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1. 发明申请

WO2010116142A3 FLUOROPHORE AND FLUORESCENT SENSOR COMPOUND CONTAINING SAME 审中-公开
公开(公告)号：WO2010116142A3
公开(公告)日：2010-10-14
申请号：PCT/GB2010/000711
申请日：2010-04-08
申请人： GLYSURE LTD , HIGGS, Timothy, charles
发明人： HIGGS, Timothy, charles
IPC分类号： C07C311/39 , C07D221/18 , C07F5/02 , G01N33/542
摘要： The invention provides fluorophores of formulae (I) and (II) and also fluorescent sensor compounds comprising fluorophore moieties based on such fluorophores in combination with a receptor moiety. There is further provided a method of sensing the presence of a target analyte using the fluorescent sensor compound, as well as the use of the fluorescent sensor compounds to sense a target analyte.

2. 发明申请

WO2011101624A1 INDICATOR SYSTEM FOR FIBRE OPTIC SENSOR 审中-公开
标题翻译：光纤传感器指示灯系统
公开(公告)号：WO2011101624A1
公开(公告)日：2011-08-25
申请号：PCT/GB2011/000207
申请日：2011-02-15
申请人： GLYSURE LTD , CRANE, Barry, Colin , JAMES, Tony , FOSSEY, John , BARWELL, Nicholas, Paul
发明人： CRANE, Barry, Colin , JAMES, Tony , FOSSEY, John , BARWELL, Nicholas, Paul
IPC分类号： G01N33/66 , G01N21/64 , A61B5/145
CPC分类号： G01N33/66 , A61B5/14532 , A61B5/1459 , A61B5/1473 , G01N21/6428 , G01N2021/6434 , G01N2021/6484 , Y10T29/49826 , Y10T436/144444
摘要： The invention provides an optical sensor, e.g a fibre optic sensor, for determining the presence or amount of an analyte in a medium, the sensor having an indicator provided in the form of a fluid. In one aspect, the sensor contains either a solution of the indicator itself, or a solution of a support material which is bonded to the indicator. Dendrimers are examples of suitable support materials.
摘要翻译：本发明提供了一种用于确定介质中分析物的存在或量的光学传感器，例如光纤传感器，该传感器具有以流体形式提供的指示器。在一个方面，传感器包含指示剂本身的溶液或粘合到指示剂的支撑材料的溶液。树枝状聚合物是合适的支撑材料的例子。

3. 发明申请

WO2009106805A1 FIBRE OPTIC SENSOR 审中-公开
标题翻译：光纤传感器
公开(公告)号：WO2009106805A1
公开(公告)日：2009-09-03
申请号：PCT/GB2009/000502
申请日：2009-02-20
申请人： GLYSURE LTD , CRANE, Barry
发明人： CRANE, Barry
IPC分类号： G01N21/64 , G01N21/77 , G02B6/02
CPC分类号： G01N21/6428 , G01N21/0303 , G01N21/7703 , G01N2021/7713 , G01N2021/7786 , G01N2021/7796 , G02B6/032
摘要： A fibre optic sensor for detecting or measuring the concentration of an analyte in a medium, the sensor having a sensing region (1) for insertion into the medium during use, which sensing region comprises a cell containing an indicator for the analyte, wherein the cell comprises a central portion (CE) arranged longitudinally within the fibre and one or more crossing portions (CRl, CR2, CR3) which intersect the central portion.
摘要翻译：一种光纤传感器，用于检测或测量介质中分析物的浓度，所述传感器具有用于在使用期间插入介质的感测区域（1），所述感测区域包括含有分析物的指示剂的细胞，其中所述细胞包括沿光纤布置的中心部分（CE）和与中心部分相交的一个或多个交叉部分（CR1，CR2，CR3）。

4. 发明申请

WO2011101627A2 FLUORESCENCE MEASUREMENT 审中-公开
标题翻译：荧光测量
公开(公告)号：WO2011101627A2
公开(公告)日：2011-08-25
申请号：PCT/GB2011000210
申请日：2011-02-15
申请人： GLYSURE LTD , CRANE BARRY COLIN , GILCHRIST JOHN , CAIRNS NEIL
发明人： CRANE BARRY COLIN , GILCHRIST JOHN , CAIRNS NEIL
IPC分类号： G01N21/64 , C07F5/02 , G01N21/77
CPC分类号： G01N21/6486 , G01N21/6408 , G01N21/7703 , G01N33/66 , G01N2021/6484 , G01N2021/772 , G01N2021/7786
摘要： A sensor for fluorescence measurement comprising: a light source arranged for emitting light to a sample region, wherein the light source intensity is modulatable; an indicator system located at the sample region, said indicator system comprising: a receptor for an analyte; and a fluorophore associated with said receptor, wherein the fluorophore has a fluorescence lifetime that changes in response to the presence of analyte at the receptor; a single photon avalanche diode arranged to receive fluorescence light emitted from said sample region in response to the light incident on the sample region from the light source, and to generate an output signal; a driver arranged to modulate the light source intensity at a first frequency; a bias voltage source arranged to apply a bias voltage to the single photon avalanche diode, wherein the bias voltage is modulated at a second frequency, different from the first frequency, and wherein the bias voltage is above the breakdown voltage of the single photon avalanche diode; and a signal processor arranged to determine information related to a fluorescence lifetime of the fluorophore based on at least the output signal of the single photon avalanche diode.
摘要翻译：一种用于荧光测量的传感器，包括：光源，被布置成将光发射到样品区域，其中所述光源强度是可调制的; 位于样品区域的指示剂系统，所述指示器系统包括：用于分析物的受体; 和与所述受体相关联的荧光团，其中所述荧光团具有响应于受体处分析物存在而发生变化的荧光寿命; 单光子雪崩二极管，被配置为响应于从光源入射到样本区域上的光，接收从所述采样区域发射的荧光，并产生输出信号; 布置成以第一频率调制光源强度的驱动器; 偏置电压源，被布置成向所述单光子雪崩二极管施加偏置电压，其中所述偏置电压以不同于所述第一频率的第二频率被调制，并且其中所述偏置电压高于所述单光子雪崩二极管的击穿电压 ; 以及信号处理器，被布置为基于至少所述单个光子雪崩二极管的输出信号来确定与所述荧光团的荧光寿命相关的信息。

5. 发明申请

WO2009087373A1 SURFACE FUNCTIONALISATION OF PLASTIC OPTICAL FIBRE 审中-公开
标题翻译：塑料光纤的表面功能
公开(公告)号：WO2009087373A1
公开(公告)日：2009-07-16
申请号：PCT/GB2009/000027
申请日：2009-01-07
申请人： GLYSURE LTD , CRANE, Barry
发明人： CRANE, Barry
IPC分类号： G01N33/543 , G01N33/66
CPC分类号： G01N33/54353 , G01N33/54393 , G01N33/66
摘要： A process is provided for the covalent attachment of an indicator to a plastic optical fibre by functionalising the surface of the optical fibre to provide a polymerisable group and polymerising an indicator monomer, optionally together with a hydrogel-forming monomer, to the fibre surface. This provides an optical fibre having covalently linked to its surface an indicator, typically an indicator encased in a hydrogel. The plastic optical fibre is useful as a sensor.
摘要翻译：提供了通过使光纤的表面功能化以提供可聚合基团并且可选地将指示剂单体与形成水凝胶的单体一起聚合到纤维表面而将指示剂共价连接到塑料光纤上的方法。这提供了一种与其表面共价连接的指示剂，通常是包封在水凝胶中的指示剂。塑料光纤可用作传感器。

6. 发明申请

WO2011101625A1 SUBCUTANEOUS GLUCOSE SENSOR 审中-公开
标题翻译：不育葡萄糖传感器
公开(公告)号：WO2011101625A1
公开(公告)日：2011-08-25
申请号：PCT/GB2011/000208
申请日：2011-02-15
申请人： GLYSURE LTD , CRANE, Barry, Colin , MACKENZIE, Alasdair, Allan , CAIRNS, Neil , GILCHRIST, John
发明人： CRANE, Barry, Colin , MACKENZIE, Alasdair, Allan , CAIRNS, Neil , GILCHRIST, John
IPC分类号： G01N33/58 , G01N33/66 , A61B5/145
CPC分类号： A61B5/14532 , G01N33/542 , G01N33/66
摘要： A glucose sensor for measurement of glucose in subcutaneous tissue, the sensor comprising: a probe for subcutaneous insertion, the probe containing an indicator system comprising a receptor for selectively binding to glucose and a fluorophore associated with said receptor, wherein the fluorophore has a fluorescence lifetime of less than 100ns; a detector head which is optically connected to the probe and which is for location outside the body; a light source; and a detector arranged to receive fluorescent light emitted from the indicator system, wherein the light source and detector are optionally located within the detector head; wherein the sensor is arranged to measure glucose concentration in subcutaneous tissue by monitoring the fluorescence lifetime of the fluorophore.
摘要翻译：一种用于测量皮下组织中的葡萄糖的葡萄糖传感器，所述传感器包括：用于皮下插入的探针，所述探针含有包含用于选择性结合葡萄糖的受体的指示剂系统和与所述受体相关联的荧光团，其中所述荧光团具有荧光寿命小于100ns; 检测器头，其被光学地连接到探针并且用于位于身体外部; 光源; 以及检测器，被布置成接收从所述指示器系统发射的荧光，其中所述光源和检测器可选地位于所述检测器头内; 其中所述传感器被布置成通过监测所述荧光团的荧光寿命来测量皮下组织中的葡萄糖浓度。

7. 发明申请

WO2010133831A1 GLUCOSE SENSOR CALIBRATION 审中-公开
标题翻译：葡萄糖传感器校准
公开(公告)号：WO2010133831A1
公开(公告)日：2010-11-25
申请号：PCT/GB2010/000992
申请日：2010-05-17
申请人： GLYSURE LTD , CRANE, Barry, Colin , PATERSON, William
发明人： CRANE, Barry, Colin , PATERSON, William
IPC分类号： C12Q1/54 , A61B5/00 , G01N33/487
CPC分类号： G01N33/66 , A61B5/14532 , A61B5/1459 , A61B5/1495 , G01N27/3274
摘要： A method of calibrating a glucose sensor, which method comprises: (a) preparing a first glucose-containing calibration solution by combining water or an aqueous solution with alpha and beta glucose, the alpha and beta glucose being provided in solid form; (b) exposing a glucose sensor to said first glucose-containing calibration solution and determining the sensor output; (c) exposing the glucose sensor to one or more further calibration solutions having different glucose concentrations from each other and from said first glucose-containing calibration solution and determining the sensor output for the or each calibration solution; and (d) determining a calibration curve from the sensor output data collected in steps (b) and (c).
摘要翻译：一种校准葡萄糖传感器的方法，所述方法包括：（a）通过将水或水溶液与α和β葡萄糖结合来制备第一含葡萄糖的校准溶液，所述α和β葡萄糖以固体形式提供; （b）将葡萄糖传感器暴露于所述第一含葡萄糖校准溶液并确定传感器输出; （c）将所述葡萄糖传感器暴露于具有彼此不同葡萄糖浓度和所述第一含葡萄糖的校准溶液的一种或多种另外的校准溶液，并确定所述或每种校准溶液的传感器输出; 和（d）从步骤（b）和（c）中收集的传感器输出数据确定校准曲线。

8. 发明申请

WO2010116142A2 FLUOROPHORE AND FLUORESCENT SENSOR COMPOUND CONTAINING SAME 审中-公开
标题翻译：荧光物质和含有荧光物质的荧光传感器化合物
公开(公告)号：WO2010116142A2
公开(公告)日：2010-10-14
申请号：PCT/GB2010000711
申请日：2010-04-08
申请人： GLYSURE LTD , HIGGS TIMOTHY CHARLES
发明人： HIGGS TIMOTHY CHARLES
IPC分类号： C07C311/39 , C07D221/18 , C07F5/02 , G01N33/542
CPC分类号： G01N33/582 , C07C311/39 , C07D221/18 , C09B5/14 , C09B57/001 , C09K11/06 , C09K2211/1007 , C09K2211/1029 , G01N2400/00 , Y10T436/144444
摘要： The invention provides fluorophores of formulae (I) and (II) and also fluorescent sensor compounds comprising fluorophore moieties based on such fluorophores in combination with a receptor moiety. There is further provided a method of sensing the presence of a target analyte using the fluorescent sensor compound, as well as the use of the fluorescent sensor compounds to sense a target analyte.
摘要翻译：本发明提供了式（I）和（II）的荧光团，并且还提供了荧光传感器化合物，其包含基于这种荧光团与受体部分组合的荧光团部分。还提供了使用荧光传感器化合物来感测目标分析物的存在的方法，以及使用荧光传感器化合物来感测目标分析物的方法。

9. 发明申请

WO2011101628A1 INTRAVASCULAR GLUCOSE SENSOR 审中-公开
标题翻译：血管葡萄糖传感器
公开(公告)号：WO2011101628A1
公开(公告)日：2011-08-25
申请号：PCT/GB2011/000211
申请日：2011-02-15
申请人： GLYSURE LTD , CRANE, Barry Colin , GILCHRIST, John , CAIRNS, Neil
发明人： CRANE, Barry Colin , GILCHRIST, John , CAIRNS, Neil
IPC分类号： A61B5/145 , G01N33/66 , G01N21/64
CPC分类号： A61B5/14532 , A61B5/1459 , G01N21/6408 , G01N21/7703 , G01N2021/772 , G01N2021/7786
摘要： A glucose sensor for intravascular measurement of glucose concentration wherein the sensor is arranged to measure glucose concentration by monitoring the lifetime of the fluorophore, the sensor comprising: - an indicator system comprising a receptor for selectively binding to glucose and a fluorophore associated with said receptor, wherein the fluorophore has a lifetime of less than 100ns; - a light source; - an optical fibre arranged to direct light from the light source onto the indicator system; - a detector arranged to receive fluorescent light emitted from the indicator system; and - a signal processor arranged to determine information related to a fluorescence lifetime of the fluorophore based on at least the output signal of the detector.
摘要翻译：一种用于葡萄糖浓度血管内测量的葡萄糖传感器，其中所述传感器被布置为通过监测所述荧光团的寿命来测量葡萄糖浓度，所述传感器包括： - 指示剂系统，其包含用于选择性结合葡萄糖的受体和与所述受体相关联的荧光团，其中所述荧光团的寿命小于100ns; - 光源; - 布置成将来自光源的光引导到指示器系统上的光纤; - 被布置成接收从所述指示器系统发出的荧光的检测器; 以及 - 信号处理器，被布置为基于至少所述检测器的输出信号来确定与所述荧光团的荧光寿命相关的信息。

10. 发明申请

WO2011101626A1 BARRIER LAYER FOR GLUSOSE SENSOR 审中-公开
标题翻译：玻璃传感器的障碍层
公开(公告)号：WO2011101626A1
公开(公告)日：2011-08-25
申请号：PCT/GB2011/000209
申请日：2011-02-15
申请人： GLYSURE LTD , CRANE, Barry , PATERSON, William , CULBERT, Bruce
发明人： CRANE, Barry , PATERSON, William , CULBERT, Bruce
IPC分类号： G01N33/66 , B01D71/00 , G01N21/64 , A61B5/145
CPC分类号： G01N33/66 , A61B5/14532 , A61B5/1459 , B01D63/00 , B01L2200/027 , G01N21/7703 , G01N2021/772 , G01N2021/775 , G01N2021/7786 , Y10T29/49826
摘要： An optical glucose sensor comprising: a sensing region comprising a boronic acid receptor for binding to glucose and a fluorophore associated with said receptor; an optical waveguide for directing incident light onto the sensing region; and a hydrophilic, polymeric, glucose-permeable barrier layer which is provided on at least a part of the sensing region; wherein the sensor is adapted so that glucose enters the sensing region of the sensor through said barrier layer.
摘要翻译：一种光学葡萄糖传感器，包括：包含用于结合葡萄糖的硼酸受体和与所述受体相关联的荧光团的感测区域; 用于将入射光引导到感测区域上的光波导; 以及设置在所述感测区域的至少一部分上的亲水性，聚合物，葡萄糖可渗透屏障层; 其中所述传感器适于使得葡萄糖通过所述阻挡层进入所述传感器的感测区域。

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