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51. 发明申请

WO1995026956A1 OXIME DERIVATIVE AND BACTERICIDE CONTAINING THE SAME AS ACTIVE INGREDIENT 审中-公开
标题翻译：含有活性成分的OXIME衍生物和杀菌剂
公开(公告)号：WO1995026956A1
公开(公告)日：1995-10-12
申请号：PCT/JP1995000604
申请日：1995-03-30
申请人： SHIONOGI & CO., LTD. , TAKASE, Akira , KAI, Hiroyuki , NISHIDA, Kuniyoshi , IWAKAWA, Tsuneo , UEDA, Kazuo , MASUKO, Michio
发明人： SHIONOGI & CO., LTD.
IPC分类号： C07D231/12
CPC分类号： C07D231/06 , A01N43/50 , C07D231/12 , C07D233/64 , C07D249/08 , C07D257/04 , C07D261/08 , C07D263/10 , C07D263/32 , C07D271/06 , C07D271/10 , C07D277/10 , C07D285/06
摘要： A compound represented by general formula (I) or a salt thereof, a process for producing the same, an intermediate for the production thereof, and a bactericide containing the same as the active ingredient wherein R represents optionally substituted aryl, optionally substituted heterocycle, mono- or di-substituted methyleneamino, optionally substituted (substituted imino)methyl, optionally substituted alkyl, optionally substituted alkenyl, optionally substituted alkynyl, substituted carbonyl or substituted sulfonyl; R represents alkyl, alkenyl, alkynyl or cycloalkyl; R represents optionally substituted heterocycle; R represents hydrogen, alkyl, alkoxy, halogen, nitro, cyano or haloalkyl; M represents oxygen, S(O)i (i being 0, 1 or 2), NR (R being hydrogen, alkyl or acyl) or a single bond; n represents 0 or 1, provided n represents 1 when R represents imidazol-1-yl or 1H-1, 2, 4-triazol-1-yl; and the symbol SIMILAR represents the E form, Z form or a mixture thereof.
摘要翻译：由通式（I）表示的化合物或其盐，其制备方法，其制备中间体和含有该活性成分的杀菌剂，其中R 1表示任选取代的芳基，任选取代的取代的亚氨基甲基，任选取代的烷基，任选取代的烯基，任选取代的炔基，取代的羰基或取代的磺酰基; R 2表示烷基，烯基，炔基或环烷基; R 3表示任选取代的杂环; R 4表示氢，烷基，烷氧基，卤素，硝基，氰基或卤代烷基; M表示氧，S（O）i（i为0,1或2），NR 16（R 16为氢，烷基或酰基）或单键; 当R 3表示咪唑-1-基或1H-1,2,4-三唑-1-基时，n表示0或1，条件是n表示1。并且符号SIMILAR表示E形式，Z形式或其混合物。

52. 发明申请

WO1995021856A1 CARBAMOYLMETHYLUREA DERIVATIVE 审中-公开
标题翻译：羧甲基衍生物
公开(公告)号：WO1995021856A1
公开(公告)日：1995-08-17
申请号：PCT/JP1995000161
申请日：1995-02-07
申请人： SHIONOGI & CO., LTD. , HAGISHITA, Sanji , KAMATA, Susumu , MURAKAMI, Yasushi , HAGA, Nobuhiro , ISHIHARA, Yasunobu , KONOIKE, Toshiro
发明人： SHIONOGI & CO., LTD.
IPC分类号： C07K05/062
CPC分类号： C07K5/0606 , A61K38/00 , C07C275/28 , C07K5/06026 , C07K5/06139
摘要： A compound represented by general formula (I) or a pharmaceutically acceptable salt thereof, having a strong affinity for gastrin receptors and/or CCK-B receptors but not for CCK-A receptors and hence being useful for curing diseases related to gastrin receptors and/or CCK-B receptors without inducing side effect related to CCK-A receptors, wherein R1 represents hydrogen or lower alkyl; R2 represents lower alkoxy, lower alkylamino, lower cycloalkyl, optionally substituted phenyl or optionally substituted heterocycle; R3 represents optionally substituted phenyl; and R4 represents optionally substituted phenyl, optionally substituted cycloalkyl, optionally substituted alkyl or optionally substituted heterocycle.
摘要翻译：由通式（I）表示的化合物或其药学上可接受的盐对胃泌素受体和/或CCK-B受体具有强亲和力，但不对CCK-A受体具有强亲和力，因此可用于治疗与胃泌素受体有关的疾病和/ 或CCK-B受体，而不诱导与CCK-A受体相关的副作用，其中R1表示氢或低级烷基; R 2表示低级烷氧基，低级烷基氨基，低级环烷基，任选取代的苯基或任选取代的杂环; R3表示任选取代的苯基; 和R 4表示任选取代的苯基，任选取代的环烷基，任选取代的烷基或任选取代的杂环。

53. 发明申请

WO1995009160A1 BENZOLACTAM DERIVATIVE 审中-公开
标题翻译：苯并咪唑衍生物
公开(公告)号：WO1995009160A1
公开(公告)日：1995-04-06
申请号：PCT/JP1994001561
申请日：1994-09-22
申请人： SHIONOGI & CO., LTD. , SHUDO, Koichi , ENDO, Yasuyuki , FUJIWARA, Tamio , SATO, Akihiko
发明人： SHIONOGI & CO., LTD.
IPC分类号： C07D245/06
CPC分类号： C07D245/06
摘要： A benzolactam derivative represented by general formula (I) and an antiretroviral drug containing the same as the active ingredient, wherein n represents an integer of 1 to 3; R represents linear or branched alkyl, or aralkyl; R represents linear or branched alkyl; and R and R represent each independently hydrogen or linear or branched alkyl, provided when R and R are bonded respectively to the adjacent carbon atoms of the benzene ring, they may be combined together with the ring carbon atoms to form a cycloalkane ring which may be substituted.
摘要翻译：由通式（I）表示的苯并内酰胺衍生物和含有与活性成分相同的抗逆转录病毒药物，其中n表示1〜3的整数， R 1表示直链或支链烷基或芳烷基; R 2表示直链或支链烷基; 当R 3和R 4分别与苯环的相邻碳原子键合时，R 3和R 4各自独立地表示氢或直链或支链烷基，它们可以与环碳原子形成可被取代的环烷烃环。

54. 发明申请

WO1994024087A1 PROCESS FOR PRODUCING LIGNAN COMPOUND 审中-公开
标题翻译：生产LIGNAN化合物的方法
公开(公告)号：WO1994024087A1
公开(公告)日：1994-10-27
申请号：PCT/JP1994000612
申请日：1994-04-12
申请人： SHIONOGI & CO., LTD. , MORI, Sachio , TAKECHI, Shozo , KIDA, Shiro
发明人： SHIONOGI & CO., LTD.
IPC分类号： C07C69/94
CPC分类号： C07C69/94
摘要： A process for regioselectively producing a lignan compound of general formula (I) by reacting a lactone compound of general formula (II) with a compound of the formula: R Cl (R being a tri(lower alkyl)silyl group) in the presence of a base, effecting the addition reaction of an acetylene compound of general formula (III) with the resultant compound, and reducing the product. In said formulas R represents alkyl, cycloalkyl, cycloalkyl-lower alkyl, aralkyl, etc.; R and R each represent lower alkoxy, etc.; R represents lower alkoxy or hydrogen; and R and R each represent lower alkyl.
摘要翻译：一种通过使通式（II）的内酯化合物与下式化合物反应来区域选择性地制备通式（I）的木酚素化合物的方法：R 7 Cl（R 7是三（低级烷基）甲硅烷基基团），进行通式（III）的乙炔化合物与所得化合物的加成反应，还原产物。在所述式中，R 1表示烷基，环烷基，环烷基 - 低级烷基，芳烷基等; R 2和R 3各自表示低级烷氧基等; R 4表示低级烷氧基或氢; R 5和R 6各自表示低级烷基。

55. 发明申请

WO1991013869A1 15-DEOXYPROSTAGLANDIN DERIVATIVE 审中-公开
标题翻译： 15-DEOXYPROSTAGLANDIN衍生物
公开(公告)号：WO1991013869A1
公开(公告)日：1991-09-19
申请号：PCT/JP1991000305
申请日：1991-03-07
申请人： SHIONOGI & CO., LTD. , KISHI, Morio , TAKAHASHI, Kimio , KAWADA, Kenji , GOH, Yasumasa
发明人： SHIONOGI & CO., LTD.
IPC分类号： C07C405/00
CPC分类号： C07C405/00
摘要： A 15-deoxyprostaglandin derivative of general formula (I) and an intraocular pressure depressant containing said derivative or a pharmaceutically acceptable salt thereof as the active ingredient . In formula (I), (a) is a five-membered ring selected from among (b), (c), (d), (e), (f); R1 represents hydrogen or lower alkyl; and R2 represents C¿6? to C12 alkyl, C6 to C12 alkenyl or C6 to C12 alkadienyl, provided that a compound of formula (II) (wherein R' represents H or CH3) is excluded.

56. 发明申请

WO1998025900A1 COMPOUNDS HAVING ANTITUMOR ACTIVITY 审中-公开
标题翻译：具有抗肿瘤活性的化合物
公开(公告)号：WO1998025900A1
公开(公告)日：1998-06-18
申请号：PCT/JP1997004574
申请日：1997-12-12
申请人： SHIONOGI & CO., LTD. , RESEARCH FOUNDATION ITSUU LABORATORY , NATSUME, Mitsutaka , UTSUNOMIYA, Iwao , MURATAKE, Hideaki
发明人： SHIONOGI & CO., LTD. , RESEARCH FOUNDATION ITSUU LABORATORY
IPC分类号： C07D209/94
CPC分类号： C07D403/06 , A61K31/404 , C07D209/96 , C07D405/06 , C07D409/06 , C07D495/10
摘要： Compounds which have potent cytostatic activity and also excellent specificity for tumor cells and are represented by general formula (I), wherein one of R and R represents methyloxy and the other represents a substituted alkyloxy or an optionally subsituted amino, optically active isomers thereof, pharmacologically acceptable salts thereof, or hydrates thereof.
摘要翻译：具有有效细胞抑制活性并且对肿瘤细胞具有优异特异性并由通式（I）表示的化合物，其中R 2和R 3之一表示甲氧基，另一个表示取代的烷氧基或任选取代的氨基，其光学活性异构体，其药理学上可接受的盐或其水合物。

57. 发明申请

WO1998018760A1 GLUTAMATE RELEASE INHIBITOR AND NOVEL COMPOUNDS 审中-公开
标题翻译：谷氨酸释放抑制剂和新化合物
公开(公告)号：WO1998018760A1
公开(公告)日：1998-05-07
申请号：PCT/JP1997003884
申请日：1997-10-27
申请人： SHIONOGI & CO., LTD. , OSHIMA, Takeo , KAMIGAUCHI, Toshiyuki , FUKUI, Yoshikazu
发明人： SHIONOGI & CO., LTD.
IPC分类号： C07D207/333
CPC分类号： C07D207/333 , C07D207/34 , C07D213/50 , C07D307/46 , C07D333/22
摘要： Compounds having a glutamate release inhibitory activity and not having the function of conventionally known sodium channel blockers and calcium channel blockers at all. The compounds are aromatic ketone derivatives represented by general formula (I), pharmacologically acceptable salts thereof, or hydrates of the salts.
摘要翻译：具有谷氨酸释放抑制活性并且根本不具有常规已知的钠通道阻断剂和钙通道阻断剂的功能的化合物。该化合物是由通式（I）表示的芳族酮衍生物，其药学上可接受的盐或其盐的水合物。

58. 发明申请

WO1998016517A1 PROCESS FOR PRODUCING ISOXAZOLE DERIVATIVES AND INTERMEDIATES FOR PRODUCING THE SAME 审中-公开
标题翻译：用于生产异噻唑衍生物的方法和用于生产异噻唑衍生物的中间体
公开(公告)号：WO1998016517A1
公开(公告)日：1998-04-23
申请号：PCT/JP1997003584
申请日：1997-10-07
申请人： SHIONOGI & CO., LTD. , KAI, Hiroyuki , TAKASE, Akira , TOMIDA, Minoru
发明人： SHIONOGI & CO., LTD.
IPC分类号： C07D261/08
CPC分类号： C07C251/36 , C07D261/08
摘要： A process for producing compounds represented by general formula (I) (wherein R and R represent each hydrogen, alkyl, alkoxy, halogeno or -(CH2)n-M-R (wherein R represents optionally substituted aryl, etc.; M represents oxygen, etc.; and n is 0 or 1)), characterized by reacting a compound represented by general formula (II) (wherein R and R are as defined above) with acetylene under basic conditions; and a process for producing compounds represented by general formula (VII) which are useful as agricultural germicides from the compounds represented by general formulae (I) and (II) as given above.
摘要翻译：一种制备由通式（I）表示的化合物的方法（其中R 1和R 2代表各自的氢，烷基，烷氧基，卤代或 - （CH 2）nMR 3（其中R 3表示任选取代的芳基等; M表示氧等，n为0或1）），其特征在于使通式（II）表示的化合物（其中R 1和R 2如上定义）与通式乙炔在碱性条件下; 以及由通式（Ⅶ）表示的化合物的制备方法，其由上述通式（I）和（II）表示的化合物可用作农业杀菌剂。

59. 发明申请

WO1998016499A1 OXIME DERIVATIVES, HYDRAZONE DERIVATIVES, AND USE THEREOF 审中-公开
标题翻译： OXIME衍生物，HYDRAZONE衍生物及其用途
公开(公告)号：WO1998016499A1
公开(公告)日：1998-04-23
申请号：PCT/JP1997003585
申请日：1997-10-07
申请人： SHIONOGI & CO., LTD. , MASUI, Moriyasu , TANIMOTO, Norihiko , NISHIDA, Kuniyoshi
发明人： SHIONOGI & CO., LTD.
IPC分类号： C07C251/36
CPC分类号： C07D213/30 , A01N37/50 , A01N41/06 , A01N41/10 , A01N43/40 , A01N43/46 , A01N43/80 , A01N47/16 , C07C251/36 , C07C251/48 , C07C251/52 , C07C251/54 , C07C251/74 , C07C259/06 , C07D207/12 , C07D211/42 , C07D211/46 , C07D211/58 , C07D211/72 , C07D243/08 , C07D261/02 , C07D295/185 , C07D295/26 , C07D333/16 , C07D401/12
摘要： Compounds having bactericidal activities and represented by general formula (I) and salts and hydrates thereof wherein R represents an optionally substituted aryl, an optionally substituted alkyl or the like; R represents an optionally substituted alkyl, an optionally substituted alkenyl, an optionally substituted alkynyl, an optionally substituted aryl, an optionally substituted heterocyclic group or the like; R represents an optionally substituted alkyl, an optionally substituted alkenyl, an optionally substituted alkynyl, an optionally substituted arylsulfonyl, an optionally substituted heterocyclic group or the like; R and R , which may be the same or different, represent each a hydrogen atom, an optionally substituted alkyl, or an optionally substituted alkoxy, or R and R may form together with the adjacent nitrogen atom an optionally substituted monocycle or polycycle; X and Y, which may be the same or different, represents each an oxygen atom or NR (wherein R represents a hydrogen atom, an optionally substituted alkyl, an optionally substituted aryl, an optionally substituted alkanoyl, or an optionally substituted aroyl); Z represents an oxygen atom or a sulfur atom; and a wavy line ( SIMILAR ) represents the configuration of an E isomer, a Z isomer, or a mixture thereof.
摘要翻译：具有杀菌活性并由通式（I）表示的化合物及其盐和水合物，其中R 1表示任选取代的芳基，任选取代的烷基等; R 2表示任选取代的烷基，任选取代的烯基，任选取代的炔基，任选取代的芳基，任选取代的杂环基等; R 3表示任选取代的烷基，任选取代的烯基，任选取代的炔基，任选取代的芳基磺酰基，任选取代的杂环基等; R 4和R 5可以相同或不同，表示氢原子，任选取代的烷基或任选取代的烷氧基，或者R 4和R 5可以与相邻氮原子，任选取代的单环或多环; X和Y可以相同或不同，表示每个氧原子或NR 6（其中R 6表示氢原子，任选取代的烷基，任选取代的芳基，任选取代的烷酰基或任选取代的芳酰基）; Z表示氧原子或硫原子; 和波浪线（SIMILAR）表示E异构体，Z异构体或其混合物的构型。

60. 发明申请

WO1998016245A1 METHOD OF AUTOANTIBODY ASSAY 审中-公开
标题翻译：自动识别方法
公开(公告)号：WO1998016245A1
公开(公告)日：1998-04-23
申请号：PCT/JP1997001259
申请日：1997-04-11
申请人： SHIONOGI & CO., LTD. , TAMINATO, Tomohiko
发明人： SHIONOGI & CO., LTD.
IPC分类号： A61K39/00
CPC分类号： C07K14/70596 , A61K38/00 , G01N33/564 , G01N2333/705
摘要： A method of assaying an anti-CD38 autoantibody with CD38 peptide fragments, which makes it possible to diagnose diabetes before onset or at an early stage; a CD38 peptide, its fragments, and its variants; products of chemical modification thereof; products of genetic engineering operations thereof; medicinal compositions prepared by using the same for curing autoimmune diseases, especially insulitis and diabetes; and a perorally administrable remedial composition prepared by using the same.
摘要翻译：用CD38肽片段测定抗CD38自身抗体的方法，这使得可以在发病前或早期阶段诊断糖尿病; CD38肽，其片段及其变体; 其化学改性产品; 产品的基因工程操作; 通过使用它来治疗自身免疫性疾病，特别是胰岛炎和糖尿病的药物组合物; 以及通过使用其制备的经口给药的补救组合物。

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