可以通过本发明的方法进行处理，以便获得在数百年内保持稳定和整体式的产品，并且因此本发明提供了除核燃料后处理以外的安全和方便的替代处理方式。

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