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51. 发明申请

WO2004006867A2 NOVEL 2-AMINO-9-[(2-HYDROXYMETHYL) CYCLOPROPYLIDENEMETHYL] PURINES AS ANTIVIRAL AGENTS 审中-公开
标题翻译：新型2-氨基-9- [（2-羟甲基）环丙基咪唑]作为抗病毒剂
公开(公告)号：WO2004006867A2
公开(公告)日：2004-01-22
申请号：PCT/US2003/007909
申请日：2003-03-13
申请人： WAYNE STATE UNIVERSITY , THE REGENTS OF THE UNIVERSITY OF MICHIGAN , ZEMLICKA, Jiri , DRACH, John, C.
发明人： ZEMLICKA, Jiri , DRACH, John, C.
IPC分类号： A61K
CPC分类号： C07D473/00 , C07F9/65616
摘要： Compounds which are active against viruses have the Formulas (1) and (2), wherein B is 2-aminopurine-9-yl, which may be unsubstituted or substituted in the 6 position with NHR 1 , OR 2 , or SR 3 ; R l is selected from the group consisting of alkyl, alkenyl, alkynyl, and C 4-18 cycloalkyl, any of which may be optionally substituted with one or more members of the group consisting of hydroxy, halo, amino, acyl, cycloalkyl, heterocyclyl and aryl; R 2 is selected from the group consisting of C 2-18 alkyl, alkenyl, alkynyl, and cycloalkyl, any of which may be branched or unbranched and optionally substituted with one or more members of the group consisting of hydroxy, halo, amino, acyl, cycloalkyl, heterocyclyl, and aryl; and R 3 is selected from the group consisting of alkyl, alkenyl, alkynyl, and cycloalkyl, any of which may be branched or unbranched and optionally substituted with one or more members of the group consisting of hydroxy, halo, amino, acyl, cycloalkyl, heterocyclyl and aryl.
摘要翻译：对病毒有活性的化合物具有式（1）和（2），其中B是2-氨基嘌呤-9-基，其可以是未取代的或在6位被NHR1，OR2或SR3取代; R 1选自烷基，烯基，炔基和C 4-18环烷基，其中任何一个可以任选地被羟基，卤素，氨基，酰基，环烷基，杂环基和芳基中的一个或多个成员取代 ; R2选自C2-18烷基，烯基，炔基和环烷基，其中任何一个可以是支链或非支链的，并且任选被一个或多个由羟基，卤素，氨基，酰基，环烷基，杂环基和芳基; 并且R 3选自烷基，烯基，炔基和环烷基，其中任何一个可以是支链或非支链的，并且任选被一个或多个由羟基，卤素，氨基，酰基，环烷基，杂环基和芳基。

52. 发明申请

WO2004005260A1 A-`7-HALO-2-QUINO (XA-) LINYLOXY!PHENOXY-PROPIONIC ACID DERIVATIVES AS ANTINEOPLASTIC AGENTS 审中-公开
标题翻译： A-7-HALO-2-QUINO（XA-）LINYLOXY！作为抗肿瘤剂的苯甲酸衍生物
公开(公告)号：WO2004005260A1
公开(公告)日：2004-01-15
申请号：PCT/US2003/021062
申请日：2003-07-03
申请人： WAYNE STATE UNIVERSITY , HORWITZ, Jerome, P. , CORBETT, Thomas, H. , PALOMINO, Eduardo , POLIN, Lisa , HAZELDINE, Stuart, T.
发明人： HORWITZ, Jerome, P. , CORBETT, Thomas, H. , PALOMINO, Eduardo , POLIN, Lisa , HAZELDINE, Stuart, T.
IPC分类号： C07D215/22
CPC分类号： C07D215/227 , C07D241/44
摘要： The invention provides compounds of the formula (I): wherein A, X, Y, and Z are as defined in the specification. The compounds are effective anti-tumor agents. The invention also provides pharmaceutical compositions comprising a compound of the above formula or a salt thereof, intermediates useful for preparing a compound of the above formula, and therapeutic methods comprising administering a compound of the above formula or a salt thereof to a mammal in need thereof.
摘要翻译：本发明提供式（I）化合物：其中A，X，Y和Z如说明书中所定义。这些化合物是有效的抗肿瘤剂。本发明还提供了包含上式化合物或其盐的药物组合物，可用于制备上式化合物的中间体，以及包括将上式化合物或其盐施用于有需要的哺乳动物的治疗方法。

53. 发明申请

WO2004003511A2 METHODS AND COMPOSITIONS FOR THE IDENTIFICATION OF ANTIBIOTICS THAT ARE NOT SUSCEPTIBLE TO ANTIBIOTIC RESISTANCE 审中-公开
标题翻译：用于鉴定对抗生素抗性不敏感的抗生素的方法和组合物
公开(公告)号：WO2004003511A2
公开(公告)日：2004-01-08
申请号：PCT/US2003/020963
申请日：2003-07-01
申请人： WAYNE STATE UNIVERSITY , CUNNINGHAM, Phillip, R.
发明人： CUNNINGHAM, Phillip, R.
IPC分类号： G01N
CPC分类号： C12N15/70 , C12N15/1058 , C12N15/1086
摘要： Compositions and methods are provided to identify functional mutant ribosomes that may be used as drug targets. The compositions and methods allow isolation and analysis of mutations that would normally be lethal and allow direct selection of rRNA mutants with predetermined levels of ribosome function. The compositions and methods of the present invention may be used to identify antibiotics to treat a large number of human pathogens through the use of genetically engineered rRNA genes from a variety of species. The invention further provides novel plasmid constructs to be used in the methods of the invention.
摘要翻译：提供组合物和方法以鉴定可用作药物靶标的功能性突变核糖体。该组合物和方法允许分离和分析通常会致死的突变，并允许直接选择具有预定水平的核糖体功能的rRNA突变体。本发明的组合物和方法可用于鉴定通过使用来自多种物种的基因工程rRNA基因来治疗大量人类病原体的抗生素。本发明还提供了用于本发明方法的新型质粒构建体。

54. 发明申请

WO2003090347A3 ACOUSTIC WAVE SENSOR APPARATUS, METHOD AND SYSTEM USING WIDE BANDGAP MATERIALS 审中-公开
公开(公告)号：WO2003090347A3
公开(公告)日：2003-10-30
申请号：PCT/US2003/011773
申请日：2003-04-16
申请人： WAYNE STATE UNIVERSITY
发明人： AUNER, Gregory, W. , ZHONG, Feng , HUGHES, Chantelle , SHREVE, Gina , YING, Hao
IPC分类号： G01N29/02
摘要： An acoustic wave sensor (100a) to detect an analyte (103a), the sensor comprising a piezoelectric material including a wide bandgap semiconductor material grown using plasma source molecular beam epitaxy.

55. 发明申请

WO2003089626A1 TRANSGENIC SACCHAROMYCES CEREVISIAE AND METHOD FOR BIOREMEDIATION 审中-公开
标题翻译：转基因生物学和生物学方法
公开(公告)号：WO2003089626A1
公开(公告)日：2003-10-30
申请号：PCT/US2003/011673
申请日：2003-04-16
申请人： WAYNE STATE UNIVERSITY , ROSEN, Barry, P. , GHOSH, Mallika,
发明人： ROSEN, Barry, P. , GHOSH, Mallika,
IPC分类号： C12N1/19
CPC分类号： C02F3/34 , C02F2101/20 , C07K14/395 , C07K14/705 , C12N1/18 , C12N9/0004 , C12N15/81
摘要： A transgenic Saccharomyces cerevisiae yeast cell and methods of using the transgenic yeast cell for the removal of contaminants from water are provided.
摘要翻译：提供了转基因酿酒酵母酵母细胞和使用转基因酵母细胞从水中去除污染物的方法。

56. 发明申请

WO2003081894A3 AUGMENTED TRACKING USING VIDEO AND SENSING TECHNOLOGIES 审中-公开
公开(公告)号：WO2003081894A3
公开(公告)日：2003-10-02
申请号：PCT/US2003/008204
申请日：2003-03-18
申请人： WAYNE STATE UNIVERSITY
发明人： ZAMORANO, Lucia , PANDYA, Abhilash
IPC分类号： H04N5/225
摘要： A system for generating an augmented reality image comprises a video camera for obtaining video data and a sensor for obtaining sensed data. An augmented reality processor (180) is coupled to the video camera and to the sensor. The augmented reality processor (180) is configured to receive the video data from the video camera and to receive the sensed data from the sensor and to receive other types of computed data, such as any imaging modality. A display device (190) is coupled to the augmented reality processor (180). The augmented reality processor (180) is further configured to generate for display on the display device (190) a video image from the video data received from the video camera and to generate a corresponding data image from the sensed data received from the sensor or other computed data. The augmented reality processor (180) is further configured to merge the video image and the corresponding data image generated from computed data or sensed data so as to generate the augmented reality image. The system employs a tracking system that tracks the position of the video camera. The system may also employ a robotic positioning device (125) for positioning the video camera, and which may be coupled to the tracking system for providing precise position information.

57. 发明申请

WO2003081894A2 AUGMENTED TRACKING USING VIDEO AND SENSING TECHNOLOGIES 审中-公开
标题翻译：使用视频和感应技术的增强跟踪
公开(公告)号：WO2003081894A2
公开(公告)日：2003-10-02
申请号：PCT/US2003/008204
申请日：2003-03-18
申请人： WAYNE STATE UNIVERSITY
发明人： ZAMORANO, Lucia , PANDYA, Abhilash
IPC分类号： H04N
CPC分类号： A61B5/6835 , A61B5/00 , A61B5/04 , A61B5/064 , A61B5/14532 , A61B7/00 , A61B2090/365
摘要： A system for generating an augmented reality image comprises a video camera for obtaining video data and a sensor for obtaining sensed data. An augmented reality processor is coupled to the video camera and to the sensor. The augmented reality processor is configured to receive the video data from the video camera and to receive the sensed data from the sensor and to receive other types of computed data, such as any imaging modality. A display device is coupled to the augmented reality processor. The augmented reality processor is further configured to generate for display on the display device a video image from the video data received from the video camera and to generate a corresponding data image from the sensed data received from the sensor or other computed data. The augmented reality processor is further configured to merge the video image and the corresponding data image generated from computed data or sensed data so as to generate the augmented reality image. The system employs a tracking system that tracks the position of the video camera. The system may also employ a robotic positioning device for positioning the video camera, and which may be coupled to the tracking system for providing precise position information.
摘要翻译：用于产生增强现实图像的系统包括用于获得视频数据的摄像机和用于获得感测数据的传感器。增强现实处理器耦合到摄像机和传感器。增强现实处理器被配置为从摄像机接收视频数据并且从传感器接收感测的数据并且接收其他类型的计算数据，诸如任何成像模态。显示装置耦合到增强现实处理器。增强现实处理器还被配置为生成用于在显示设备上显示来自从摄像机接收的视频数据的视频图像，并且从从传感器接收的感测数据或其他计算数据生成相应的数据图像。增强现实处理器还被配置为合并视频图像和从计算数据或感测数据生成的对应数据图像，以便生成增强现实图像。该系统采用跟踪摄像机位置的跟踪系统。该系统还可以使用用于定位摄像机的机器人定位装置，并且其可以耦合到跟踪系统以提供精确的位置信息。

58. 发明申请

WO2003079971A3 QUANTUM DYNAMIC DISCRIMINATOR FOR MOLECULAR AGENTS 审中-公开
公开(公告)号：WO2003079971A3
公开(公告)日：2003-10-02
申请号：PCT/US2002/040574
申请日：2002-12-18
申请人： TRUSTEES OF PRINCETON UNIVERSITY , WAYNE STATE UNIVERSITY
发明人： HERSCHEL, Rabitz , SCHREIBER, Elmar , LEVIS, Robert, J.
IPC分类号： C12Q1/68
摘要： The disclosed invention (fig. 5.2) is related to the field of quantum dynamic discriminators, sample identification systems, mass spectrometers and methods for identifying a component in a composition. Also disclosed are quantum dynamic discriminators and methods for ascertaining the quantum dynamic states of a component in a composition. Optimal identification devices and methods for ascertaining quantum Hamiltonians of quantum systems are further disclosed.

59. 发明申请

WO2003016879A2 HAND-HELD SOUND SOURCE GUN FOR INFRARED IMAGING OF SUB-SURFACE DEFECTS IN MATERIALS 审中-公开
标题翻译：手持声源枪用于材料中次表面缺陷的红外成像
公开(公告)号：WO2003016879A2
公开(公告)日：2003-02-27
申请号：PCT/US2002/007027
申请日：2002-03-08
申请人： WAYNE STATE UNIVERSITY , THOMAS, Robert, L. , FAVRO, Lawrence, D. , HAN, Xiaoyan
发明人： THOMAS, Robert, L. , FAVRO, Lawrence, D. , HAN, Xiaoyan
IPC分类号： G01N21/00
CPC分类号： G01N29/449 , G01N25/72 , G01N29/223 , G01N29/228 , G01N29/2412 , G01N29/2437 , G01N29/2462 , G01N29/28 , G01N29/346 , G01N29/348 , G01N29/46 , G01N2291/02483 , G01N2291/02881 , G01N2291/0289 , G01N2291/101 , G01N2291/2638 , G01N2291/2694
摘要： A system (10) for the thermal imaging of sonically or ultrasonically excited subsurface defects in a structure (12). The system (10) includes a hand-held sound source gun (70), a thermal imaging camera (22) and a control unit (30). The sound source gun (70) emits pulses of sound energy into the structure (12), and the camera (22)generates images of defects in the structure (12) that are heated by the sound energy. The control unit (30) controls the operation of the sound source gun (70) and the camera (22) for timing purposes. The sound source gun (70)includes a transducer (74) that is positioned against the structure (12) at a desirable location. The gun (70) further includes a pair of legs (82, 84) that are also positioned against the structure (12) to define a plane in combination with the transducer (74). The length of each leg (82, 84) is adjustable relative to the length of the transducer (74) so that the gun (70) can be used against irregular surfaces. The legs (82, 84) include a rubber tip 886,88) to further prevent the transducer (74) from slipping on the structure (12). In an alternate embodiment, the gun (110) includes three transducers (114, 116, 118) that define a plane that act to stabilize the gun (110) against movement.
摘要翻译：一种用于结构（12）中的声学或超声激励表面缺陷的热成像的系统（10）。系统（10）包括手持式声源枪（70），热成像相机（22）和控制单元（30）。声源枪（70）将声能脉冲发射到结构（12）中，并且相机（22）产生由声能加热的结构（12）中的缺陷图像。为了定时目的，控制单元（30）控制声源枪（70）和相机（22）的操作。声源枪（70）包括换能器（74），该换能器在期望的位置处抵靠结构（12）定位。枪（70）还包括一对腿（82,84），其也抵靠结构（12）定位以限定与换能器（74）组合的平面。每个腿（82,84）的长度相对于换能器（74）的长度是可调整的，使得枪（70）可用于抵抗不规则表面。腿（82,84）包括橡胶尖端886,88）以进一步防止换能器（74）在结构（12）上滑动。在一个替代实施例中，枪（110）包括三个换能器（114,116,118），这三个换能器限定了用于稳定枪（110）防止移动的平面。

60. 发明申请

WO2002077165A3 GLYCOCONJUGATE SYNTHESIS USING A PATHWAY-ENGINEERED ORGANISM 审中-公开
公开(公告)号：WO2002077165A3
公开(公告)日：2002-10-03
申请号：PCT/US2002/000819
申请日：2002-01-10
申请人： WAYNE STATE UNIVERSITY
发明人： WANG, Peng, George , CHEN,Xi , LIU, Zye , ZHANG, Wei
IPC分类号： C12N9/00
摘要： This invention relates to methods and compositions of the production of glycoconjugates. In particular, organisms are provided with at least one heterologous gene encoding an enzyme for regenerating a sugar nucleotide along with at least one glycosyltransterase. Such organisms are useful for the large-scale synthesis of glycoconjugates.

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